[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Item 1 of about 1
1. Duan M, Fan J, Huo S: Conformations of islet amyloid polypeptide monomers in a membrane environment: implications for fibril formation. PLoS One; 2012;7(11):e47150

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conformations of islet amyloid polypeptide monomers in a membrane environment: implications for fibril formation.
  • The amyloid fibrils formed by islet amyloid polypeptide (IAPP) are associated with type II diabetes.
  • One of the proposed mechanisms of the toxicity of IAPP is that it causes membrane damage.
  • The fatal mutation of S20G human IAPP was reported to lead to early onset of type II diabetes and high tendency of amyloid formation in vitro.
  • Characterizing the structural features of the S20G mutant in its monomeric state is experimentally difficult because of its unusually fast aggregation rate.
  • Computational work complements experimental studies.
  • We performed a series of molecular dynamics simulations of the monomeric state of human variants in the membrane.
  • Our simulations are validated by extensive comparisons with experimental data.
  • We find that a helical disruption at His18 is common to both human variants.
  • An L-shaped motif of S20G mutant is observed in one of the conformational families.
  • This motif that bends at His18 resembles the overall topology of IAPP fibrils.
  • The conformational preorganization into the fibril-like topology provides a possible explanation for the fast aggregation rate of S20G IAPP.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Biochim Biophys Acta. 2011 Oct;1808(10):2337-42 [21723249.001]
  • [Cites] Physiol Rev. 2011 Jul;91(3):795-826 [21742788.001]
  • [Cites] J Biol Chem. 2012 Feb 17;287(8):5235-41 [22187437.001]
  • [Cites] Biophys J. 2012 Mar 7;102(5):1059-68 [22404928.001]
  • [Cites] Acc Chem Res. 2012 Mar 20;45(3):454-62 [21942864.001]
  • [Cites] PLoS One. 2012;7(5):e38191 [22693597.001]
  • [Cites] J Mol Biol. 2012 Aug 10;421(2-3):282-95 [22206987.001]
  • [Cites] J Biol Chem. 2000 May 12;275(19):14077-83 [10799482.001]
  • [Cites] Am J Pathol. 2000 Dec;157(6):2101-9 [11106582.001]
  • [Cites] Clin Endocrinol (Oxf). 2001 Apr;54(4):541-6 [11318791.001]
  • [Cites] Amyloid. 2001 Dec;8(4):242-9 [11791616.001]
  • [Cites] Biochemistry. 2002 Sep 24;41(38):11338-43 [12234175.001]
  • [Cites] J Biomol NMR. 2003 Jul;26(3):215-40 [12766419.001]
  • [Cites] Biophys J. 2004 Mar;86(3):1574-86 [14990484.001]
  • [Cites] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254.001]
  • [Cites] J Comput Chem. 2004 Oct;25(13):1656-76 [15264259.001]
  • [Cites] J Clin Endocrinol Metab. 2004 Aug;89(8):3629-43 [15292279.001]
  • [Cites] J Mol Biol. 2004 Aug 27;341(5):1175-87 [15321714.001]
  • [Cites] Ups J Med Sci. 1972;77(2):91-4 [4116019.001]
  • [Cites] J Mol Biol. 1984 May 5;175(1):75-81 [6427470.001]
  • [Cites] Biochemistry. 1992 Feb 18;31(6):1647-51 [1737021.001]
  • [Cites] Endocr Rev. 1994 Apr;15(2):163-201 [8026387.001]
  • [Cites] Lipids. 1994 Oct;29(10):685-92 [7861935.001]
  • [Cites] J Biomol NMR. 1995 Jan;5(1):67-81 [7881273.001]
  • [Cites] J Biol Chem. 1996 Jan 26;271(4):1988-92 [8567648.001]
  • [Cites] Diabetes. 1996 Sep;45(9):1279-81 [8772735.001]
  • [Cites] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2256-68 [15572779.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10427-32 [16020533.001]
  • [Cites] Biochemistry. 2005 Sep 13;44(36):12113-9 [16142909.001]
  • [Cites] Biochemistry. 2005 Nov 8;44(44):14626-37 [16262262.001]
  • [Cites] J Mol Biol. 2006 Mar 3;356(4):1049-63 [16403526.001]
  • [Cites] J Phys Chem B. 2005 Aug 11;109(31):15052-9 [16852905.001]
  • [Cites] Biochemistry. 2006 Aug 8;45(31):9496-508 [16878984.001]
  • [Cites] Biochim Biophys Acta. 2007 Aug;1768(8):2002-9 [17349968.001]
  • [Cites] Biochemistry. 2007 Nov 27;46(47):13505-22 [17979302.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6033-8 [18408164.001]
  • [Cites] J Biol Chem. 2008 Jun 20;283(25):17205-10 [18442979.001]
  • [Cites] J Phys Chem B. 2009 Feb 26;113(8):2498-505 [19182939.001]
  • [Cites] J Biol Chem. 2009 May 1;284(18):11982-91 [19244249.001]
  • [Cites] Annu Rev Biophys. 2009;38:125-52 [19416063.001]
  • [Cites] Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6614-9 [19346479.001]
  • [Cites] J Phys Chem B. 2009 May 21;113(20):7308-14 [19402658.001]
  • [Cites] Biophys J. 2009 Jun 3;96(11):4552-60 [19486677.001]
  • [Cites] J Am Chem Soc. 2009 Jun 17;131(23):8252-61 [19456151.001]
  • [Cites] Protein Sci. 2009 Jul;18(7):1521-30 [19475663.001]
  • [Cites] J Comput Chem. 2009 Sep;30(12):1952-8 [19090582.001]
  • [Cites] Protein Eng Des Sel. 2009 Aug;22(8):497-513 [19596697.001]
  • [Cites] J Mol Biol. 2009 Oct 23;393(2):383-96 [19647750.001]
  • [Cites] J Am Chem Soc. 2009 Dec 30;131(51):18283-92 [19950949.001]
  • [Cites] Biophys J. 2010 Feb 3;98(3):443-51 [20141758.001]
  • [Cites] J Comput Chem. 2010 Aug;31(11):2169-74 [20336801.001]
  • [Cites] J Am Chem Soc. 2010 Jul 7;132(26):8973-83 [20536124.001]
  • [Cites] Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5628-54 [20623810.001]
  • [Cites] Biophys J. 2010 Oct 6;99(7):2208-16 [20923655.001]
  • [Cites] J Am Chem Soc. 2010 Dec 29;132(51):18223-32 [21138275.001]
  • [Cites] J Biol Chem. 2011 Feb 25;286(8):6291-300 [21148563.001]
  • [Cites] J Comput Chem. 2011 May;32(7):1400-10 [21425293.001]
  • [Cites] J Am Chem Soc. 2011 Jun 1;133(21):8094-7 [21534603.001]
  • [Cites] Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9460-5 [21606325.001]
  • [Cites] J Phys Chem B. 2012 Jan 12;116(1):646-52 [22126397.001]
  • (PMID = 23133593.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM088326; United States / NIGMS NIH HHS / GM / 1R01-GM088326
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid; 0 / Disulfides; 0 / Islet Amyloid Polypeptide; 0 / Lipid Bilayers; 0 / Lipids; 0 / Peptides; 0 / Phosphatidylcholines; 0 / Phosphatidylserines; 0 / Proteins; 70614-14-1 / 1,2-dioleoylphosphatidylserine; H026DM5V6U / 1,2-oleoylphosphatidylcholine
  • [Other-IDs] NLM/ PMC3487734
  •  go-up   go-down


Advertisement





Advertisement