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1. Yano M, Sasaki H, Moriyama S, Hikosaka Y, Okuda K, Shitara M, Tatematsu T, Fujii Y: Clinicopathological analysis of small-sized anterior mediastinal tumors. Surg Today; 2014 Oct;44(10):1817-22
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  • [Title] Clinicopathological analysis of small-sized anterior mediastinal tumors.
  • PURPOSE: The purpose of this study was to determine the clinicopathological findings and prognosis of small-sized anterior mediastinal tumors (SSAMTs).
  • The pathological diagnoses of the solid lesions included thymoma (n = 24), thymic carcinoma (n = 1), mucosa-associated lymphoid tissue lymphoma (n = 1), teratoma (n = 1) and neurofibroma (n = 1), and those of the cystic lesions included thymic cysts (n = 8), thymoma (n = 3), bronchogenic cysts (n = 2), teratoma, (n = 1) and a pericardial cyst (n = 1).
  • SSAMTs are good candidates for video-assisted thoracic surgery procedures, as conversion to sternotomy can be selected based on the intraoperative findings of pericardial invasion and a rapid pathological diagnosis of thymic carcinoma.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Thymoma / pathology. Thymus Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphoma, B-Cell, Marginal Zone / classification. Lymphoma, B-Cell, Marginal Zone / diagnosis. Lymphoma, B-Cell, Marginal Zone / pathology. Lymphoma, B-Cell, Marginal Zone / surgery. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Neurofibroma / classification. Neurofibroma / diagnosis. Neurofibroma / pathology. Neurofibroma / surgery. Prognosis. Sternotomy. Teratoma / classification. Teratoma / diagnosis. Teratoma / pathology. Teratoma / surgery. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 24065193.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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2. Syrios J, Diamantis N, Fergadis E, Katsaros L, Logothetis M, Iakovidou I, Lianos E, Grivas A, Athanasiou AE: Advances in thymic carcinoma diagnosis and treatment: a review of literature. Med Oncol; 2014 Jul;31(7):44
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  • [Title] Advances in thymic carcinoma diagnosis and treatment: a review of literature.
  • Thymomas account for up to 50 % of anterior mediastinal neoplasms with an incidence of 0.13 per 100,000 person-years in the USA.
  • Thymic carcinoma is a rare malignancy of the thymus gland distinguished from thymomas as it has a more invasive and metastasizing potential conferring poor prognosis.
  • Due to the rarity of thymic carcinoma and the great variety of its histological subtypes, there is no solid evidence on optimal staging, imaging and treatment guidelines.
  • Herein, we systematically review the literature on current clinical practice with regard to diagnostic evaluation, histopathological assessment, management and treatment of squamous thymic carcinoma.
  • [MeSH-major] Thymus Neoplasms / diagnosis. Thymus Neoplasms / therapy

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  • (PMID = 24906655.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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3. Wang S, Li J, Zhang Y, Wang W, Li F, Fan T, Xu M, Shao Q: Measurement of intra-fraction displacement of the mediastinal metastatic lymph nodes using four-dimensional CT in non-small cell lung cancer. Korean J Radiol; 2012 Jul-Aug;13(4):417-24
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  • [Title] Measurement of intra-fraction displacement of the mediastinal metastatic lymph nodes using four-dimensional CT in non-small cell lung cancer.
  • OBJECTIVE: To measure the intra-fraction displacements of the mediastinal metastatic lymph nodes by using four-dimensional CT (4D-CT) in non-small cell lung cancer (NSCLC).
  • The mediastinal metastatic lymph nodes were delineated on the CT images of 10 phases of the breath cycle.
  • The lymph nodes were grouped as the upper, middle and lower mediastinal groups depending on the mediastinal regions.
  • The displacements of the center of the lymph node in the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions were measured.
  • RESULTS: The mean displacements of the center of the mediastinal lymph node in the LR, AP, and SI directions were 2.24 mm, 1.87 mm, and 3.28 mm, respectively.
  • For the middle and lower mediastinal lymph nodes, the displacement difference between the AP and SI was statistically significant (p = 0.005; p = 0.015), while there was no significant difference between the LR and AP directions (p < 0.05).
  • CONCLUSION: The metastatic mediastinal lymph node movements are different in the LR, AP, and SI directions in patients with NSCLC, particularly for the middle and lower mediastinal lymph nodes.
  • The spatial non-uniform margins should be considered for the metastatic mediastinal lymph nodes in involved-field radiotherapy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiography. Four-Dimensional Computed Tomography / methods. Lung Neoplasms / radiography. Lymphatic Metastasis / radiography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Female. Humans. Iohexol / analogs & derivatives. Male. Mediastinum / radiography. Middle Aged. Radiographic Image Interpretation, Computer-Assisted. Statistics, Nonparametric

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  • (PMID = 22778563.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Contrast Media; 182ECH14UH / iobitridol; 4419T9MX03 / Iohexol
  • [Other-IDs] NLM/ PMC3384823
  • [Keywords] NOTNLM ; Displacement measurement / Four-dimensional computed tomography / Mediastinal lymph nodes / Non-small cell lung cancer
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4. Rabbani M, Sarrami AH: Computed tomography-guided percutaneous core needle biopsy for diagnosis of mediastinal mass lesions: Experience with 110 cases in two university hospitals in Isfahan, Iran. Adv Biomed Res; 2016;5:152
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  • [Title] Computed tomography-guided percutaneous core needle biopsy for diagnosis of mediastinal mass lesions: Experience with 110 cases in two university hospitals in Isfahan, Iran.
  • BACKGROUND: Computed tomography-guided percutaneous core needle biopsy (PCNB) is a diagnostic technique for initial assessment of mediastinal mass lesions.
  • MATERIALS AND METHODS: We reviewed the records of CT-guided PCNB in 110 patients with mediastinal mass lesions performed in Kashani and Alzahra Hospitals, Isfahan, from 2006 to 2012.
  • Gender, age at biopsy, size, and anatomic location of the lesion, number of passes, site of approach, complications, and final diagnosis were extracted.
  • The most common site of involvement was the anterior mediastinum (91.8% of cases).
  • Lymphoma (49.5%) and bronchogenic carcinoma (33.3%) were the most frequent lesions in our series.
  • CONCLUSION: CT-guided PCNB is a safe and reliable procedure that can provide a precise diagnosis for patients with both benign and malignant mediastinal masses, and it is considered the preferred first diagnostic procedure use for this purpose.

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  • (PMID = 27713873.001).
  • [Journal-full-title] Advanced biomedical research
  • [ISO-abbreviation] Adv Biomed Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Keywords] NOTNLM ; Computed tomography scan / mediastinal mass / percutaneous core needle biopsy / pneumothorax
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5. Karapetyan L, Rai M, Dawani O, Laird-Fick HS: Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass. Case Rep Oncol Med; 2017;2017:5264564
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  • [Title] Metastatic Sarcomatoid Squamous Cell Carcinoma of the Cervix Presenting with Chest Mass.
  • BACKGROUND: Sarcomatoid squamous cell carcinoma is a rare and aggressive form of cervical cancer.
  • We report a case of metastatic sarcomatoid squamous cell carcinoma (SSCC) of cervix that presented with an anterior chest wall mass.
  • On current presentation, the CT chest revealed anterior mediastinal destructive soft tissue mass involving sternum, and the biopsy showed SSCC.

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  • (PMID = 29062577.001).
  • [ISSN] 2090-6706
  • [Journal-full-title] Case reports in oncological medicine
  • [ISO-abbreviation] Case Rep Oncol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Lasala JD, Tsai J, Rodriguez-Restrepo A, Atay SM, Sepesi B: Systolic anterior motion of the mitral valve-the mechanism of postural hypotension following left intrapericardial pneumonectomy. J Thorac Dis; 2017 Apr;9(4):E354-E357
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  • [Title] Systolic anterior motion of the mitral valve-the mechanism of postural hypotension following left intrapericardial pneumonectomy.
  • Systolic anterior motion (SAM) is defined as displacement of the distal portion of the anterior leaflet of the mitral valve toward the left ventricular outflow tract obstruction.
  • We present a case of persistent orthostatic hypotension caused by SAM following left intrapericardial pneumonectomy and mediastinal lymph node dissection for squamous cell carcinoma of the lung invading intrapericardial portion of the inferior pulmonary vein.
  • Diagnosis of SAM was possible with the use of transesophageal echocardiography (TEE).

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  • (PMID = 28523177.001).
  • [ISSN] 2072-1439
  • [Journal-full-title] Journal of thoracic disease
  • [ISO-abbreviation] J Thorac Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Anesthesia / cardiac function / complications / echocardiography / physiology / surgery / ultrasound
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7. Steger CM, Morresi-Hauf A, Krugmann J, Schirmacher P, Rieker RJ, Mechtersheimer G: Two malignant tumours in the anterior mediastinum positive for CD5. BMJ Case Rep; 2010;2010
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  • [Title] Two malignant tumours in the anterior mediastinum positive for CD5.
  • To our knowledge, the simultaneous involvement of the anterior mediastinum by a thymic carcinoma and a B-cell chronic lymphocytic leukaemia has not been reported previously.
  • Chest x-ray and CT scan showed a mediastinal tumour, resected short-time after diagnosis.
  • First, standard based histological examination revealed a thymic carcinoma admixed by a dense lymphatic infiltrate.
  • Additional immunohistochemical staining for CD5-labelled epithelial thymic carcinoma cells as well as neoplastic B cells and led in combination with blood tests to confirm the diagnosis of the composite occurrence of a thymic carcinoma and a B-cell chronic lymphocytic leukaemia.
  • [MeSH-major] Antigens, CD5 / analysis. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Mediastinal Neoplasms / diagnosis. Thymoma / diagnosis. Thymus Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 22752456.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD5
  • [Other-IDs] NLM/ PMC3034205
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8. McNab P, Quigley B, Mendoza T, Hakam A, Khalil F, Fishman M, Altiok S: The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source. Int J Clin Exp Pathol; 2012;5(9):982-90
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  • [Title] The histogenic origin of melanoma arising in respiratory epithelium of a teratomatous germ cell tumor of the mediastinum: an enigma unraveled from an unlikely source.
  • Mixed germ cell tumors are rare neoplasms that are known to occur in the anterior mediastinum.
  • Characterized by two or more types of germ cell components, these tumors comprise upwards of 25% of mediastinal germ cell tumors.
  • Even rarer are those harboring somatic-type malignancies such as carcinoma, sarcoma, and hematopoietic malignancies.
  • To date, however, there are no known cases of melanoma arising in a malignant mixed germ cell tumor of the anterior mediastinum.
  • We describe the first case of malignant melanoma with spindle and epithelioid components arising from respiratory epithelium in a mediastinal malignant mixed germ cell tumor of a 32-year-old male.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Melanoma / pathology. Neoplasms, Complex and Mixed / pathology. Respiratory Mucosa / pathology. Teratoma / pathology

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  • (PMID = 23119117.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC3484497
  • [Keywords] NOTNLM ; Histogenic origin / mediastinum / melanoma / respiratory epithelium / teratomatous germ cell tumor
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9. Munakata W, Ohashi K, Sakaguchi K, Horio H, Hishima T, Akiyama H, Sakamaki H: Erythrocytosis caused by erythropoietin-producing thymic carcinoma. Int J Clin Oncol; 2010 Apr;15(2):220-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erythrocytosis caused by erythropoietin-producing thymic carcinoma.
  • We describe the first reported case, in an 82-year-old man, of erythrocytosis caused by an erythropoietin (EPO)-producing thymic carcinoma.
  • The patient underwent computed tomography-guided fine-needle aspiration of a 6-cm anterior mediastinal mass, and histological findings revealed thymic squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Erythropoietin / metabolism. Paraneoplastic Syndromes / etiology. Polycythemia / etiology. Thymoma / metabolism. Thymus Neoplasms / metabolism

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  • (PMID = 20179983.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 11096-26-7 / Erythropoietin
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10. Rashid OM, Cassano AD, Takabe K: Thymic neoplasm: a rare disease with a complex clinical presentation. J Thorac Dis; 2013 Apr;5(2):173-83
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  • In this review, we discuss the evaluation of the patient with an anterior mediastinal mass, the classification and staging of thymic neoplasms, the role of surgery, radiation and chemotherapy in treating this disease, as well as future directions in research for novel targeted therapies.

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  • (PMID = 23585946.001).
  • [ISSN] 2072-1439
  • [Journal-full-title] Journal of thoracic disease
  • [ISO-abbreviation] J Thorac Dis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA160688
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3621939
  • [Keywords] NOTNLM ; Thymic neoplasm / thymic carcinoma / thymoma
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