[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Item 1 of about 1
1. Manev H, Manev R: Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection. Cardiovasc Psychiatry Neurol; 2010;2010:838164
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Benefits of neuropsychiatric phenomics: example of the 5-lipoxygenase-leptin-Alzheimer connection.
  • Phenomics is a systematic study of phenotypes on a genomewide scale that is expected to unravel, as of yet, unsuspected functional roles of the genome.
  • It remains to be determined how to optimally approach and analyze the available phenomics databases to spearhead innovation in neuropsychiatry.
  • By serendipitously connecting two unrelated phenotypes of increased blood levels of the adipokine leptin, a molecule that regulates appetite, in 5-lipoxygenase- (5-LOX) deficient mice and patients with a lower risk for Alzheimer's disease (AD), we postulated a leptin-mediated basis for beneficial effects of ALOX5 (a gene encoding 5-LOX) gene-deficiency in AD.
  • We suggest that it might be possible to avoid relying on serendipity and develop data-mining tools capable of extracting from phenomics databases indications for such novel hypotheses.
  • Hence, we provide an example of using a free-access Arrowsmith two-node search interface to identify ALOX5 as unsuspected putative mechanisms for the previously described clinical association between increased plasma levels of leptin and a lower risk of incident dementia and AD.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] FASEB J. 2008 Apr;22(4):1169-78 [17998412.001]
  • [Cites] Diabetologia. 2008 Jun;51(6):978-88 [18421434.001]
  • [Cites] JAMA. 2009 Dec 16;302(23):2565-72 [20009056.001]
  • [Cites] Comput Methods Programs Biomed. 2009 May;94(2):190-7 [19185946.001]
  • [Cites] Neuroscience. 2009 Nov 24;164(1):30-42 [19344640.001]
  • [Cites] J Histochem Cytochem. 2008 Dec;56(12):1065-73 [18678882.001]
  • (PMID = 20672007.001).
  • [ISSN] 2090-0171
  • [Journal-full-title] Cardiovascular psychiatry and neurology
  • [ISO-abbreviation] Cardiovasc Psychiatry Neurol
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG015347
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2905908
  •  go-up   go-down


Advertisement





Advertisement