Refine your query (more in Advanced-Search):
 Focus on the recent 5 years   Focus on the current year   Focus on the last 30 days   More choices ...
 Focus on articles with free fulltexts   More choices ...
 Do simple 'keyword' search (no query expansion)

[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 10 of about 4108
1. Alves P, Sales C, Ashworth M: Does outcome measurement of treatment for substance use disorder reflect the personal concerns of patients? A scoping review of measures recommended in Europe. Drug Alcohol Depend; 2017 Oct 01;179:299-308
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does outcome measurement of treatment for substance use disorder reflect the personal concerns of patients? A scoping review of measures recommended in Europe.
  • There are a growing number of authors stating that outcome measurement in treatment for substance use disorders should go beyond substance use and include other bio-psycho-social variables of interest.
  • However, little is known about which topics tend to be covered by outcome measures and whether they reflect the typical concerns of this patient group.
  • This study followed a scoping review methodology in which 42 outcome measures recommended by an EU agency for substance use disorders were reviewed.
  • We identified the domains of problems covered by these 42 measures and then compared them with 54 domains derived from patients, in a previous study.
  • We also explored how similar the existing measures were in terms of domains covered, and which patient derived domains tended to be represented in those measures.
  • We identified 31domains of problems across the 42 measures, with 'substance use' and 'psychological health' among the commonest.
  • Most measures were similar in content to each other and multidimensional.
  • Almost all domains of problems identified in the outcome measures corresponded to concerns reported by patients.
  • On the other hand, we found that several topics of relevance for patients were not covered by any of the measure included in our study.
  • This suggests that existing outcome measurement does not always target aspects that affect patients' lives, as reported directly by patients.
  • Our study shows that outcome measurement needs to adopt a more flexible and comprehensive approach, by taking on board the problems experienced by patients in this population.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.
  • (PMID = 28830035.001).
  • [ISSN] 1879-0046
  • [Journal-full-title] Drug and alcohol dependence
  • [ISO-abbreviation] Drug Alcohol Depend
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Keywords] NOTNLM ; Outcome measurement / Patient perspectives / Thematic analysis
  •  go-up   go-down


3. Varoquier M, Hoffmann CP, Perrenot C, Tran N, Parietti-Winkler C: Construct, Face, and Content Validation on Voxel-Man® Simulator for Otologic Surgical Training. Int J Otolaryngol; 2017;2017:2707690
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Construct, Face, and Content Validation on Voxel-Man® Simulator for Otologic Surgical Training.
  • <i>Objective</i>.
  • To assess the face, content, and construct validity of the Voxel-Man TempoSurg Virtual Reality simulator.
  • <i>Participants and Methods</i>.
  • 74 ear, nose, and throat (ENT) surgeons participated.
  • They were assigned to one of two groups according to their level of expertise: the expert group (<i>n</i> = 16) and the novice group (<i>n</i> = 58).
  • The participants performed four temporal bone dissection tasks on the simulator.
  • Performances were assessed by a global score and then compared to assess the construct validity of the simulator.
  • Finally, the expert group assessed the face and content validity by means of a five-point Likert-type scale. <i>Results</i>.
  • experienced surgeons performed better (<i>p</i> < .01) and faster (<i>p</i> < .001) than the novices.
  • However, the groups did not differ in terms of bone volume removed (<i>p</i> = .11) or number of injuries (<i>p</i> = .37).
  • 93.7% of experienced surgeons stated they would recommend this simulator for anatomical learning.
  • Most (87.5%) also thought that it could be integrated into surgical training. <i>Conclusion</i>.
  • The Voxel-Man TempoSurg Virtual Reality simulator constitutes an interesting complementary tool to traditional teaching methods for training in otologic surgery.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Laryngoscope. 2007 Feb;117(2):258-63 [17204992.001]
  • [Cites] World J Surg. 2011 Feb;35(2):245-52 [21086125.001]
  • [Cites] Curr Opin Otolaryngol Head Neck Surg. 2007 Jun;15(3):163-9 [17483684.001]
  • [Cites] Am J Surg. 2008 Jul;196(1):74-80 [18417086.001]
  • [Cites] Ir J Med Sci. 2009 Dec;178(4):393-5 [19562408.001]
  • [Cites] Laryngoscope. 2012 Jun;122(6):1385-91 [22487895.001]
  • [Cites] Am J Surg. 2006 Jan;191(1):28-32 [16399102.001]
  • [Cites] Clin Otolaryngol. 2015 Apr;40(2):153-9 [25403097.001]
  • [Cites] Surgery. 2010 May;147(5):622-30 [20015529.001]
  • [Cites] Ann R Coll Surg Engl. 2011 Apr;93(3):205-8 [21477431.001]
  • [Cites] J Endourol. 2007 Mar;21(3):244-7 [17444766.001]
  • [Cites] Otol Neurotol. 2012 Sep;33(7):1225-31 [22858711.001]
  • [Cites] BMJ. 2004 Feb 21;328(7437):418-9 [14976074.001]
  • [Cites] Otolaryngol Head Neck Surg. 2010 Nov;143(5 Suppl 3):S30-5 [20970690.001]
  • [Cites] Surg Endosc. 2005 Mar;19(3):401-5 [15624062.001]
  • [Cites] J Laryngol Otol. 2012 Jul;126(7):663-9 [22643313.001]
  • [Cites] Otolaryngol Head Neck Surg. 2012 Mar;146(3):497-503 [22051543.001]
  • [Cites] Laryngorhinootologie. 2001 Jun;80(6):298-302 [11475607.001]
  • [Cites] Simul Healthc. 2009 Summer;4(2):98-103 [19444047.001]
  • [Cites] Acta Otorhinolaryngol Ital. 2013 Aug;33(4):273-81 [24043916.001]
  • (PMID = 28553354.001).
  • [ISSN] 1687-9201
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


Advertisement
4. Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R: Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet; 2012 Sep;44(9):1006-14
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
  • We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas.
  • Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-shielded acral, mucosal and uveal melanomas.
  • Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
  • Notably, we identified a recurrent UV-signature, an activating mutation in RAC1 in 9.2% of sun-exposed melanomas.
  • This activating mutation, the third most frequent in our cohort of sun-exposed melanoma after those of BRAF and NRAS, changes Pro29 to serine (RAC1(P29S)) in the highly conserved switch I domain.
  • Crystal structures, and biochemical and functional studies of RAC1(P29S) showed that the alteration releases the conformational restraint conferred by the conserved proline, causes an increased binding of the protein to downstream effectors, and promotes melanocyte proliferation and migration.
  • These findings raise the possibility that pharmacological inhibition of downstream effectors of RAC1 signaling could be of therapeutic benefit.


5. Ma S: Empirical study of supervised gene screening. BMC Bioinformatics; 2006 Dec 18;7:537
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Empirical study of supervised gene screening.
  • BACKGROUND: Microarray studies provide a way of linking variations of phenotypes with their genetic causations.
  • Constructing predictive models using high dimensional microarray measurements usually consists of three steps:.
  • (1) unsupervised gene screening;.
  • (2) supervised gene screening; and (3) statistical model building.
  • Supervised gene screening based on marginal gene ranking is commonly used to reduce the number of genes in the model building.
  • Various simple statistics, such as t-statistic or signal to noise ratio, have been used to rank genes in the supervised screening.
  • Despite of its extensive usage, statistical study of supervised gene screening remains scarce.
  • Our study is partly motivated by the differences in gene discovery results caused by using different supervised gene screening methods.
  • RESULTS: We investigate concordance and reproducibility of supervised gene screening based on eight commonly used marginal statistics.
  • Concordance is assessed by the relative fractions of overlaps between top ranked genes screened using different marginal statistics.
  • We propose a Bootstrap Reproducibility Index, which measures reproducibility of individual genes under the supervised screening.
  • Empirical studies are based on four public microarray data.
  • We consider the cases where the top 20%, 40% and 60% genes are screened.
  • CONCLUSION: From a gene discovery point of view, the effect of supervised gene screening based on different marginal statistics cannot be ignored.
  • Empirical studies show that (1) genes passed different supervised screenings may be considerably different;.
  • (2) concordance may vary, depending on the underlying data structure and percentage of selected genes;.
  • (3) evaluated with the Bootstrap Reproducibility Index, genes passed supervised screenings are only moderately reproducible; and (4) concordance cannot be improved by supervised screening based on reproducibility.

  • MedlinePlus Health Information. consumer health - Genetic Testing.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11462-7 [11562467.001]
  • [Cites] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499.001]
  • [Cites] Cancer Cell. 2003 Feb;3(2):185-97 [12620412.001]
  • [Cites] Bioinformatics. 2003 Jun 12;19(9):1061-9 [12801866.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 [10359783.001]
  • [Cites] Science. 1999 Oct 15;286(5439):531-7 [10521349.001]
  • [Cites] N Engl J Med. 2004 Nov 18;351(21):2159-69 [15548776.001]
  • [Cites] Biostatistics. 2005 Jan;6(1):59-75 [15618528.001]
  • [Cites] Lancet. 2005 Feb 5-11;365(9458):488-92 [15705458.001]
  • [Cites] Pac Symp Biocomput. 2005;:272-83 [15759633.001]
  • [Cites] Bioinformatics. 2005 Jul 1;21(13):3001-8 [15814556.001]
  • [Cites] BMC Bioinformatics. 2005;6:120 [15904488.001]
  • [Cites] Bioinformatics. 2005 Sep 1;21 Suppl 2:ii108-14 [16204088.001]
  • [Cites] Bioinformatics. 2005 Dec 15;21(24):4356-62 [16234316.001]
  • [Cites] BMC Bioinformatics. 2006;7:50 [16451725.001]
  • [Cites] Biostatistics. 2006 Apr;7(2):268-85 [16284340.001]
  • [Cites] BMC Bioinformatics. 2006;7:253 [16684357.001]
  • [Cites] Biostatistics. 2007 Jan;8(1):9-31 [16613834.001]
  • [Cites] Nature. 2000 Feb 3;403(6769):503-11 [10676951.001]
  • [Cites] Nat Genet. 2000 Mar;24(3):227-35 [10700174.001]
  • [Cites] Biometrics. 2000 Jun;56(2):337-44 [10877287.001]
  • [Cites] Bioinformatics. 2002 Dec;18(12):1625-32 [12490447.001]
  • (PMID = 17176468.001).
  • [ISSN] 1471-2105
  • [Journal-full-title] BMC bioinformatics
  • [ISO-abbreviation] BMC Bioinformatics
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / S10 RR019895; United States / NCRR NIH HHS / RR / RR19895-02
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1764766
  •  go-up   go-down


6. Muhlstein J, Monceau E, Lamy C, Tran N, Marchal F, Judlin P, Malartic C, Morel O: [Contribution of robot-assisted surgery in the management of female infertility]. J Gynecol Obstet Biol Reprod (Paris); 2012 Sep;41(5):409-17
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Contribution of robot-assisted surgery in the management of female infertility].
  • [Transliterated title] Apport de la chirurgie robot-assistée dans la prise en charge de l'infertilité féminine.
  • Although considerable progresses were made in the field of medically assisted procreation, surgery keeps its place in the therapeutic armamentarium of female infertility.
  • Indeed, its results are very interesting, both in its tubal, myometrial and endometriosis indications.
  • Laparotomy is the first step in the development of any surgical technique.
  • Laparoscopy brings benefits concerning recovery, but also in terms of fertility because of the reduction of postoperative adhesions.
  • Nevertheless, comfort of the surgeon, so the ease of skills, are often altered, especially for complex operations such as those implicated in infertility treatment.
  • Robot-assistance takes here all its interest.
  • It allows indeed a quality in the realization of precise and complex skills, and results at least as interesting as standard laparoscopy can be provided.
  • An overview of robot-assistance in surgery of female infertility is here presented.
  • A review of world literature furnished multiple studies evaluating the tubal robotic surgery, and demonstrating its interesting results.
  • Other indications could, according to us, emerge and be evaluated in this area, such as myomectomy and endometriosis surgery.
  • [MeSH-major] Infertility, Female / surgery. Laparoscopy / methods. Robotics
  • [MeSH-minor] Clinical Competence. Endometriosis / complications. Endometriosis / surgery. Fallopian Tube Diseases / surgery. Fallopian Tubes / surgery. Female. Humans. Uterine Myomectomy / methods

  • Genetic Alliance. consumer health - infertility.
  • MedlinePlus Health Information. consumer health - Female Infertility.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2012 Elsevier Masson SAS. All rights reserved.
  • (PMID = 22726865.001).
  • [ISSN] 1773-0430
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  •  go-up   go-down


7. Ma S: Biology and clinical implications of CD133(+) liver cancer stem cells. Exp Cell Res; 2013 Jan 15;319(2):126-32
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Biology and clinical implications of CD133(+) liver cancer stem cells.
  • Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver, accounting for 80%-90% of all liver cancers.
  • The disease ranks as the fifth most common cancer worldwide and is the third leading cause of all cancer-associated deaths.
  • Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late presentation and tumor recurrence.
  • Only 25% of HCC patients are deemed suitable for curative treatment, with the overall survival at just a few months for inoperable patients.
  • Apart from surgical resection, loco-regional ablation and liver transplantation, current treatment protocols include conventional cytotoxic chemotherapy.
  • But due to the highly resistant nature of the disease, the efficacy of the latter regimen is limited.
  • The recent emergence of the cancer stem cell (CSC) concept lends insight into the explanation of why treatment with chemotherapy often may seem to be initially successful but results in not only a failure to eradicate the tumor but also possibly tumor relapse.
  • Commonly used anti-cancer drugs in HCC work by targeting the rapidly proliferating and differentiated liver cancer cells that constitute the bulk of the tumor.
  • However, a subset of CSCs exists within the tumor, which are more resistant and are able to survive and maintain residence after treatment, thus, growing and self-renewing to generate the development and spread of recurrent tumors in HCC.
  • In the past few years, compelling evidence has emerged in support of the hierarchic CSC model for solid tumors, including HCC.
  • And in particular, CD133 has drawn significant attention as a critical liver CSC marker.
  • Understanding the characteristics and function of CD133(+) liver CSCs has also shed light on HCC management and treatment, including the implications for prognosis, prediction and treatment resistance.
  • In this review, a detailed summary of the recent progress in CD133(+) liver CSC research with regard to identification, regulation and clinical implications will be discussed.
  • [MeSH-major] Antigens, CD / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / metabolism. Glycoproteins / metabolism. Liver Neoplasms / pathology. Liver Neoplasms / therapy. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology. Peptides / metabolism
  • [MeSH-minor] Animals. Humans. MicroRNAs / metabolism. Signal Transduction

  • Genetic Alliance. consumer health - Liver cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22999864.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / MicroRNAs; 0 / Peptides
  •  go-up   go-down


8. Ma S: Electrophilic addition and cyclization reactions of allenes. Acc Chem Res; 2009 Oct 20;42(10):1679-88
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Electrophilic addition and cyclization reactions of allenes.
  • Modern organic synthesis depends on the development of highly selective methods for the efficient construction of potentially useful target molecules.
  • A primary goal in our laboratory is the discovery of new reactions that convert readily available starting materials to complex products with complete control of regio- and stereoselectivity.
  • Allenes are one underused moiety in organic synthesis, because these groups are often thought to be highly reactive.
  • However, many compounds containing the allene group, including natural products and pharmaceuticals, are fairly stable.
  • The chemistry of allenes has been shown to have significant potential in organic synthesis.
  • Electrophilic additions to allenes have often been considered to be synthetically less attractive due to the lack of efficient control of the regio- and stereoselectivity.
  • However, this Account describes electrophilic reactions of allenes with defined regio- and stereoselectivity developed in our laboratory.
  • Many substituted allenes are readily available from propargylic alcohols.
  • Our work has involved an exploration of the reactions of these allenes with many different electrophiles: the E- or Z-halo- or seleno-hydroxylations of allenyl sulfoxides, sulfones, phosphine oxides, carboxylates, sulfides or selenides, butenolides, and arenes, and the halo- or selenolactonization reactions of allenoic acids and allenoates.
  • These reactions have produced a host of new compounds such as stereodefined allylic alcohols, ethers, amides, thiiranes, and lactones.
  • In all these reactions, water acts as a reactant and plays an important role in determining the reaction pathway and the stereoselectivity.
  • The differing electronic properties of the two C=C bonds in these allenes determine the regioselectivity of these reactions.
  • Through mechanistic studies of chirality transfer, isolation and reactivity of cyclic intermediates, (18)O-labeling, and substituent effects, we discovered that the E-stereoselectivity of some reactions results from the neighboring group participation of functional groups forming cyclic intermediates.
  • We rationalize Z-stereoselectivity under other conditions by soft Lewis acid-base interactions and steric effects.
  • These electrophilic reactions of allenes are efficient and useful methods for the synthesis of stereodefined alkenes and lactones, useful functionalities for synthesis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19603781.001).
  • [ISSN] 1520-4898
  • [Journal-full-title] Accounts of chemical research
  • [ISO-abbreviation] Acc. Chem. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


9. Tyrala EE, Manser JI, Brodsky NL, Tran N: Serum zinc concentrations in growing premature infants. Acta Paediatr Scand; 1983 Sep;72(5):695-8
PDF icon [Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum zinc concentrations in growing premature infants.
  • Serial serum zinc concentrations were measured in 31 relatively well, growing premature infants during the first 26 weeks of life.
  • Zinc concentrations declined progressively from 17.9 mumol (1.17 mg/l) at birth (normal adult value) to 8.9 mumol (0.58 mg/l) at 6 weeks of age despite a zinc intake of greater than 13.7 mumol (900 micrograms)/kg/day after the second week of life.
  • The serum zinc increased after 16 weeks of age to 10.7 mumol/dl (0.7 mg/l).
  • No infant demonstrated clinical signs of zinc deficiency.
  • This data may serve as a reference against which serum zinc concentrations in other premature infants may be compared in order to help define the deficiency state.
  • [MeSH-major] Infant, Premature. Zinc / blood
  • [MeSH-minor] Body Weight. Energy Intake. Humans. Infant Food. Infant Nutritional Physiological Phenomena. Infant, Newborn

  • MedlinePlus Health Information. consumer health - Premature Babies.
  • Hazardous Substances Data Bank. ZINC, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 6637467.001).
  • [ISSN] 0001-656X
  • [Journal-full-title] Acta paediatrica Scandinavica
  • [ISO-abbreviation] Acta Paediatr Scand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SWEDEN
  • [Chemical-registry-number] J41CSQ7QDS / Zinc
  •  go-up   go-down


10. Ma S: Penalized multivariate linear mixed model for longitudinal genome-wide association studies. BMC Proc; 2014;8(Suppl 1):S73
PDF icon [Fulltext service] Download fulltext PDF of this article and others, as many as you want.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penalized multivariate linear mixed model for longitudinal genome-wide association studies.
  • We consider analysis of Genetic Analysis Workshop 18 data, which involves multiple longitudinal traits and dense genome-wide single-nucleotide polymorphism (SNP) markers.
  • We use a multivariate linear mixed model to account for the covariance of random effects and multivariate residuals.
  • We divide the SNPs into groups according to the genes they belong to and score them using weighted sum statistics.
  • We propose a penalized approach for genetic variant selection at the gene level.
  • The overall modeling and penalized selection method is referred to as the penalized multivariate linear mixed model.
  • Cross-validation is used for tuning parameter selection.
  • A resampling approach is adopted to evaluate the relative stability of the identified genes.
  • Application to the Genetic Analysis Workshop 18 data shows that the proposed approach can effectively select markers associated with phenotypes at gene level.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Genet Res (Camb). 2013 Jun;95(2-3):68-77 [23938111.001]
  • [Cites] Lifetime Data Anal. 2010 Apr;16(2):176-95 [20013308.001]
  • [Cites] Ann Appl Stat. 2011 Jan 1;5(1):232-253 [22081779.001]
  • [Cites] PLoS Genet. 2009 Feb;5(2):e1000384 [19214210.001]
  • [Cites] PLoS One. 2012;7(12):e51198 [23272092.001]
  • [Cites] Stat Sin. 2012 Oct 1;22(4):1403-1426 [23559831.001]
  • (PMID = 25519343.001).
  • [ISSN] 1753-6561
  • [Journal-full-title] BMC proceedings
  • [ISO-abbreviation] BMC Proc
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM031575; United States / NCATS NIH HHS / TR / UL1 TR000142
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4143695
  •  go-up   go-down






Advertisement