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1. Dralle H: [Surgical strategies for accidental detection of appendix carcinoids]. Chirurg; 2011 Jul;82(7):598-606
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  • [Title] [Surgical strategies for accidental detection of appendix carcinoids].
  • Carcinoids (neuroendocrine tumors NET) of the appendix are rare tumors and even today mostly detected only postoperatively by histopathology following operations for acute appendicitis or other abdominal procedures.
  • Most NETs of the appendix are located at the tip of the appendix, less than 2 cm in size and non-metastasizing.
  • To decide upon secondary surgery histopathological risk factors, such as grading, invasion of the mesoappendix, and tumor type in addition to tumor localization and size should be taken into consideration.
  • Up to 20% of NETs of the appendix are associated with various neoplasms of the gastrointestinal tract.
  • Follow-up examination should therefore also consider both appendix carcinoids and synchronous or metachronous neoplasms of the gastrointestinal tract.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery. Incidental Findings
  • [MeSH-minor] Adult. Appendectomy. Appendicitis / pathology. Appendicitis / surgery. Child. Colectomy. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / surgery. Humans. Lymph Node Excision. Neoplasm Grading. Neoplasm Invasiveness. Neoplasm Staging. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Prognosis

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  • (PMID = 21491093.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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2. Gupta A, Patel T, Dargar P, Shah M: Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. J Cytol; 2013 Apr;30(2):136-8
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  • [Title] Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall.
  • Goblet cell carcinoids are rare tumors of appendix having a mixed phenotype, with partial neuroendocrine differentiation and intestinal type goblet cell morphology.
  • The reported incidence of this tumor is still limited.
  • Till now, only two cases of metastatic goblet cell appendiceal carcinoid on effusion cytology have been reported in literature.
  • We describe the clinico-pathological details and lay stress on fluid cytology of metastatic goblet cell carcinoid to ascitic fluid.

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  • (PMID = 23833405.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3701339
  • [Keywords] NOTNLM ; Appendix / ascitic fluid / effusion cytology / goblet cell / goblet cell carcinoid / neuroendocrine
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3. Akbulut S, Tas M, Sogutcu N, Arikanoglu Z, Basbug M, Ulku A, Semur H, Yagmur Y: Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol; 2011 Apr 21;17(15):1961-70
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  • [Title] Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review.
  • AIM: To document unusual findings in appendectomy specimens.
  • METHODS: The clinicopathological data of 5262 patients who underwent appendectomies for presumed acute appendicitis from January 2006 to October 2010 were reviewed retrospectively.
  • We focused on 54 patients who had unusual findings in their appendectomy specimens.
  • We conducted a literature review via the PubMed and Google Scholar databases of English language studies published between 2000 and 2010 on unusual findings in appendectomy specimens.
  • RESULTS: Unusual findings were determined in 54 (1%) cases by histopathology.
  • Final pathology revealed 37 cases of enterobiasis, five cases of carcinoids, four mucinous cystadenomas, two eosinophilic infiltrations, two mucoceles, two tuberculosis, one goblet-cell carcinoid, and one neurogenic hyperplasia.
  • All tumors were located at the distal part of the appendix with a mean diameter of 6.8 mm (range, 4-10 mm).
  • All patients with tumors were alive and disease-free during a mean follow-up of 17.8 mo.
  • CONCLUSION: Although unusual pathological findings are seldom seen during an appendectomy, all appendectomy specimens should be sent for routine histopathological examination.
  • [MeSH-major] Appendicitis / pathology. Appendicitis / surgery. Appendix / pathology. Appendix / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Appendectomy. Enterobiasis / complications. Female. Humans. Intestinal Neoplasms / complications. Intestinal Neoplasms / pathology. Male. Middle Aged. Retrospective Studies. Turkey. Young Adult

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  • (PMID = 21528073.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3082748
  • [Keywords] NOTNLM ; Appendicitis / Carcinoid / Enterobius vermicularis / Goblet cell carcinoid / Mucocele / Unusual findings
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4. Reissman P, Shmailov S, Grozinsky-Glasberg S, Gross DJ: Laparoscopic resection of primary midgut carcinoid tumors. Surg Endosc; 2013 Oct;27(10):3678-82
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  • [Title] Laparoscopic resection of primary midgut carcinoid tumors.
  • However, no series on laparoscopic resection of intestinal midgut carcinoid tumors (MCTs) has been reported to date.
  • This is related to the rarity of these tumors as well as the technical difficulties resecting the large mesenteric root lymph node mass commonly found with these tumors and the occasional difficulty identifying the primary MCT, which may be small and undetected on preoperative imaging studies.
  • This is the first series to report the results for laparoscopic resection of MCT.
  • METHODS: All consecutive patients with MCT (excluding appendiceal carcinoid tumor) between 2002 and 2012 underwent laparoscopic resection.
  • RESULTS: During the study period, 35 patients underwent surgery for primary intestinal carcinoid tumor.
  • Of the 35 patients, 20 (12 women and 8 men ages 26-86 years) had surgery for primary MCT, and the remainder had a colorectal carcinoid tumor.
  • All the patients underwent a laparoscopic resection with en bloc resection of the corresponding mesenteric root mass.
  • Similar to the large-scale prospective studies that proved the oncologic safety of laparoscopic surgery for colorectal cancer, this small series showed that the laparoscopic technique also may be oncologically safe for these rare tumors.
  • [MeSH-major] Carcinoid Tumor / surgery. Ileal Neoplasms / surgery. Jejunal Neoplasms / surgery. Laparoscopy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystectomy, Laparoscopic. Female. Hand-Assisted Laparoscopy / methods. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Premedication. Retrospective Studies. Somatostatin / agonists. Treatment Outcome

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  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
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5. Wittekind C: [TNM 2010. What's new?]. Pathologe; 2010 Oct;31 Suppl 2:153-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [TNM 2010. What's new?].
  • [Transliterated title] TNM 2010. Was ist neu?
  • In the seventh edition of the TNM Classification of Malignant Tumours there are several entirely new classifications: upper aerodigestive mucosal melanoma, gastrointestinal stromal tumour, gastrointestinal carcinoid (neuroendocrine tumour), intrahepatic cholangiocarcinoma, Merkel cell carcinoma, uterine sarcomas, and adrenal cortical carcinoma.
  • Significant modifications concern carcinomas of the oesophagus, oesophagogastric junction, stomach, appendix, biliary tract, lung, skin, prostate and ophthalmic tumours, which will be not addressed in this article.
  • For several tumour entities only minor changes were introduced which might be of importance in daily practice.
  • The new classifications and changes will be commented on without going into details.
  • [MeSH-major] Neoplasm Staging / methods. Neoplasm Staging / trends. Neoplasms / pathology
  • [MeSH-minor] Adrenal Cortex Neoplasms / classification. Adrenal Cortex Neoplasms / pathology. Bile Duct Neoplasms / classification. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Merkel Cell / classification. Carcinoma, Merkel Cell / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Digestive System Neoplasms / classification. Digestive System Neoplasms / pathology. Female. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Respiratory Tract Neoplasms / classification. Respiratory Tract Neoplasms / pathology. Sarcoma / classification. Sarcoma / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology. Uterine Neoplasms / classification. Uterine Neoplasms / pathology

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  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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6. Holt N, Grønbæk H: Goblet cell carcinoids of the appendix. ScientificWorldJournal; 2013;2013:543696
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  • [Title] Goblet cell carcinoids of the appendix.
  • Goblet cell carcinoid (GCC) tumors are a rare subgroup of neuroendocrine tumors almost exclusively originating in the appendix.
  • The tumor most often presents in the fifth or sixth decade with a clinical picture of appendicitis or in advanced cases an abdominal mass associated with abdominal pain.
  • Histologically tumors are most often positive for chromogranin A and synaptophysin, however, less homogenous than for classic appendix carcinoids.
  • The malignant potential is higher than that for the classic appendix carcinoids due to local spread and distant metastases at diagnosis and the proliferation markers (Ki67 index) may determine prognosis.
  • Chromogranin A is usually negative and other biomarkers related to the mucinous component or the tumor (CEA, CA-19-9, and CA-125) may be used.
  • Surgery is the main treatment with appendectomy and right hemicolectomy while patients with disseminated disease should be treated with chemotherapy.
  • The diagnosis and treatment of GCC tumors should be restricted to high volume NET centers in order to accumulate knowledge and improve survival in GCC NET patients.
  • The aim of this paper is to update on epidemiology, clinical presentation, and diagnostic markers including Ki67 index, treatment, and survival.
  • [MeSH-major] Appendectomy / methods. Appendiceal Neoplasms / diagnosis. Appendiceal Neoplasms / therapy. Biomarkers, Tumor / blood. Carcinoid Tumor / diagnosis. Carcinoid Tumor / therapy. Ki-67 Antigen / blood

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  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  • [Other-IDs] NLM/ PMC3556879
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7. Charfi S, Sellami A, Affes A, Yaïch K, Mzali R, Boudawara TS: Histopathological findings in appendectomy specimens: a study of 24,697 cases. Int J Colorectal Dis; 2014 Aug;29(8):1009-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological findings in appendectomy specimens: a study of 24,697 cases.
  • Histopathological examination of the appendix is routinely performed.
  • RESULTS: Appendectomy specimens represent 17 % of all pathological reports.
  • Neoplastic lesions were present in 171 cases (0.7 %); they include carcinoid, adenocarcinoma, and mucinous neoplasms.
  • [MeSH-major] Appendectomy. Appendix / pathology

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  • [CommentIn] Int J Colorectal Dis. 2015 Oct;30(10):1431 [25618167.001]
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8. Sushma S, Prasad CS, Kumar KM: An Unusual Case of Appendiceal Carcinoid Tumor in a Child- Case Report. Indian J Surg Oncol; 2016 Mar;7(1):95-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An Unusual Case of Appendiceal Carcinoid Tumor in a Child- Case Report.
  • Carcinoid tumors of the appendix are rare in children.
  • Local disease carries an excellent prognosis and simple appendicectomy suffices, whereas advanced cases need a right hemicolectomy.
  • Clinicians must be aware of this under reported and rare tumor in chidren.
  • We report a case of appendiceal carcinoid tumor in a 10 year old male child who presented with clinical features of acute appendicitis which was diagnosed on histopathological examination.

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  • [Journal-full-title] Indian journal of surgical oncology
  • [ISO-abbreviation] Indian J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4811812 [Available on 03/01/17]
  • [Keywords] NOTNLM ; Appendicectomy / Carcinoid tumor / Child
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9. Romeo M, Quer A, Tarrats A, Molina C, Radua J, Manzano JL: Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature. World J Surg Oncol; 2015;13:325
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  • [Title] Appendiceal mixed adenoneuroendocrine carcinomas, a rare entity that can present as a Krukenberg tumor: case report and review of the literature.
  • BACKGROUND: Mixed adenoneuroendocrine carcinoma is a rare tumor recently recognized as a new category in the last World Health Organization (WHO) classification of appendiceal tumors (2010).
  • This term has been proposed to designate carcinomas of the appendix that arise by progression from a pre-existing goblet cell carcinoid.
  • Mixed adenoneuroendocrine carcinomas are more aggressive tumors than typical goblet cell carcinoids and usually present with peritoneal spreading and ovarian masses.
  • CASE PRESENTATION: We report the case of a mixed adenoneuroendocrine carcinoma--signet ring cell subtype--that presented as a Krukenberg tumor of unknown primary.
  • CONCLUSION: The review of literature is focused on the most recent WHO pathologic classification of appendiceal tumors containing goblet cell clusters, which seems to correlate with prognosis.
  • [MeSH-major] Adenocarcinoma / diagnosis. Appendiceal Neoplasms / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Signet Ring Cell / diagnosis. Krukenberg Tumor / diagnosis. Ovarian Neoplasms / diagnosis

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  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
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  • [Other-IDs] NLM/ PMC4661956
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10. Malkan AD, Wahid FN, Fernandez-Pineda I, Sandoval JA: Appendiceal carcinoid tumor in children: implications for less radical surgery? Clin Transl Oncol; 2015 Mar;17(3):197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Appendiceal carcinoid tumor in children: implications for less radical surgery?
  • The discovery of an appendiceal carcinoid tumor found incidentally or during the course of diagnostic or therapeutic procedures is a burden to both the patient and clinician.
  • The role of the correct surgical operation is paramount for lesions suspected to be malignant.
  • In the pediatric population, appendiceal carcinoids continue to challenge the clinician in choosing the optimal treatment when lesions are larger than 2 cm or involve the appendical base.
  • The purpose of this article is to give an overview regarding the history, diagnosis, histopathology, management, and controversies associated with appendiceal carcinoid in the pediatric population.
  • [MeSH-major] Appendiceal Neoplasms / surgery. Carcinoid Tumor / surgery

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  • [Cites] Med Pediatr Oncol. 2000 Mar;34(3):218-20 [10696132.001]
  • (PMID = 24965691.001).
  • [ISSN] 1699-3055
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] Italy
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