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1. Cerrillo M, Herrero L, Guillén A, Mayoral M, García-Velasco JA: Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates. Rambam Maimonides Med J; 2017 Apr 28;8(2)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: It has been reported that a natural cycle (NC) is similar to or even better than hormone replacement therapy (HRT) in patients with regular cycles who undergo frozen embryo transfer (FET).
  • METHODS: Hence we carried out a prospective study between June 2011 and June 2012, which included 530 patients (570 FET cycles) randomly allocated to two study groups: Group 1 (n=280 cycles), artificial cycle (HRT); or group 2 (n=290 cycles), natural cycle.
  • Natural cycles were later divided into two groups: 169 patients scheduled with human chorionic gonadotropin (hCG) and 121 with endogenous luteinizing hormone (LH) surge.
  • The exclusion criteria were polycystic ovarian syndrome and endometriosis stage III/IV.
  • RESULTS: No statistical differences were found in the baseline characteristics among groups, nor between implantation or ongoing pregnancy rates (30.8% HRT group; 32.7% hCG group; 34.5% LH surge group).
  • However, a higher miscarriage rate was observed in the HRT group when compared to hCG or LH surge (21.2% versus 12.9% versus 11.1%, P<0.01).
  • CONCLUSIONS: We conclude that scheduling FET with HRT on weekdays and avoiding work overload at weekends prove efficient and safe in cycle outcome terms.
  • Another reason for the convenience of an HRT protocol is having fewer visits to the clinic compared to natural cycle protocols.

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  • (PMID = 28467767.001).
  • [Journal-full-title] Rambam Maimonides medical journal
  • [ISO-abbreviation] Rambam Maimonides Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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2. Patel BP, Kumar A: Biodegradation of 4-chlorophenol in an airlift inner loop bioreactor with mixed consortium: effect of HRT, loading rate and biogenic substrate. 3 Biotech; 2016 Dec;6(2):117
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biodegradation of 4-chlorophenol in an airlift inner loop bioreactor with mixed consortium: effect of HRT, loading rate and biogenic substrate.
  • During the study, the effect of various reactor parameters such as hydraulic retention time (HRT), biogenetic substrate concentration, loading rate, and initial substrate concentration on the removal efficiency of 4-CP was investigated.
  • Bioreactor showed a maximum removal rate of 16.59 mg/L/h at the optimum conditions of 24 h HRT, 400 mg/L initial 4-CP, and 0.2 g/L peptone.
  • The optimum HRT found was 24 h after that the washout occured, and the degradation efficiency almost dropped to 50 % at 18 h HRT.

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  • (PMID = 28330191.001).
  • [ISSN] 2190-572X
  • [Journal-full-title] 3 Biotech
  • [ISO-abbreviation] 3 Biotech
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; 4-chlorophenol / Airlift reactor / Biodegradation / Biogenic substrate / Wastewater
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3. Wang S, Wang Y, Xu J, Chen Y: Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. Medicine (Baltimore); 2017 Apr;96(14):e6556

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis.
  • BACKGROUND: Association between exogenous estrogen intake and cholelithiasis risk has been reported in several epidemiological studies, including oral contraceptive (OC) and hormone replacement therapy (HRT), while the results were controversial.
  • However, the pooled RR of OC intake and cholelithiasis risk was 1.19 (95% CI: 0.97-1.45), and the RR for HRT was 1.79 (95% CI: 1.61-2.00).
  • CONCLUSION: The HRT was positively associated with the cholelithiasis risk, and the OC will not increase the risk of cholelithiasis.
  • [MeSH-major] Contraceptives, Oral, Hormonal / adverse effects. Estrogen Replacement Therapy / adverse effects. Estrogens / adverse effects. Gallstones / chemically induced

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  • (PMID = 28383429.001).
  • [ISSN] 1536-5964
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / Estrogens
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4. Griffiths F: Women's control and choice regarding HRT. Soc Sci Med; 1999 Aug;49(4):469-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Women's control and choice regarding HRT.
  • The promotion and use of hormone replacement therapy (HRT) is the focus of much medical activity and a social phenomenon studied by sociology.
  • The decision to prescribe HRT by a doctor may be a response to a woman's distress and is a decision involving uncertainty about risks and benefits.
  • Sociological analysis has seen the promotion and use of HRT as medicalisation of the menopause.
  • Through individual interviews and focus groups, this study hears from women how they approach the decision to take HRT or not, and what influences them.
  • The interviews reveal how women who dislike medication in general may consider HRT, influenced by fear of ill health which may be enhanced by the experience of illness in the family and by medical advice.
  • For the women the media and their social contacts were the major sources of information about HRT.
  • In the focus groups the women explored the control they had over the choice to take HRT and what limited this control and they explored the uncertainties and complexities of the decision to take HRT or not.
  • This study brings lay women's voices to the debate about the use and promotion of HRT.
  • The results are also used to test the limits of the theory of medicalisation and to inform doctors of the issues women may bring to a consultation about HRT.
  • [MeSH-major] Attitude to Health. Decision Making. Estrogen Replacement Therapy / psychology. Patient Participation

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  • (PMID = 10414807.001).
  • [ISSN] 0277-9536
  • [Journal-full-title] Social science & medicine (1982)
  • [ISO-abbreviation] Soc Sci Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
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5. Mkanya A, Pellicane G, Pini D, Caccamo C: Theory and computer simulation of hard-core Yukawa mixtures: thermodynamical, structural and phase coexistence properties. J Phys Condens Matter; 2017 Jun 29;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report extensive calculations, based on the modified hypernetted chain (MHNC) theory, on the hierarchical reference theory (HRT), and on Monte Carlo simulations, of thermodynamical, structural and phase coexistence properties of symmetric binary hard-core Yukawa mixtures (HCYM) with attractive interactions at equal species concentration.
  • &#13; The HRT is equally accurate for thermodynamics, and slightly less accurate for structure.
  • Liquid-vapor (LV) and liquid-liquid (LL) consolute coexistence conditions as emerging from simulations, are also highly satisfactorily reproduced by both the MHNC and HRT for relatively long ranged potentials.
  • The HRT also predicts with good accuracy the CEP position.

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  • [Copyright] © 2017 IOP Publishing Ltd.
  • (PMID = 28661404.001).
  • [ISSN] 1361-648X
  • [Journal-full-title] Journal of physics. Condensed matter : an Institute of Physics journal
  • [ISO-abbreviation] J Phys Condens Matter
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; binary mixtures / hard-core Yukawa / theory and computer simulation
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6. Sismondi P, Biglia N, Giai M, Ponzone R, Roagna R, Sgro L, Campagnoli C: HRT, breast and endometrial cancers: strategies and intervention options. Maturitas; 1999 Aug 16;32(3):131-9
MedlinePlus Health Information. consumer health - Hormone Replacement Therapy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HRT, breast and endometrial cancers: strategies and intervention options.
  • The demand for hormone replacement therapy (HRT) by women who enter the menopause is rapidly increasing in all developed countries.
  • The concern that HRT may enhance morbidity and mortality from malignant diseases still limits the widespread adoption of hormonal treatments.
  • Overall, epidemiological data on cancer incidence and HRT are reassuring, although long-term or inappropriate therapies may slightly increase the risk of developing malignant diseases.
  • Many commercial hormonal compounds are currently available and the safest HRT regimen with regard to cancer risk must be identified.
  • It is equally important that the best strategies for breast and endometrial surveillance in women commencing HRT be outlined, bearing in mind that the diffusion of hormonal therapies may be halted by unnecessary medical interventions.
  • [MeSH-major] Breast Neoplasms / chemically induced. Endometrial Neoplasms / chemically induced. Hormone Replacement Therapy / adverse effects

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  • (PMID = 10515669.001).
  • [ISSN] 0378-5122
  • [Journal-full-title] Maturitas
  • [ISO-abbreviation] Maturitas
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] IRELAND
  • [Number-of-references] 33
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7. Szeto DP, Griffin KJ, Kimelman D: HrT is required for cardiovascular development in zebrafish. Development; 2002 Nov;129(21):5093-101
ZFIN. ZFIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HrT is required for cardiovascular development in zebrafish.
  • The recently identified zebrafish T-box gene hrT is expressed in the developing heart and in the endothelial cells forming the dorsal aorta.
  • Orthologs of hrT are expressed in cardiovascular cells from Drosophila to mouse, suggesting that the function of hrT is evolutionarily conserved.
  • The role of hrT in cardiovascular development, however, has not thus far been determined in any animal model.
  • Using morpholino antisense oligonucleotides, we show that zebrafish embryos lacking hrT function have dysmorphic hearts and an absence of blood circulation.
  • Although the early events in heart formation were normal in hrT morphant embryos, subsequently the hearts failed to undergo looping, and late onset defects in chamber morphology and gene expression were observed.
  • In particular, we found that the loss of hrT function led to a dramatic upregulation of tbx5, a gene required for normal heart morphogenesis.
  • Conversely, we show that overexpression of hrT causes a significant downregulation of tbx5, indicating that one key role of hrT is to regulate the levels of tbx5.
  • Secondly, we found that HrT is required to inhibit the expression of the blood lineage markers gata1 and gata2 in the most posterior lateral plate mesoderm.
  • Finally, we show that HrT is required for vasculogenesis in the trunk, leading to similar vascular defects to those observed in midline mutants such as floating head. hrT expression in the vascular progenitors depends upon midline mesoderm, indicating that this expression is one important component of the response to a midline-derived signal during vascular morphogenesis.
  • [MeSH-minor] Animals. Gene Expression Regulation, Developmental. Heart Defects, Congenital / embryology. Heart Defects, Congenital / genetics. Hematopoiesis / genetics. Hematopoiesis / physiology. Homeodomain Proteins / genetics. Homeodomain Proteins / physiology. Humans. In Situ Hybridization. Mice. Mutation. Oligodeoxyribonucleotides, Antisense / genetics. Oligodeoxyribonucleotides, Antisense / pharmacology. Recombinant Fusion Proteins / genetics. Transcription Factors / genetics. Transcription Factors / physiology

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  • (PMID = 12397116.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / F32 HD08725; United States / PHS HHS / / T32 07312
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Oligodeoxyribonucleotides, Antisense; 0 / Recombinant Fusion Proteins; 0 / T-Box Domain Proteins; 0 / T-box transcription factor 5; 0 / TBX20 protein, human; 0 / Tbx20 protein, mouse; 0 / Transcription Factors; 0 / Zebrafish Proteins; 0 / flh protein, zebrafish; 0 / tbx20 protein, zebrafish
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8. Maslin JS, Mansouri K, Dorairaj SK: HRT for the Diagnosis and Detection of Glaucoma Progression. Open Ophthalmol J; 2015;9:58-67

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HRT for the Diagnosis and Detection of Glaucoma Progression.
  • Confocal scanning laser ophthalmoscopy through the Heidelberg Retina Tomograph (HRT) provides a rapid, safe, noncontact, and noninvasive imaging of the optic disc in three-dimensions, and provides precise detailed information about the optic disc beyond that which the clinical exam can measure.
  • The HRT I was developed for research purposes only and was not used clinically.
  • The HRT II was developed to be user-friendly, more rapid, and was used as an adjunct to clinical examination in the detection and progression of glaucoma.
  • One of the main pitfalls of the HRT II was that it was operator-dependent.
  • The HRT III was developed to be operator-independent.
  • Numerous studies have compared these two methods of analysis, with the conclusion that the Glaucoma Probability Score provides a higher sensitivity and a lower specificity than the Moorsfield Regression Analysis, which may indicate that it has potential as a screening test for glaucoma.
  • However, there is no consensus on the use of the Glaucoma Probability Score as a screening test for glaucoma.
  • While HRT data may be useful as a clinical adjunct in the screening and diagnosis of glaucoma, it should ultimately only be used to support clinical examination.

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  • (PMID = 26069518.001).
  • [ISSN] 1874-3641
  • [Journal-full-title] The open ophthalmology journal
  • [ISO-abbreviation] Open Ophthalmol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4460217
  • [Keywords] NOTNLM ; Glaucoma / Heidelberg retina tomograph / retinal nerve fiber layer / topographic change analysis
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9. Koch EC, Plange N, Fuest M, Schimitzek H, Kuerten D: [Diagnostic Precision of the Confocal Scanning Laser Ophthalmoscopy in the Large Optic Disc with Physiological Excavation - a Long-Term Study]. Klin Monbl Augenheilkd; 2017 Jul 06;

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We repeatedly examined 17 subjects with presumed bilateral physiological excavation labeled as pathological and/or borderline via HRT to verify the diagnosis of physiological cupping or to monitor the long-term progression into normal tension glaucoma.
  • All subjects underwent regular detailed ophthalmologic examinations, including intraocular pressure measurement via Goldmann applanation tonometry (GAT), retinal nerve fiber layer imaging via optical coherence tonometry (OCT) and visual field testing and optic disc imaging using the HRT.
  • Glaucomatous progression was identified using the HRT's tools (stereometric trend analysis [STA] and topographic change analysis [TCA]).
  • <b>Results</b> In the initial examination, all 17 subjects were classified as "pathological", by the HRT's Moorfield's Regression Analysis (MRA).
  • In 5 out of these 16 subjects, progressive changes of the optic disc could be recorded via HRT.
  • Therefore, the diagnostic precision of the HRT measurements seems to be limited in patients with large discs and physiological cupping.
  • Diese Probanden waren in einer initialen Messung pathologisch oder grenzwertig durch den Heidelberg Retina Tomograph (HRT, Softwareversion 3.0) gewertet worden.
  • <b>Probanden und Methoden</b> 17 Probanden einer initialen Studie zum HRT konnten für diese Langzeituntersuchung rekrutiert werden.
  • In den regelmäßigen Untersuchungen wurden der intraokulare Druck mittels Goldmann-Applanationstonometrie (GAT) und die retinale Nervenfaserschichtdicke mittels optischer Kohärenztomografie (OCT) gemessen sowie Gesichtsfelduntersuchungen und wiederholte HRT-Messungen durchgeführt.
  • Eine Veränderung der Papillenexkavation wurde mittels der im HRT enthaltenen Analyseverfahren (Stereometric Trend Analysis [STA] und Topographic Change Analysis [TCA]) untersucht.
  • <b>Ergebnisse</b> In der Moorfields Regression Analysis (MRA) waren alle 17 Probanden in einer initialen HRT-Messung als „pathologisch“ bzw.
  • Bei 5 weiteren Probanden zeigten die HRT-Messungen eine statistisch signifikante Progression, ohne dass Veränderungen des Gesichtsfelds gefunden werden konnten.

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  • [Copyright] Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 28683479.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblatter fur Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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10. Basham MM, Bryan T: Postmenopausal pregnancy? Evaluation of elevated hCG in a 59-year-old woman. BMJ Case Rep; 2017 Jun 05;2017

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Stable serum hCG levels, elevated follicle-stimulating hormone and negative transvaginal ultrasound ruled out both malignancy and pregnancy.
  • Positive serum pregnancy test and hCG elevation was attributed to normal postmenopausal state.

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  • [Copyright] © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
  • (PMID = 28583921.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; General practice / family medicine / Menopause (including HRT) / Pregnancy
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