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1. Izumi H, Yazawa N, Furukawa D, Masuoka Y, Yamada M, Mashiko T, Kawashima Y, Ogawa M, Kawaguchi Y, Mine T, Hirabayashi K, Nakagohri T: Bile duct carcinoma associated with congenital biliary dilatation in a 16-year-old female: a case report and literature review. Surg Case Rep; 2016 Dec;2(1):5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bile duct carcinoma associated with congenital biliary dilatation in a 16-year-old female: a case report and literature review.
  • We encountered a very rare case of bile duct carcinoma associated with congenital biliary dilatation (CBD) in a 16-year-old female who was admitted to our hospital because of right upper abdominal pain and vomiting.
  • Abdominal computed tomography demonstrated a cystic dilatation of the common bile duct measuring 7 cm in diameter and two enhanced tumors 4 cm in diameter located in the inferior bile duct and middle bile duct.
  • Magnetic resonance cholangiopancreatography clearly demonstrated a cystic dilatation of the extrahepatic bile duct (Todani's CBD classification: type 4-A).
  • Biopsy results of one of the tumors confirmed adenocarcinoma.
  • Excision of the perihilar bile duct and subtotal stomach-preserving pancreaticoduodenectomy with dissection of the major lymph nodes were performed.
  • A postoperative histopathologic examination revealed a well-differentiated tubular adenocarcinoma, which remained within the mucosal layer, and no lymph node metastasis was found.

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  • (PMID = 26943681.001).
  • [ISSN] 2198-7793
  • [Journal-full-title] Surgical case reports
  • [ISO-abbreviation] Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC4722045
  • [Keywords] NOTNLM ; Bile duct carcinoma / Congenital biliary dilatation / Pancreaticobiliary maljunction / Pancreaticoduodenectomy
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2. Min KW, Kim DH, Son BK, Kim EK, Ahn SB, Kim SH, Jo YJ, Park YS, Seo J, Oh YH, Oh S, Kim HY, Kwon MJ, Min SK, Park HR, Choe JY, Jeon JY, Ha HI, Lee JW: Invasion Depth Measured in Millimeters is a Predictor of Survival in Patients with Distal Bile Duct Cancer: Decision Tree Approach. World J Surg; 2017 01;41(1):232-240
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasion Depth Measured in Millimeters is a Predictor of Survival in Patients with Distal Bile Duct Cancer: Decision Tree Approach.
  • BACKGROUND: AJCC staging system is unreliable for predicting survival in distal bile duct (DBD) cancer patients, due to inter-observer variation.
  • METHODS: Data of 179 patients with DBD adenocarcinoma treated in three institutions were investigated.
  • RESULTS: Deeply invading tumors exhibited a greater tendency toward the infiltrative type, high histological grade, AJCC stage, and pancreatic, duodenal, lymphovascular and perineural invasion.
  • [MeSH-major] Adenocarcinoma / pathology. Bile Duct Neoplasms / mortality. Bile Duct Neoplasms / pathology. Cholangiocarcinoma / pathology. Decision Trees. Neoplasm Invasiveness / pathology

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  • (PMID = 27549598.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Lee JK, Capanu M, O'Reilly EM, Ma J, Chou JF, Shia J, Katz SS, Gansukh B, Reidy-Lagunes D, Segal NH, Yu KH, Chung KY, Saltz LB, Abou-Alfa GK: A phase II study of gemcitabine and cisplatin plus sorafenib in patients with advanced biliary adenocarcinomas. Br J Cancer; 2013 Aug 20;109(4):915-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: This study evaluated the addition of sorafenib to gemcitabine and cisplatin in biliary adenocarcinoma first-line therapy.
  • The primary end point was an improvement in 6-month progression-free survival (PFS6) from historical 57-77% (90% power, type I error of 10%).
  • The most common grade 3-4 toxicities noted in >10% of patients were fatigue, elevated liver function tests and haematologic toxicities including thromboemboli, hyponatraemia and hypophosphataemia.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biliary Tract Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / drug therapy. Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / drug therapy. Cholangiocarcinoma / pathology. Cisplatin / administration & dosage. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Disease-Free Survival. Female. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / pathology. Humans. Male. Middle Aged. Niacinamide / administration & dosage. Niacinamide / analogs & derivatives. Phenylurea Compounds / administration & dosage. Treatment Outcome

  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
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  • (PMID = 23900219.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Phenylurea Compounds; 0W860991D6 / Deoxycytidine; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC3749586
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4. Cho JY, Han HS, Yoon YS, Hwang DW, Jung K, Kim YK: Postoperative complications influence prognosis and recurrence patterns in periampullary cancer. World J Surg; 2013 Sep;37(9):2234-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Clinical data were reviewed from 200 consecutive patients who had periampullary cancer and underwent PD between October 2003 and July 2010, and survival outcomes and recurrence patterns were analyzed.
  • There were no differences in gender, mean age, tumor node metastasis stage, biliary drainage, type of resection, and radicality between the two groups (P > 0.05).
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Duodenal Neoplasms / mortality. Pancreatic Neoplasms / mortality. Pancreaticoduodenectomy. Postoperative Complications / mortality


5. Murakami M, Katayama K, Kato S, Fujimoto D, Morikawa M, Koneri K, Hirono Y, Goi T: Large-cell neuroendocrine carcinoma of the common bile duct: a case report and a review of literature. Surg Case Rep; 2016 Dec;2(1):141
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  • [Title] Large-cell neuroendocrine carcinoma of the common bile duct: a case report and a review of literature.
  • BACKGROUND: Large-cell neuroendocrine carcinoma (LCNEC) of the bile duct is extremely rare and is a high-grade type of neuroendocrine tumor with an aggressive clinical course.
  • Here, we report a case of LCNEC of the extrahepatic bile duct.
  • Endoscopic retrograde cholangiography and enhanced computed tomography revealed complete obstruction of the common bile duct (CBD) by a dense tumor measuring 1.5 cm in diameter.
  • Although there were no malignant cells in the biliary brush cytology, we suspected a cholangiocarcinoma and performed extrahepatic bile duct resection.
  • Histologically, the LCNEC occupied most of the places deeper than the stratum submucosum and an adenocarcinoma component, approximately 15%, was present in the mucosa.
  • The patient died of multiple liver, lung, and peritoneal metastases 3 months after surgery.

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  • (PMID = 27888490.001).
  • [ISSN] 2198-7793
  • [Journal-full-title] Surgical case reports
  • [ISO-abbreviation] Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Common bile duct / Large-cell neuroendocrine carcinoma / Neuroendocrine tumor
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6. Sung R, Kang L, Han JH, Choi JW, Lee SH, Lee TH, Park SH, Kim HJ, Lee ES, Kim YS, Choi YW, Park SM: Differential expression of E-cadherin, β-catenin, and S100A4 in intestinal type and nonintestinal type ampulla of Vater cancers. Gut Liver; 2014 Jan;8(1):94-101
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  • [Title] Differential expression of E-cadherin, β-catenin, and S100A4 in intestinal type and nonintestinal type ampulla of Vater cancers.
  • BACKGROUND/AIMS: Epithelial-mesenchymal transition (EMT)-related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs).
  • We evaluated the expression of E-cadherin, β-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival.
  • The association between clinicopathological parameters, histological type, and expression of EMT proteins and their effects on survival were analyzed.
  • RESULTS: Sixty-five intestinal type, 35 pancreatobiliary type, and five other types of AVCs were identified.
  • The severity of EMT changes differed between the AVC types; membranous loss of E-cadherin and β-catenin was observed in nonintestinal type tumors, whereas aberrant nonmembranous β-catenin expression was observed in intestinal type tumors.
  • Among the clinicopathological parameters, a desmoplastic reaction was related to overall survival, and the reaction was more severe in nonintestinal type than in intestinal type AVCs.
  • [MeSH-major] Ampulla of Vater / metabolism. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / metabolism

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 24516707.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / S100 Proteins; 0 / beta Catenin; 142662-27-9 / S100A4 protein, human
  • [Other-IDs] NLM/ PMC3916694
  • [Keywords] NOTNLM ; Ampullary adenocarcinoma / Epithelial-mesenchymal transition / Intestinal type / Pancreatobiliary type
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7. Kondo NI, Shirabe K, Mano Y, Taketomi A, Yoshizumi T, Ikegami T, Masuda T, Kayashima H, Hashimoto N, Morita K, Matsuo M, Maehara Y: Late recurrence after resection of mass-forming intrahepatic cholangiocarcinoma: report of a case. Surg Today; 2012 Dec;42(12):1210-4
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  • The gross appearance showed a mass-forming type tumor.
  • The histopathological examination revealed well to moderately differentiated adenocarcinoma associated with portal vein invasion.
  • [MeSH-major] Cholangiocarcinoma / secondary. Cholangiocarcinoma / surgery. Head and Neck Neoplasms / secondary. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Bile Duct Neoplasms. Bile Ducts, Intrahepatic. Fatal Outcome. Female. Follow-Up Studies. Hepatectomy. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis


8. Nakanuma Y, Sato Y, Ojima H, Kanai Y, Aishima S, Yamamoto M, Ariizumi S, Furukawa T, Hayashi H, Unno M, Ohta T, Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi): Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". Int J Clin Exp Pathol; 2014;7(6):3112-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)".
  • Cholangiocarcinoma (CC) of the biliary tract occasionally presents a predominant intraductal papillary growth in the bile ducts, called as biliary tract carcinoma (BTC) of papillary growth (PG) and intrahepatic CC (ICC) of intraductal growth (IG) type.
  • Recently, intraductal papillary neoplasm of bile duct (IPNB) has been proposed as a pre-invasive biliary neoplasm.
  • This study was performed to characterize pathologically BTC of PG type and ICC of IG type with respect to IPNB.
  • It was found that 126 of such 154 CCs (81.8%) fulfilled the criteria of IPNB, while the remaining 28 cases showed different histologies, such as tubular adenocarcinoma and carcinosarcoma.
  • These IPNBs occurred in old aged patients with a male predominance, and the left lobe was rather frequently affected in the liver.
  • Pancreatobiliary type was predominant (48 cases) followed by gastric (30 cases), intestinal (29 cases) and oncocytic (19 cases) types.
  • Mucus hypersecretion was found in 45 cases, and this was frequent in IPNB at the intrahepatic large bile duct and hilar bile ducts but rare at the extrahepatic bile ducts.
  • In conclusion, a majority of ICC of IG type and BTC of PG type could be regarded as a IPNB lineage, and clinically detectable IPNBs were already a malignant papillary lesion.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Papillary / pathology. Cholangiocarcinoma / pathology

  • MedlinePlus Health Information. consumer health - Bile Duct Cancer.
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  • (PMID = 25031730.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4097227
  • [Keywords] NOTNLM ; Biliary tree / intraductal cholangiocarcinoma / intraductal papillary neoplasm / papillary cholangiocarcinoma / phenotype
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9. French JB, Coe AW, Pawa R: Endoscopic ultrasound-guided choledochoduodenostomy with a lumen-apposing, self-expandable fully covered metal stent for palliative biliary drainage. Clin J Gastroenterol; 2016 Apr;9(2):79-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In addition to the poor prognosis associated with pancreatic adenocarcinoma, it can also lead to several other conditions including obstructive jaundice that can affect a patient's quality of life.
  • We describe two cases in which this type of stent was used in patients for palliative biliary drainage in pancreatic adenocarcinoma where standard ERCP was not feasible.
  • [MeSH-major] Common Bile Duct / surgery. Duodenostomy / methods. Endosonography / methods. Jaundice, Obstructive / surgery. Palliative Care / methods. Self Expandable Metallic Stents
  • [MeSH-minor] Adenocarcinoma / complications. Aged. Aged, 80 and over. Drainage / methods. Female. Humans. Pancreatic Neoplasms / complications. Quality of Life

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  • (PMID = 26956721.001).
  • [ISSN] 1865-7265
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Biliary drainage / EUS / Lumen apposing metal stent
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10. Gonzalez RS, Bagci P, Basturk O, Reid MD, Balci S, Knight JH, Kong SY, Memis B, Jang KT, Ohike N, Tajiri T, Bandyopadhyay S, Krasinskas AM, Kim GE, Cheng JD, Adsay NV: Intrapancreatic distal common bile duct carcinoma: Analysis, staging considerations, and comparison with pancreatic ductal and ampullary adenocarcinomas. Mod Pathol; 2016 Nov;29(11):1358-1369
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intrapancreatic distal common bile duct carcinoma: Analysis, staging considerations, and comparison with pancreatic ductal and ampullary adenocarcinomas.
  • Distal common bile duct carcinoma is a poorly characterized entity for reasons such as variable terminology and difficulty in determining site of origin of intrapancreatic lesions.
  • We compared clinicopathologic features of pancreatobiliary-type adenocarcinomas within the pancreas, but arising from the distal common bile duct, with those of pancreatic and ampullary origin.
  • Upon careful review of 1017 pancreatoduodenectomy specimens with primary adenocarcinoma, 52 (5%) qualified as intrapancreatic distal common bile duct carcinoma.
  • Distal common bile duct carcinoma patients had a younger median age (58 years) than pancreatic ductal adenocarcinoma patients (65 years) and ampullary carcinoma patients (68 years).
  • Distal common bile duct carcinoma was intermediate between pancreatic ductal adenocarcinoma and ampullary carcinoma with regard to tumor size and rates of node metastases and margin positivity.
  • Median survival was better than for pancreatic ductal adenocarcinoma (P=0.0010) but worse than for ampullary carcinoma (P=0.0006).
  • Distal common bile duct carcinoma often formed an even band around the common bile duct and commonly showed intraglandular neutrophil-rich debris and a small tubular pattern.
  • Primary distal common bile duct carcinoma is seen in younger patients than pancreatic ductal adenocarcinoma or ampullary carcinoma.
  • Its prognosis is significantly better than pancreatic ductal adenocarcinoma and worse than ampullary carcinoma, at least partly because of differences in clinical presentation.
  • Invasive pancreatobiliary-type distal common bile duct carcinomas are uncommon in the West and have substantial clinicopathologic differences from carcinomas arising from the pancreas and ampulla.

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  • (PMID = 27469329.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748
  • [Publication-type] Journal Article
  • [Publication-country] United States
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