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Items 1 to 10 of about 6800
1. Liang W, Xu S: Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases. J Comput Assist Tomogr; 2015 Sep-Oct;39(5):747-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic Resonance Imaging Findings of Intrahepatic Bile Duct Adenoma: A Report of 4 Cases.
  • Intrahepatic bile duct adenoma (BDA) is a rare type of benign hepatic lesions.
  • In this study, 4 cases of BDA diagnosed from surgical resection pathology were examined.
  • Their clinical and magnetic resonance imaging (MRI) data were retrospectively analyzed.
  • The 4 cases (1 men and 3 women) were aged 21 to 55 years without obvious clinical symptoms.
  • Three were identified through routine examination.
  • Three had a history of chronic hepatitis B virus infection.
  • Two cases were accompanied by hepatocellular carcinoma, and one had a higher level of α-fetoprotein.
  • The MRI images of BDA all manifested as peripheral hepatic nodules with abnormal signals.
  • The diameters of the lesions in the 4 cases were 7.7 to 17.0 mm.
  • The MRI images showed slight hypointensity on T1WI and slight hyperintensity on T2WI in all cases, and they showed slight hyperintensity in 2 cases and hyperintensity in 2 cases on diffusion-weighted imaging.
  • Dynamic contrast-enhanced MRI scans show hyperintensity in the arterial phase and slight hyperintensity in the late stage in 3 cases.
  • The other case shows hyperintensity in the arterial and portal phases and isointensity at the delayed phase.
  • During follow-up, 3 cases were recurrence-free.
  • The other case was complicated by the reoccurrence of HCC.
  • In general, BDA shows specific MRI characteristics, and peripheral hepatic nodules show slight hypointensity on T1WI and slight hyperintensity on T2WI.
  • Dynamic contrast-enhanced MRI scans showed obvious enhancement in the arterial phase and continuous enhancement at the late stage.
  • [MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Contrast Media. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Image Enhancement. Male. Middle Aged. Neoplasm Recurrence, Local. Young Adult

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  • (PMID = 26248149.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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2. Montgomery MK, Xu S, Fire A: RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc Natl Acad Sci U S A; 1998 Dec 22;95(26):15502-7
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  • [Title] RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans.
  • Introduction of exogenous double-stranded RNA (dsRNA) into Caenorhabditis elegans has been shown to specifically and potently disrupt the activity of genes containing homologous sequences.
  • In this study we present evidence that the primary interference effects of dsRNA are post-transcriptional.
  • First, we examined the primary DNA sequence after dsRNA-mediated interference and found no evidence for alterations.
  • Second, we found that dsRNA-mediated interference with the upstream gene in a polar operon had no effect on the activity of the downstream gene; this finding argues against an effect on initiation or elongation of transcription.
  • Third, we observed by in situ hybridization that dsRNA-mediated interference produced a substantial, although not complete, reduction in accumulation of nascent transcripts in the nucleus, while cytoplasmic accumulation of transcripts was virtually eliminated.
  • These results indicate that the endogenous mRNA is the target for interference and suggest a mechanism that degrades the targeted RNA before translation can occur.
  • This mechanism is not dependent on the SMG system, an mRNA surveillance system in C. elegans responsible for targeting and destroying aberrant messages.
  • We suggest a model of how dsRNA might function in a catalytic mechanism to target homologous mRNAs for degradation.

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  • (PMID = 9860998.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / F32 GM017164; United States / NIGMS NIH HHS / GM / R01 GM037706; United States / NIGMS NIH HHS / GM / GM17164; United States / NIGMS NIH HHS / GM / R01-GM37706
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Calmodulin-Binding Proteins; 0 / Helminth Proteins; 0 / Muscle Proteins; 0 / RNA, Double-Stranded; 0 / RNA, Helminth; 0 / RNA, Messenger; 0 / unc-22 protein, C elegans
  • [Other-IDs] NLM/ PMC28072
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3. Fu M, Xu S, Zhang J, Pang Y, Liu N, Su J, Tang C: Involvement of calcineurin in angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibroblast hyperplasia of rats. Heart Vessels; 1999;14(6):283-8
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  • [Title] Involvement of calcineurin in angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibroblast hyperplasia of rats.
  • A rapidly emerging body of literature implicates a pivotal role for the Ca2+-calmodulin-dependent phosphatase, calcineurin, as a cellular target for a variety of Ca2+-dependent signaling pathways culminating in cardiac hypertrophy.
  • The aim of the present study was to test whether calcineurin is involved in the signal transduction of angiotensin II (AngII)-induced cardiac myocyte hypertrophy and fibroblast hyperplasia.
  • Firstly, we observed that calcineurin activity was significantly increased in AngII-stimulated cardiac myocytes as well as fibroblasts, but was markedly inhibited by Losartan (50 micromol/l), H7 (50 micromol/l), and Fura-2/AM (5 micromol/l).
  • It is indicated that AngII-induced activation of calcineurin is through an ATI receptor, may be dependent on the sustained increases of [Ca2+]i, and be regulated by protein kinase C.
  • In a second experiment, we found that cyclosporin (0.1-10micromol/l), a specific inhibitor of calcineurin, decreased the protein synthesis rate in AngII-stimulated cardiomyocytes and the DNA synthesis rate in AngII-treated fibroblasts in a dose-dependent manner.
  • In the latter experiment, calcineurin inhibition reduced the mRNA level of the atrial natriuretic factor gene.
  • These results indicate that calcineurin is involved in the signal transduction of AngII-induced cardiomyocyte hypertrophy and fibroblast hyperplasia.
  • [MeSH-major] Angiotensin II / toxicity. Calcineurin / metabolism. Cardiomegaly / metabolism. Myocardium / metabolism
  • [MeSH-minor] Animals. Animals, Newborn. Atrial Natriuretic Factor / genetics. Atrial Natriuretic Factor / metabolism. Calcineurin Inhibitors. Calcium / metabolism. Cell Division / drug effects. Cells, Cultured. Cyclosporine / pharmacology. DNA / biosynthesis. Fibroblasts / drug effects. Fibroblasts / metabolism. Fibroblasts / pathology. Fura-2 / analogs & derivatives. Fura-2 / pharmacology. Hyperplasia. Losartan / pharmacology. Protein Kinase C / metabolism. RNA, Messenger / metabolism. Rats. Rats, Wistar. Receptor, Angiotensin, Type 1. Receptor, Angiotensin, Type 2. Receptors, Angiotensin / metabolism. Signal Transduction / drug effects. Signal Transduction / genetics

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  • (PMID = 10901483.001).
  • [ISSN] 0910-8327
  • [Journal-full-title] Heart and vessels
  • [ISO-abbreviation] Heart Vessels
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Calcineurin Inhibitors; 0 / RNA, Messenger; 0 / Receptor, Angiotensin, Type 1; 0 / Receptor, Angiotensin, Type 2; 0 / Receptors, Angiotensin; 105344-37-4 / fura-2-am; 11128-99-7 / Angiotensin II; 83HN0GTJ6D / Cyclosporine; 85637-73-6 / Atrial Natriuretic Factor; 9007-49-2 / DNA; EC 2.7.11.13 / Protein Kinase C; EC 3.1.3.16 / Calcineurin; JMS50MPO89 / Losartan; SY7Q814VUP / Calcium; TSN3DL106G / Fura-2
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4. Sun C, Dong Y, Xu S, Yao S, Dai J, Han S, Wang L: Trace analysis of dissolved polychlorinated organic compounds in the water of the Yangtse River (Nanjing, China). Environ Pollut; 2002;117(1):9-14
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  • [Title] Trace analysis of dissolved polychlorinated organic compounds in the water of the Yangtse River (Nanjing, China).
  • Eighteen organochlorine contaminants from the water samples of the Yangtse River have been qualitatively and quantitatively analyzed.
  • The analysis of polychlorinated organic compounds (PCOCs) extracted by C18 Solid Phase Extract (SPE) was performed using HP6890 gas chromatograph coupled by ECD detector.
  • The analytical results demonstrate that the analytical methods are reliable based on the fact that most of the recoveries for the targeted compounds are 60-90%.
  • Most of the concerned contaminants, i.e. chlorinated pesticides and PCBs were found in the water samples of the Yangtse River, but their concentration was very low, <2.97 ng l(-1), which is far less than 1 microg l(-1)--the standard of drinking water of China.
  • It is apparent that the PCOCs were in high concentration during the dry season, and in low concentration during the rainy season.
  • The situation of PCOCs contamination in the water of the Yangtse River in 1999 was greatly improved in comparison with 10 years ago.
  • [MeSH-major] Fresh Water. Hydrocarbons, Chlorinated / analysis. Water Pollutants, Chemical / analysis. Water Supply
  • [MeSH-minor] China. Chromatography, Gas

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  • (PMID = 11843542.001).
  • [ISSN] 0269-7491
  • [Journal-full-title] Environmental pollution (Barking, Essex : 1987)
  • [ISO-abbreviation] Environ. Pollut.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hydrocarbons, Chlorinated; 0 / Water Pollutants, Chemical
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5. Xu S, Xiao J, Posfai J, Maunus R, Benner J 2nd: Cloning of the BssHII restriction-modification system in Escherichia coli : BssHII methyltransferase contains circularly permuted cytosine-5 methyltransferase motifs. Nucleic Acids Res; 1997 Oct 15;25(20):3991-4
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  • [Title] Cloning of the BssHII restriction-modification system in Escherichia coli : BssHII methyltransferase contains circularly permuted cytosine-5 methyltransferase motifs.
  • BssHII restriction endonuclease cleaves 5'-GCGCGC-3' on double-stranded DNA between the first and second bases to generate a four base 5'overhang.
  • BssHII restriction endonuclease was purified from the native Bacillus stearothermophilus H3 cells and its N-terminal amino acid sequence was determined.
  • Degenerate PCR primers were used to amplify the first 20 codons of the BssHII restriction endonuclease gene.
  • The BssHII restriction endonuclease gene (bssHIIR) and the cognate BssHII methyltransferase gene (bssHIIM) were cloned in Escherichia coli by amplification of Bacillus stearothermophilus genomic DNA using PCR and inverse PCR.
  • BssHII methyltransferase (M.BssHII) contains all 10 conserved cytosine-5 methyltransferase motifs, but motifs IX and X precede motifs I-VIII.
  • Thus, the conserved motifs of M.
  • BssHII are circularly permuted relative to the motif organizations of other cytosine-5 methyltransferases.
  • M.BssHII and the non-cognate multi-specific phiBssHII methyltransferase, M.phiBss HII [Schumann,J. et al . (1995) Gene, 157, 103-104] share 34% identity in amino acid sequences from motifs I-VIII, and 40% identity in motifs IX-X.
  • A conserved arginine is located upstream of a TV dipeptide in the N-terminus of M.BssHII that may be responsible for the recognition of the guanine 5' of the target cytosine.
  • The BssHII restriction endonuclease gene was expressed in E.coli via a T7 expression vector.

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  • (PMID = 9321648.001).
  • [ISSN] 0305-1048
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ AF020002
  • [Grant] United States / NIGMS NIH HHS / GM / GM46127
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.1.1.- / BSSHII methyltransferase; EC 2.1.1.- / DNA-Cytosine Methylases; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase; EC 3.1.21.- / endodeoxyribonuclease BSSHII; EC 3.1.21.4 / Deoxyribonucleases, Type II Site-Specific
  • [Other-IDs] NLM/ PMC147014
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6. Xu S, Weihua Z: Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin. Prostate; 2011 Aug 1;71(11):1216-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin.
  • BACKGROUND: The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is over-expressed in advanced prostate cancer but tyrosine kinase inhibitors are not clinically effective in the treatment of prostate cancer.
  • Recently it was found that EGFR in cancer cells has a kinase-independent pro-survival function, preventing cells from undergoing autophagy.
  • In the present study we investigated whether the anti-autophagic function of EGFR may contribute to resistance of hormone-refractory prostate cancer cells to chemotherapeutic-induced apoptosis.
  • METHODS: We first characterized the autophagic phenotype induced by knocking down EGFR in hormone refractory prostate cancer cells (PC-3MM2 and DU-145), then we tested whether loss of EGFR-induced autophagy could sensitize cancer cells to adriamycin.
  • RESULTS: Using continuous live cell imaging techniques, we observed that knocking down EGFR lead to typical autophagic morphological/molecular changes, cell shrinkage without detachment, aggregation of microtubule-associated protein 1 light chain 3 (LC3) protein and absence of activation of apoptotic caspases 3/7.
  • Loss of EGFR also increased the activity of calpain, which is pro-apoptotic.
  • Knocking down EGFR, but not inhibiting its tyrosine kinase activity, significantly sensitized cells to adriamycin-induced apoptosis.
  • Adriamycin-induced apoptosis could be inhibited by increased extracellular glucose level, suggesting intracellular glucose deficiency is a key mediator of the sensitization.
  • The loss of EGFR induced autophagy and sensitization to adriamycin were also reproduced by using another hormone refractory prostate cancer cell line, Du145.
  • CONCLUSION: Taken together, these data suggest that decreasing the expression level of EGFR protein, rather than inhibiting its tyrosine kinase activity, may enhance the efficiency of EGFR targeted therapy for prostate cancer.
  • [MeSH-major] Antibiotics, Antineoplastic / pharmacology. Autophagy / drug effects. Doxorubicin / pharmacology. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology. Receptor, Epidermal Growth Factor / deficiency
  • [MeSH-minor] Cell Line, Tumor. Drug Resistance, Neoplasm / genetics. Gene Knockdown Techniques / methods. Humans. Male. Protein Kinase Inhibitors / pharmacology

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  • [Copyright] This article is a US Government work and, as such, is in the public domain in the United States of America. Published in 2011 Wiley-Liss, Inc.
  • (PMID = 21656832.001).
  • [ISSN] 1097-0045
  • [Journal-full-title] The Prostate
  • [ISO-abbreviation] Prostate
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Protein Kinase Inhibitors; 80168379AG / Doxorubicin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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7. Liang W, Xu S: CT and MR Imaging Findings of Pancreatic Paragangliomas: A Case Report. Medicine (Baltimore); 2016 Mar;95(9):e2959
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  • [Title] CT and MR Imaging Findings of Pancreatic Paragangliomas: A Case Report.
  • Previous studies on pancreatic paraganglioma, a rare neoplasm, have primarily reported its ultrasound and routine and contrast-enhanced computed tomography (CT) findings.
  • To our knowledge, we are the first to report the contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) sequence findings of pancreatic paraganglioma.
  • A male patient, ages 41 years, was admitted to our hospital due to a pancreatic space-occupying lesion that had been present for more than 10 days.
  • The patient had no obvious discomfort.
  • He had a history of hypertension and hyperthyroidism.
  • Physical examination revealed upper abdominal tenderness without a palpable mass.
  • Routine and contrast-enhanced abdominal CT showed a soft tissue mass at the pancreatic head/uncinate process, with patchy calcification within the lesion.
  • On a contrast-enhanced CT scan, severe enhancement of the mass in the arterial phase was noted, as was slightly reduced but still marked enhancement in the venous phase.
  • The celiac trunk and superior mesenteric artery segment were wrapped by the tumor.
  • Thickened, tortuous vessels were observed at the lesion edges, around which there were multiple enlarged lymph nodes.
  • The main pancreatic duct was markedly dilated.
  • Routine and contrast-enhanced pancreatic MRI demonstrated an abnormal nodular signal in the pancreatic head/uncinate process that was approximately 4.3 × 6.4 cm² in size.
  • T1-weighted imaging (T1WI) revealed hypointensity, whereas T2-weighted imaging (T2WI) revealed nonhomogeneous, slight hyperintensity.
  • Patchy hypointensity on both T1WI and T2WI was observed within the lesion.
  • DWI showed slight hyperintensity.
  • Grossly heterogeneous enhancement of the mass was observed on a contrast-enhanced MRI scan, with the tumor wrapped around the adjacent vasculature, and multiple enlarged lymph nodes were observed peripherally.
  • After preoperative preparation, the patient underwent pancreatoduodenectomy.
  • Histopathology and immunohistochemistry of the resected tumor indicated pancreatic paraganglioma.
  • After surgery, the patient recovered well, without presenting any recurrence or metastasis during short-term follow-up.
  • For hypervascular pancreatic tumors on contrast-enhanced CT or MRI, and particularly those occurring in the pancreatic head, with a clear display of draining veins, the possibility of pancreatic paraganglioma should be considered.
  • These tumors usually exhibit necrosis or cystic changes and are occasionally accompanied by calcification.
  • [MeSH-major] Magnetic Resonance Imaging. Pancreatic Neoplasms / diagnosis. Paraganglioma / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Diffusion Magnetic Resonance Imaging. Humans. Male

  • MedlinePlus Health Information. consumer health - CT Scans.
  • MedlinePlus Health Information. consumer health - MRI Scans.
  • MedlinePlus Health Information. consumer health - Pancreatic Cancer.
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  • (PMID = 26945413.001).
  • [ISSN] 1536-5964
  • [Journal-full-title] Medicine
  • [ISO-abbreviation] Medicine (Baltimore)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4782897
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8. Shi G, Chen Z, Bi C, Li Y, Teng J, Wang L, Xu S: Comprehensive assessment of toxic metals in urban and suburban street deposited sediments (SDSs) in the biggest metropolitan area of China. Environ Pollut; 2010 Mar;158(3):694-703
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comprehensive assessment of toxic metals in urban and suburban street deposited sediments (SDSs) in the biggest metropolitan area of China.
  • A set of toxic metals, i.e.
  • As, Hg, Pb, Cd, Cu, Zn, Ni and Cr, in urban and suburban SDSs were investigated comparatively in the biggest metropolitan area of China, Shanghai.
  • Results showed that all of the metals except As were accumulated greatly, much higher than background values.
  • Geo-accumulation index indicated that metal contamination in urban SDSs was generally heavier than that in suburban SDSs.
  • Potential ecological risk index demonstrated that overall risks caused by metals were considerable.
  • Cd contributed 52% to the overall risk.
  • Multivariate statistical analysis revealed that in urban SDSs, Zn, Ni, Cd, Pb, Cu and Cr were related to traffic and industry; coal combustion led to elevated levels of Hg; soil parent materials controlled As contents.
  • In suburban SDSs, Pb, Cu, As and Cd largely originated from traffic pollution; Zn, Ni and Cr were associated with industrial contaminants; Hg was mainly from domestic solid waste.
  • [MeSH-major] Geologic Sediments / analysis. Metals / analysis. Soil Pollutants / analysis
  • [MeSH-minor] China. Urban Health

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19926184.001).
  • [ISSN] 1873-6424
  • [Journal-full-title] Environmental pollution (Barking, Essex : 1987)
  • [ISO-abbreviation] Environ. Pollut.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metals; 0 / Soil Pollutants
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9. Xu S, Xie C, Ju Z, Dai X, Gong H, Wang L, Yang J: Dose verification of helical tomotherapy intensity modulated radiation therapy planning using 2D-array ion chambers. Biomed Imaging Interv J; 2010 Apr-Jun;6(2):e24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dose verification of helical tomotherapy intensity modulated radiation therapy planning using 2D-array ion chambers.
  • PURPOSE: To investigate the clinical usage of dose verification of Helical Tomotherapy plans by using 2D-array ion chambers, and to develop an efficient way to validate the dose delivered for the patients during treatments.
  • MATERIALS AND METHODS: A pixel-segmented ionisation chamber device, IMRT MatriXX™ and Multicube™ phantom from IBA were used on ten selected Tomotherapy IMRT/IGRT head and neck plans in this study.
  • The combined phantom was set up to measure the dose distribution from coronal and sagittal planes.
  • The setup of phantom was guided for verifying the correction position by pre-treatment Tomotherapy MVCT images.
  • After the irradiation, the measured dose distributions of coronal and sagittal planes were compared with those from calculation by the planning system for cross verification.
  • The results were evaluated by the absolute and relative doses as well as Gamma (γ) function.
  • The feasibility of the different measuring methods was studied for this rotational treatment technique.
  • RESULTS: The dose distributions measured by the MatriXX 2D array were in good agreements with plans calculated by Tomotherapy planning system.
  • The discrepancy between the measured dose and predicted dose in the selected points was within ±3%.
  • In the comparison of the pixel-segmented ionisation chamber versus treatment planning system using the 3 mm/3% γ-function criteria, the mean passing rates of 2 mm dose grid with γ-parameter ≤1 were 97.37% and 96.91%, in two orthogonal planes (coronal and sagittal directions), respectively.
  • CONCLUSION: MatriXX with Multicube is a new system created for rotational delivery quality assurance (QA) and found to be reliable to measure both absolute dose and relative dose distributions, simultaneously.
  • It achieves the goal of an efficient and accurate dosimetry validation method of the helical delivery pattern for the Helical Tomotherapy IMRT planning.

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  • (PMID = 21611040.001).
  • [ISSN] 1823-5530
  • [Journal-full-title] Biomedical imaging and intervention journal
  • [ISO-abbreviation] Biomed Imaging Interv J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3097769
  • [Keywords] NOTNLM ; IMRT / QA / Tomotherapy / dose verification / radiation therapy
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10. Xu S, Gong R: Clivodens Angle: A New Diagnostic Method for Basilar Invagination at Computed Tomography. Spine (Phila Pa 1976); 2016 Sep;41(17):1365-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clivodens Angle: A New Diagnostic Method for Basilar Invagination at Computed Tomography.
  • STUDY DESIGN: Retrospective study.
  • OBJECTIVE: To investigate whether clivodens angle (CDA) could diagnose basilar invagination (BI) at computed tomography (CT).
  • SUMMARY OF BACKGROUND DATA: Over the years, multiple craniometric methods such as Chamberlain line, McGregor line, McRae line, Wackenheim clivus baseline, and Welcher basal angle have been described for evaluation of craniovertebral junction anomalies, initially with radiography and later with CT.
  • However, such a variety of measurements in turn reflects the difficulty in making a definite diagnosis of BI and there is a certain disadvantage in all of these criteria because the anatomic landmarks vary within a normal range.
  • METHODS: CDA, described an angle formed at the intersetion of a line that runs along the long axis of the clivus and one that runs along the long axis of the dens, was measured on mid-sagittal reconstructed CT images from 63 BI patients and 100 control participants to compare the two groups by using independent-sample t test.
  • Interobserver reliability was evaluated with Kendall correlation coefficient.
  • For evaluating the diagnostic performance and determining the cutoff value of CDA, receiver operating characteristic curve was utilized.
  • RESULTS: The measurement of CDA showed good interobserver agreement (KCC = 0.891).
  • Compared with control participants whose mean value was 135.8 degrees ± 9.2 (range, 118-156°), BI patients had a significantly smaller one (P < 0.001), 110.4 degrees ± 15.8 (range, 55-140°).
  • The area under receiver operating characteristic curve was 0.937 (95% confidence interval: 0.901, 0.973), and the cutoff value of 125 degrees had the largest Youden index (J), 0.715.
  • CONCLUSION: Having a better diagnostic performance than clivoaxial angle, CDA can be utilized for diagnosing BI.
  • LEVEL OF EVIDENCE: 3.
  • [MeSH-major] Cephalometry. Occipital Bone / surgery. Odontoid Process / surgery. Tomography Scanners, X-Ray Computed
  • [MeSH-minor] Adolescent. Adult. Aged. Atlanto-Axial Joint / diagnostic imaging. Female. Humans. Male. Middle Aged. Platybasia / diagnostic imaging. ROC Curve. Reproducibility of Results. Retrospective Studies. Young Adult

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  • (PMID = 26909827.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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