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1. Smalheiser NR, Torvik VI, Zhou W: Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE. Comput Methods Programs Biomed; 2009 May;94(2):190-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Arrowsmith two-node search interface: a tutorial on finding meaningful links between two disparate sets of articles in MEDLINE.
  • The Arrowsmith two-node search is a strategy that is designed to assist biomedical investigators in formulating and assessing scientific hypotheses.
  • More generally, it allows users to identify biologically meaningful links between any two sets of articles A and C in PubMed, even when these share no articles or authors in common and represent disparate topics or disciplines.
  • The key idea is to relate the two sets of articles via title words and phrases (B-terms) that they share.
  • We have created a free, public web-based version of the two-node search tool (http://arrowsmith.psych.uic.edu), have described its development and implementation, and have presented analyses of individual two-node searches.
  • In this paper, we provide an updated tutorial intended for end-users, that covers the use of the tool for a variety of potential scientific use case scenarios.
  • For example, one can assess a recent experimental, clinical or epidemiologic finding that connects two disparate fields of inquiry--identifying likely mechanisms to explain the finding, and choosing promising follow-up lines of investigation.
  • Alternatively, one can assess whether the existing scientific literature lends indirect support to a hypothesis posed by the user that has not yet been investigated.
  • One can also employ two-node searches to search for novel hypotheses.
  • Arrowsmith provides a service that cannot be carried out feasibly via standard PubMed searches or by other available text mining tools.

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  • (PMID = 19185946.001).
  • [ISSN] 1872-7565
  • [Journal-full-title] Computer methods and programs in biomedicine
  • [ISO-abbreviation] Comput Methods Programs Biomed
  • [Language] ENG
  • [Grant] United States / NLM NIH HHS / LM / R01 LM007292; United States / NLM NIH HHS / LM / LM008364; United States / NLM NIH HHS / LM / R21 LM008364; United States / NLM NIH HHS / LM / R01 LM007292-05; United States / NLM NIH HHS / LM / LM008364-02; United States / NLM NIH HHS / LM / R21 LM008364-02; United States / NLM NIH HHS / LM / LM007292
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Other-IDs] NLM/ NIHMS105821; NLM/ PMC2693227
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