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Items 1 to 10 of about 38802
1. Zhang J, Wei L, Hu X, Zhang Y, Zhou D, Li C, Wang X, Feng H, Yin X, Xie B, Wang J: Specific frequency band of amplitude low-frequency fluctuation predicts Parkinson's disease. Behav Brain Res; 2013 Sep 1;252:18-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Specific frequency band of amplitude low-frequency fluctuation predicts Parkinson's disease.
  • Resting-state functional magnetic resonance imaging (RS-fMRI) has been considered for development as a biomarker and analytical tool for evaluation of Parkinson's disease (PD).
  • Here we utilized analysis of the amplitude low-frequency fluctuations (ALFF) to determine changes in intrinsic neural oscillations in 72 patients with PD.
  • Two different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed.
  • In the slow-5 band, PD patients compared with controls had increased ALFF values mainly in the caudate and several temporal regions, as well as decreased ALFF values in the cerebellum and the parieto-temporo-occipital cortex.
  • Additionally, in the slow-4 band, PD patients relative to controls exhibited reduced ALFF value in the thalamus, cerebellum, and several occipital regions.
  • Together, our data demonstrate that PD patients have widespread abnormal intrinsic neural oscillations in the corticostriatal network in line with the pathophysiology of PD, and further suggest that the abnormalities are dependent on specific frequency bands.
  • Thus, frequency domain analyses of resting state BOLD signals may provide a useful means to study the pathophysiology of PD and the physiology of the brain's dopaminergic pathways.
  • [MeSH-major] Brain / blood supply. Brain Mapping. Parkinson Disease / diagnosis. Parkinson Disease / physiopathology
  • [MeSH-minor] Aged. Female. Functional Laterality. Head Movements. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Male. Middle Aged. Oxygen / blood. Predictive Value of Tests

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23727173.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] S88TT14065 / Oxygen
  • [Keywords] NOTNLM ; Amplitude low-frequency fluctuation / Corticostriatal network / Parkinson's disease / Resting-state functional magnetic resonance imaging
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2. Yin X, Watanabe M, Rutishauser U: Effect of polysialic acid on the behavior of retinal ganglion cell axons during growth into the optic tract and tectum. Development; 1995 Oct;121(10):3439-46
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  • [Title] Effect of polysialic acid on the behavior of retinal ganglion cell axons during growth into the optic tract and tectum.
  • We have demonstrated previously that the polysialic acid (PSA) moiety of the neural cell adhesion molecule (NCAM) can regulate peripheral nerve branching during development.
  • In particular, it was found that specific enzymatic removal of PSA from motor axons causes them to form tight fascicles that are less responsive to normal guidance cues.
  • In the present study, the role of PSA in the behavior of axons in the central nervous system has been examined through an analysis of chick optic axons during development.
  • Unlike peripheral axons, which generally grow in a PSA-free environment, PSA was found to be present both on retinal ganglion cell axons and their environment in the tract and tectum.
  • Furthermore, the enzymatic removal of PSA from the optic axons caused them to defasciculate in the tract/tectal region.
  • This response was morphologically similar to targeting corrections made by these axons at a later stage when PSA levels have decreased, suggesting that the PSA may serve to shield them from responding prematurely to some guidance cues in their target region.
  • [MeSH-major] Eye / embryology. Polysaccharides / physiology. Retinal Ganglion Cells / physiology. Sialic Acids / physiology
  • [MeSH-minor] Animals. Axons / physiology. Chick Embryo. Immunohistochemistry. Microscopy, Fluorescence. Morphogenesis. Neural Pathways. Superior Colliculi

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  • (PMID = 7588076.001).
  • [ISSN] 0950-1991
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY06107; United States / NICHD NIH HHS / HD / HD18369
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Polysaccharides; 0 / Sialic Acids; 0 / polysialic acid
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3. Poduslo SE, Yin X: A new locus on chromosome 19 linked with late-onset Alzheimer's disease. Neuroreport; 2001 Dec 4;12(17):3759-61
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  • [Title] A new locus on chromosome 19 linked with late-onset Alzheimer's disease.
  • Alzheimer's disease (AD) is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology.
  • APOE 4 and APOCI A on chromosome 19 are risk factors for late-onset disease.
  • Using large extended families with multiple siblings affected, we have identified several microsatellite markers which are also linked with late- onset Alzheimer's disease.
  • These microsatellites are distal from the apolipoprotein cluster on chromosome 19.
  • It is likely that multiple genes will be involved with late-onset disease, either as risk factors or as causative agents.
  • [MeSH-major] Alzheimer Disease / genetics. Apolipoproteins / genetics. Chromosomes, Human, Pair 19 / genetics. Genetic Linkage / genetics. Microsatellite Repeats / genetics. Mutation / genetics
  • [MeSH-minor] Age of Onset. Aged. Aged, 80 and over. Brain / metabolism. Brain / pathology. Brain / physiopathology. Chromosome Mapping. DNA Mutational Analysis. Female. Genetic Testing. Humans. Male

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  • (PMID = 11726789.001).
  • [ISSN] 0959-4965
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apolipoproteins
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4. Poduslo SE, Yin X: Chromosome 12 and late-onset Alzheimer's disease. Neurosci Lett; 2001 Sep 14;310(2-3):188-90
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  • [Title] Chromosome 12 and late-onset Alzheimer's disease.
  • Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology.
  • Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease.
  • These markers were downstream from the gene for alpha-2 macroglobulin.
  • It is likely that multiple genes will be identified either as risk factors or as causative agents for late-onset Alzheimer's disease.
  • [MeSH-major] Alzheimer Disease / genetics. Chromosomes, Human, Pair 12. Genetic Linkage
  • [MeSH-minor] Age of Onset. Genetic Markers. Humans

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  • (PMID = 11585598.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Genetic Markers
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5. Yacoub E, Hu X: Detection of the early negative response in fMRI at 1.5 Tesla. Magn Reson Med; 1999 Jun;41(6):1088-92
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  • [Title] Detection of the early negative response in fMRI at 1.5 Tesla.
  • Recent experimental studies have revealed an initial decrease in magnetic resonance (MR) signal that is consistent with optical imaging results.
  • This initial response, thought to arise from a transient increase in deoxyhemoglobin concentration, is probably more localized to the site of neuronal activation.
  • However, with MR imaging, this early response has only been demonstrated at high fields.
  • In this paper, the observation of the initial response at 1.5 T is reported.
  • Compared with results obtained at 4 T, the present study reveals that the initial response grows more rapidly with the field strength than the late positive response, suggesting a more microvascular origin of the initial response.
  • [MeSH-major] Brain / anatomy & histology. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Echo-Planar Imaging. Female. Humans. Male

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  • (PMID = 10371439.001).
  • [ISSN] 0740-3194
  • [Journal-full-title] Magnetic resonance in medicine
  • [ISO-abbreviation] Magn Reson Med
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / R01MH55346; United States / NCRR NIH HHS / RR / RR08079
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
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6. Hu T, Shi J, Jiao X, Zhou J, Yin X: Measurement of annexin V uptake and lactadherin labeling for the quantification of apoptosis in adherent Tca8113 and ACC-2 cells. Braz J Med Biol Res; 2008 Sep;41(9):750-7
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  • [Title] Measurement of annexin V uptake and lactadherin labeling for the quantification of apoptosis in adherent Tca8113 and ACC-2 cells.
  • Phosphatidylserine (PS) exposure occurs during the cell death program and fluorescein-labeled lactadherin permits the detection of PS exposure earlier than annexin V in suspended cell lines.
  • Adherent cell lines were studied for this apoptosis-associated phenomenon to determine if PS probing methods are reliable because specific membrane damage may occur during harvesting.
  • Apoptosis was induced in the human tongue squamous carcinoma cell line (Tca8113) and the adenoid cystic carcinoma cell line (ACC-2) by arsenic trioxide.
  • Cells were harvested with a modified procedure and labeled with lactadherin and/or annexin V.
  • PS exposure was localized by confocal microscopy and apoptosis was quantified by flow cytometry.
  • The detachment procedure without trypsinization did not induce cell damage.
  • In competition binding experiments, phospholipid vesicles competed for more than 95 and 90% of lactadherin but only about 75 and 70% of annexin V binding to Tca8113 and ACC-2 cells.
  • These data indicate that PS exposure occurs in three stages during the cell death program and that fluorescein-labeled lactadherin permitted the detection of early PS exposure.
  • A similar pattern of PS exposure has been observed in two malignant cell lines with different adherence, suggesting that this pattern of PS exposure is common in adherent cells.
  • Both lactadherin and annexin V could be used in adherent Tca8113 and ACC-2 cell lines when an appropriate harvesting procedure was used.
  • Lactadherin is more sensitive than annexin V for the detection of PS exposure as the physical structure of PS in these blebs and condensed apoptotic cell surface may be more conducive to binding lactadherin than annexin V.

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  • (PMID = 18820763.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Antigens, Surface; 0 / Fluorescent Dyes; 0 / Milk Proteins; 0 / Phosphatidylserines; TPY09G7XIR / Fluorescein
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7. Hu X, Totake K: Molecular typing of Staphylococcus epidermidis and other CNS with repetitive element sequence-based PCR. Microbiol Immunol; 1997;41(12):933-8
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  • [Title] Molecular typing of Staphylococcus epidermidis and other CNS with repetitive element sequence-based PCR.
  • The chromosomal distribution of the repetitive DNA sequence found in Mycoplasma pneumoniae (REP-MP2) provides an ideal target for detecting DNA fragment patterns specific to individual Staphylococcus epidermidis and S. haemolyticus strains.
  • A REP-MP2 sequence-based PCR (rep-PCR) was developed and applied to CNS isolates.
  • We identified a 450 bp genomic DNA fragment which was common and specific to S. epidermidis isolates and not found in other CNS.
  • In addition, S. epidermidis isolates showed several bands that could be grouped into 14 different fragment patterns.
  • Similarly, S. haemolyticus isolates were classified into 10 groups.
  • Significant correlations between the typing patterns of S. epidermidis and resistance to oxacillin (P< 0.05), gentamicin (P< 0.01), erythromycin (P< 0.02), and sulfamethoxazole-trimethoprim (P< 0.001) were found.
  • The rep-PCR method is a rapid and reproducible discriminatory means for molecular typing of S. epidermidis and other CNS.
  • [MeSH-major] Bacterial Typing Techniques. Polymerase Chain Reaction / methods. Staphylococcus / classification. Staphylococcus epidermidis / classification
  • [MeSH-minor] Anti-Bacterial Agents / pharmacology. Coagulase / metabolism. DNA Fingerprinting. DNA, Bacterial. Drug Resistance, Microbial. Humans. Methicillin Resistance. Microbial Sensitivity Tests. Repetitive Sequences, Nucleic Acid. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 9492178.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Coagulase; 0 / DNA, Bacterial
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8. Yin X, Gu S, Jiang JX: The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation. J Biol Chem; 2001 Sep 14;276(37):34567-72
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  • [Title] The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation.
  • Gap junctions are important in maintaining lens transparency and metabolic homeostasis.
  • In this paper, we report that the gap junction-forming protein, connexin (Cx) 45.6, was specifically truncated during lens development and that the majority of the truncated fragments were located in the differentiated lens fibers.
  • When isolated lens membranes were treated by caspase-3, the truncated fragments of Cx45.6 were reproduced, and this truncation occurred at the COOH terminus of Cx45.6.
  • Moreover, when primary lens cells were treated with apoptosis-inducing reagents, Cx45.6 was cleaved similarly as the in vitro treatment by caspase-3, and this cleavage was blocked by a caspase-3 inhibitor.
  • These results suggest that caspase-3 is responsible for the development-associated cleavage of Cx45.6.
  • The cleavage site of Cx45.6 was identified between amino acid residues Glu(367) and Gly(368).
  • We have shown previously that Ser(363) is an in vivo phosphorylated site by casein kinase II, and this specific phosphorylation leads to a rapid turnover of Cx45.6.
  • Interestingly, we found here that when Ser(363) was phosphorylated by casein kinase II, the cleavage of Cx45.6 catalyzed by caspase-3 was inhibited.
  • This study, for the first time, demonstrates that a connexin can be a direct target of an apoptotic protease and that cleavage by caspase-3-like protease leads to the development-associated truncation of a lens connexin.
  • Finally, caspase-3-mediated cleavage can be regulated by casein kinase II-mediated phosphorylation, suggesting that Cx45.6 turnover and specific cleavage by caspase-3-like protease is alternatively modulated.
  • [MeSH-major] Caspases / physiology. Connexins / metabolism. Lens, Crystalline / metabolism. Protein-Serine-Threonine Kinases / physiology
  • [MeSH-minor] Animals. Apoptosis. Casein Kinase II. Caspase 3. Chickens. Phosphorylation

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  • (PMID = 11448971.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY-12085
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Connexins; 0 / connexin 45; EC 2.7.11.1 / Casein Kinase II; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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9. Yacoub E, Hu X: Detection of the early decrease in fMRI signal in the motor area. Magn Reson Med; 2001 Feb;45(2):184-90
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  • [Title] Detection of the early decrease in fMRI signal in the motor area.
  • The initial decrease in BOLD signal at stimulus onset (i.e., the initial dip) has generated a great deal of interest because of its potential for providing more spatially specific mapping.
  • Despite a number of experimental fMRI studies demonstrating its existence in the visual cortex, the initial dip has not been reported in other areas.
  • The present work examined the initial dip in the motor area.
  • Using a visually-guided finger-tapping paradigm, the dip was detected in both motor and visual areas simultaneously.
  • The dip in the motor area was found to exhibit characteristics similar to those revealed by visual stimulation studies.
  • The motor dip peaked approximately 2 sec after stimulus onset and reached an amplitude that was roughly 0.3 times of the positive amplitude.
  • Furthermore, the dip in the motor area was more localized and less sensitive to large vessels, indicating an improvement in spatial specificity despite the relatively low spatial resolution used in this study.
  • These data indicate that the initial dip is a general phenomenon that can be employed for more spatially specific functional mapping, although its full utility in humans remains to be further demonstrated.
  • Magn Reson Med 45:184-190, 2001.
  • [MeSH-major] Magnetic Resonance Imaging. Motor Cortex / anatomy & histology. Motor Cortex / physiology
  • [MeSH-minor] Humans. Visual Cortex / physiology

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  • [Copyright] Copyright 2001 Wiley-Liss, Inc.
  • (PMID = 11180423.001).
  • [ISSN] 0740-3194
  • [Journal-full-title] Magnetic resonance in medicine
  • [ISO-abbreviation] Magn Reson Med
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P41RR08079; United States / NIMH NIH HHS / MH / R01MH55346
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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10. Wesson D, Hu X: The real incidence of pediatric trauma. Semin Pediatr Surg; 1995 May;4(2):83-7
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  • [Title] The real incidence of pediatric trauma.
  • Trauma care is one of the major components of modern surgery.
  • This is especially true of pediatric surgery, because injuries are by far the leading cause of death for children from early childhood through adolescence.
  • Recently, the epidemiological model of host, agent, and environment has been applied to the study of childhood injuries to increase understanding of their causes and to provide a basis for primary and secondary prevention strategies.
  • We now know that injury patterns vary with age, sex, race, place of residence, and family income, and that the rates of fatal injury from violence, whether interpersonal or self inflicted, are increasing.
  • We also know that firearms are involved in an ever-increasing proportion of cases.
  • As trauma care has improved, the key to further reductions in the toll of injuries on our children is prevention.
  • [MeSH-major] Cause of Death. Wounds and Injuries / mortality
  • [MeSH-minor] Burns / mortality. Burns / prevention & control. Child. Child Abuse / mortality. Child Abuse / prevention & control. Cross-Sectional Studies. Drowning / mortality. Drowning / prevention & control. Humans. Incidence. North America / epidemiology. Wounds, Nonpenetrating / mortality. Wounds, Penetrating / mortality. Wounds, Penetrating / prevention & control

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  • (PMID = 7633854.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] UNITED STATES
  • [Number-of-references] 29
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