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1. El-Gammal TA, El-Sayed A, Kotb MM, Saleh WR, Ragheb YF: Knee joint reconstruction after hemiarticular resection using pedicled patella and vascularized fibular graft. Microsurgery; 2010 Nov;30(8):603-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Between 1999 and 2005, seven patients had resection of tumors around the knee joint that involved half of the articular surface of the femoral or tibial side.
  • Tumor pathology was giant cell tumor in four patients, osteoblastoma in two, and benign fibrous histocytoma in one patient.
  • Average time to bone union was 3.5 months (range, 3-4 months), and average time to full weight-bearing was 5 months (range, 4-6 months).
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Knee Joint / surgery. Surgical Flaps
  • [MeSH-minor] Adolescent. Adult. Female. Histiocytoma, Benign Fibrous / surgery. Humans. Male. Osteoblastoma / surgery. Range of Motion, Articular. Young Adult

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 20853338.001).
  • [ISSN] 1098-2752
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Pattamparambath M, Sathyabhama S, Khatri R, Varma S, Narayanan NM: Benign Fibrous Histiocytoma of Mandible: A Case Report and Updated Review. J Clin Diagn Res; 2016 Jun;10(6):ZD24-6
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  • [Title] Benign Fibrous Histiocytoma of Mandible: A Case Report and Updated Review.
  • Benign Fibrous Histiocytoma (BFH) is a well recognised tumour of the soft tissue, developing entirely within the subcutaneous tissue, the deep soft tissues or in the parenchymal organs.
  • It has been rarely reported in the bones with femur, tibia and pelvic bone being the most commonly affected bones.
  • The case emphasizes the need for considering BFH in the differential diagnosis of swellings of the jaws.

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  • (PMID = 27504429.001).
  • [ISSN] 2249-782X
  • [Journal-full-title] Journal of clinical and diagnostic research : JCDR
  • [ISO-abbreviation] J Clin Diagn Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4963789
  • [Keywords] NOTNLM ; Fibroblasic / Histiocytic / Swelling
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3. Kim SB, Jang JS, Lee SH: Surgical treatment of benign fibrous histiocytoma as a form of intraspinal extradural tumor at lumbar spine. Asian Spine J; 2010 Dec;4(2):132-5
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  • [Title] Surgical treatment of benign fibrous histiocytoma as a form of intraspinal extradural tumor at lumbar spine.
  • A benign fibrous histiocytoma (BFH) is one of the fibrohistiocytic groups of soft-tissue tumors for which spinal involvement is extremely rare.
  • To the best of our knowledge, most spine-originating BFHs are bone tumors.

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  • (PMID = 21165318.001).
  • [ISSN] 1976-7846
  • [Journal-full-title] Asian spine journal
  • [ISO-abbreviation] Asian Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2996626
  • [Keywords] NOTNLM ; Benign fibrous / Histiocytoma / Lumbar vertebrae / Soft tissue neoplasms
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4. Sadat-Ali M, Azzam Q, Bluwi M, Al-Umran AS: Case report: Fibroxanthoma: a complication of a biodegradable screw. Clin Orthop Relat Res; 2010 Aug;468(8):2284-7
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  • [MeSH-major] Absorbable Implants / adverse effects. Bone Neoplasms / pathology. Bone Screws / adverse effects. Histiocytoma, Benign Fibrous / pathology. Tibia / pathology

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  • [CommentIn] Clin Orthop Relat Res. 2011 Jan;469(1):300-1; author reply 302 [20878555.001]
  • (PMID = 19936858.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / HAM-56 antibody
  • [Other-IDs] NLM/ PMC2895830
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5. Hemingway F, Kashima TG, Mahendra G, Dhongre A, Hogendoorn PC, Mertens F, Athanasou NA: Smooth muscle actin expression in primary bone tumours. Virchows Arch; 2012 May;460(5):525-34
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  • [Title] Smooth muscle actin expression in primary bone tumours.
  • Alpha isoform of smooth muscle actin (SMA) expression has been reported in giant cell tumour of bone (GCTB) and other benign and malignant bone tumours, but the pattern of SMA expression and the precise nature of SMA-expressing cells in these lesions is uncertain.
  • We determined by immunohistochemistry the expression of SMA and other muscle and vascular markers in normal bone, GCTB and a wide range of primary benign and malignant bone tumours.
  • Cultured stromal cells of GCTB, chondroblastoma (CB), and aneurysmal bone cyst (ABC) were also analysed for SMA expression.
  • SMA was only noted in blood vessels in normal bone.
  • SMA was strongly and diffusely expressed by MSC in non-ossifying fibroma, fibrous dysplasia, and "brown tumour" of hyperparathyroidism.
  • SMA expression was also noted in GCTB, ABC, CB, chondromyxoid fibroma, malignant fibrous histiocytoma of bone and osteosarcoma.
  • Little or no SMA was noted in Langerhans cell histiocytosis, simple bone cyst, Ewing's sarcoma, osteoblastoma, osteoid osteoma, enchondroma, osteochondroma, chondrosarcoma, myeloma, lymphoma, chordoma and adamantinoma.
  • Our findings show that there is differential SMA expression in primary bone tumours and that identifying the presence or absence of SMA is useful in the differential diagnosis of these lesions.
  • The nature of SMA-expressing cells in bone tumours is uncertain but they are negative for desmin and caldesmon and could represent either myofibroblasts or perivascular cells, such as pericytes.
  • [MeSH-major] Actins / analysis. Actins / biosynthesis. Biomarkers, Tumor / analysis. Bone Neoplasms / metabolism

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  • (PMID = 22543453.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Biomarkers, Tumor
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6. Ding ZQ, Zhang HF, Kang LQ, Sha M: Case report: Bone tumor of the scapula in a patient undergoing liver transplantation. Clin Orthop Relat Res; 2012 Apr;470(4):1232-5
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  • [Title] Case report: Bone tumor of the scapula in a patient undergoing liver transplantation.
  • Such posttransplant de novo malignancies are apparently rarely found in bone.
  • CASE DESCRIPTION: We describe a patient with a low-grade, aggressive fibrous histiocytoma of the scapula.
  • According to the literature, tumors apparently are rare in bone after liver transplantation, with no clearly documented cases.
  • However, in the presence of such a finding, our study might be the first clearly documented case study of this kind of bone tumor.
  • CLINICAL RELEVANCE: We describe a patient with a bone tumor after liver transplantation.
  • [MeSH-major] Bone Neoplasms / surgery. Histiocytoma, Benign Fibrous / surgery. Liver Transplantation / adverse effects. Scapula / surgery

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  • (PMID = 22215480.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3293983
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7. Picci P, Sieberova G, Alberghini M, Balladelli A, Vanel D, Hogendoorn PC, Mercuri M: Late sarcoma development after curettage and bone grafting of benign bone tumors. Eur J Radiol; 2011 Jan;77(1):19-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late sarcoma development after curettage and bone grafting of benign bone tumors.
  • BACKGROUND AND AIM: Rarely sarcomas develop in previous benign lesions, after a long term disease free interval.
  • PATIENTS AND METHODS: 12 cases curetted and grafted, without radiotherapy developed sarcomas, between 1970 and 2005, 6.5-28 years from curettage (median 18, average 19).
  • Age ranged from 13 to 55 years (median 30, average 32) at first diagnosis; tumors were located in the extremities (9 GCT, benign fibrous histiocytoma, ABC, and solitary bone cyst).
  • Radiographic and clinic documentation, for the benign and malignant lesions, were available.
  • Histology was available for 7 benign and all malignant lesions.
  • RESULTS: To fill cavities, autogenous bone was used in 4 cases, allograft in 2, allograft and tricalcium-phosphate/hydroxyapatite in 1, autogenous/allograft in 1, heterogenous in 1.
  • Secondary sarcomas, all high grade, were 8 osteosarcoma, 3 malignant fibrous histiocytoma, and 1 fibrosarcoma.
  • CONCLUSIONS: Recurrences with progression from benign tumors are possible, but the very long intervals here reported suggest a different cancerogenesis for these sarcomas.
  • This condition is extremely rare accounting for only 0.26% of all malignant bone sarcomas treated in the years 1970-2005 and represents only 8.76% of all secondary bone sarcomas treated in the same years.
  • This incidence is the same as that of sarcomas arising on fibrous dysplasia, and is lower than those arising on bone infarcts or on Paget's disease.
  • This possible event must be considered during follow-up of benign lesions.
  • [MeSH-major] Bone Neoplasms / radiography. Bone Neoplasms / surgery. Bone Transplantation. Curettage. Neoplasms, Second Primary / radiography. Neoplasms, Second Primary / surgery. Sarcoma / radiography. Sarcoma / surgery

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20828957.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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8. Onovo OD, Eyesan SU, Abdulkareem FB: Benign fibrous histiocytoma of a metacarpal bone. BMJ Case Rep; 2011;2011
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  • [Title] Benign fibrous histiocytoma of a metacarpal bone.
  • Benign fibrous histiocytoma (BFH) is a rare skeletal tumour.
  • The authors present a case of BFH involving the second metacarpal bone.
  • [MeSH-major] Bone Neoplasms / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Metacarpal Bones

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  • (PMID = 22715263.001).
  • [ISSN] 1757-790X
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9. Petrey WB, LeGallo RD, Fox MG, Gaskin CM: Imaging characteristics of angiomatoid fibrous histiocytoma of bone. Skeletal Radiol; 2011 Feb;40(2):233-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging characteristics of angiomatoid fibrous histiocytoma of bone.
  • We present the first report of a patient with angiomatoid fibrous histiocytoma of bone in the radiology literature.
  • This tumor initially eluded diagnosis due to its similarities with chronic hematoma and aneurysmal bone cyst.
  • Only two cases of angiomatoid fibrous histiocytoma have been reported in the radiology literature and both of these lesions were in the soft tissues.
  • The fairly distinctive findings in our patient of multiple large cystic chambers with fluid-fluid levels are similar to the findings in the two soft tissue case reports, suggesting that imaging may be used to suggest this specific diagnosis regardless of location, especially in the clinical setting of unexplained hematoma or anemia.
  • Mention of this diagnosis in the radiology report may aid in the final diagnosis at pathology, because special techniques, including fluorescent in situ hybridization, must be applied in order to fully evaluate for the diagnosis.
  • [MeSH-major] Bone Neoplasms / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Ischium / diagnostic imaging. Ischium / pathology. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods






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