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Items 1 to 10 of about 1921
1. Danckwerth F, Wuisman P, Ritter J, Blasius S, Jürgens H, Ozaki T, Winkelmann W: [Osteosarcoma in 2 siblings. A case report]. Klin Padiatr; 1995 Sep-Oct;207(5):298-301
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  • [Title] [Osteosarcoma in 2 siblings. A case report].
  • [Transliterated title] Osteosarkom bei zwei Geschwistern. Eine kasuistische Darstellung.
  • With a brother and sister, osteosarcoma developed at the age of 11 and 14 respectively.
  • With both there was no previous retinoblastoma or other bone disease with a proclivity to develop osteosarcoma.
  • We discuss possible explanations for familial aggregation of osteosarcoma, citing external or genetic factors.
  • We suggest that it is the retinoblastoma gene RB and the tumor suppressor gene p53 which play an important part in the development of osteosarcoma.
  • [MeSH-major] Bone Neoplasms / genetics. Femoral Neoplasms / genetics. Fibula. Osteosarcoma / genetics
  • [MeSH-minor] Adolescent. Amputation. Chemotherapy, Adjuvant. Child. Combined Modality Therapy. Diagnostic Imaging. Female. Femur / pathology. Humans. Male


2. Tobe M, Kondo J, Imoto K, Ozaki T, Sakamoto A, Uchida K, Matsumoto A, Yamaki S: [Correlation between pulmonary vascular changes and hemodynamic parameters during exercise before and after mitral valve surgery]. Nihon Kyobu Geka Gakkai Zasshi; 1995 Dec;43(12):1929-35
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  • [Title] [Correlation between pulmonary vascular changes and hemodynamic parameters during exercise before and after mitral valve surgery].
  • Sixteen cases with mitral valvular disease were studied with regard to the correlation between pathological changes in the pulmonary vasculature and pulmonary hemodynamics during exercise before and after surgery.
  • In muscular pulmonary arteries obtained by open lung biopsy, medial wall thickness (MWT) was 13.8 +/- 3.2% and intimal thickness (IT) was 37.3 +/- 13.5%.
  • MWT was correlated with IT (r = 0.60, p < 0.05).
  • Wall thickness in pulmonary veins was 8.21 +/- 1.8%.
  • Preoperative mean pulmonary arterial pressure (MPAP) during exercise was 45.9 +/- 9.4 mmHg, and decreased significantly to 38.1 +/- 11.3 mmHg postoperatively.
  • However, in 4 patients, MPAP during exercise increased after surgery.
  • Pulmonary vascular resistance (PVR) during exercise was unchanged before and after surgery (2.74 +/- 1.90 U.M2-->2.69 +/- 1.3 U.M2).
  • MWT was significantly correlated with preoperative MPAP at rest only.
  • In patients showing an increase of MPAP during exercise postoperatively, mean MWT was 16.2% and mean IT was 47.4%.
  • In conclusion our data suggest that postoperative pulmonary hemodynamics does not improve in patients whose MWT exceeds 15% and IT exceeds 40% and that irreversibility may be due to pulmonary vascular lesions.
  • [MeSH-major] Exercise / physiology. Lung / blood supply. Lung / pathology. Mitral Valve Insufficiency / surgery. Mitral Valve Stenosis / surgery. Pulmonary Circulation
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Mitral Valve / surgery

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  • (PMID = 8551074.001).
  • [ISSN] 0369-4739
  • [Journal-full-title] [Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai
  • [ISO-abbreviation] Nihon Kyobu Geka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
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3. Elouga Bom LB, Pertot Y, Bhardwaj VR, Ozaki T: Multi-µJ coherent extreme ultraviolet source generated from carbon using the plasma harmonic method. Opt Express; 2011 Feb 14;19(4):3077-85
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  • [Title] Multi-µJ coherent extreme ultraviolet source generated from carbon using the plasma harmonic method.
  • We demonstrate intense high-order harmonic generation from plasma that is created from different carbon targets.
  • We obtain high-order harmonic energy in the multi-microjoule range for each harmonic order from the 11th to the 17th harmonic.
  • By analyzing the target morphology and the plasma composition, we conclude that the intense harmonics from the bulk carbon targets originate from nanoparticles target.

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  • (PMID = 21369130.001).
  • [ISSN] 1094-4087
  • [Journal-full-title] Optics express
  • [ISO-abbreviation] Opt Express
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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4. Ohkawa T, Majima K, Maeda S: A cysteine protease encoded by the baculovirus Bombyx mori nuclear polyhedrosis virus. J Virol; 1994 Oct;68(10):6619-25
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  • [Title] A cysteine protease encoded by the baculovirus Bombyx mori nuclear polyhedrosis virus.
  • Sequence analysis of the BamHI F fragment of the genome of Bombyx mori nuclear polyhedrosis virus (BmNPV) revealed an open reading frame whose deduced amino acid sequence had homology to those of cysteine proteases of the papain superfamily.
  • The putative cysteine protease sequence (BmNPV-CP) was 323 amino acids long and showed 35% identity to a cysteine proteinase precursor from Trypanosoma brucei.
  • Of 36 residues conserved among cathepsins B, H, L, and S and papain, 31 were identical in BmNPV-CP.
  • In order to determine the activity and function of the putative cysteine protease, a BmNPV mutant (BmCysPD) was constructed by homologous recombination of the protease gene with a beta-galactosidase gene cassette.
  • BmCysPD-infected BmN cell extracts were significantly reduced in acid protease activity compared with wild-type virus-infected cell extracts.
  • The cysteine protease inhibitor E-64 [trans-epoxysuccinylleucylamido-(4-guanidino)butane] inhibited wild-type virus-expressed protease activity.
  • Deletion of the cysteine protease gene had no significant effect on viral growth or polyhedron production in BmN cells, indicating that the cysteine protease was not essential for viral replication in vitro.
  • However, B. mori larvae infected with BmCysPD showed symptoms different from those of wild-type BmNPV-infected larvae, e.g., less degradation of the body, including fat body cells, white body surface color due presumably to undegraded epidermal cells, and an increase in the number of polyhedra released into the hemolymph.
  • This is the first report of (i) a virus-encoded protease with activity on general substrates and (ii) evidence that a virus-encoded protease may play a role in degradation of infected larvae to facilitate horizontal transmission of the virus.
  • [MeSH-major] Bombyx / microbiology. Cysteine Endopeptidases / biosynthesis. Genome, Viral. Nucleopolyhedrovirus / enzymology. Nucleopolyhedrovirus / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Cell Line. Conserved Sequence. Databases, Factual. Humans. Molecular Sequence Data. Open Reading Frames. Papain / chemistry. Papain / genetics. Restriction Mapping. Sequence Homology, Amino Acid. Viral Plaque Assay

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  • (PMID = 8083997.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ U12688
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.2 / Papain
  • [Other-IDs] NLM/ PMC237082
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5. Inoue Y, Abe O, Kawakami T, Ozaki T, Inoue M, Yokoyama I, Yoshikawa K, Ohtomo K: Metabolism of 99mTc-ethylcysteinate dimer in infarcted brain tissue of rats. J Nucl Med; 2001 May;42(5):802-7
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  • [Title] Metabolism of 99mTc-ethylcysteinate dimer in infarcted brain tissue of rats.
  • Brain SPECT with 99mTc-ethylcysteinate dimer (99mTc-ECD) reveals a subacute cerebral infarct as a hypoactive area, even in the presence of postischemic hyperperfusion.
  • The brain retention of 99mTc-ECD depends on hydrophilic conversion mediated by enzymes, and impaired enzymatic trapping is hypothesized to depress the retention efficiency in the infarcted region.
  • The aim of this study was to determine whether the metabolic rate of 99mTc-ECD is actually reduced in infarcted brain tissue.
  • METHODS: In 50 mmol/L phosphate buffer (pH 7.4), 99mTc-ECD was incubated for 30 min with homogenates of rat brain tissue with and without triphenyltetrazolium chloride (TTC) staining.
  • The ratio of polar products was determined by thin-layer chromatography as a function of incubation time, and metabolic rates were obtained.
  • Permanent focal ischemia was induced by occlusion of the right middle cerebral artery (MCA) in rats.
  • The brain was removed 24 h after MCA occlusion, and the infarcted area was defined by TTC staining.
  • The metabolic rate of 99mTc-ECD was determined in homogenates of infarcted tissue, contralateral noninfarcted tissue, and tissue sampled from sham-operated rats.
  • The infarct volume was measured by direct and indirect methods to assess volume expansion caused by edema, and the metabolic rate in infarcted tissue was corrected for the effect of edema.
  • RESULTS: TTC staining had no effect on the metabolic rate of 99mTc-ECD.
  • The metabolic rates in the infarcted tissue were 0.222%/min +/- 0.054%/min and 0.285%/min +/- 0.064%/min before and after correction for edema, respectively.
  • These rates were significantly lower than those in the contralateral noninfarcted tissue (0.426%/min +/- 0.028%/min) and the tissue sampled from the sham-operated rats (0.439%/min +/- 0.031%/min).
  • No substantial difference in rates was observed between the contralateral tissue and the tissue from the sham-operated rats.
  • CONCLUSION: The results of this study showed that infarction decreases the activity of enzymes that mediate the hydrophilic conversion of 99mTc-ECD in the brain and suggest that reduced metabolic activity is related to decreased accumulation of 99mTc-ECD in hyperperfused infarcts.
  • [MeSH-major] Brain / metabolism. Cerebral Infarction / metabolism. Cerebral Infarction / radionuclide imaging. Cysteine / metabolism. Organotechnetium Compounds / metabolism. Radiopharmaceuticals / metabolism
  • [MeSH-minor] Animals. Coloring Agents. Male. Rats. Rats, Wistar. Tetrazolium Salts

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  • (PMID = 11337580.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / Tetrazolium Salts; 7OL20RET2I / triphenyltetrazolium; H25WJA31XE / technetium Tc 99m bicisate; K848JZ4886 / Cysteine
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6. Maeda K, Ozaki T, Kawamata T: [Survey for management of BPSD in care managers and special psychiatric wards for people with severe dementia]. Seishin Shinkeigaku Zasshi; 2013;115(1):41-8
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  • [Title] [Survey for management of BPSD in care managers and special psychiatric wards for people with severe dementia].
  • OBJECTIVES: The integration of medical care and long-term care services is very important in managing dementia patients.
  • We performed two surveys to explore how dementia patients and their symptoms were managed in care facilities (study 1) and at special psychiatric wards for people with severe dementia (study 2).
  • METHODS: (Study 1) One hundred and sixty-six care managers were subjects for the survey.
  • The questionnaires were distributed at the meeting and recovered at the same meeting place. (Study 2) The questionnaires were sent by mail to 405 psychiatric hospitals with special psychiatric wards.
  • The questionnaires were recovered from 105 wards (recovery rate: 26.0%).
  • RESULTS: (Study 1) Over 60% of people the care managers take care of have dementia, and 1/3 of them showed severe dementia.
  • The care managers felt that it is very difficult to manage dementia patients with severe BPSD.
  • They were of the opinion that psychiatric care should be administered to those people. (Study 2) The average period of stay on the wards was about 2 years.
  • One third of people stayed on the wards for over 3 years.
  • The reasons why the people have to stay longer on the wards were as follows: severe BPSD, limited number of care facilities for patients to go to after discharge from the wards, and patients' families do not accept them in their homes.
  • CONCLUSIONS: Care managers supposed that dementia patients with severe BPSD should be managed by specialists in dementia, psychiatrists, etc., at psychiatric hospitals.
  • Patients on special psychiatric wards stayed for longer because of a limited number of care facilities which can manage them.
  • [MeSH-major] Dementia / therapy. Mental Disorders / therapy
  • [MeSH-minor] Data Collection / methods. Hospitals, Psychiatric. Humans. Japan. Long-Term Care / statistics & numerical data. Nursing Homes. Patient Admission / statistics & numerical data

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  • (PMID = 23691793.001).
  • [ISSN] 0033-2658
  • [Journal-full-title] Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
  • [ISO-abbreviation] Seishin Shinkeigaku Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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7. Shibusawa H, Sano Y, Yamamoto T, Kambegawa A, Ohkawa T, Satoh N, Okinaga S, Arai K: A radioimmunoassay of serum 16alpha-hydroxypregnenolone with specific antiserum. Endocrinol Jpn; 1978 Apr;25(2):185-9
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  • [Title] A radioimmunoassay of serum 16alpha-hydroxypregnenolone with specific antiserum.
  • A radioimmunoassay for plasma 16alpha-hydroxypregnenolone has been developed using anti-16alpha-hydroxypregnenolone antiserum produced in rabbits immunized with 16 alpha-hydroxypregnenolone-3-succinate-bovine serum albumin.
  • Radioimmunoassay data were processed and analysed for its validity using a four parameter logistic curve fitting routine with use of the IBM call system.
  • The assay system was satisfactory for a routine use.
  • The 16alpha-hydroxypregnenolone concentrations in the umbilical cord blood at term ranged from 223 to 324 ng/ml.
  • Gas liquid chromatographic analysis revealed a similar result, and also the presence of this steroid in the adrenal gland of the human fetus at midtrimester was confirmed.
  • It is speculated that this steroid is secreted from fetal adrenals.
  • [MeSH-major] 17-alpha-Hydroxypregnenolone / blood. Immune Sera. Radioimmunoassay / methods
  • [MeSH-minor] Adrenal Glands / analysis. Cross Reactions. Female. Fetal Blood / analysis. Fetus. Humans. Pregnancy

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  • (PMID = 668632.001).
  • [ISSN] 0013-7219
  • [Journal-full-title] Endocrinologia japonica
  • [ISO-abbreviation] Endocrinol. Jpn.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Immune Sera; 387-79-1 / 17-alpha-Hydroxypregnenolone
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8. Uekado Y, Ogawa T, Yoshida T, Yamamoto S, Hirano A, Watanabe T, Shinka T, Ohkawa T: [Chemotherapy for advanced bladder cancer: clinical evaluation of chemotherapy for locally advanced or metastatic bladder cancer and adjuvant chemotherapy for deeply invasive bladder cancer following radical cystectomy]. Hinyokika Kiyo; 1985 Aug;31(8):1365-70
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  • [Title] [Chemotherapy for advanced bladder cancer: clinical evaluation of chemotherapy for locally advanced or metastatic bladder cancer and adjuvant chemotherapy for deeply invasive bladder cancer following radical cystectomy].
  • Sixteen patients with locally advanced or metastatic bladder cancer were treated with cis-diamminedichloroplatinum (cis-DDP) alone or in combination with other drugs.
  • Eight patients were given cis-DDP intravenously, 6 patients intraarterially and 2 by both methods.
  • Seven patients (44%) showed a partial response, 2 showed a minor response and 4 remained unchanged.
  • Of the 6 patients treated with arterial infusion, 3 achieved a partial response while only 2 of the 8 patients administered intravenously showed a partial response.
  • Eight patients with deeply invasive bladder cancer were treated with cis-DDP alone or in combination with other drugs following radical cystectomy.
  • Cis-DDP was administered every week for 3 courses and every month for 12 courses at a dose of 50 mg and cis-DDP, adriamycin and 5-FU (CAF) were administered at 3 weeks interval for 3 courses and every month for 12 courses.
  • All patients in this group were alive with a median survival of 20 months.
  • One patient had a recurrence 5 months postoperatively.
  • Adjuvant chemotherapy with cis-DDP or their combination was effective.
  • Toxicity was generally tolerable.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Transitional Cell / drug therapy. Cisplatin / administration & dosage. Urinary Bladder / surgery. Urinary Bladder Neoplasms / drug therapy
  • [MeSH-minor] Aged. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Infusions, Intra-Arterial. Infusions, Parenteral. Male. Middle Aged

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  • (PMID = 3841260.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CAF protocol
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9. Uchida T, Naito S, Kato H, Hatano I, Harashima A, Terada Y, Ohkawa T, Chino F, Eto K: Thimerosal induces toxic reaction in non-sensitized animals. Int Arch Allergy Immunol; 1994 Jul;104(3):296-301
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  • [Title] Thimerosal induces toxic reaction in non-sensitized animals.
  • The effects of injection of thimerosal solution on nonsensitized animals was investigated.
  • Intrafootpad injection of thimerosal solution in nonsensitized mice resulted in a swelling response which peaked 1 h after injection and lasted for more than 24 h.
  • Histopathological examination showed that there were severe edema and infiltration of polymorphonuclear neutrophils at the site of injection.
  • An increased vascular permeability was observed after cutaneous injection of thimerosal solution on the back of nonsensitized rats.
  • Since mercuric chloride and methyl mercury induced severer reactions, and thiosalicylic acid had no effect, mercury contained in thimerosal would have caused the reactions observed in this study.
  • These results suggest that part of these hypersensitivity reactions against thimerosal observed among patients were possibly induced by the toxic effect of thimerosal.
  • Therefore, thimerosal contained as a preservative in vaccine may augment the side-effects of the vaccination.
  • [MeSH-major] Edema / chemically induced. Hypersensitivity, Immediate / chemically induced. Thimerosal / toxicity
  • [MeSH-minor] Animals. Capillary Permeability. Cell Degranulation / immunology. Female. Foot. Histamine Release. Mercury Compounds / toxicity. Mice. Mice, Inbred BALB C. Mice, Inbred C3H. Mice, Inbred C57BL. Rats. Rats, Sprague-Dawley. Skin / pathology

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  • [CommentIn] Int Arch Allergy Immunol. 1994 Dec;105(4):408 [7981614.001]
  • (PMID = 7518269.001).
  • [ISSN] 1018-2438
  • [Journal-full-title] International archives of allergy and immunology
  • [ISO-abbreviation] Int. Arch. Allergy Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Mercury Compounds; 2225PI3MOV / Thimerosal
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10. Hirano A, Sawada Y, Aoshi H, Komura T, Matsumoto M, Kohjimoto Y, Inagaki T, Ohkawa T: [A case of retrovesical fibrosarcoma with severe hypoglycemia]. Hinyokika Kiyo; 1992 Jun;38(6):685-8
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  • [Title] [A case of retrovesical fibrosarcoma with severe hypoglycemia].
  • We report a case of retrovesical fibrosarcoma with severe hypoglycemia.
  • A 67-year-old man was admitted to our hospital with second recurrence of the retrovesical tumor with hypoglycemia.
  • The episodes of hypoglycemia were accompanied by the advance of tumor size.
  • Complete tumor resection with total cystectomy was performed on December 21, 1989, and the tumor was diagnosed histopathologically as fibrosarcoma.
  • Soon after removal of the tumor, hypoglycemia disappeared and the patient has been well without local recurrence or distant metastasis for more than 20 months.
  • [MeSH-major] Fibrosarcoma / complications. Hypoglycemia / complications. Urinary Bladder Neoplasms / complications
  • [MeSH-minor] Aged. Humans. Male






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