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1. Ramasamy S, Abrol R, Suloway CJ, Clemons WM Jr: The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation. Structure; 2013 May 7;21(5):777-88
Hazardous Substances Data Bank. (L)-ARGININE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation.
  • In bacteria, two signal-sequence-dependent secretion pathways translocate proteins across the cytoplasmic membrane.
  • Although the mechanism of the ubiquitous general secretory pathway is becoming well understood, that of the twin-arginine translocation pathway, responsible for translocation of folded proteins across the bilayer, is more mysterious.
  • TatC, the largest and most conserved of three integral membrane components, provides the initial binding site of the signal sequence prior to pore assembly.
  • Here, we present two crystal structures of TatC from the thermophilic bacteria Aquifex aeolicus at 4.0 Å and 6.8 Å resolution.
  • The membrane architecture of TatC includes a glove-shaped structure with a lipid-exposed pocket predicted by molecular dynamics to distort the membrane.
  • Correlating the biochemical literature to these results suggests that the signal sequence binds in this pocket, leading to structural changes that facilitate higher order assemblies.

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • [Cites] Biochemistry. 2007 Mar 13;46(10):2892-8 [17300178.001]
  • [Cites] J Biol Chem. 2007 Mar 16;282(11):7903-11 [17229735.001]
  • [Cites] EMBO J. 2007 Jul 11;26(13):3039-49 [17568769.001]
  • [Cites] J Bacteriol. 2007 Aug;189(15):5482-94 [17545291.001]
  • [Cites] J Cell Biol. 2007 Oct 8;179(1):87-99 [17908913.001]
  • [Cites] J Mol Biol. 2007 Nov 23;374(2):283-91 [17936785.001]
  • [Cites] Bioinformatics. 2007 Nov 1;23(21):2947-8 [17846036.001]
  • [Cites] Science. 2007 Nov 23;318(5854):1266-73 [17962519.001]
  • [Cites] Biophys J. 2008 May 1;94(9):3393-404 [18212019.001]
  • [Cites] J Biol Chem. 2008 Nov 28;283(48):33267-75 [18836181.001]
  • [Cites] FEBS J. 2008 Dec;275(24):6159-67 [19016855.001]
  • [Cites] J Biol Chem. 2012 Apr 13;287(16):13430-41 [22362773.001]
  • [Cites] Annu Rev Biophys. 2012;41:21-40 [22224601.001]
  • [Cites] Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13284-9 [19666509.001]
  • [Cites] Mol Microbiol. 2009 Oct;74(1):209-26 [19732346.001]
  • [Cites] Mol Biosyst. 2010 Jun;6(6):999-1007 [20485744.001]
  • [Cites] Biochim Biophys Acta. 2011 Mar;1808(3):866-75 [20800571.001]
  • [Cites] PLoS One. 2011;6(3):e18140 [21479178.001]
  • [Cites] Protein Sci. 2011 Jul;20(7):1256-64 [21563225.001]
  • [Cites] Biochim Biophys Acta. 2011 Sep;1808(9):2289-96 [21683683.001]
  • [Cites] J Mol Microbiol Biotechnol. 2011;20(3):168-75 [21709427.001]
  • [Cites] Future Microbiol. 2011 Nov;6(11):1315-27 [22082291.001]
  • [Cites] Nat Rev Mol Cell Biol. 2011 Dec;12(12):787-98 [22086371.001]
  • [Cites] Biochim Biophys Acta. 2012 Dec;1818(12):3025-31 [22960285.001]
  • [Cites] Nature. 2012 Dec 13;492(7428):210-4 [23201679.001]
  • [Cites] Nat Commun. 2012;3:1311 [23250441.001]
  • [Cites] J Biol Chem. 2000 Dec 29;275(52):41350-7 [11007775.001]
  • [Cites] J Bacteriol. 2001 Mar;183(5):1663-71 [11160097.001]
  • [Cites] J Biol Chem. 2001 Jun 8;276(23):20213-9 [11279240.001]
  • [Cites] Eur J Biochem. 2001 Jun;268(12):3361-7 [11422364.001]
  • [Cites] J Cell Biol. 2001 Aug 20;154(4):719-29 [11502764.001]
  • [Cites] J Bacteriol. 2001 Dec;183(23):6727-32 [11698358.001]
  • [Cites] J Biol Chem. 2001 Nov 16;276(46):42761-6 [11526115.001]
  • [Cites] Nucleic Acids Res. 2012 Jan;40(Database issue):D290-301 [22127870.001]
  • [Cites] Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1029-46 [22411976.001]
  • [Cites] Nat Rev Microbiol. 2012 Jul;10(7):483-96 [22683878.001]
  • [Cites] PLoS One. 2012;7(6):e39867 [22761916.001]
  • [Cites] Mol Microbiol. 2012 Sep;85(5):945-61 [22742417.001]
  • [Cites] J Biol Chem. 1999 Dec 17;274(51):36073-82 [10593889.001]
  • [Cites] J Mol Microbiol Biotechnol. 2000 Apr;2(2):179-89 [10939242.001]
  • [Cites] J Bacteriol. 2001 Jan;183(1):139-44 [11114910.001]
  • [Cites] J Biol Chem. 2002 Mar 22;277(12):10362-6 [11781311.001]
  • [Cites] Mol Microbiol. 2002 Mar;43(6):1457-70 [11952898.001]
  • [Cites] Arch Microbiol. 2002 Jun;177(6):441-50 [12029389.001]
  • [Cites] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8312-7 [12034867.001]
  • [Cites] FEBS Lett. 2002 Aug 14;525(1-3):65-70 [12163163.001]
  • [Cites] Nature. 2002 Aug 8;418(6898):662-5 [12167867.001]
  • [Cites] Mol Microbiol. 2002 Aug;45(4):943-50 [12180915.001]
  • [Cites] J Mol Biol. 2002 Oct 4;322(5):1135-46 [12367533.001]
  • [Cites] Microbiology. 2002 Nov;148(Pt 11):3335-46 [12427925.001]
  • [Cites] J Bacteriol. 2003 Feb;185(4):1478-83 [12562823.001]
  • [Cites] Eur J Biochem. 2003 Aug;270(16):3345-52 [12899691.001]
  • [Cites] Mol Microbiol. 2003 Sep;49(5):1377-90 [12940994.001]
  • [Cites] Mol Cell. 2003 Oct;12(4):937-46 [14580344.001]
  • [Cites] Science. 2003 Nov 7;302(5647):1009-14 [14526088.001]
  • [Cites] Nature. 2004 Jan 1;427(6969):36-44 [14661030.001]
  • [Cites] FEMS Microbiol Lett. 2004 May 15;234(2):303-8 [15135537.001]
  • [Cites] J Mol Biol. 2004 Aug 20;341(4):901-9 [15328603.001]
  • [Cites] EMBO J. 1995 Jun 15;14(12):2715-22 [7796800.001]
  • [Cites] Mol Microbiol. 1996 Nov;22(3):393-404 [8939424.001]
  • [Cites] Science. 1997 Nov 21;278(5342):1467-70 [9367960.001]
  • [Cites] Cell. 1998 Apr 3;93(1):93-101 [9546395.001]
  • [Cites] EMBO J. 1998 Jul 1;17(13):3640-50 [9649434.001]
  • [Cites] J Biol Chem. 1998 Jul 17;273(29):18003-6 [9660752.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9459-64 [10449714.001]
  • [Cites] Mol Microbiol. 2004 Dec;54(5):1319-25 [15554971.001]
  • [Cites] Biochem Biophys Res Commun. 2005 Apr 8;329(2):693-8 [15737641.001]
  • [Cites] J Mol Biol. 2005 Mar 25;347(2):453-63 [15740752.001]
  • [Cites] FEBS J. 2005 May;272(9):2261-75 [15853811.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10482-6 [16027357.001]
  • [Cites] J Cell Biol. 2005 Oct 24;171(2):281-9 [16230459.001]
  • [Cites] J Bacteriol. 2005 Dec;187(23):8104-13 [16291683.001]
  • [Cites] Biochemistry. 2006 Feb 21;45(7):2243-9 [16475812.001]
  • [Cites] FEMS Microbiol Lett. 2006 Mar;256(1):44-9 [16487318.001]
  • [Cites] J Bacteriol. 2006 Sep;188(18):6669-79 [16952959.001]
  • [Cites] J Biol Chem. 2006 Nov 10;281(45):34072-85 [16973610.001]
  • [Cites] J Biol Chem. 2007 Feb 23;282(8):5263-72 [17172598.001]
  • (PMID = 23583035.001).
  • [ISSN] 1878-4186
  • [Journal-full-title] Structure (London, England : 1993)
  • [ISO-abbreviation] Structure
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / DP1 GM105385; United States / NIH HHS / OD / DP1 OD008304; United States / NIH HHS / OD / 1DP1OD008304-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Membrane Transport Proteins; 0 / Protein Sorting Signals; 94ZLA3W45F / Arginine
  • [Other-IDs] NLM/ NIHMS459474; NLM/ PMC3653977
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