BioMedLib Search Engine [ goto HOMEPAGE ]

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic relevance of genetic alterations in the p32 region of chromosome 1 in neuroblastoma.

Thirty-six neuroblastomas were analysed for chromosome 1p alterations and their prognostic relevance.

In 72% (26/36) of the patients, 1p alterations were identified in the tumours using 24 polymorphic loci ranging 1p22-1p36.3.

LOH was identified in 25 children, and in 10 additional allelic imbalance was identified.

In 1 child allelic imbalance was the sole alteration.

Imbalance was termed as gain in intensity of one allele with or without reduction of the second allele (< 50%).

The imbalance was identified in adjacent regions to the LOH.

Two distinct regions of LOH were identified: 1p36.1-p36.3 and 1p31-p32.

The common imbalance regions overlapped the common LOH regions.

The children with LOH and imbalance had improved survival (100%) compared to the children with LOH only (26%) after 48 months of follow-up.

The imbalance had an advantageous effect that is reflected by the improved outcome in children with other unfavourable clinical features.

[MeSH-major] Chromosomes, Human, Pair 1 / genetics. Loss of Heterozygosity / genetics. Neuroblastoma / genetics

[MeSH-minor] Alleles. Humans. Infant. Prognosis. Survival Analysis

Genetic Alliance. consumer health - Neuroblastoma.

Genetic Alliance. consumer health - Neuroblastoma 1.

MedlinePlus Health Information. consumer health - Neuroblastoma.

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 9516838.001).

[ISSN] 0959-8049

[Journal-full-title] European journal of cancer (Oxford, England : 1990)

[ISO-abbreviation] Eur. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] ENGLAND

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The hope and the reality of reduced intensity transplants in children with malignant diseases.

Reduced intensity preparative regimens are increasingly used for conditioning prior to allogeneic stem cell transplantation.

As opposed to classical methods of pre-transplant conditioning, patients receive predominantly immunosuppressive therapies that facilitate early engraftment, while cells within the graft itself promote continuation of the engraftment process.

Despite early hopes that this form of transplant would be devoid of grade III and IV acute toxicities, there is a substantial amount of short-term morbidity associated with the technique.

Although long-term follow-up is not yet available, it is hoped that these regimens will spare young patients many of the late effects (cataracts, growth retardation, endocrine and reproductive problems) that are often associated with classical pre-transplant conditioning regimens.

Reliable engraftment and leukemic control have been demonstrated in a large number of both adult and pediatric transplant recipients of these regimens, many of whom were deemed at high risk for standard conditioning because of serious co-morbidities, previous autologous transplantation or multiply relapsed disease.

A brief review of the state of the art of this technology as it applies to pediatric transplantation is presented.

Preliminary results of a survey of pediatric transplant centers indicate that a variety of protocols are used for a variety of indications.

The use of standardized criteria for implementation of reduced intensity preparative regimens, the use of a limited number of regimens, and more extensive data collection will permit the elaboration of prospective comparative studies of this new and exciting modality.

[MeSH-major] Neoplasms / therapy. Stem Cell Transplantation / standards. Transplantation Conditioning / standards

[MeSH-minor] Adult. Child. Child, Preschool. Female. Humans. Male. Transplantation, Homologous

MedlinePlus Health Information. consumer health - Cancer in Children.

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 15812529.001).

[ISSN] 0268-3369

[Journal-full-title] Bone marrow transplantation

[ISO-abbreviation] Bone Marrow Transplant.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 36

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Diagnostic and prognostic value of factor VIII binding antibodies in acquired hemophilia A: data from the GTH-AH 01/2010 study.

Essentials Factor VIII (FVIII) binding IgG detected by ELISA could be an alternative to the Bethesda assay.

We studied the performance of anti-FVIII IgG ELISA in patients with acquired hemophilia and controls.

Anti-FVIII IgG > 99th percentile of controls was highly sensitive and specific.

Patients with high anti-FVIII IgG have a lower chance of achieving remission.

SUMMARY: Background Acquired hemophilia A is a severe bleeding disorder that requires fast and accurate diagnosis as it occurs often unexpectedly in previously healthy men and women of every age.

The Nijmegen-modified Bethesda assay is the diagnostic reference standard for detecting neutralizing autoantibodies against factor VIII (FVIII), but is not widely available, not ideal for quantifying the complex type 2 inhibitors seen in acquired hemophilia, and suffers from high inter-laboratory variability.

Objectives To assess the diagnostic and prognostic value of FVIII-binding antibodies as detected by ELISA compared with the Nijmegen Bethesda assay.

Methods Samples from the time of first diagnosis and clinical data were available from 102 patients with acquired hemophilia enrolled in the prospective GTH-AH 01/2010 study.

Controls (n = 102) were matched for gender and age.

Diagnostic cut-offs were determined by receiver-operator curve analysis.

The prognostic value was assessed in 92 of the 102 patients by Cox regression analysis of time to partial remission.

Results Anti-FVIII IgG above the 99th percentile (> 15 arbitrary units per mL) revealed high sensitivity and specificity (both 0.99; 95% confidence interval, 0.95-1.0) for diagnosing acquired hemophilia.

The likelihood of achieving partial remission was related to anti-FVIII IgG concentration (< 300 arbitrary units, 1.0; 300-1050, 0.65; > 1050, 0.39).

The Bethesda titer was only associated with the likelihood of partial remission when analyzed in the central laboratory, but not when data from local GTH study sites were used.

Conclusion Although the Nijmegen-modified Bethesda assay is the reference standard for demonstrating neutralizing antibodies, the detection of FVIII-binding antibodies by ELISA is similarly sensitive and specific for diagnosing acquired hemophilia.

In addition, anti-FVIII IgG may provide prognostic information.

[Email] Email this result item

Email the results to the following email address:   [X] Close

[Copyright] © 2016 International Society on Thrombosis and Haemostasis.

(PMID = 26988717.001).

[ISSN] 1538-7836

[Journal-full-title] Journal of thrombosis and haemostasis : JTH

[ISO-abbreviation] J. Thromb. Haemost.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Keywords] NOTNLM ; ELISA / antibodies / factor VIII / hemophilia A, acquired / inhibitors

   

Advertisement

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Adult-onset Still's disease. Differential diagnosis in recurrent pharyngitis, fever of unknown original and excessive hyperferritinemia].

[Transliterated title] Morbus Still des Erwachsenen. Differentialdiagnose bei rekurrenter Pharyngitis, Fieber unklarer Genese und exzessiver Hyperferritinämie.

HISTORY AND PHYSICAL EXAMINATION: Six weeks before admission a 43-year old previously healthy woman got right-sided pharyngitis, accompanied with Herpes labialis and oral candidiasis.

Two weeks later she travelled to a holiday in the Caribbean.

During the first week of holiday she developed pharyngitis again, this time accompanied with fever and arthralgies.

Therapeutic trial with antibiotics, antimalaric drugs and antiamoebics, given at the holiday resort, did not reduce fever.

Immediately after return to Germany a therapeutic trial with imipenem was was attempted, without any apparent improvement.

At admission, the patient was febrile, had pinky patchy exanthema and arthralgias.

EXAMINATIONS: At admission, abnormal findings included anaemia (Hb 8.8 mg/dl), severe leukocytosis (35.3/nl), increased ESR (43/89 mm), CRP (24.2 mg/dl) and ferritin (5751 micrograms/l).

Ultrasound examination revealed mild splenomegaly.

Computed tomography of the abdomen and chest were without apparent abnormalities.

TREATMENT AND CLINICAL COURSE: Infection, autoimmune diseases and neoplasia were ruled out.

The diagnosis of adult onset Still's disease was established on the basis of a typical triad of symptoms (fever, exanthema, arthritis).

Treatment with 100 mg/d prednisolon (started intravenously) was beneficial for fever and arthralgia, and resulted in the normalisation of laboratory findings.

After gradual reduction in the corticosteroid dosage, maintenance treatment with 20 mg/d prednisolon was continued over following months.

CONCLUSION: Recurrent prodromal pharyngitis and excessive hyperferritinaemia are, in addition to the triad fever-exanthema-arthritis, further important diagnostic criteria of adult onset Still's disease.

[MeSH-major] Ferritins / blood. Fever of Unknown Origin / etiology. Pharyngitis / etiology. Still's Disease, Adult-Onset / diagnosis

[MeSH-minor] Adult. Diagnosis, Differential. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Humans. Prednisolone / administration & dosage. Recurrence

Genetic Alliance. consumer health - Diagnosis Unknown.

Genetic Alliance. consumer health - Still's disease adult onset.

MedlinePlus Health Information. consumer health - Sore Throat.

Hazardous Substances Data Bank. PREDNISOLONE .

NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

[Email] Email this result item

Email the results to the following email address:   [X] Close

[CommentIn] Dtsch Med Wochenschr. 1999 Dec 17;124(50):1541 [10633783.001]

(PMID = 10432943.001).

[ISSN] 0012-0472

[Journal-full-title] Deutsche medizinische Wochenschrift (1946)

[ISO-abbreviation] Dtsch. Med. Wochenschr.

[Language] ger

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] GERMANY

[Chemical-registry-number] 9007-73-2 / Ferritins; 9PHQ9Y1OLM / Prednisolone

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Innovative antibacterial drugs: nothing ventured, nothing gained.

The current paradox of the widespread clinical demand for novel anti-bacterial drugs and lack of commensurate industrial research activity is unprecedented in modern drug discovery.

Although the root causes of the pharmaceutical industry's disengagement from antibacterial drug discovery have been discussed at length and attributed largely to a lack of productivity coupled with pharmacoeconomic and regulatory considerations, the challenges faced by privately held biotech companies in addressing this therapeutic need originate from the conflict between the capital intensive nature of early-stage drug discovery and the current venture capital funding paradigm.

Continued innovation of antibacterial drugs will require a fundamental shift in how discovery through preclinical research is supported.

[MeSH-major] Anti-Bacterial Agents / therapeutic use. Drug Industry / trends. Drugs, Investigational / therapeutic use

[MeSH-minor] Animals. Humans

MedlinePlus Health Information. consumer health - Antibiotics.

The Lens. Cited by Patents in .

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 15757389.001).

[ISSN] 1744-7658

[Journal-full-title] Expert opinion on investigational drugs

[ISO-abbreviation] Expert Opin Investig Drugs

[Language] eng

[Publication-type] Editorial

[Publication-country] England

[Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Drugs, Investigational

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Synthesis and investigation of a chiral enterobactin analogue based on a macrocyclic peptide scaffold.

A chiral C(3)-symmetric enterobactin analogue (1) has been synthesized by attachment of three 2,3-dihydroxybenzoyl units to a chiral oxazole-containing macrocyclic peptide scaffold.

Complex formation kinetics and stoichiometry with various metal ions were investigated by spectrophotometric methods.

In the cases of Al(III), In(III) and Fe(III) complexes, UV absorption and CD kinetics showed nonlinearity, which results from slow conformational changes of the octahedral complexes.

Virtual binding constants were determined from UV absorption data and showed selective binding of Ga(III) in preference to Fe(III), by two orders of magnitude.

CD spectroscopy revealed highly diastereoselective binding of Al(III), Ga(III), In(III), Fe(III) and Ge(IV) ions at room temperature, corresponding to the helical chirality opposite to that of the analogous enterobactin complexes.

Ab initio calculations confirmed the energetic stabilization of the Lambda isomers relative to the Delta isomers.

[MeSH-major] Enterobactin / analogs & derivatives. Peptides, Cyclic / chemistry

[MeSH-minor] Kinetics. Macrocyclic Compounds / chemistry. Metals, Heavy / chemistry. Models, Molecular. Molecular Conformation. Spectrum Analysis

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 18989856.001).

[ISSN] 1521-3765

[Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)

[ISO-abbreviation] Chemistry

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Macrocyclic Compounds; 0 / Metals, Heavy; 0 / Peptides, Cyclic; 28384-96-5 / Enterobactin

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The role of Compensatory Health Beliefs in eating behavior change: A mixed method study.

Compensatory Health Beliefs (CHBs), defined as beliefs that an unhealthy behavior can be compensated for by engaging in another healthy behavior, are assumed to hinder health behavior change.

The aim of the present study was to investigate the role of CHBs for two distinct eating behaviors (increased fruit and vegetable consumption and eating fewer unhealthy snacks) with a mixed method approach.

Participants (N = 232, mean age = 27.3 years, 76.3% women) were randomly assigned to a fruit and vegetable or an unhealthy snack condition.

For the quantitative approach, path models were fitted to analyze the role of CHBs within a social-cognitive theory of health behavior change, the Health Action Process Approach (HAPA).

With a content analysis, the qualitative approach investigated the occurrence of CHBs in smartphone chat groups when pursuing an eating goal.

Both analyses were conducted for each eating behavior separately.

Path models showed that CHBs added predictive value for intention, but not behavior over and above HAPA variables only in the unhealthy snack condition.

CHBs were significantly negatively associated with intention and action planning.

Content analysis revealed that people generated only a few CHB messages.

However, CHBs were more likely to be present and were also more diverse in the unhealthy snack condition compared to the fruit and vegetable condition.

Based on a mixed method approach, this study suggests that CHBs play a more important role for eating unhealthy snacks than for fruit and vegetable consumption.

[Email] Email this result item

Email the results to the following email address:   [X] Close

[Copyright] Copyright © 2017 Elsevier Ltd. All rights reserved.

(PMID = 28433774.001).

[ISSN] 1095-8304

[Journal-full-title] Appetite

[ISO-abbreviation] Appetite

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Keywords] NOTNLM ; Compensatory Health Beliefs / Fruit and vegetable consumption / Health Action Process Approach / Smartphone chat groups / Unhealthy snacks

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Interpersonal Processes of Couples' Daily Support for Goal Pursuit: The Example of Physical Activity.

Little is known about how couples' social support facilitates the pursuit of important goals in daily life.

Using an interpersonal perspective, we examined the effects of support provision and receipt on same-day physical activity, and studied the role of partners' joint engagement in activities.

One hundred nineteen heterosexual couples reported on target persons' received and partners' provided support across 28 diary days, yielding 2,854 valid days.

A dyadic report on couples' joint engagement was obtained from a subset of 88 couples.

Target persons' daily activity was objectively assessed via accelerometers.

On days with high versus low levels of provided support, target persons' activity was 25 min higher.

Support receipt mediated 20% of this effect.

Joint engagement accounted for around half of the effects of provided and received support.

Support provision is uniquely linked to goal implementation in everyday life.

Joint engagement in activities may be one explanation for how support is facilitated.

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 29121824.001).

[ISSN] 1552-7433

[Journal-full-title] Personality & social psychology bulletin

[ISO-abbreviation] Pers Soc Psychol Bull

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Keywords] NOTNLM ; daily diary / goal pursuit / physical activity / romantic relationships / social support

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Mediators of Physical Activity Adherence: Results from an Action Control Intervention in Couples.

BACKGROUND: Behavior change interventions targeting self-regulation skills have generally shown promising effects.

However, the psychological working mechanisms remain poorly understood.

PURPOSE: We examined theory-based mediators of a randomized controlled trial in couples targeting action control (i.e., continuously monitoring and evaluating an ongoing behavior).

Self-reported action control was tested as the main mediating mechanism of physical activity adherence, and in addition self-efficacy and received social support from the partner.

METHODS: Overweight individuals (N = 121) and their heterosexual partners were randomly allocated to an intervention (information + action control text messages) or a control group (information only).

Across a period of 28 days, participants reported on action control, self-efficacy, and received support in end-of-day diaries, and wore triaxial accelerometers to assess stable between-person differences in mediators and the outcome adherence to recommended daily activity levels (≥30 min of moderate activity in bouts of at least 10 min).

RESULTS: On average, participants in the intervention group showed higher physical activity adherence levels and higher action control, self-efficacy, and received support compared to participants in the control group.

Action control and received support emerged as mediating mechanisms, explaining 19.7 and 24.6% of the total intervention effect, respectively, in separate analyses, and 13.9 and 22.2% when analyzed simultaneously.

No evidence emerged for self-efficacy as mediator.

CONCLUSIONS: Action control and received support partly explain the effects of an action control intervention on physical activity adherence levels.

Continued research is needed to better understand what drives intervention effects to guide innovative and effective health promotion.

TRIAL REGISTRATION NUMBER: ( controlled-trials.com ISRCTN15705531).

[Email] Email this result item

Email the results to the following email address:   [X] Close

(PMID = 28710666.001).

[ISSN] 1532-4796

[Journal-full-title] Annals of behavioral medicine : a publication of the Society of Behavioral Medicine

[ISO-abbreviation] Ann Behav Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Keywords] NOTNLM ; Action control / Couples / Mediation / Physical activity / Randomized controlled trial / Self-efficacy / Social support

   

[Fulltext service] Get downloadable fulltext PDFs of articles closely matching to this article, as many as you want.

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Double Pancake Versus Long Chalcogen-Chalcogen Bonds in Six-Membered C,N,S-Heterocycles.

The double "pancake" bonding in the dimers of the six-membered heterocycles 1,3-dithia-2,4,6-triazine (4) and 1,3-dithia-2,4-diazine (16) were investigated by means of high-level quantum chemical calculations (B3LYP and CCSD(T)).

It was found that the S-S dimers, 20 a and 27, are not the most stable isomers, but the dimers showing short S-N (21 a) and S-C (25, 28) bonds.

An investigation of the 5-phenyl-1,3-dithia-2,4,6-triazine (4 b) yields that the syn dimer with two S-S bonds (2.57 Å) is the most stable one.

In this dimer, the phenyl groups are placed on top of each other.

The additional dispersion energy of the phenyl rings causes a stabilization of the syn-S-S (C2v -like) isomer.

As a result, two weak albeit relevant single S-S bonds (2.57 Å) are predicted.

These findings contradict the recently published concept of double "pancake" bonding in the dimer 4 b2 .

[Email] Email this result item

Email the results to the following email address:   [X] Close

[Copyright] © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

(PMID = 27172139.001).

[ISSN] 1521-3765

[Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)

[ISO-abbreviation] Chemistry

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Keywords] NOTNLM ; ab initio calculations / density functional calculations / nitrogen / pancake bonds / sulfur