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1. Cavallaro A, Piccolo G, Panebianco V, Lo Menzo E, Berretta M, Zanghì A, Di Vita M, Cappellani A: Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding. World J Gastroenterol; 2012 Aug 14;18(30):4019-27
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  • [Title] Incidental gallbladder cancer during laparoscopic cholecystectomy: managing an unexpected finding.
  • AIM: To evaluate the impact of incidental gallbladder cancer on surgical experience.
  • Gallbladder pathology was diagnosed by history, physical examination, and laboratory and imaging studies [ultrasonography and computed tomography (CT)].
  • Patients with gallbladder cancer (GBC) were further analyzed for demographic data, and type of operation, surgical morbidity and mortality, histopathological classification, and survival.
  • Preoperative diagnosis was made in 10 cases, and eight were diagnosed postoperatively.
  • Preoperative diagnosis of the 19 patients with GBC was: GBC with liver invasion diagnosed by preoperative CT (nine cases), gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum (one case), porcelain gallbladder (one case), gallbladder adenoma (one case), and chronic cholelithiasis (eight cases).
  • Six of the nine patients with incidental diagnosis reached 5-year DFS.
  • Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Cholecystectomy, Laparoscopic. Gallbladder Neoplasms / pathology. Gallbladder Neoplasms / surgery. Incidental Findings

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  • (PMID = 22912553.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3419999
  • [Keywords] NOTNLM ; Hepatic resection / Incidental gallbladder cancer / Laparoscopic cholecystectomy / Lymph nodes / Management / Outcome
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2. Chung WC, Wang J, Zhou Y, Xu K: Kras<sup>G12D</sup> upregulates Notch signaling to induce gallbladder tumorigenesis in mice. Oncoscience; 2017 Sep;4(9-10):131-138
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  • [Title] Kras<sup>G12D</sup> upregulates Notch signaling to induce gallbladder tumorigenesis in mice.
  • Background: Kras mutations and increased Notch activation occur frequently in gallbladder cancer.
  • However, their roles in gallbladder carcinogenesis have not been defined.
  • This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether Notch deregulation played a role in this context.
  • Methods: We determined Cre recombination activity of <i>Pdx1-Cre</i> in the gallbladder using a reporter strain and examined gallbladder tumor development in the <i>Kras<sup>LSL- G12D/+</sup>;Pdx1-Cre</i> mice.
  • We analyzed expression of Notch pathway genes in the mouse gallbladder by immunohistochemistry, quantitative RT-PCR, and Western blot analysis.
  • We also determined the effect of <i>Jag1</i> deletion on Kras-induced gallbladder tumor development.
  • Results: <i>Pdx1-Cre</i> exhibits robust recombination activity in the gallbladder epithelium.
  • <i>Kras<sup>LSL-G12D/+</sup>;Pdx1-Cre</i> mice form early onset adenoma in the gallbladder and adjacent biliary tract with complete penetrance, albeit short of invasive adenocarcinoma.
  • Kras<sup>G12D</sup> upregulates expressions of <i>Notch2, Notch3, Notch4</i>, <i>Jag1</i> and downstream target genes <i>Hes1</i>, <i>Hey1</i> and <i>Hey2</i>, and deletion of <i>Jag1</i> partially suppresses Kras<sup>G12D</sup>-induced adenoma development.
  • Conclusions: Kras<sup>G12D</sup> induces gallbladder adenoma and Notch plays a key role in Kras-initiated gallbladder tumorigenesis.

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  • (PMID = 29142904.001).
  • [ISSN] 2331-4737
  • [Journal-full-title] Oncoscience
  • [ISO-abbreviation] Oncoscience
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Kras mutation / Notch signaling / adenoma / gallbladder tumorigenesis / mouse model
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3. Ogawa T, Horaguchi J, Fujita N, Noda Y, Kobayashi G, Ito K, Koshita S, Kanno Y, Masu K, Sugita R: High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy. J Gastroenterol; 2012 Dec;47(12):1352-60
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  • [Title] High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: differentiation between benignity and malignancy.
  • However, only a few studies on gallbladder diseases have been published.
  • The aim of this study was to evaluate the usefulness and limitations of high b-value DWI for gallbladder diseases.
  • METHODS: A total of 153 patients (mean age 60 ± 15 years, 78 males) who had undergone DWI for evaluating gallbladder wall thickening or polypoid lesions were included in this study.
  • Of these 153 patients, 36 had gallbladder cancer and 117 had benign gallbladder diseases (67 chronic cholecystitis, 44 adenomyomatosis, four cholesterol polyp, one gallbladder adenoma, and one xanthogranulomatous cholecystitis).
  • RESULTS: The positive signal rate with DWI was significantly higher in gallbladder cancer (78 %) than in benign gallbladder diseases (22 %) (p < 0.001).
  • The mean ADC value of gallbladder cancer was (1.83 ± 0.69) × 10(-3) mm(2)/s and that of benign gallbladder diseases was (2.60 ± 0.54) × 10(-3) mm(2)/s (p < 0.001).
  • Benign gallbladder diseases with acute cholecystitis or a history of that had a higher positive signal rate with DWI (p < 0.001) and a lower ADC value (p = 0.018) than those without such conditions.
  • CONCLUSION: DWI can contribute to the improvement of the diagnostic capability for gallbladder wall thickening or polypoid lesions by compensating for weaknesses of other modalities by its many advantages, although cases with acute cholecystitis or such history sometimes show false-positive on DWI.
  • [MeSH-major] Gallbladder Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cholecystitis, Acute / diagnosis. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging / methods. Female. Gallbladder Neoplasms / diagnosis. Gallbladder Neoplasms / pathology. Gallstones / diagnosis. Humans. Image Interpretation, Computer-Assisted / methods. Male. Middle Aged

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  • [ISSN] 1435-5922
  • [Journal-full-title] Journal of gastroenterology
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4. Kamisawa T, Kuruma S, Chiba K, Tabata T, Koizumi S, Kikuyama M: Biliary carcinogenesis in pancreaticobiliary maljunction. J Gastroenterol; 2017 Feb;52(2):158-163
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  • According to the results of a nationwide survey, bile duct and gallbladder cancers were found in 6.9 and 13.4 % of adult patients with congenital biliary dilatation, respectively, and in 3.1 and 37.4 % of those with PBM without biliary dilatation, respectively.
  • The carcinogenesis of biliary tract cancer accompanying PBM is considered to involve a hyperplasia-dysplasia-carcinoma sequence induced by chronic inflammation caused by the reflux of pancreatic juice into the biliary tract, which differs from the adenoma-carcinoma sequence or the de novo carcinogenesis associated with biliary tract cancers in the population without PBM.
  • Patients with a relatively long common channel have a similar, albeit slightly lower, risk for gallbladder cancer compared with PBM patients.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts / abnormalities. Gallbladder Neoplasms / pathology. Pancreatic Ducts / abnormalities

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  • (PMID = 27704265.001).
  • [ISSN] 1435-5922
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Bile duct cancer / Congenital biliary dilatation / Gallbladder cancer / Pancreaticobiliary maljunction / Pancreatobiliary reflux
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5. Chen Y, Chen C, Ma C, Sun S, Zhang J, Sun Y: Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance. Int J Clin Exp Pathol; 2015;8(2):1946-53
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  • [Title] Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance.
  • PURPOSE: To detect the expression and prognostic clinical significance of heat-shock protein gp96 (HSP gp96) in gallbladder cancer.
  • METHODS: Immunohistochemistry was used to detect and compare the rate of HSP gp96 expression in 107 samples of gallbladder cancer, 70 of gallbladder adenoma and 67 of chronic cholecystitis.
  • RESULTS: The expression positive rate of HSP gp96 was 90.7% (97/107) in gallbladder cancer, 71.4% (50/70) in gallbladder adenoma and 47.76% (32/67) in chronic cholecystitis respectively.
  • The positive rate of HSP gp96 in gallbladder cancer tissues was significantly higher than that in gallbladder adenoma and chronic cholecystitis tissues (P < 0.01).
  • Multivariate and Cox regression analysis showed that positive of HSP gp96 (P = 0.026) expression was an independent poor prognostic predictor in gallbladder cancer.
  • CONCLUSIONS: HSP gp96-positive expression is closely correlated with poor survival in gallbladder cancer.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Gallbladder Neoplasms / metabolism. Heat-Shock Proteins / metabolism

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  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Heat-Shock Proteins
  • [Other-IDs] NLM/ PMC4396202
  • [Keywords] NOTNLM ; HSP gp96 / chronic cholecystitis / gallbladder adenoma / gallbladder cancer
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6. Rubio CA: Traditional serrated adenomas of the upper digestive tract. J Clin Pathol; 2016 Jan;69(1):1-5
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  • For many years, it was generally accepted that the vast majority of the colorectal carcinomas (CRCs) evolved from conventional adenomas, via the adenoma-carcinoma sequence.
  • In this work, we review the literature on TSA in the oesophagus, the stomach, the duodenum, the pancreatic main duct and the gallbladder.
  • [MeSH-major] Adenoma / pathology. Duodenal Neoplasms / pathology. Esophageal Neoplasms / pathology. Gallbladder / pathology. Pancreatic Neoplasms / pathology. Stomach Neoplasms / pathology

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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
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  • (PMID = 26468393.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC4717432
  • [Keywords] NOTNLM ; GALL BLADDER CANCER / GASTRIC CANCER / OESOPHAGUS / PANCREATIC CANCER
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7. Pilgrim CH, Groeschl RT, Christians KK, Gamblin TC: Modern perspectives on factors predisposing to the development of gallbladder cancer. HPB (Oxford); 2013 Nov;15(11):839-44
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  • [Title] Modern perspectives on factors predisposing to the development of gallbladder cancer.
  • BACKGROUND: Gallbladder cancer (GBC) is a rare malignancy, yet certain groups are at higher risk.
  • Knowledge of predisposing factors may facilitate earlier diagnosis by enabling targeted investigations into otherwise non-specific presenting signs and symptoms.
  • The significance of polyps in predisposing to GBC is probably overstated given the known dysplasia-carcinoma and adenoma-carcinoma sequences active in this disease.
  • Traditional risk factors such as porcelain gallbladder, Mirizzi's syndrome and bile reflux remain important as predisposing factors.
  • CONCLUSIONS: Subcentimetre gallbladder polyps rarely become cancerous.
  • Because gallbladder wall thickening is often the first sign of malignancy, all gallbladder imaging should be scrutinized carefully for this feature.
  • [MeSH-major] Cholecystitis / complications. Gallbladder Neoplasms / etiology. Gallstones / complications. Risk Assessment

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  • [Copyright] © 2013 International Hepato-Pancreato-Biliary Association.
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  • (PMID = 23458506.001).
  • [ISSN] 1477-2574
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4503280
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8. Kim J, Jang KT, Kim KH, Park JW, Chang BJ, Lee KH, Lee JK, Heo JS, Choi SH, Choi DW, Rhee JC, Lee KT: Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer. Tumour Biol; 2010 Oct;31(5):471-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Aberrant maspin expression is involved in early carcinogenesis of gallbladder cancer.
  • Recently, we identified several genes that may be tumor markers for gallbladder (GB) cancer using a DNA microarray method.
  • The aims of this study were to determine maspin expression in normal mucosa, adenoma, dysplasia and carcinoma of GB, and to compare the pattern of maspin expression in early and advanced GB cancers.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / metabolism. Cell Transformation, Neoplastic / metabolism. Gallbladder Neoplasms / metabolism. Serpins / biosynthesis
  • [MeSH-minor] Adenoma / metabolism. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Tissue Array Analysis

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  • (PMID = 20517662.001).
  • [ISSN] 1423-0380
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Hong SN, Lee TY, Yun SC: The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases. J Korean Med Sci; 2015 Sep;30(9):1288-94
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  • [Title] The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases.
  • Cholecystectomy is associated with an increased risk of colorectal cancer, but little is known about the relationship between gallbladder disease and colorectal adenoma.
  • Gallbladder polyps and colorectal neoplasia (CRN) share several risk factors such as obesity, diabetes and metabolic syndrome, which might account for their association.
  • In this study, we investigated whether asymptomatic patients with gallbladder disease are at increased risk of CRN and identified the factors to their association.
  • The prevalence of CRNs in patients with gallbladder polyps or gallstones was significantly higher than that in the control group (32.1% vs. 26.8%; P = 0.032, 35.8% vs. 26.9%; P = 0.020).
  • A multivariate regression analysis showed that gallbladder polyps were an independent risk factor for CRN [adjusted odds ratio (OR): 1.29; 95% confidence interval (CI); 1.03-1.62] whereas gallstones were not (adjusted OR: 1.14; 95% CI: 0.79-1.63).
  • The adjusted OR for the risk of CRN was 1.12 for gallbladder polyps < 5 mm (95% CI, 0.85-1.46) and 1.79 for gallbladder polyps ≥ 5 mm (95% CI, 1.15-2.77).
  • Our results suggest that colorectal neoplasia is significantly related to gallbladder polyps, especially those ≥ 5 mm.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / epidemiology. Gallbladder Diseases / diagnosis. Gallbladder Diseases / epidemiology

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  • (PMID = 26339169.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4553676
  • [Keywords] NOTNLM ; Colorectal Neoplasms / Gallbladder / Korea / Risk Factors
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10. Wang W, Ai KX, Yuan Z, Huang XY, Zhang HZ: Different expression of S100A8 in malignant and benign gallbladder diseases. Dig Dis Sci; 2013 Jan;58(1):150-62
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  • [Title] Different expression of S100A8 in malignant and benign gallbladder diseases.
  • Comparative proteomic analysis of human bile from malignant and benign gallbladder diseases may be helpful in research into gallbladder cancer.
  • AIMS: Our objective was to establish biliary protein content for gallbladder cancer, gallbladder adenoma, and chronic calculous cholecystitis for comparative proteomic analysis.
  • METHODS: Bile samples were collected from patients with gallbladder cancer, gallbladder adenoma, and chronic calculous cholecystitis.
  • RESULTS: Up to 544, 221, and 495 unique proteins were identified in bile samples from gallbladder cancer, gallbladder adenoma, and chronic calculous cholecystitis.
  • Among these, 30 proteins including S100A8 were overexpressed in gallbladder cancer, compared with benign gallbladder diseases.
  • CONCLUSIONS: Compared with benign gallbladder diseases, consistently elevated S100A8 levels in malignant gallbladder bile and tissue indicate that gallbladder cancer is an inflammation-associated cancer.
  • S100A8 may be a biomarker for gallbladder cancer.
  • [MeSH-major] Adenoma / metabolism. Bile / chemistry. Calgranulin A / metabolism. Cholecystitis / metabolism. Gallbladder Neoplasms / metabolism. Gene Expression Regulation, Neoplastic / physiology

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  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Calgranulin A
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