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Items 1 to 10 of about 361
1. Semb G, Enemark H, Friede H, Paulin G, Lilja J, Rautio J, Andersen M, Åbyholm F, Lohmander A, Shaw W, Mølsted K, Heliövaara A, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Whitby D, Leonard A, Neovius E, Elander A, Willadsen E, Bannister RP, Bradbury E, Henningsson G, Persson C, Eyres P, Emborg B, Kisling-Møller M, Küseler A, Granhof Black B, Schöps A, Bau A, Boers M, Andersen HS, Jeppesen K, Marxen D, Paaso M, Hölttä E, Alaluusua S, Turunen L, Humerinta K, Elfving-Little U, Tørdal IB, Kjøll L, Aukner R, Hide Ø, Feragen KB, Rønning E, Skaare P, Brinck E, Semmingsen AM, Lindberg N, Bowden M, Davies J, Mooney J, Bellardie H, Schofield N, Nyberg J, Lundberg M, Karsten AL, Larson M, Holmefjord A, Reisæter S, Pedersen NH, Rasmussen T, Tindlund R, Sæle P, Blomhoff R, Jacobsen G, Havstam C, Rizell S, Enocson L, Hagberg C, Najar Chalien M, Paganini A, Lundeborg I, Marcusson A, Mjönes AB, Gustavsson A, Hayden C, McAleer E, Slevan E, Gregg T, Worthington H: A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management. J Plast Surg Hand Surg; 2017 Feb;51(1):2-13
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  • [Title] A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
  • BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed.
  • This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP).
  • It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project.
  • METHOD: Ten established national or regional cleft centres participated.
  • Lip and soft palate closure at 3-4 months, and hard palate closure at 12 months served as a common method in each trial.
  • Trial 1 compared this with hard palate closure at 36 months.
  • Trial 2 compared it with lip closure at 3-4 months and hard and soft palate closure at 12 months.
  • Trial 3 compared it with lip and hard palate closure at 3-4 months and soft palate closure at 12 months.
  • The primary outcomes were speech and dentofacial development, with a series of perioperative and longer-term secondary outcomes.
  • RESULTS: Recruitment of 448 infants took place over a 9-year period, with 99.8% subsequent retention at 5 years.
  • CONCLUSION: The series of reports that follow this introductory paper include comparisons at age 5 of surgical outcomes, speech outcomes, measures of dentofacial development and appearance, and parental satisfaction.
  • The outcomes recorded and the numbers analysed for each outcome and time point are described in the series.
  • TRIAL REGISTRATION: ISRCTN29932826.

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  • (PMID = 28218559.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Keywords] NOTNLM ; Scandcleft Project / multicentre study / randomised controlled trials / surgery for unilateral complete cleft lip and palate
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2. Shaw W, Smith J, Spierto FW, Agnese ST: Linearization of data for saturation-type competitive protein binding assay and radioimmunoassay. Clin Chim Acta; 1977 Apr 1;76(1):15-24
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  • [Title] Linearization of data for saturation-type competitive protein binding assay and radioimmunoassay.
  • Most of the commonly-performed competitive protein-binding radioassay methods utilized in the clinical laboratory are based on the principle of saturation analysis.
  • Although many different methods for linearization of saturation-type assays have been proposed, the algebraic equivalency of all of these methods has not been adequately documented.
  • In this manuscript we have shown the physical and mathematical basis for various methods for linearlization of saturation type assays and the algebraic equivalency of these linearization methods.
  • We have also shown that key parameters such as slope and intercept may be dependent on different components of the assays system with differnt linearization methods.
  • An understanding of these key parameters can help the analyst to evaluate changes in these key parameters and to integrate these parameters in a complete quality control system.
  • [MeSH-major] Radioimmunoassay. Radioligand Assay
  • [MeSH-minor] Binding, Competitive. Digoxin / analysis. Mathematics. Regression Analysis

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  • (PMID = 852137.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 73K4184T59 / Digoxin
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3. TURRELL RC, SHAW W, SCHMIDT RP, LEVY LL, ROSEMAN E: Electroencephalographic studies of the encephalopathies. II. Serial studies in tuberculous meningitis. Electroencephalogr Clin Neurophysiol; 1953 Feb;5(1):53-63
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  • [Title] Electroencephalographic studies of the encephalopathies. II. Serial studies in tuberculous meningitis.
  • [MeSH-major] Brain Diseases. Electroencephalography. Tuberculosis. Tuberculosis, Meningeal

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  • (PMID = 13033808.001).
  • [ISSN] 0013-4694
  • [Journal-full-title] Electroencephalography and clinical neurophysiology
  • [ISO-abbreviation] Electroencephalogr Clin Neurophysiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Other-IDs] CLML/ 5324:3948:211:669
  • [Keywords] NLM ; ELECTROENCEPHALOGRAPHY (major topic) / TUBERCULOSIS, MENINGEAL (major topic)
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4. Chiche B, Dupin P, Louvel A, Leger L: [Emergency almost total colectomy for occlusion by a colon tumour. Report on two cases (author's transl)]. Chirurgie; 1981;107(4):275-8
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  • [Title] [Emergency almost total colectomy for occlusion by a colon tumour. Report on two cases (author's transl)].
  • [Transliterated title] Colectomie presque totale d'urgence pour occlusion par tumeur colique. 2 observations.
  • [MeSH-major] Colectomy / methods. Colonic Neoplasms / surgery. Intestinal Obstruction / surgery
  • [MeSH-minor] Aged. Emergencies. Humans. Male

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  • (PMID = 7249862.001).
  • [ISSN] 0001-4001
  • [Journal-full-title] Chirurgie; mémoires de l'Académie de chirurgie
  • [ISO-abbreviation] Chirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] FRANCE
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5. Gehanno JF, Rollin L, Darmoni S: Is the coverage of Google Scholar enough to be used alone for systematic reviews. BMC Med Inform Decis Mak; 2013 Jan 09;13:7
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  • [Title] Is the coverage of Google Scholar enough to be used alone for systematic reviews.
  • BACKGROUND: In searches for clinical trials and systematic reviews, it is said that Google Scholar (GS) should never be used in isolation, but in addition to PubMed, Cochrane, and other trusted sources of information.
  • We therefore performed a study to assess the coverage of GS specifically for the studies included in systematic reviews and evaluate if GS was sensitive enough to be used alone for systematic reviews.
  • METHODS: All the original studies included in 29 systematic reviews published in the Cochrane Database Syst Rev or in the JAMA in 2009 were gathered in a gold standard database.
  • GS was searched for all these studies one by one to assess the percentage of studies which could have been identified by searching only GS.
  • RESULTS: All the 738 original studies included in the gold standard database were retrieved in GS (100%).
  • CONCLUSION: The coverage of GS for the studies included in the systematic reviews is 100%.
  • If the authors of the 29 systematic reviews had used only GS, no reference would have been missed.
  • With some improvement in the research options, to increase its precision, GS could become the leading bibliographic database in medicine and could be used alone for systematic reviews.
  • [MeSH-major] Information Storage and Retrieval / methods. Internet
  • [MeSH-minor] PubMed

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  • (PMID = 23302542.001).
  • [ISSN] 1472-6947
  • [Journal-full-title] BMC medical informatics and decision making
  • [ISO-abbreviation] BMC Med Inform Decis Mak
  • [Language] eng
  • [Grant] United Kingdom / Department of Health / / DRF-2010-03-97
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3544576
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6. Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP: Meeting report: a hard look at the state of enamel research. Int J Oral Sci; 2017 Nov 22;9(11):e3
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  • [Title] Meeting report: a hard look at the state of enamel research.
  • The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research (NIDCR).
  • Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids.
  • Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field.

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  • (PMID = 29165423.001).
  • [ISSN] 2049-3169
  • [Journal-full-title] International journal of oral science
  • [ISO-abbreviation] Int J Oral Sci
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE015846
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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7. Karsten A, Marcusson A, Hurmerinta K, Heliövaara A, Küseler A, Skaare P, Bellardie H, Rønning E, Shaw W, Mølsted K, Sæle P, Brinck E, Rizell S, Najal Chalier M, Eyres P, Semb G: Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 7. Occlusion in 5 year-olds according to the Huddart and Bodenham index. J Plast Surg Hand Surg; 2017 Feb;51(1):58-63
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  • [Title] Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 7. Occlusion in 5 year-olds according to the Huddart and Bodenham index.
  • BACKGROUND AND AIM: Good dentofacial development and good occlusion are main goals in the treatment of UCLP.
  • The aim was to evaluate dental occlusion at age 5 years with the Huddart and Bodenham index after four different protocols of primary surgery for UCLP.
  • DESIGN: Three parallel randomised controlled trials were undertaken as an international multicentre study by 10 cleft teams in five countries: Denmark, Finland, Sweden, Norway, and the UK.
  • METHODS: Three different surgical procedures for primary palatal repair (Arms B, C, and D) were tested against a common procedure (Arm A) in the total cohort of 448 children born with non-syndromic UCLP.
  • Dental casts of 418 patients (272 boys, 146 girls), at the mean age of 5.1 years (range =4.7-6.9) were blindly assessed by 10 orthodontists with the original Huddart and Bodenham index.
  • The main outcome measure was dental occlusion.
  • RESULTS: The inter- and intra-examiner reliability was good-to-excellent (0.61-0.94; 0.66-1.0, respectively).
  • The mean total scores (+2 to -18) varied from -5.56 (Trial 2C) to -7.21 (Trial 3D).
  • The mean anterior scores (+2 to -6) varied from -1.66 (Trial 2C) to -2.56 (Trial 3A).
  • The mean posterior cleft-side scores (0 to -6) varied from -3.24 (Trial 3A) to -3.82 (Trial 3D) and the mean non-cleft-side scores (0 to -6) varied from -0.60 (Trial 2C) to -1.30 (Trial 3A); however, no significant differences were found within the trials.
  • CONCLUSION: There was no statistical evidence of a difference in occlusion between the two surgical methods in each trial.
  • TRIAL REGISTRATION: ISRCTN29932826.

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  • (PMID = 28218557.001).
  • [ISSN] 2000-6764
  • [Journal-full-title] Journal of plastic surgery and hand surgery
  • [ISO-abbreviation] J Plast Surg Hand Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Keywords] NOTNLM ; Scandcleft / Unilateral cleft lip and palate / dental occlusion at 5 years / randomised controlled trials / the original Huddart and Bodenham index
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8. Rubio A, Moore J, Varoglu M, Conrad M, Chu M, Shaw W, Silverman JA: LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF. Mol Membr Biol; 2012 Feb;29(1):1-8
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  • [Title] LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF.
  • Daptomycin (DAP) is a cyclic lipopeptide antibiotic used for the treatment of certain Staphylococcus aureus infections.
  • Although rare, strains have been isolated that are DAP resistant.
  • These strains usually have mutations in mprF, a gene encoding a membrane protein with both lysylphosphatidylglycerol (LPG) synthase and flippase activities.
  • Because ΔmprF strains have increased DAP susceptibility, the mechanism of resistance is not likely due to a loss of mprF function.
  • In this study, we developed an LC-MS assay to examine the effect of different mprF mutations on the ratio of phosphatidylglycerol (PG) to LPG in the membrane.
  • Our assay demonstrated that some, but not all, mutations in the flippase and synthase domains result in small but reproducible increases in the proportion of LPG relative to PG.
  • Techniques described herein represent a higher throughput and more sensitive method for measuring relative phospholipids levels.
  • These results offer guidance in the understanding of how mprF confers DAP resistance; namely, mprF-mediated resistance may be through more than one mechanism, including increased overall LPG synthesis and increased LPG present on the outer leaflet of the cytoplasmic membrane.
  • [MeSH-major] Aminoacyltransferases / genetics. Anti-Bacterial Agents / pharmacology. Bacterial Proteins / genetics. Daptomycin / pharmacology. Mutation. Phospholipids / chemistry. Staphylococcus aureus / drug effects. Staphylococcus aureus / genetics
  • [MeSH-minor] Chromatography, Liquid. Ions / chemistry. Lysine / analysis. Lysine / chemistry. Microbial Sensitivity Tests. Phosphatidylglycerols / analysis. Phosphatidylglycerols / chemistry. Tandem Mass Spectrometry

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  • (PMID = 22276671.001).
  • [ISSN] 1464-5203
  • [Journal-full-title] Molecular membrane biology
  • [ISO-abbreviation] Mol. Membr. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Bacterial Proteins; 0 / Ions; 0 / Phosphatidylglycerols; 0 / Phospholipids; 42241-11-2 / lysylphosphatidylglycerol; EC 2.3.2.- / Aminoacyltransferases; EC 2.3.2.- / mprF protein, Staphylococcus aureus; K3Z4F929H6 / Lysine; NWQ5N31VKK / Daptomycin
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9. Le Charpentier Y, Louvel A, de Saint-Maur PP, Daudet-Monsac M, Léger L, Abelanet R: [Ultrastructural study of an amyloid-producing insuloma. Discussion on histogenesis of focal amyloidosis (author's transl)]. Virchows Arch A Pathol Anat Histol; 1974 Jan 30;362(2):169-83
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  • [Title] [Ultrastructural study of an amyloid-producing insuloma. Discussion on histogenesis of focal amyloidosis (author's transl)].
  • [Transliterated title] Etude ultrastructurale d'un insulome á stroma amyloöde. Discussion de l'histogénèse des amyloses localisées.
  • [MeSH-major] Adenoma, Islet Cell / pathology. Amyloidosis / complications. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Fibroblasts. Humans. Male. Microscopy, Electron

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  • (PMID = 4363184.001).
  • [ISSN] 0340-1227
  • [Journal-full-title] Virchows Archiv. A, Pathological anatomy and histology
  • [ISO-abbreviation] Virchows Arch A Pathol Anat Histol
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY, WEST
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10. Shaw W, McHan J: Adaptation of EMIT procedures for maximum cost effectiveness to two different centrifugal analyzer systems. Ther Drug Monit; 1981;3(2):185-91
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  • [Title] Adaptation of EMIT procedures for maximum cost effectiveness to two different centrifugal analyzer systems.
  • We have adapted commercial immunoassay (EMIT) procedures for dilantin, phenobarbital, theophylline, carbamazepine, tobramycin, disopyramide, quinidine, procainamide, N-acetyl procainamide, and mysoline to two different centrifugal analyzers (Centrifichem and Multistat) using maximum dilutions of reagents to reduce reagent costs to approximately one-tenth of that incurred using the manufacturer's protocol.
  • This savings due to the dilutions of reagents was primarily because of the ability to prolong the reaction time to achieve acceptably large absorbance changes over the absorbance measurement period.
  • Correlation coefficients between values for drugs analyzed by these modified EMIT protocols and values obtained by other methods ranged from 0.927 to 0.994.
  • Within-run precision and recovery values for these drugs were also entirely acceptable.
  • We found that premature mixing of reagents in the rotors of the Multistat system and variable delivery of reagent in the Centrifichem 400 system were both caused by the surfactant in the EMIT buffer.
  • The former problem is being resolved by the manufacturer; the latter problem was resolved by siliconizing the reagent pipet tips.
  • [MeSH-major] Immunoenzyme Techniques / economics. Pharmaceutical Preparations / analysis
  • [MeSH-minor] Centrifugation / instrumentation. Cost-Benefit Analysis. Humans. Indicator Dilution Techniques

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  • (PMID = 6791317.001).
  • [ISSN] 0163-4356
  • [Journal-full-title] Therapeutic drug monitoring
  • [ISO-abbreviation] Ther Drug Monit
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Pharmaceutical Preparations
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