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2. Liau SS, Qureshi MS, Praseedom R, Huguet E: Molecular pathogenesis of hepatic adenomas and its implications for surgical management. J Gastrointest Surg; 2013 Oct;17(10):1869-82
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  • [Title] Molecular pathogenesis of hepatic adenomas and its implications for surgical management.
  • INTRODUCTION: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration.
  • DISCUSSION: The pathogenesis and natural history of this disease entity were previously unknown.
  • Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas.
  • In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease.
  • [MeSH-major] Adenoma / genetics. Adenoma / surgery. Liver Neoplasms / genetics. Liver Neoplasms / surgery
  • [MeSH-minor] Cell Transformation, Neoplastic. Decision Trees. Genotype. Humans. Phenotype. Risk Factors

  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • (PMID = 23835731.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G1002543
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3782654
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3. Liu W, Wang D, Liu J, Li D, Yin D: Quality Evaluation of Potentilla fruticosa L. by High Performance Liquid Chromatography Fingerprinting Associated with Chemometric Methods. PLoS One; 2016;11(2):e0149197
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  • For this quantitative analysis, the main active phytochemical compositions and the antioxidant activity in P. fruticosa were also investigated.
  • Similarity analysis (SA) of HPLC fingerprints, hierarchical cluster analysis (HCA), principle component analysis (PCA), and discriminant analysis (DA) were further employed to provide accurate classification and quality estimates of P. fruticosa.
  • The results strongly supported the conclusion that the eight samples from different regions were clustered into three major groups, corresponding with their morphological classification, for which HPLC analysis confirmed the considerable variation in phytochemical compositions and that P. fruticosa samples from Kangding, Sichuan were of high quality.
  • The results of SA, HCA, PCA, and DA were in agreement and performed well for the quality assessment of P. fruticosa.
  • [MeSH-minor] Antioxidants / chemistry. Antioxidants / pharmacology. Cluster Analysis. Flavonoids / chemistry. Oxidation-Reduction / drug effects. Phenols / chemistry. Plant Extracts / chemistry. Plant Extracts / pharmacology. Reproducibility of Results. Tannins / chemistry

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  • (PMID = 26890416.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Drugs, Chinese Herbal; 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Tannins
  • [Other-IDs] NLM/ PMC4758616
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4. Fan J, Wang S, Yu S, He J, Zheng W, Zhang J: N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147. Glycoconj J; 2012 Aug;29(5-6):323-34
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  • [Title] N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147.
  • Our recent study indicates that the expression of GnT-IVa in Hca-F cells was much higher than that in Hepa1-6 cells, these two mouse hepatocarcinoma cell lines have high and no metastatic potential in lymph nodes respectively.
  • To investigate the effects of GnT-IVa on the metastasis of hepatocarcinoma, exogenous GnT-IVa was introduced into Hepa1-6 cells, and on the other hand, the expression of GnT-IVa was down-regulated in Hca-F cells.
  • The engineered overexpression of GnT-IVa in Hepa1-6 cells increased the antennary branches of complex N-glycans and reduced bisecting branches in vitro and in vivo, which leads to the increase in migration and metastatic capability of hepatocarcinoma cells.
  • Conversely, down-regulated expression of GnT-IVa in Hca-F cells showed reduced tetra-antennary branches of N-Glycans, and significantly decreased the migration and metastatic capability.
  • Furthermore, we found that the regulated GnT-IVa converts the heterogeneous N-glycosylated forms of CD147 in Hepa1-6 and Hca-F cells, and significantly changed the antennary oligosaccharide structures on CD147.
  • These results suggest that GnT-IVa could be acting as a key role in migration and metastasis of mouse hepatocarcinoma cells through altering the glycosylation of CD147.
  • [MeSH-major] Antigens, CD147 / genetics. Carcinoma, Hepatocellular / genetics. Gene Expression Regulation, Neoplastic. Liver Neoplasms / genetics. N-Acetylglucosaminyltransferases / genetics
  • [MeSH-minor] Animals. Carbohydrate Conformation. Cell Line, Tumor. Cell Movement. Glycosylation. Isoenzymes / genetics. Isoenzymes / metabolism. Mice. Plasmids. Polysaccharides / chemistry. Signal Transduction / genetics. Transfection

  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • (PMID = 22736280.001).
  • [ISSN] 1573-4986
  • [Journal-full-title] Glycoconjugate journal
  • [ISO-abbreviation] Glycoconj. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; 0 / Polysaccharides; 136894-56-9 / Antigens, CD147; EC 2.4.1.- / N-Acetylglucosaminyltransferases; EC 2.4.1.145 / alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase
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6. Zhang S, Shi Q, Albrecht U, Shatters RG Jr, Stange R, McCollum G, Zhang S, Fan C, Stover E: Comparative transcriptome analysis during early fruit development between three seedy citrus genotypes and their seedless mutants. Hortic Res; 2017;4:17041
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  • [Title] Comparative transcriptome analysis during early fruit development between three seedy citrus genotypes and their seedless mutants.
  • Transcriptome analysis was conducted at three time points during early fruit development (Phase 1) of three seedy citrus genotypes: Fallglo (Bower citrus hybrid (<i>Citrus reticulata</i>×<i>C. reticulata</i>×<i>C. paradisi</i>)×Temple (<i>C. reticulata</i>×<i>C. sinensis</i>)), grapefruit (<i>C. paradisi</i>), Pineapple sweet orange (<i>C. sinensis</i>), and their seedless mutants.
  • Affymetrix transcriptomic analysis revealed 359 to 1077 probe sets with differential transcript abundance in the comparison of seedless versus seedy fruits for each citrus genotypes and time points.
  • Hierarchical clustering analysis revealed a range of GDTA associated with development, hormone and protein metabolism, all of which may reflect genes associated with seedless fruit development.

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  • (PMID = 28904803.001).
  • [ISSN] 2052-7276
  • [Journal-full-title] Horticulture research
  • [ISO-abbreviation] Hortic Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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7. Hamdi OA, Anouar el H, Shilpi JA, Trabolsy ZB, Zain SB, Zakaria NS, Zulkefeli M, Weber JF, Malek SN, Rahman SN, Awang K: A Quantum Chemical and Statistical Study of Cytotoxic Activity of Compounds Isolated from Curcuma zedoaria. Int J Mol Sci; 2015;16(5):9450-68
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  • A series of 21 compounds isolated from Curcuma zedoaria was subjected to cytotoxicity test against MCF7; Ca Ski; PC3 and HT-29 cancer cell lines; and a normal HUVEC cell line.
  • Statistical analyses were carried out using simple and multiple linear regressions (SLR; MLR); principal component analysis (PCA); and hierarchical cluster analysis (HCA).
  • SLR analyses showed that the cytotoxicity of the isolated compounds against a given cell line depend on certain descriptors; and the corresponding correlation coefficients (R2) vary from 0%-55%.
  • Based on PCA; HCA and MLR analyses; active compounds were classified into subgroups; which was in agreement with the cell based cytotoxicity assay.
  • [MeSH-major] Curcuma / chemistry. Drug Screening Assays, Antitumor. Phytochemicals / chemistry
  • [MeSH-minor] Calcium / chemistry. Cell Line, Tumor. Cluster Analysis. HT29 Cells / drug effects. Human Umbilical Vein Endothelial Cells / drug effects. Humans. Inhibitory Concentration 50. Linear Models. MCF-7 Cells / drug effects. Molecular Structure. Principal Component Analysis. Quantitative Structure-Activity Relationship. Quantum Theory. Regression Analysis. Sesquiterpenes / chemistry

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 25923077.001).
  • [ISSN] 1422-0067
  • [Journal-full-title] International journal of molecular sciences
  • [ISO-abbreviation] Int J Mol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Phytochemicals; 0 / Sesquiterpenes; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC4463598
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8. Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y: Cholestenoic acids regulate motor neuron survival via liver X receptors. J Clin Invest; 2014 Nov;124(11):4829-42
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  • [Title] Cholestenoic acids regulate motor neuron survival via liver X receptors.
  • Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and determined that specific cholestenoic acids activate the liver X receptors (LXRs), enhance islet-1 expression in zebrafish, and increase the number of oculomotor neurons in the developing mouse in vitro and in vivo.
  • While 3β,7α-dihydroxycholest-5-en-26-oic acid (3β,7α-diHCA) promoted motor neuron survival in an LXR-dependent manner, 3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) promoted maturation of precursors into islet-1+ cells.
  • Unlike 3β,7α-diHCA and 3βH,7O-CA, 3β-hydroxycholest-5-en-26-oic acid (3β-HCA) caused motor neuron cell loss in mice.
  • Analysis of CSF and plasma from patients with SPG5 revealed an excess of the toxic LXR ligand, 3β-HCA, while patients with CTX and SPG5 exhibited low levels of the survival-promoting LXR ligand 3β,7α-diHCA.
  • Moreover, 3β,7α-diHCA prevented the loss of motor neurons induced by 3β-HCA in the developing mouse midbrain in vivo.Our results indicate that specific cholestenoic acids selectively work on motor neurons, via LXR, to regulate the balance between survival and death.
  • [MeSH-minor] Animals. Cell Survival. Cells, Cultured. Female. Humans. LIM-Homeodomain Proteins / metabolism. Liver X Receptors. Male. Mice, Inbred C57BL. Mice, Knockout. Paraparesis, Spastic / blood. Paraparesis, Spastic / cerebrospinal fluid. Transcription Factors / metabolism. Xanthomatosis, Cerebrotendinous / blood. Xanthomatosis, Cerebrotendinous / cerebrospinal fluid. Zebrafish

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  • (PMID = 25271621.001).
  • [ISSN] 1558-8238
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/C515771/2; United Kingdom / Biotechnology and Biological Sciences Research Council / / BBI0017351; United Kingdom / Biotechnology and Biological Sciences Research Council / / BBH0010181; United Kingdom / Medical Research Council / / MR/K026992/1; United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/C511356/1; United Kingdom / Wellcome Trust / / WT73429; United Kingdom / Biotechnology and Biological Sciences Research Council / / BBC5113561; United Kingdom / Biotechnology and Biological Sciences Research Council / / BBC5157712; United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/H001018/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholestenes; 0 / LIM-Homeodomain Proteins; 0 / Liver X Receptors; 0 / Orphan Nuclear Receptors; 0 / Transcription Factors; 0 / cholestenoic acid; 0 / insulin gene enhancer binding protein Isl-1
  • [Other-IDs] NLM/ PMC4347238
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9. Allen JG, Weiss ES, Wilson MA, Arnaoutakis GJ, Blue ME, Talbot CC Jr, Jie C, Lange MS, Troncoso JC, Johnston MV, Baumgartner WA: Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass. Ann Thorac Surg; 2010 Jun;89(6):1965-71
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  • [Title] Hawley H. Seiler Resident Award. Transcriptional profile of brain injury in hypothermic circulatory arrest and cardiopulmonary bypass.
  • BACKGROUND: Little is known about the molecular mechanisms of neurologic complications after hypothermic circulatory arrest (HCA) with cardiopulmonary bypass (CPB).
  • Canine genome sequencing allows profiling of genomic changes after HCA and CPB alone.
  • METHODS: Dogs underwent 2-hour HCA at 18 degrees C (n = 10), 1-hour HCA (n = 8), or 2-hour CPB at 32 degrees C alone (n = 8).
  • After neurologic scoring, brains were harvested for genomic analysis.
  • RESULTS: Consistent with prior work, dogs that underwent 2-hour HCA experienced severe neurologic injury.
  • One hour of HCA caused intermediate clinical damage.
  • Cardiopulmonary bypass, 1-hour HCA, and 2-hour HCA groups historically demonstrated increasing degrees of histopathologic damage (previously published).
  • Exploratory analysis revealed differences in significantly regulated genes (false discovery rate < 10%, absolute fold change > or = 1.2), with increases in differential gene expression with injury severity.
  • At 8 hours and 24 hours after insult, 2-hour HCA dogs had 502 and 1,057 genes regulated, respectively; 1-hour HCA dogs had 179 and 56 genes regulated; and CPB alone dogs had 5 and 0 genes regulated.
  • CONCLUSIONS: Our genomic profile of canine brains after HCA and CPB revealed 1-hour and 2-hour HCA induced markedly increased gene regulation, in contrast to the minimal effect of CPB alone.

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  • [Copyright] 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20494057.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL091541-18; United States / NHLBI NIH HHS / HL / HL091541-18; United States / NIDDK NIH HHS / DK / 2T32DK007713-12; United States / NINDS NIH HHS / NS / R37 NS031238; United States / NINDS NIH HHS / NS / R37NS31238-10; United States / NIDDK NIH HHS / DK / T32 DK007713; United States / NHLBI NIH HHS / HL / R01 HL091541
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS262168; NLM/ PMC3031914
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10. Iverson W, Straley E, Oldham S, Rojko J, Turman S, Wang Y: A lifetime aging study of human CD19 transgenic mice. Transgenic Res; 2017 Jun;26(3):363-373
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  • Clinical pathology evaluations revealed a declining red cell mass with a regenerative anemia, increasing total white blood cell counts and decreasing glucose level.
  • The most common neoplasms in this study were bronchiolar alveolar adenomas in the lung, histiocytic sarcoma in several different tissues, and hepatocellular adenomas.

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  • [ISSN] 1573-9368
  • [Journal-full-title] Transgenic research
  • [ISO-abbreviation] Transgenic Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Aged / CD19 / Inebilizumab / huCD19 Tg
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