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1. Schwarz S, Müller M, Ettl T, Stockmann P, Zenk J, Agaimy A: Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Int J Clin Exp Pathol; 2011 Apr;4(4):336-48
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  • [Title] Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
  • We analyzed 41 oral salivary gland carcinomas from consecutive 290 salivary gland carcinoma database (14%) with emphasis on the histological spectrum and clinical outcome of adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA).
  • The cohort included 14 ACCs, 14 mucoepidermoid carcinomas (MECs), 8 PLGAs, 3 adenocarcinomas, not otherwise specified and 2 acinic cell carcinomas.
  • Eight patients (19.5%) died of tumor at a mean interval of 66.5 months.
  • However, ACC tended to show higher tumor stage and residual tumor (R1/R2) more frequently than PLGA, but this was statistically not significant.
  • Fluorescence in situ hybridization (FISH) performed on all 290 salivary carcinomas confirmed the specificity of the translocation t (11;.
  • Our results emphasize the diversity of oral salivary gland carcinomas and the overlapping clinicopathological features of ACC and PLGA.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Adenoid Cystic / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / pathology. Carcinoma, Mucoepidermoid / pathology. Cell Differentiation. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 19. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Kaplan-Meier Estimate. Keratin-5 / analysis. Keratin-7 / analysis. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prognosis. Proto-Oncogene Proteins c-kit / analysis. Time Factors. Translocation, Genetic. Ubiquitin-Protein Ligases / analysis. Young Adult

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  • MedlinePlus Health Information. consumer health - Salivary Gland Cancer.
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  • (PMID = 21577319.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT5 protein, human; 0 / KRT7 protein, human; 0 / Keratin-5; 0 / Keratin-7; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
  • [Other-IDs] NLM/ PMC3093058
  • [Keywords] NOTNLM ; Oral salivary gland carcinoma / acinic cell carcinoma / adenoid cystic carcinoma / polymorphous low-grade adenocarcinoma
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2. Costa AF, Altemani A, Hermsen M: Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors. Patholog Res Int; 2011;2011:325965
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  • [Title] Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors.
  • The concept of dedifferentiation had previously been used in salivary gland carcinomas.
  • Recently, the term "high-grade transformation" was introduced for adenoid cystic carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, and polymorphous low-grade adenocarcinoma and may better reflect this phenomenon, although transformation into moderately differentiated adenocarcinoma (i.e., not "high grade") has also been described.
  • The overexpression of p53 was observed in the transformed component in all tumor types studied, despite few cases having been demonstrated to carry mutations or deletions in TP53 gene.
  • Genetic studies in salivary gland tumors with dedifferentiation/high-grade transformation are rare and deserve further investigation.
  • This paper aims at providing an overview on the recent concepts in histopathological classification of salivary gland tumors, complemented by immunohistochemical and genetic findings.

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  • (PMID = 21876843.001).
  • [ISSN] 2042-003X
  • [Journal-full-title] Pathology research international
  • [ISO-abbreviation] Patholog Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3160012
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3. Suzuki S, Dobashi Y, Minato H, Tajiri R, Yoshizaki T, Ooi A: EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas. Virchows Arch; 2012 Sep;461(3):271-82
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  • [Title] EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.
  • Salivary gland carcinomas encompass a wide spectrum of histological entities.
  • To identify candidate therapeutic targets and innovative treatment options for these carcinomas, we examined epidermal growth factor receptor (EGFR), phosphorylated EGFR (p-EGFR), HER2, and phosphorylated forms of Akt (p-Akt) and mammalian target of rapamycin (p-mTOR) in 47 salivary gland tumors using immunohistochemistry.
  • EGFR overexpression was found in 51 % of the tumors (24/47); in particular, EGFR overexpression occurred in mucoepidermoid (seven out of seven) and salivary duct carcinomas (9/12).
  • Although EGFR amplification was not detected by fluorescence in situ hybridization analysis, increased copy number due to polysomy of chromosome 7, which houses EGFR, was observed in 4 of the 24 tumors with EGFR overexpression; this polysomy occurred most frequently in salivary duct carcinomas (three out of nine).
  • (1) an EGFR/HER2(-Akt)-mTOR-dependent axis, with gene gains of HER2 and/or EGFR, activated in salivary duct carcinoma and carcinoma ex pleomorphic adenoma;.
  • (2) an EGFR(-Akt)-mTOR-dependent pathway activated in mucoepidermoid carcinoma or acinic cell carcinoma, without HER2 or EGFR gene alterations; and (3) an Akt-dependent pathway without EGFR/HER2 activation in other types.
  • [MeSH-major] Carcinoma, Mucoepidermoid / metabolism. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism. Salivary Gland Neoplasms / metabolism. TOR Serine-Threonine Kinases / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. DNA, Neoplasm / analysis. Female. Gene Duplication. Gene Expression Regulation, Neoplastic. Humans. In Situ Hybridization, Fluorescence. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Phosphorylation. Proto-Oncogene Proteins c-akt. Salivary Ducts / pathology. Signal Transduction


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4. Cha W, Kim MS, Ahn JC, Cho SW, Sunwoo W, Song CM, Kwon TK, Sung MW, Kim KH: Clinical analysis of acinic cell carcinoma in parotid gland. Clin Exp Otorhinolaryngol; 2011 Dec;4(4):188-92
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  • [Title] Clinical analysis of acinic cell carcinoma in parotid gland.
  • OBJECTIVES: Acinic cell carcinoma (AciCC) is a rarely encountered malignancy in parotid gland.
  • METHODS: We retrospectively reviewed medical records of the 20 patients with AciCC of parotid gland diagnosed from 1990 to 2009.
  • The AJCC tumor stage distributions of the patients were 70%, 15%, and 15% for stages I, II, and IV, respectively.
  • CONCLUSION: AciCC of the parotid gland is a rare malignancy that has features of less aggressive behavior, and good prognosis.
  • Intraoperative frozen section examination may be helpful in the diagnosis of AciCC of the parotid gland because of the low sensitivity of preoperative computed tomography scan and FNAC.

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  • (PMID = 22232714.001).
  • [ISSN] 2005-0720
  • [Journal-full-title] Clinical and experimental otorhinolaryngology
  • [ISO-abbreviation] Clin Exp Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3250583
  • [Keywords] NOTNLM ; Acinic cell carcinoma / Parotid neoplasms / Salivary gland neoplasms
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5. Nichols AC, Chan-Seng-Yue M, Yoo J, Agrawal SK, Starmans MH, Waggott D, Harding NJ, Dowthwaite SA, Palma DA, Fung K, Wehrli B, Macneil SD, Lambin P, Winquist E, Koropatnick J, Mymryk JS, Boutros PC, Barrett JW: A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. Case Rep Oncol Med; 2013;2013:270362
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  • [Title] A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.
  • We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland.
  • The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53.
  • Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

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  • (PMID = 23653877.001).
  • [ISSN] 2090-6706
  • [Journal-full-title] Case reports in oncological medicine
  • [ISO-abbreviation] Case Rep Oncol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3638544
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7. Al-Otaibi SS, Alotaibi F, Al Zaher Y, Al Zaher N, Dababo MA: High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant. Case Rep Otolaryngol; 2017;2017:7296467
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant.
  • Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature.
  • We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size.
  • The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.

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  • (PMID = 28589053.001).
  • [ISSN] 2090-6765
  • [Journal-full-title] Case reports in otolaryngology
  • [ISO-abbreviation] Case Rep Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Remenschneider A, Meier J, VanderLaan P, Faquin W, Deschler D, Frankenthaler R: Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy. Laryngoscope; 2014 Jan;124(1):188-195
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  • [Title] Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy.
  • OBJECTIVES/HYPOTHESIS: To review the known histopathologic findings and clinical behavior of mammary analogue secretory carcinoma (MASC).
  • REVIEW METHODS: Literature search using the terms "Mammary analogue secretory carcinoma," "Mammary analog secretory carcinoma," and "MASC" to identify all relevant publications.
  • RESULTS: MASC is an unusual and rare malignant salivary gland tumor first described in 2010.
  • It shares histologic, immunohistochemical, and genetic features with secretory carcinoma of the breast.
  • Many cases of MASC were discovered in archived cases previously classified as acinic cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma not otherwise specified.
  • CONCLUSION: MASC is a newly recognized variant of salivary gland malignancy.
  • [MeSH-major] Carcinoma. Salivary Gland Neoplasms

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  • [Copyright] © 2013 The American Laryngological, Rhinological and Otological Society, Inc.
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  • (PMID = 23775296.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / T32 DC000020
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Secretory breast carcinoma
  • [Other-IDs] NLM/ NIHMS698521; NLM/ PMC4500055
  • [Keywords] NOTNLM ; Salivary gland carcinoma / head and neck surgery / mammary analogue secretory carcinoma / parotid malignancy
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9. Hsieh MS, Chou YH, Yeh SJ, Chang YL: Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland. Virchows Arch; 2015 Aug;467(2):145-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland.
  • Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 translocation and morphologically overlaps with acinic cell carcinoma (AciCC).
  • We used comprehensive histologic subtyping to provide a semiquantitive assessment of histologic patterns in each tumor and performed immunohistochemical analyses including S100/vimentin/mammaglobin/DOG1.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Salivary Gland Cancer.
  • antibodies-online. View related products from antibodies-online.com (subscription/membership/fee required).
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  • (PMID = 25976476.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ETV6-NTRK3 fusion protein, human; 0 / Oncogene Proteins, Fusion
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10. Askari M, Darabi M, Jahanzad E, Mostakhdemian Hosseini Z, Musavi Chavoshi M, Darabi M: Immunohistochemichal Assessment of the CrkII Proto-oncogene Expression in Common Malignant Salivary Gland Tumors and Pleomorphic Adenoma. J Dent Res Dent Clin Dent Prospects; 2015;9(1):29-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemichal Assessment of the CrkII Proto-oncogene Expression in Common Malignant Salivary Gland Tumors and Pleomorphic Adenoma.
  • Various morphologies are seen in different salivary gland tumorsor within an individual tumor, and the lesions show divers biological behaviors.
  • Experimental results support the hypothesis that increased CrkII proto-oncogene is associated with cytokine-induced tumor initiation and progression by altering cell motility signaling pathway.
  • The aim of this study was to assess the CrkII expression in common malignant salivary gland tumors and pleomorphic ade-noma.
  • Immunohistochemical analysis of CrkII expression was performed on paraffin blocks of 64 car-cinomas of salivary glands, 10 pleomorphic adenomas, and 10 normal salivary glands.
  • Evaluation of immunoreactivity of CrkII was based on the immunoreaction intensity and percentage of stained tumor cells which were scored semi-quantitatively on a scale with four grades 0 to 3.
  • Results. Increased expression of CrkII was seen (P=0.005) in malignant tumors including: mucoepidermoid carcinoma, adenoid cystic carcinoma, and carcinoma ex pleomorphic adenoma, but CrkII expression in acinic cell carcinoma was weak.
  • A weak staining was sparsely seen in normal acinar serous cell.
  • Conclusion. Increased expression of CrkII and its higher intensity of staining in tumors with more aggressive biologic behavior in carcinomas of salivary gland is consistent with a role for this proto-oncogene in salivary gland tumorigenesis and cancer progression.

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  • (PMID = 25973151.001).
  • [ISSN] 2008-210X
  • [Journal-full-title] Journal of dental research, dental clinics, dental prospects
  • [ISO-abbreviation] J Dent Res Dent Clin Dent Prospects
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC4417490
  • [Keywords] NOTNLM ; CrkII / immunohistochemistry / salivary gland carcinoma
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