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Items 1 to 10 of about 4966
1. Lu Z, Hunter L: Go molecular function terms are predictive of subcellular localization. Pac Symp Biocomput; 2005;:151-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Go molecular function terms are predictive of subcellular localization.
  • A protein's function is closely linked to its subcellular localization.
  • Use of Gene Ontology (GO) molecular function terms to extend sequence-based subcellular localization prediction has been previously shown to improve predictive performance.
  • Here, we explore directly the relationship between GO function annotations and localization information, identifying both highly predictive single terms, and terms with large information gain with respect to location.
  • The results identify a number of predictive and informative GO terms with respect to subcellular location, particularly nucleus, extracellular space, membrane, mitochondrion, endoplasmic reticulum and Golgi.
  • There are several clear examples illustrating why the addition of function information provides additional predictive power over sequence alone.
  • Other interesting phenomena can also be seen in the results.
  • Most predictive or informative terms are imperfect, and incorrect prediction may often call out significant biological phenomena.
  • Finally, these results may be useful in the GO annotation process.

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  • (PMID = 15759622.001).
  • [ISSN] 2335-6936
  • [Journal-full-title] Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
  • [ISO-abbreviation] Pac Symp Biocomput
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / AA013524-05; United States / NIGMS NIH HHS / GM / T32 GM07635-25; United States / NIAAA NIH HHS / AA / U01 AA013524; United States / NIAAA NIH HHS / AA / 5U01 AA13524-03; United States / NIGMS NIH HHS / GM / T32 GM007635; United States / NIAAA NIH HHS / AA / U01 AA013524-05; United States / NIAAA NIH HHS / AA / AA013524-03; United States / NIAAA NIH HHS / AA / U01 AA013524-03
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins
  • [Other-IDs] NLM/ NIHMS91740; NLM/ PMC2652875
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2. Qi J, Xu M, Lu Z: [An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat]. Hua Xi Yi Ke Da Xue Xue Bao; 1993 Mar;24(1):31-5
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  • [Title] [An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat].
  • The experiments were performed on 20 adult cats anesthetized with chloralose and urethane, paralyzed and artificially ventilated.
  • The rostral ventrolateral medulla (RVL) was explored by electrical stimulation.
  • We found that an area, 3-5 mm rostral to the obex, 3-4 mm lateral to the midline, and 0-1 mm from the ventral surface of the medulla, was the most effective region for producing a pressor response.
  • After bilateral microinjection of kainic acid into or electrolytic lesion of the above-mentioned active RVL area, a large decrease in arterial blood pressure was elicited, and the pressor response induced by electrical stimulation of the hypothalamic paraventricular nucleus (PA) was nearly eliminated.
  • The results suggest that the RVL mediates the PA pressor response.

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  • (PMID = 8340088.001).
  • [ISSN] 0257-7712
  • [Journal-full-title] Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
  • [ISO-abbreviation] Hua Xi Yi Ke Da Xue Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] SIV03811UC / Kainic Acid
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3. Spassova M, Lu Z: Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel. J Gen Physiol; 1999 Sep;114(3):415-26
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  • [Title] Tuning the voltage dependence of tetraethylammonium block with permeant ions in an inward-rectifier K+ channel.
  • To understand the role of permeating ions in determining blocking ion-induced rectification, we examined block of the ROMK1 inward-rectifier K+ channel by intracellular tetraethylammonium in the presence of various alkali metal ions in both the extra- and intracellular solutions.
  • We found that the channel exhibits different degrees of rectification when different alkali metal ions (all at 100 mM) are present in the extra- and intracellular solution.
  • A quantitative analysis shows that an external ion site in the ROMK1 pore binds various alkali metal ions (Na+, K+, Rb+, and Cs+) with different affinities, which can in turn be altered by the binding of different permeating ions at an internal site through a nonelectrostatic mechanism.
  • Consequently, the external site is saturated to a different level under the various ionic conditions.
  • Since rectification is determined by the movement of all energetically coupled ions in the transmembrane electrical field along the pore, different degrees of rectification are observed in various combinations of extra- and intracellular permeant ions.
  • Furthermore, the external and internal ion-binding sites in the ROMK1 pore appear to have different ion selectivity: the external site selects strongly against the smaller Na+, but only modestly among the three larger ions, whereas the internal site interacts quite differently with the larger K+ and Rb+ ions.

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  • (PMID = 10469731.001).
  • [ISSN] 0022-1295
  • [Journal-full-title] The Journal of general physiology
  • [ISO-abbreviation] J. Gen. Physiol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / F32 GM019215; United States / NIGMS NIH HHS / GM / R01 GM055560; United States / NIGMS NIH HHS / GM / GM19215; United States / NHLBI NIH HHS / HL / HL03814; United States / NIGMS NIH HHS / GM / GM55560
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Kcnj1 protein, rat; 0 / Metals, Alkaline Earth; 0 / Potassium Channel Blockers; 0 / Potassium Channels; 0 / Potassium Channels, Inwardly Rectifying; 66-40-0 / Tetraethylammonium; RWP5GA015D / Potassium
  • [Other-IDs] NLM/ PMC2229458
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4. Fröhlich A, Lu Z: The "rosette-like" structures in the cuticle of Petrobius brevistylis are the openings of epidermal glands. Arthropod Struct Dev; 2013 Jan;42(1):89-94
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  • [Title] The "rosette-like" structures in the cuticle of Petrobius brevistylis are the openings of epidermal glands.
  • We examined the "rosette-like" structures (RS), found in Archaeognatha and Thysanura, in the compound eyes and the antennae of the machilid Petrobius brevistylis using SEM and TEM.
  • The nature of the RS was unknown until now, and hypothesized to be either a sensillum or the opening of a gland.
  • Our studies show that RS are the orifices of epidermal glands.
  • A gland consists of a single glandular unit of 4 cells: a duct cell, a secretory cell, a ciliary cell and an enveloping cell.
  • The glands are class 3 epidermal glands as defined by Noirot and Quennedey (1974).
  • [MeSH-major] Insects / ultrastructure
  • [MeSH-minor] Animals. Arthropod Antennae / ultrastructure. Compound Eye, Arthropod / ultrastructure. Epidermis / ultrastructure. Microscopy, Electron, Scanning. Microscopy, Electron, Transmission

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  • [Copyright] Copyright © 2012 Elsevier Ltd. All rights reserved.
  • (PMID = 23064145.001).
  • [ISSN] 1873-5495
  • [Journal-full-title] Arthropod structure & development
  • [ISO-abbreviation] Arthropod Struct Dev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Liu Y, Hu Y, Lu Z: [Cells culture of human lumbar disc and its morphological observation]. Zhonghua Yi Xue Za Zhi; 1999 Feb;79(2):109-11
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  • [Title] [Cells culture of human lumbar disc and its morphological observation].
  • OBJECTIVE: To observe the continuous changes of disc cells, and explore the degeneration influenced by the cell effects.
  • METHODS: Three discs were obtained from three human embryos and one was from a healthy adult.
  • They were dissected and were digested with trypsin and collagenase.
  • The isolated cells were cultured in HAM F-12 medium and 10% fetal bovine serum.
  • The cultured cells were refrigerated and revived for observation under light microscope and TEM.
  • RESULTS: The biological characteristics of the primary and the second generation of the disc cells were similar to those of the cells in vivo.
  • After subculture, notochordal cells and chondrocytes were shown the characteristics of dedifferentiation.
  • The metabolism of the revived cells after refrigeration was normal.
  • The structures of the organellae in disc cells varied with the changes of cell biological characteristics.
  • CONCLUSION: This successful model is useful for the study of biology and pharmacology of human disc cells.
  • [MeSH-major] Intervertebral Disc / cytology
  • [MeSH-minor] Adult. Cells, Cultured. Chondrocytes / ultrastructure. Fetus. Humans

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  • (PMID = 11601015.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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6. Li L, Lu Z, Han O: [Epidemiology of melioidosis in China]. Zhonghua Liu Xing Bing Xue Za Zhi; 1994 Oct;15(5):292-5
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  • [Title] [Epidemiology of melioidosis in China].
  • From 1975 to 1989, a total of 73 strains of P. pseudomallei was isolated from the water samples and the pathological samples of human and domestic animals in 13 counties and cities located different latitude from four provinces Qiong, Yue, Gui and Xiang in China.
  • Serological investigation demonstrated that the geographical distribution of the organism had a significant correlation with the positive rate of antibodies against P. pseudomallei and the native foci of the organisms distributed over the southern subtropical zone and the edge of tropical zone in Qiong, Yue and Gui.
  • In endemic areas, the positive rates of antibodies against P. pseudomallei in human-beings, horses, oxen and pigs are 3.8%-15.2%, 9.1%-18.4%, 6.6%-33.0% and 35% respectively.
  • The investigation results showed the horses and mules infected by the organism would interfere with quarantine of the animals, meanwhile, the meat contaminated by the bacterium would endanger the public health.
  • In Sept. and Oct. of 1989, three cases in Zhanjiang and Sanya of Hainan were reported, two cases died of acute melioidosis with septicemia, another case was the chronic leg ulcers.
  • So, it was predicated that there could have some cases of melioidosis which were misdiagnosed or missed out.
  • [MeSH-major] Antibodies, Bacterial / blood. Burkholderia pseudomallei / isolation & purification. Horses / microbiology. Melioidosis / epidemiology. Swine / microbiology
  • [MeSH-minor] Animals. Cattle. China / epidemiology. Horse Diseases / epidemiology. Humans. Seroepidemiologic Studies. Swine Diseases / epidemiology. Water Microbiology

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  • (PMID = 7532109.001).
  • [ISSN] 0254-6450
  • [Journal-full-title] Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
  • [ISO-abbreviation] Zhonghua Liu Xing Bing Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] CHINA
  • [Chemical-registry-number] 0 / Antibodies, Bacterial
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7. Liu M, Ma P, Lu Z: [Local chemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma]. Zhonghua Jie He He Hu Xi Za Zhi; 2000 Sep;23(9):550-1
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  • [Title] [Local chemotherapy by fibrobronchoscopy for advanced bronchogenic carcinoma].
  • OBJECTIVE: To observe the effectiveness of treatment in the patients with advanced bronchogenic carcinoma of local chemotherapy with fibrobronchoscopy, combined with systematic chemotherapy.
  • METHODS: 40 patients with advanced bronchogenic carcinoma were divided into the tested group (20 patients) and the control group (20 patients) randomly.
  • By fibrobronchoscopy with its matched injecting needle, carboplatin 300 mg were injected into the centre of the tumor and the surroundings, combined with the routine carboplatin and etoposide (CE) regimen.
  • While the control group was treated only by intravenous chemotherapy with the routine CE regimen.
  • RESULTS: In the 20 patients with local chemotherapy by fibrobronchoscopy combined with intravenous chemotherapy, 7 cases (35%) were completely cured and 11 cases (55%) showed partial recovery, other 2 cases without change.
  • The 90% effective rate was significantly higher than 55% of the control group (P < 0.05).
  • CONCLUSIONS: The local chemotherapy by fibrobronchoscopy can remarkably reduce the size of tumor, and relieve symptom of dyspnea.
  • Intravenous chemotherapy alleviated the obstruction caused by tracheal or bronchial neoplasms.
  • The combined therapies led to much better therapeutic effect and symptomatic relief than those by the routine CE regimen.
  • [MeSH-major] Carcinoma, Bronchogenic / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Aged. Bronchoscopy. Drug Therapy. Female. Humans. Infusions, Intravenous. Male. Middle Aged. Survival Rate. Treatment Outcome

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  • (PMID = 11778530.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
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8. Lu Z, Qi W, Liu Z: [A procedure for developing selective isolation of Pseudonocardiacetes from soil samples]. Wei Sheng Wu Xue Bao; 2000 Aug;40(4):406-14
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  • [Title] [A procedure for developing selective isolation of Pseudonocardiacetes from soil samples].
  • Pseudonocardiacetes are a group of rare-actinomyces with type IV cell walls and without mycolic acids.
  • Five different selective isolation media S1, S2, S3, S4 and S5 were devised and practiced to improve their selective isolation efficiency.
  • The media were detected by 33 type strains of Pseudonocardiaceae, 4 strains of Saccharothrix and 15 type strains of Streptomyces cultured on them.
  • Soil samples were examined on media S1 ad S2 compared with glucose-asparagine agar.
  • It shows that media S1 and S2 are effective for growth and isolation of Amycolata, Pseudonocardia, Saccharomonospora and other genera of Pseudonocardiaceae.
  • [MeSH-major] Actinomycetales / isolation & purification. Soil Microbiology
  • [MeSH-minor] Culture Media

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  • (PMID = 12548963.001).
  • [ISSN] 0001-6209
  • [Journal-full-title] Wei sheng wu xue bao = Acta microbiologica Sinica
  • [ISO-abbreviation] Wei Sheng Wu Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Culture Media
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9. Xu W, Liu D, Lu Z: [CT scanning of the cervical lymph node metastases: compared with histologic sections]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 1998 Mar;12(3):99-102
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  • [Title] [CT scanning of the cervical lymph node metastases: compared with histologic sections].
  • With the development of new imaging modality, MRI and CT scanning has become the most useful adjunct to physical examination for the preoperative evaluation of cervical lymph node metastases of squamous cell carcinoma of the head and neck(SCHN).
  • The study was designed to compare CT scans of metastatic lymph node with corresponding histologic sections on 26 dissections in total and discussed the criteria for assessment of nodal metastases with histologic sections.
  • With pathologic findings as the standard, sensitivity, specificity and accuracy of CT in the detection of nodal disease is 93.8%, 90.0% and 92.3%.
  • Regarding extracapsular nodal spread, CT scanning results in the accuracy of 72.7%.
  • The accuracy of CT detecting central nodal necrosis was 88.9%.
  • This study indicated that CT is accurate in detecting cervical lymph node metastases from head and neck squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / radiography. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiography. Lymph Nodes / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Double-Blind Method. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck. Sensitivity and Specificity

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  • (PMID = 11189141.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
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10. Spassova M, Lu Z: Coupled ion movement underlies rectification in an inward-rectifier K+ channel. J Gen Physiol; 1998 Aug;112(2):211-21
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  • [Title] Coupled ion movement underlies rectification in an inward-rectifier K+ channel.
  • We studied block of the internal pore of the ROMK1 inward-rectifier K+ channel by Mg2+ and five quaternary ammoniums (tetramethylammonium, tetraethylammonium, tetrapropylammonium, tetrabutylammonium, and tetrapentylammonium).
  • The apparent affinity of these blockers varied as a function of membrane voltage.
  • As a consequence, the channel conducted K+ current more efficiently in the inward than the outward direction; i.e., inward rectification.
  • Although the size of some monovalent quaternary ammoniums is rather large, the zdelta values (which measure voltage dependence of their binding to the pore) were near unity in symmetric 100 mM K+.
  • Furthermore, we observed that not only the apparent affinities of the blockers themselves, but also their dependence on membrane voltage (or zdelta), varied as a function of the concentration of extracellular K+.
  • These results suggest that there is energetic coupling between the binding of blocking and permeating (K+) ions, and that the voltage dependence of channel blockade results, at least in part, from the movement of K+ ions in the electrical field.
  • A further quantitative analysis of the results explains why the complex phenomenon of inward rectification depends on both membrane voltage and the equilibrium potential for K+.

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  • (PMID = 9689028.001).
  • [ISSN] 0022-1295
  • [Journal-full-title] The Journal of general physiology
  • [ISO-abbreviation] J. Gen. Physiol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM055560; United States / NHLBI NIH HHS / HL / T32 HL007027; United States / NIGMS NIH HHS / GM / GM-55560; United States / NHLBI NIH HHS / HL / HL07027
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Potassium Channels; 0 / Potassium Channels, Inwardly Rectifying; 66-40-0 / Tetraethylammonium; I38ZP9992A / Magnesium; RWP5GA015D / Potassium
  • [Other-IDs] NLM/ PMC2525747
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