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1. Shaheen S, Guddati AK: Gastrointestinal stromal tumor: a rare abdominal tumor. Case Rep Oncol; 2013 Jan;6(1):148-53
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  • [Title] Gastrointestinal stromal tumor: a rare abdominal tumor.
  • Gastrointestinal stromal tumors (GISTs) are rare abdominal tumors which arise from the interstitial cells of Cajal in the gastrointestinal tract.
  • Gastric GISTs are the most commonly seen GIST tumors and may grow to a very large size.
  • They are often associated with abdominal pain, anorexia and weight loss.
  • These tumors have been found to harbor mutations in CD117 which causes constitutional activation of the tyrosine kinase signaling pathway and is considered to be pathognomic.
  • Tyrosine kinase inhibitors such as imatinib have revolutionized the treatment of these tumors, which are otherwise resistant to conventional chemotherapy and radiotherapy.
  • We present a case of gastric GIST which grew to a very large size and was associated with abdominal pain and weight loss.

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  • (PMID = 23569450.001).
  • [ISSN] 1662-6575
  • [Journal-full-title] Case reports in oncology
  • [ISO-abbreviation] Case Rep Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3618098
  • [Keywords] NOTNLM ; Abdominal tumor / CD117 / Gastric tumor / Gastrointestinal stromal tumor / Rare tumor / Size
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2. Yamada S, Nabeshima A, Noguchi H, Nawata A, Nishii H, Guo X, Wang KY, Hisaoka M, Nakayama T: Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma. World J Gastroenterol; 2015 Jan 28;21(4):1349-56
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  • [Title] Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma.
  • Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter.
  • Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed.
  • On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern.
  • Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor (PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma.
  • The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease.
  • [MeSH-major] Adenocarcinoma / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Perivascular Epithelioid Cell Neoplasms / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Back Pain / etiology. Biomarkers, Tumor / analysis. Biopsy. Carcinoma / pathology. Diagnosis, Differential. Gastrectomy. Humans. Immunohistochemistry. Male. Pneumonectomy. Predictive Value of Tests. Thyroid Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 25632212.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; Adenocarcinoma of lung; Thyroid cancer, papillary
  • [Other-IDs] NLM/ PMC4306183
  • [Keywords] NOTNLM ; Gastric serosa / Lung adenocarcinoma / Malignant / Metastatic carcinoma / Perivascular epithelioid cell tumor
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4. Rudloff U, Bhanot U, Gerald W, Klimstra DS, Jarnagin WR, Brennan MF, Allen PJ: Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality. Ann Surg Oncol; 2010 Aug;17(8):2229-36
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  • METHODS: A prospective institutional review board-approved protocol for the banking of abdominal neoplasms was initiated at Memorial Sloan-Kettering Cancer Center in 2001.
  • [MeSH-major] Pancreatic Neoplasms. RNA, Neoplasm / analysis. Specimen Handling / methods. Tissue Banks

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  • (PMID = 20162455.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm
  • [Other-IDs] NLM/ NIHMS479692; NLM/ PMC3877690
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5. Kalaskar RR, Kalaskar AR: Neuroblastoma in early childhood: A rare case report and review of literature. Contemp Clin Dent; 2016 Jul-Sep;7(3):401-4
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  • Neuroblastoma is an extremely rare pediatric neoplasm whose prognosis becomes poor and poor as the age advances.
  • It is primarily a tumor of abdominal origin from where it metastasis to lymph nodes, liver, intracranial and orbital sites, and central nervous system.

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  • (PMID = 27630510.001).
  • [ISSN] 0976-237X
  • [Journal-full-title] Contemporary clinical dentistry
  • [ISO-abbreviation] Contemp Clin Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC5004559
  • [Keywords] NOTNLM ; Displaced teeth / hard palate / neuroblastoma / preventive / proptosis
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6. Miyamoto Y, Muguruma N, Kimura T, Okamoto K, Sogabe M, Miyamoto H, Kohno S, Nakasono M, Hayashi H, Bando Y, Takayama T: Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer. Clin J Gastroenterol; 2016 Jun;9(3):134-9
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  • She was diagnosed as having multiple polyps in the stomach and colon by gastroscopy and sigmoidoscopy as well as multiple liver tumors by abdominal CT.
  • Total colonoscopy revealed a type 2 tumor in the transverse colon and more than 200 polyps distributed throughout the colorectum.
  • Biopsies of the tumor and polyps showed histological characteristics of adenocarcinoma and tubulovillous adenoma, respectively.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Colonic Neoplasms / complications. Protein-Losing Enteropathies / etiology
  • [MeSH-minor] Adult. Colonoscopy. DNA Mutational Analysis / methods. Edema / etiology. Female. Gastroscopy. Genes, APC. Humans. Leg. Liver Neoplasms / diagnostic imaging. Mutation. Pedigree. Radionuclide Imaging. Tomography, X-Ray Computed

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  • (PMID = 27170298.001).
  • [ISSN] 1865-7265
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; APC gene mutation / Leg edema / Tubulovillous adenoma
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7. Ocak M, Gillman AG, Bresee J, Zhang L, Vlad AM, Müller C, Schibli R, Edwards WB, Anderson CJ, Gach HM: Folate receptor-targeted multimodality imaging of ovarian cancer in a novel syngeneic mouse model. Mol Pharm; 2015 Feb 2;12(2):542-53
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  • A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, murine ovarian cancer cell line that emulates the human disease and induces widespread intraperitoneal (i.p.) tumors in immunocompetent mice within 4-8 weeks of implantation.
  • Tumor development was monitored using a new positron emission tomography (PET) FR-targeting reporter with PET/computerized tomography (PET/CT) and fluorescence molecular tomography (FMT) using a commercial FR-targeting reporter.
  • Imaging was performed weekly beginning 2 weeks after tumor induction.
  • The albumin-binding, FR-targeting ligand cm09 was radiolabeled with the positron emitter (68)Ga and used to image the tumors with a small animal PET/CT.
  • Tumors were visible by all three imaging modalities.
  • PET/CT had the highest imaging sensitivity at 3-3.5 h postadministration (mean %IA/g mean > 6) and visualized tumors earlier than the other two modalities with lower kidney uptake (mean %IA/g mean < 17) than previously reported FR-targeting agents in late stage disease.
  • MRI produced the highest resolution images, but it was difficult to distinguish tumors from abdominal organs during early progression since a FR-targeting MRI reporter was not used.
  • Tumors in the mouse ovarian cancer model could be detected using FR-targeted imaging as early as 2 weeks post i.p. injection of tumor cells.
  • An imaging protocol should combine one or more of the modalities, e.g., PET/CT or PET/MRI for optimal tumor detection and delineation from surrounding tissues.

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  • (PMID = 25536192.001).
  • [ISSN] 1543-8392
  • [Journal-full-title] Molecular pharmaceutics
  • [ISO-abbreviation] Mol. Pharm.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA047904; United States / NCI NIH HHS / CA / R01 CA163462; United States / NCI NIH HHS / CA / P30CA047904; United States / NCI NIH HHS / CA / R01CA163462
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Folate Receptors, GPI-Anchored
  • [Other-IDs] NLM/ PMC4319688
  • [Keywords] NOTNLM ; 68Ga / FolateRSense / MRI / PET/CT / cm09 / fluorescence molecular tomography / folate receptor targeting / immunocompetent ovarian cancer mouse model
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8. Ansil PN, Wills PJ, Varun R, Latha MS: Cytotoxic and apoptotic activities of Amorphophallus campanulatus (Roxb.) Bl. tuber extracts against human colon carcinoma cell line HCT-15. Saudi J Biol Sci; 2014 Dec;21(6):524-31
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  • This tuber has also been traditionally used for the treatment of abdominal tumors, liver diseases, piles etc.

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  • (PMID = 25473360.001).
  • [ISSN] 1319-562X
  • [Journal-full-title] Saudi journal of biological sciences
  • [ISO-abbreviation] Saudi J Biol Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC4250507
  • [Keywords] NOTNLM ; Amorphophallus campanulatus / Annexin-V / Colon cancer / DAPI / JC-1 / MTT
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9. Rasalkar DD, Chu WC, Cheng FW, Hui SK, Ling SC, Li CK: A pictorial review of imaging of abdominal tumours in adolescence. Pediatr Radiol; 2010 Sep;40(9):1552-61; quiz 1589-90
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  • [Title] A pictorial review of imaging of abdominal tumours in adolescence.
  • Neoplastic abdominal tumours, particularly those originating from embryonal tissue (such as hepatoblastoma and nephroblastoma) and neural crest cells (such as neuroblastoma), are well-documented in young children.
  • Neoplasms of adulthood, most commonly carcinoma of different visceral organs, are also well-documented.
  • Abdominal tumours in adolescence constitute a distinct pathological group.
  • The radiological features of some of these tumours have been described only in isolated reports.
  • The purpose of this pictorial essay was to review the imaging findings of various kinds of abdominal tumours in adolescent patients (with an age range of 10-16 years) who presented to the Children Cancer Center of our institution in the past 15 years.
  • Some tumours, though rare, have characteristic imaging appearances (especially in CT) that enable an accurate diagnosis before definite histological confirmation.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Diagnostic Imaging. Neuroectodermal Tumors / diagnosis

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  • (PMID = 20602098.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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10. Brzezinski J, Shuman C, Choufani S, Ray P, Stavropoulos DJ, Basran R, Steele L, Parkinson N, Grant R, Thorner P, Lorenzo A, Weksberg R: Wilms tumour in Beckwith-Wiedemann Syndrome and loss of methylation at imprinting centre 2: revisiting tumour surveillance guidelines. Eur J Hum Genet; 2017 Sep;25(9):1031-1039
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Wilms tumour in Beckwith-Wiedemann Syndrome and loss of methylation at imprinting centre 2: revisiting tumour surveillance guidelines.
  • Children with BWS have a significant risk of developing Wilms tumours with the degree of risk being dependent on the underlying molecular mechanism.
  • In particular, only a relatively small number of children with loss of methylation at the centromeric imprinting centre (IC2) were reported to have developed Wilms tumour.
  • Discontinuation of tumour surveillance for children with BWS and loss of methylation at IC2 has been proposed in several recent publications.
  • We report here three children with BWS reported to have loss of methylation at IC2 on clinical testing who developed Wilms tumour or precursor lesions.
  • These cases highlight the current challenges in definitively assigning tumour risk based on molecular classification in BWS.
  • The confirmed cases of loss of methylation at IC2 also suggest that the risk of Wilms tumour in this population is not as low as previously thought.
  • Therefore, we recommend that for now, all children with a clinical or molecular diagnosis of BWS be screened for Wilms tumour by abdominal ultrasonography until the age of eight years regardless of the molecular classification.
  • [MeSH-major] Beckwith-Wiedemann Syndrome / genetics. DNA Methylation. Genomic Imprinting. Wilms Tumor / genetics

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  • (PMID = 28699632.001).
  • [ISSN] 1476-5438
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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