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1. Nada WM, Al Aswad MA, El-Haig WM: Combined intrastromal injection of amphotericin B and topical fluconazole in the treatment of resistant cases of keratomycosis: a retrospective study. Clin Ophthalmol; 2017;11:871-874
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined intrastromal injection of amphotericin B and topical fluconazole in the treatment of resistant cases of keratomycosis: a retrospective study.
  • PURPOSE: To evaluate the efficacy of combination therapy of a single intrastromal injection of amphotericin B and topical fluconazole in resistant cases of fungal keratitis, and also topical amphotericin B as monotherapy in terms of the duration of the recovery period and toxic drug effects.
  • Thus, they were treated with a single intrastromal injection of amphotericin B in addition to topical fluconazole as combined antifungal therapy, representing group A.
  • Twenty-seven cases were treated with topical amphotericin B as antifungal monotherapy, representing group B.
  • Topical atropine 1% and different antibiotic eye drops were added to the antifungal agents in both groups.
  • CONCLUSION: Combined intrastromal injection of amphotericin B and topical fluconazole can provide a good modality in the treatment of resistant cases of fungal keratitis, exhibiting highly potent antifungal effects, shorter recovery period, and reduced corneal toxicity.

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  • (PMID = 28503064.001).
  • [ISSN] 1177-5467
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Keywords] NOTNLM ; amphotericin B / combined therapy / fluconazole / fungal keratitis / intrastromal injection
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2. Capoor MR, Sarabahi S, Tiwari VK, Narayanan RP: Fungal infections in burns: Diagnosis and management. Indian J Plast Surg; 2010 Sep;43(Suppl):S37-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Burn wound infection (BWI) is a major public health problem and the most devastating form of trauma worldwide.
  • There is a need to speciate fungi as far as the topical and systemic antifungal is concerned.
  • Patients with FWC should be treated by aggressive surgical debridement and, in the case of fungal wound infection (FWI), in addition to surgical debridement, an intravenous antifungal drug, most commonly amphotericin B or caspofungin, is prescribed followed by de-escalating with voriconazole or itraconazole, or fluconazole depending upon the species or antifungal susceptibility, if available.
  • Therefore, the development of products to close the wound more rapidly, improvement in topical antifungal therapy with mould activity and implementation of appropriate systemic antifungal therapy guided by antifungal susceptibility may improve the outcome for severely injured burn victims.

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  • (PMID = 21321655.001).
  • [ISSN] 1998-376X
  • [Journal-full-title] Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
  • [ISO-abbreviation] Indian J Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3038393
  • [Keywords] NOTNLM ; Burns / fungal infections / moulds / yeasts
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3. Mahajan VK, Mehta KS, Chauhan PS, Gupta M, Sharma R, Rawat R: Fixed cutaneous sporotrichosis treated with topical amphotericin B in an immune suppressed patient. Med Mycol Case Rep; 2015 Mar;7:23-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fixed cutaneous sporotrichosis treated with topical amphotericin B in an immune suppressed patient.
  • Her lesion healed after 8weeks of topical amphotericin-B (0.1% w/w).
  • Topical amphotericin-B appears useful treatment modality for uncomplicated cutaneous sporotrichosis when systemic treatment needs deferment, remains contraindicated, or in pediatric patients.

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  • (PMID = 27330943.001).
  • [ISSN] 2211-7539
  • [Journal-full-title] Medical mycology case reports
  • [ISO-abbreviation] Med Mycol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4909862
  • [Keywords] NOTNLM ; Amphotericin B gel / Cutaneous sporotrichosis / Fixed cutaneous sporotrichosis / Lymphocutaneous sporotrichosis / Sporothrix schenckii / Thermotherapy
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4. Lafleur MD, Qi Q, Lewis K: Patients with long-term oral carriage harbor high-persister mutants of Candida albicans. Antimicrob Agents Chemother; 2010 Jan;54(1):39-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Persisters form upon attachment to a surface, an important step in the pathogenesis of Candida strains.
  • In order to test this possibility, 150 isolates of Candida albicans and C. glabrata were obtained from cancer patients who were at high risk for the development of oral candidiasis and who had been treated with topical chlorhexidine once a day.
  • Persister levels were measured by exposing biofilms growing in the wells of microtiter plates to high concentrations of amphotericin B and plating for survivors.
  • All of the high-persister isolates had an amphotericin B MIC that was the same as that for the wild type, indicating that these strains were drug-tolerant rather than drug-resistant mutants.

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  • (PMID = 19841146.001).
  • [ISSN] 1098-6596
  • [Journal-full-title] Antimicrobial agents and chemotherapy
  • [ISO-abbreviation] Antimicrob. Agents Chemother.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM061162; United States / NIGMS NIH HHS / GM / 2R01GM061162-09
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mouthwashes; R4KO0DY52L / Chlorhexidine
  • [Other-IDs] NLM/ PMC2798516
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5. Troke P, Obenga G, Gaujoux T, Goldschmidt P, Bienvenu AL, Cornet M, Grenouillet F, Pons D, Ranque S, Sitbon K, Chaumeil C, Borderie V, Lortholary O: The efficacy of voriconazole in 24 ocular Fusarium infections. Infection; 2013 Feb;41(1):15-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Prior therapy included topical and/or systemic amphotericin (46 %), fluconazole (17 %) or others (33 %), often in combination.
  • In 13 patients (77 %), voriconazole was used in combination (response 69 vs. 64 % alone) with topical [amphotericin B 10/24 (42 %), caspofungin 5 (21 %), natamycin 1 (4 %)] and systemic agents [caspofungin 3 (13 %), amphotericin 2 (8 %)].
  • CONCLUSIONS: Topical and systemic voriconazole appears to be effective alone or in combination with other agents for treating severe Fusarium keratitis or endophthalmitis.

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  • (PMID = 22718362.001).
  • [ISSN] 1439-0973
  • [Journal-full-title] Infection
  • [ISO-abbreviation] Infection
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Pyrimidines; 0 / Triazoles; JFU09I87TR / Voriconazole
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