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Items 1 to 10 of about 8828
1. Lu Z, Hunter L: Go molecular function terms are predictive of subcellular localization. Pac Symp Biocomput; 2005;:151-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Go molecular function terms are predictive of subcellular localization.
  • A protein's function is closely linked to its subcellular localization.
  • Use of Gene Ontology (GO) molecular function terms to extend sequence-based subcellular localization prediction has been previously shown to improve predictive performance.
  • Here, we explore directly the relationship between GO function annotations and localization information, identifying both highly predictive single terms, and terms with large information gain with respect to location.
  • The results identify a number of predictive and informative GO terms with respect to subcellular location, particularly nucleus, extracellular space, membrane, mitochondrion, endoplasmic reticulum and Golgi.
  • There are several clear examples illustrating why the addition of function information provides additional predictive power over sequence alone.
  • Other interesting phenomena can also be seen in the results.
  • Most predictive or informative terms are imperfect, and incorrect prediction may often call out significant biological phenomena.
  • Finally, these results may be useful in the GO annotation process.

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  • [Cites] J Mol Biol. 2001 Jan 19;305(3):567-80 [11152613.001]
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  • (PMID = 15759622.001).
  • [ISSN] 2335-6936
  • [Journal-full-title] Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
  • [ISO-abbreviation] Pac Symp Biocomput
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / AA013524-05; United States / NIGMS NIH HHS / GM / T32 GM07635-25; United States / NIAAA NIH HHS / AA / U01 AA013524; United States / NIAAA NIH HHS / AA / 5U01 AA13524-03; United States / NIGMS NIH HHS / GM / T32 GM007635; United States / NIAAA NIH HHS / AA / U01 AA013524-05; United States / NIAAA NIH HHS / AA / AA013524-03; United States / NIAAA NIH HHS / AA / U01 AA013524-03
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins
  • [Other-IDs] NLM/ NIHMS91740; NLM/ PMC2652875
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2. Huang M, Pittard J: Genetic analysis of mutant strains of Escherichia coli requiring p-aminobenzoic acid for growth. J Bacteriol; 1967 Jun;93(6):1938-42
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  • [Title] Genetic analysis of mutant strains of Escherichia coli requiring p-aminobenzoic acid for growth.
  • Mutant strains of Escherichia coli K-12 which required p-aminobenzoic acid for growth were isolated.
  • The mutations were mapped by conjugation and by transduction, and two genes concerned with the biosynthesis of p-aminobenzoic acid were identified.
  • [MeSH-major] Aminobenzoates / metabolism. Chromosome Mapping. Escherichia coli / metabolism
  • [MeSH-minor] Molecular Biology. Mutation

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  • (PMID = 5337773.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Aminobenzoates
  • [Other-IDs] NLM/ PMC276713
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3. Huang M, Chalfie M: Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature; 1994 Feb 3;367(6462):467-70
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  • [Title] Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans.
  • Genetic screening has identified a group of mec (mechanosensory) genes that are required for the function of a set of six touch-receptor neurons in the nematode Caenorhabditis elegans.
  • Such genes potentially encode components of the mechanosensory apparatus.
  • We have cloned one of these genes, mec-10, which is a member of the degenerin gene family (genes such as mec-4 and deg-1 that can be mutated to cause neurodegeneration).
  • Because components of an amiloride-sensitive sodium channel (alpha, beta and gamma rENaC) from rat share considerable sequence similarity with the C. elegans genes, it is likely that degenerins may function as channel proteins.
  • Here we show that two degenerin homologues (mec-4 and mec-10) are expressed in the same cells, although each provides a unique function.
  • Based on genetic data of mutations affecting mec-10-induced degeneration, we propose that the products of three genes (mec-4, mec-10 and mec-6) form a complex needed for mechanosensation, and that several other mec genes may be important in regulating the putative channel complex.
  • [MeSH-major] Caenorhabditis elegans / genetics. Caenorhabditis elegans Proteins. Genes, Helminth. Helminth Proteins / genetics. Mechanoreceptors / physiology. Membrane Proteins. Neural Conduction / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. DNA. Ion Channels / genetics. Ion Channels / physiology. Molecular Sequence Data. Nerve Degeneration / genetics

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  • [CommentIn] Nature. 1994 Feb 3;367(6462):412-3 [7509038.001]
  • (PMID = 7509039.001).
  • [ISSN] 0028-0836
  • [Journal-full-title] Nature
  • [ISO-abbreviation] Nature
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ L25312
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Helminth Proteins; 0 / Ion Channels; 0 / Mec-4 protein, C elegans; 0 / Membrane Proteins; 154008-78-3 / MEC-10 protein, C elegans; 9007-49-2 / DNA
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4. Huang M, Lindahl R: Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells. Carcinogenesis; 1990 Jul;11(7):1059-65
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  • [Title] Effects of hepatocarcinogenic initiators on aldehyde dehydrogenase gene expression in cultured rat hepatic cells.
  • The effects of certain in vivo inducers of tumor-associated aldehyde dehydrogenase (aldehyde:NAD+ oxidoreductase, EC 1.2.1.3;.
  • ALDH) activity on the expression of tumor-associated ALDH (T-ALDH) in vitro have been investigated using cultured rat hepatocytes and hepatoma cell lines.
  • Two distinct groups of T-ALDH inducers have been identified.
  • Three hepatocarcinogenic initiators 2-acetylaminofluorene, diethylnitrosamine and ethionine, which cause changes in T-ALDH in vivo, do not induce T-ALDH activity in cultured rat hepatocytes or hepatoma cell lines following either short-term or long-term exposures.
  • In contrast, polycyclic aromatic hydrocarbons, such as 3-methylcholanthrene, benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, induce an immediate increase of T-ALDH activity in both cultured rat hepatocytes and hepatoma cell lines.
  • Synthesis and degradation rates of T-ALDH mRNA and protein have also been determined.
  • The synthesis of T-ALDH protein is coupled with the increased synthesis of T-ALDH mRNA when the T-ALDH gene is constitutively expressed or activated by an inducer.
  • Both T-ALDH mRNA (t1/2 = 25 - 34 h) and protein (t1/2 = 88 - 95 h) in high T-ALDH activity cell lines or low-activity cell lines treated with an inducer are relatively stable.
  • Combined with previous studies, the results suggest that at least two different mechanisms are involved in T-ALDH gene expression; events occurring during initiation as well as during promotion appear to be involved in the genetically stable changes in T-ALDH gene expression which occur in vivo.
  • The results also indicate that the lack of T-ALDH activity in normal hepatocytes or low-activity hepatoma cell lines is due to repression of the T-ALDH gene rather than to the differential stability of T-ALDH mRNA or protein.
  • [MeSH-major] Aldehyde Dehydrogenase / genetics. Gene Expression Regulation, Enzymologic / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Liver Neoplasms, Experimental / genetics
  • [MeSH-minor] 2-Acetylaminofluorene. Animals. Diethylnitrosamine. Enzyme Induction / drug effects. Ethionine. Methylcholanthrene. RNA, Messenger / biosynthesis. RNA, Neoplasm / biosynthesis. Rats. Tumor Cells, Cultured / enzymology

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  • (PMID = 2372865.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-21103
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Neoplasm; 3IQ78TTX1A / Diethylnitrosamine; 56-49-5 / Methylcholanthrene; 9M98QLJ2DL / 2-Acetylaminofluorene; EC 1.2.1.3 / Aldehyde Dehydrogenase; WX1BN24WZT / Ethionine
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5. Huang M, Lindahl R: Aldehyde dehydrogenase heterogeneity in rat hepatic cells. Arch Biochem Biophys; 1990 Mar;277(2):296-300
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  • [Title] Aldehyde dehydrogenase heterogeneity in rat hepatic cells.
  • In normal rat liver, aldehyde dehydrogenase (Aldehyde:NAD+ oxidoreductase, EC 1.2.1.3;.
  • ALDH) is found primarily in mitochondrial and microsomal fractions.
  • During hepatocarcinogenesis, an additional tumor-associated aldehyde dehydrogenase (T-ALDH) is detectable in the cytosol of preneoplastic and neoplastic cells.
  • We report here differences in the ALDH distribution pattern in different rat hepatoma cell lines compared to normal rat hepatocytes.
  • Of the four basal ALDH enzymes, one mitochondrial ALDH and one microsomal ALDH account for 96% of total ALDH molecules detectable with our probes in normal hepatocytes.
  • The other two mitochondrial and microsomal ALDH enzymes are only detectable in the appropriate subcellular fraction from large populations of cells.
  • The tumor-associated ALDH is not detectable in normal hepatocytes.
  • In addition to varying amounts of T-ALDH in the six different rat hepatoma cell lines examined, differences in the amounts of mitochondrial and microsomal ALDHs also occur in both high and low T-ALDH activity hepatoma cell lines.
  • Each of five ALDH enzymes examined has a characteristic half-life varying from 45 min to 95 h.
  • [MeSH-major] Aldehyde Dehydrogenase / metabolism. Isoenzymes / metabolism. Liver / enzymology. Liver Neoplasms, Experimental / enzymology
  • [MeSH-minor] Animals. Cells, Cultured. Kinetics. Microsomes, Liver / enzymology. Mitochondria, Liver / enzymology. Rats

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  • (PMID = 2310196.001).
  • [ISSN] 0003-9861
  • [Journal-full-title] Archives of biochemistry and biophysics
  • [ISO-abbreviation] Arch. Biochem. Biophys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-21103
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.2.1.3 / Aldehyde Dehydrogenase
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6. Huang M, Summers J: pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome. J Virol; 1994 Mar;68(3):1564-72
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  • [Title] pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome.
  • We have found that transcription of the pregenome of an avian hepadnavirus, duck hepatitis B virus (DHBV), is dependent on the presence of a small element in the 5' transcribed region of the pregenome-encoding sequence.
  • This element, which we have named pet (positive effector of transcription), exerts its effect in cis in a position and orientation-dependent manner, suggesting that it may function as part of the nascent pregenome transcript.
  • The requirement for pet depends on the presence in the transcription unit of a region of the DHBV genome located upstream of the envelope promoters, which specifically suppresses transcription of templates lacking pet.
  • In the presence of this region, deletion of pet activates transcription from downstream promoters, suggesting that pregenome transcription complexes fail to reach the downstream promoters.
  • In vitro transcription experiments support the model that pet is required for transcription elongation on the DHBV template.
  • We speculate that pet is required to suppress transcription termination during the first passage of pregenome transcription complexes through a viral termination region on the circular viral DNA.

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  • (PMID = 8107218.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA42542
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC236613
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7. Wu W, Su J, Huang M: [An epidemiological study on reproductive effects in female workers exposed to acrylonitrile]. Zhonghua Yu Fang Yi Xue Za Zhi; 1995 Mar;29(2):83-5
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  • [Title] [An epidemiological study on reproductive effects in female workers exposed to acrylonitrile].
  • Four hundred and seventy-seven female workers exposed to acrylonitrile and 527 controls were studied by retrospective cohort method.
  • Results showed incidence rates of pernicious vomiting and anemia, preterm delivery, and birth defects in exposed women were obviously higher than those in controls, with statistical significance.
  • Logistic regression analysis revealed exposure to acrylonitrile in pregnant workers caused increasing risk of preterm delivery and birth defects.
  • In addition, illness, medicine taking and X-ray irradiation during pregnancy related to the increase of incidence of preterm delivery in exposed women.
  • [MeSH-major] Acrylonitrile / adverse effects. Hyperemesis Gravidarum / epidemiology. Obstetric Labor, Premature / epidemiology. Occupational Exposure
  • [MeSH-minor] China / epidemiology. Cohort Studies. Female. Humans. Logistic Models. Pregnancy. Retrospective Studies

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  • (PMID = 7796687.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] CHINA
  • [Chemical-registry-number] MP1U0D42PE / Acrylonitrile
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8. Tan A, Wu K, Huang M: [Inhibition of ornithine decarboxylase activity and epidermal papilloma in mice by beta-carotene]. Zhonghua Yu Fang Yi Xue Za Zhi; 1995 Nov;29(6):360-2
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  • [Title] [Inhibition of ornithine decarboxylase activity and epidermal papilloma in mice by beta-carotene].
  • Anticarcinogenic action of beta-carotene was analyzed with determination of ornithine decarboxylase (ODC) activity induced by TPA and a two-stage model of skin papilloma-genesis in mice.
  • Results showed increase of ODC activity induced by TPA could be significantly inhibited, onset of tumor postponed, and number of tumor foci decreased by beta-carotene.
  • It suggested beta-carotene had an obvious chemoprophylactic effect on tumor.
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Carotenoids / pharmacology. Ornithine Decarboxylase / metabolism. Papilloma / prevention & control. Skin Neoplasms / prevention & control
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene. Animals. Female. Mice. Tetradecanoylphorbol Acetate. beta Carotene

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  • (PMID = 8697943.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] CHINA
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 01YAE03M7J / beta Carotene; 36-88-4 / Carotenoids; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 4.1.1.17 / Ornithine Decarboxylase; NI40JAQ945 / Tetradecanoylphorbol Acetate
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9. Qi J, Xu M, Lu Z: [An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat]. Hua Xi Yi Ke Da Xue Xue Bao; 1993 Mar;24(1):31-5
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  • [Title] [An investigation of the effect of rostral ventrolateral medulla lesion on pressor response induced by electrical stimulation of hypothalamic paraventricular nucleus in the cat].
  • The experiments were performed on 20 adult cats anesthetized with chloralose and urethane, paralyzed and artificially ventilated.
  • The rostral ventrolateral medulla (RVL) was explored by electrical stimulation.
  • We found that an area, 3-5 mm rostral to the obex, 3-4 mm lateral to the midline, and 0-1 mm from the ventral surface of the medulla, was the most effective region for producing a pressor response.
  • After bilateral microinjection of kainic acid into or electrolytic lesion of the above-mentioned active RVL area, a large decrease in arterial blood pressure was elicited, and the pressor response induced by electrical stimulation of the hypothalamic paraventricular nucleus (PA) was nearly eliminated.
  • The results suggest that the RVL mediates the PA pressor response.

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  • (PMID = 8340088.001).
  • [ISSN] 0257-7712
  • [Journal-full-title] Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
  • [ISO-abbreviation] Hua Xi Yi Ke Da Xue Xue Bao
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] SIV03811UC / Kainic Acid
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10. Huang M, Liu M, Li X: [The analgesic effect of red nucleus and preliminary research on its mechanism]. Zhen Ci Yan Jiu; 1992;17(3):166-70
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  • [Title] [The analgesic effect of red nucleus and preliminary research on its mechanism].
  • The spontaneous discharges of neurons in red nucleus (RN) of rats have been recorded with microelectrode.
  • The discharge frequency of most RN neurons was changed by nociceptive electrical stimulation of nervi peronaeus communis or nervi tibialis or by nociceptive mechanical stimulation of tail or hind leg.
  • The electrical activities of the somatic sensory neurons in the nucleus ventralis posterolateralis (VPL) of thalamus and of the visceral sensory neurons in the nucleus anterior and nucleus parafascicularis of thalamus have been recorded.
  • According to the form of response to the peripheral nociceptive stimulation the neurons concerned could be divided into three types: pain-excited, pain-inhibited and pain-nonrelated.
  • Electrical stimulating RN could change the spontaneous discharge frequency of somatic pain-related neurons of VPL and visceral pain-related neurons of nucleus anterior and nucleus parafascicularis, and could inhibit their response to somatic and visceral nociceptive stimulation respectively, but did not have influence on the activity of most pain-nonrelated neurons in VPL.
  • The effects of electrical stimulating RN and microinjecting Ach into RN on the same pain-related neuron in VPL were similar.
  • The experimental results show that RN can receive the somatic afferent impulses, that the excited RN can inhibit the transmission of somatic and visceral nociceptive impulses into the thalamus, and that the analgesic effect of RN is concerned with Ach.

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  • (PMID = 1339625.001).
  • [ISSN] 1000-0607
  • [Journal-full-title] Zhen ci yan jiu = Acupuncture research
  • [ISO-abbreviation] Zhen Ci Yan Jiu
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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