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1. Hommel T, Szeimies RM: [Actinic keratoses]. Hautarzt; 2016 Nov;67(11):867-875
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  • [Title] [Actinic keratoses].
  • [Transliterated title] Aktinische Keratosen.
  • Actinic keratosis (AK) is a very common skin diagnosis in office-based dermatology.
  • Due to the demographic changes with increasing numbers of elderly people, the proportion of patients with AK is expected rise.
  • In addition to targeted therapies for isolated AK many field-directed treatment modalities are available.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / prevention & control. Keratosis, Actinic / pathology. Keratosis, Actinic / therapy. Skin Neoplasms / pathology. Skin Neoplasms / prevention & control

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • (PMID = 27613022.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Keywords] NOTNLM ; Field-directed treatment / Keratinocytes / Lesions / Precancerous conditions / Squamous cell carcinoma
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2. Cohen DK, Lee PK: Photodynamic Therapy for Non-Melanoma Skin Cancers. Cancers (Basel); 2016 Oct 04;8(10)
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  • Actinic keratosis (AKs) are considered precancerous lesions that eventually may progress to squamous cell carcinoma (SCC).
  • Nodular BCC and Bowen's disease (SCC in situ) have shown acceptable response rates with PDT, although recurrence rates are higher for these two NMSC subtypes.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 27782043.001).
  • [Journal-full-title] Cancers
  • [ISO-abbreviation] Cancers (Basel)
  • [Language] eng
  • [Publication-type] Review; Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; basal cell carcinoma / non‐melanoma skin cancer / photodynamic therapy / squamous cell carcinoma
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3. Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH, Tuong ZK: A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury. EBioMedicine; 2016 Jul;9:314-323
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  • Here we examine keratin gene expression profile in skin from mice expressing the E7 oncoprotein of HPV16 (K14E7) demonstrating persistently hyperproliferative epithelium, in nontransgenic mouse skin, and in hyperproliferative actinic keratosis lesions from human skin.
  • We demonstrate that K14E7 mouse skin overexpresses stress keratins in a similar manner to human actinic keratoses, that overexpression is a consequence of epithelial hyperproliferation induced by E7, and that overexpression further increases in response to injury.
  • [MeSH-major] Keratins / metabolism. Keratosis / pathology. Skin / metabolism
  • [MeSH-minor] Animals. Cell Differentiation. Cytoskeleton / metabolism. Disease Models, Animal. Gene Expression. Human papillomavirus 16 / genetics. Humans. Keratin-14 / genetics. Mice. Mice, Inbred C57BL. Mice, Transgenic. Microscopy, Confocal. Papillomavirus E7 Proteins / genetics. Promoter Regions, Genetic. Transplantation, Homologous

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  • [Copyright] Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
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  • (PMID = 27333029.001).
  • [ISSN] 2352-3964
  • [Journal-full-title] EBioMedicine
  • [ISO-abbreviation] EBioMedicine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratin-14; 0 / Papillomavirus E7 Proteins; 0 / oncogene protein E7, Human papillomavirus type 16; 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC4972546
  • [Keywords] NOTNLM ; E7 / HPV16 / Hyperplasia / Keratins
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4. Ko DY, Kim KH, Song KH: Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up. Ann Dermatol; 2014 Jun;26(3):321-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative Study of Photodynamic Therapy with Topical Methyl Aminolevulinate versus 5-Aminolevulinic Acid for Facial Actinic Keratosis with Long-Term Follow-Up.
  • BACKGROUND: Few studies have compared the efficacy, cosmetic outcomes, and adverse events between 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and methyl aminolevulinate-PDT (MAL-PDT) for actinic keratoses (AKs) in Asian ethnic populations with dark-skin.

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  • (PMID = 24966631.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4069642
  • [Keywords] NOTNLM ; 5-aminolevulinic acid / Long-term efficacy / Methyl aminolevulinate / Multiple actinic keratoses / Photodynamic therapy
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5. Sato Y, Fujimura T, Tamabuchi E, Haga T, Aiba S: Dermoscopy findings of hidroacanthoma simplex. Case Rep Dermatol; 2014 May;6(2):154-8
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  • Hidroacanthoma simplex (HAS), also known as intraepidermal eccrine poroma, is a rare eccrine adnexal tumor that tends to be misdiagnosed as other types of benign skin tumor, including clonal seborrheic keratosis.
  • Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma.
  • Therefore, accurate diagnosis of HAS is indispensable for dermatologists to avoid the development of malignant tumors by an unsuitable treatment.
  • Indeed, the dermoscopy findings might be related to the melanin-rich necrotic cells in the epidermis, which are quite different from dermoscopy findings of clonal seborrheic keratosis.
  • As a previous report suggested, it is difficult for a dermatologist to differentiate HAS from clonal seborrheic keratosis by the naked eye.
  • Our findings might be supportive for the early diagnosis of HAS.

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  • (PMID = 24987351.001).
  • [ISSN] 1662-6567
  • [Journal-full-title] Case reports in dermatology
  • [ISO-abbreviation] Case Rep Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC4067718
  • [Keywords] NOTNLM ; Dermoscopy / Hidroacanthoma simplex / Muskmelon appearance
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7. Terada T: Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis. Int J Clin Oncol; 2010 Dec;15(6):608-10
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  • [Title] Pigmented Bowen disease arising in pigmented reticulated seborrheic keratosis.
  • A clinical diagnosis of basal cell carcinoma was made, and an excision with wide margins was performed.
  • The periphery of the tumor showed typical features of pigmented reticulated seborrheic keratosis.
  • This case suggests that pigmented Bowen disease can arise in pigmented reticulated seborrheic keratosis.
  • [MeSH-major] Bowen's Disease / etiology. Carcinoma, Basal Cell / complications. Keratosis, Seborrheic / complications. Skin Neoplasms / etiology

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8. Lanfredini S, Olivero C, Borgogna C, Calati F, Powell K, Davies KJ, De Andrea M, Harries S, Tang HKC, Pfister H, Gariglio M, Patel GK: HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion. J Invest Dermatol; 2017 Oct;137(10):2208-2216
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  • In patients with epidermodysplasia verruciformis, β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma.
  • Epidermodysplasia verruciformis keratosis and in some cases actinic keratoses demonstrated similar histology associated with β-HPV reactivation and nuclear p63 expression within the HF infundibulum and perifollicular epidermis.
  • [MeSH-major] Keratinocytes / pathology. Keratosis, Actinic / pathology. Membrane Glycoproteins / metabolism. Neoplasms, Experimental. Neoplastic Stem Cells / pathology. Nerve Tissue Proteins / metabolism. Skin Neoplasms / pathology

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  • [Copyright] Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
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  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
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9. King AJ, Brown GD, Gilday AD, Larson TR, Graham IA: Production of bioactive diterpenoids in the euphorbiaceae depends on evolutionarily conserved gene clusters. Plant Cell; 2014 Aug;26(8):3286-98
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  • These diterpenoids include ingenol mebutate, which is licensed for the treatment of a precancerous skin condition (actinic keratosis), and phorbol derivatives such as resiniferatoxin and prostratin, which are undergoing investigation for the treatment of severe pain and HIV, respectively.

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  • [Copyright] © 2014 American Society of Plant Biologists. All rights reserved.
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  • (PMID = 25172144.001).
  • [ISSN] 1532-298X
  • [Journal-full-title] The Plant cell
  • [ISO-abbreviation] Plant Cell
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ KF986809/ KF986810/ KF986811/ KF986812/ KF986813/ KF986814/ KF986815/ KF986816/ KF986817/ KF986818/ KF986819/ KF986820/ KF986821/ KF986822/ KF986823/ KF986824/ KF986825/ KF986826/ KJ026362
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diterpenes; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 4.2.3.8 / casbene synthetase; EC 4.6.- / Phosphorus-Oxygen Lyases
  • [Other-IDs] NLM/ PMC4371829
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10. Siegel DH, Mann JA, Krol AL, Rauen KA: Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development. Br J Dermatol; 2012 Mar;166(3):601-7
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  • Individuals with CS are less likely than individuals with CFC to present with sparse or absent eyebrows (9% vs. 90%, P<0·001) or keratosis pilaris (33% vs. 80%, P=0·001).
  • CONCLUSIONS: While there is significant phenotypic overlap among syndromes of the Ras/MAPK pathway, individuals with CS are more likely than individuals with CFC syndrome to present with cutaneous papillomas, palmoplantar keratoderma and full eyebrows, and are less likely to present with ulerythema ophryogenes, keratosis pilaris or multiple naevi.

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  • [Copyright] © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
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  • (PMID = 22098123.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / K23 HD048502; United States / NICHD NIH HHS / HD / K23 HD048502-01; United States / NCRR NIH HHS / RR / UL1 RR024140; United States / NICHD NIH HHS / HD / HD048502
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS339752; NLM/ PMC4063554
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