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Items 1 to 10 of about 12858
1. Agarwal S, Wee JJ, Hadley M, Draper HH: Identification of a deoxyguanosine-malondialdehyde adduct in rat and human urine. Lipids; 1994 Jun;29(6):429-32
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  • [Title] Identification of a deoxyguanosine-malondialdehyde adduct in rat and human urine.
  • In an ongoing study, rat and human urine have been examined for the presence of malondialdehyde (MDA) derivatives as indicators of the nature of lipid peroxidative damage caused by this compound in vivo.
  • MDA in urine was found to be present mainly in the form of two lysine adducts, one acetylated and the other unacetylated, reflecting in vivo reactions with tissue proteins.
  • Two minor metabolites were identified as adducts with the phospholipid bases serine and ethanolamine and a third one as an adduct with the nucleic acid base guanine.
  • The identification of an MDA adduct with deoxyguanosine (dG-MDA) among the products of hydrolysis of rat liver DNA suggested the possible occurrence of this compound in urine.
  • In the present study dG-MDA was identified in rat and in human urine, and a high-performance liquid chromatographic method utilizing fluorescence detection was developed for its estimation.
  • The method is sensitive to 1 pmol of dG-MDA and requires a minimum of 1 mL of rat urine or 5 mL of human urine.
  • Its rate of excretion by five-week-old rats (28.54 +/- 2.28 nmol/kg/24 h) (mean +/- SEM) was higher than that for nine-week-old rats (6.29 +/- 1.02) and much higher than that for adult humans (0.40 +/- 0.05).
  • The results indicate that, as reported for 8-hydroxy-deoxyguanosine, dG-MDA excretion is related to metabolic rate.
  • Excretion of dG-MDA by the rat, like the excretion of total MDA, declines during growth on a body weight basis at a rate similar to the decrease in resting energy metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
  • [MeSH-major] Deoxyguanosine / urine. Lipid Peroxidation. Malondialdehyde / urine
  • [MeSH-minor] Acetylation. Animals. Chromatography, High Pressure Liquid. DNA / metabolism. Female. Humans. Liver / metabolism. Middle Aged. Rats. Vitamin E Deficiency / urine

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  • [Cites] J Nutr. 1969 Aug;98(4):390-4 [5800478.001]
  • [Cites] Proc Natl Acad Sci U S A. 1988 Apr;85(8):2706-8 [3128794.001]
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  • [Cites] Lipids. 1990 Feb;25(2):82-5 [2329925.001]
  • [Cites] J Biol Chem. 1985 Dec 15;260(29):15427-31 [3934158.001]
  • [Cites] Carcinogenesis. 1988 Mar;9(3):473-7 [3125998.001]
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  • [Cites] Lipids. 1984 Nov;19(11):836-43 [6521608.001]
  • (PMID = 8090064.001).
  • [ISSN] 0024-4201
  • [Journal-full-title] Lipids
  • [ISO-abbreviation] Lipids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 4Y8F71G49Q / Malondialdehyde; 9007-49-2 / DNA; G9481N71RO / Deoxyguanosine
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2. Gulati RK, Agarwal S, Agrawal SS: Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin. Indian J Exp Biol; 1995 Apr;33(4):261-8
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  • [Title] Hepatoprotective studies on Phyllanthus emblica Linn. and quercetin.
  • Phyllanthus emblica is a constituent of many hepatoprotective formulations available in market.
  • 50% alcoholic extract of P. emblica and quercetin isolated from it were studied for hepatoprotective effect against country made liquor (CML) and paracetamol challenge in albino rats and mice respectively.
  • The extract at the dose of 100 mg/100 g [corrected], po and quercetin at the dose of 15 mg/100 g, po, produced significant hepatoprotection.
  • [MeSH-major] Drug-Induced Liver Injury / prevention & control. Medicine, Ayurvedic. Plants, Medicinal. Quercetin / therapeutic use
  • [MeSH-minor] Animals. Female. Male. Mice. Rats

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  • [ErratumIn] Indian J Exp Biol 1995 Aug;33(8):precedi
  • (PMID = 7558182.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] INDIA
  • [Chemical-registry-number] 9IKM0I5T1E / Quercetin
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3. Sharma M, Agarwal S, Wadhwa N, Mishra K, Gadre DJ: Spectrum of cytomorphology of tuberculous lymphadenitis and changes during anti-tubercular treatment. Cytopathology; 2007 Jun;18(3):180-3
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  • [Title] Spectrum of cytomorphology of tuberculous lymphadenitis and changes during anti-tubercular treatment.
  • OBJECTIVE: To analyse the morphological changes in tuberculous lymph nodes and the clinical response during short course anti tubercular chemotherapy.
  • METHODS: Thirty-six patients with tuberculous lymphadenitis under treatment were followed up clinically and cytologically at 0, 2, 4 and 6 months.
  • RESULTS: Twenty-six (72.2%) patients had palpable lymph nodes at the end of chemotherapy.
  • Of the 14 patients with residual lymph nodes exceeding 1 cm in size, 92.8% (13) still had evidence of continuation of the disease.
  • Acid-fast bacilli could be found in 38.8% patients at the end of 6 months.
  • Intense lymphocytic infiltration of granulomata in the early phase of chemotherapy predicted a favourable outcome.
  • CONCLUSIONS: Following completion of anti-tubercular treatment a significant percentage of patients have persistent lymphadenopathy and harbour the disease.
  • Morphological follow up of these patients is essential as they may be at increased risk of relapse.
  • [MeSH-major] Antitubercular Agents / therapeutic use. Lymph Nodes / pathology. Tuberculosis, Lymph Node / drug therapy. Tuberculosis, Lymph Node / pathology. Tuberculosis, Pulmonary / drug therapy. Tuberculosis, Pulmonary / pathology
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle / methods. Child. Child, Preschool. Drug Therapy, Combination. Female. Humans. Male. Mycobacterium tuberculosis / drug effects. Mycobacterium tuberculosis / isolation & purification. Prospective Studies. Treatment Outcome

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  • (PMID = 17388932.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antitubercular Agents
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4. Gauba V, Saleh GM, Dua G, Agarwal S, Ell S, Vize C: Radiological classification of anterior skull base anatomy prior to performing medial orbital wall decompression. Orbit; 2006 Jun;25(2):93-6
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  • [Title] Radiological classification of anterior skull base anatomy prior to performing medial orbital wall decompression.
  • PURPOSE: To study a radiological classification, originally described by Keros in 1965, which provides an objective assessment of anterior skull base anatomy relevant in patients undergoing external medial orbital decompression.
  • MATERIALS AND METHODS: The classification is based on anatomical landmarks measured via coronal CT-scan.
  • The patients are divided into 3 Keros categories based on their olfactory fossa depth; Keros 1 (1-3 mm), Keros 2 (4-7 mm) and Keros 3 (8-16 mm).
  • A cross-sectional group of 32 consecutive patients on the hospital radiology database with coronal CT scans were classified according to the Keros system.
  • RESULTS: All the patients fell into one of the three Keros categories.
  • Anatomical associations of the Keros classification suggest that Keros 1 patients have the least risk of intracranial entry whilst Keros 3 patients carry the greatest risk.
  • CONCLUSION: Keros classification provides an objective assessment of anterior skull base anatomy and can therefore guide the surgeon on the superior extent of medial wall bone removal during orbital decompression.
  • This may help improve the safety profile of the procedure.
  • [MeSH-major] Decompression, Surgical. Orbit / surgery. Skull Base / radiography
  • [MeSH-minor] Humans. Intraoperative Complications. Tomography, X-Ray Computed

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  • (PMID = 16754215.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Agarwal S, Corbley MJ, Roberts TM: Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene; 1995 Aug 3;11(3):427-38
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  • [Title] Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways.
  • We have attempted to dissect signaling pathways involved in transmitting activating signals from the cell surface to the nucleus by reconstituting them in the baculovirus/Sf9 cell system.
  • We have used this system to coexpress different combinations of the critical signaling proteins pp60v-src, p21v-ras, Raf-1 and ERK-1 and assayed the effects of resulting signaling cascades on the modifications of coexpressed transcription factors c-jun or c-fos.
  • We observe that activation of ERK-1 via Raf-1 and p21ras dependent signals can result in the hyperphosphorylation of c-jun.
  • In contrast, c-fos appears to be the target of two Raf-1 activated modifying signals: one independent of ERK-1 and the other dependent on ERK-1 stimulation.
  • Thus, coexpression of c-fos with pp60v-src, p21v-ras or constitutively active forms of Raf-1 results in a dramatic reduction of its electrophoretic mobility in the absence of coexpressed ERK-1.
  • Activation of this ERK-1-independent pathway together with the ERK-1 dependent pathway that modifies c-jun results in additional modification of c-fos.
  • Our observation of a Raf-1 activated, ERK-independent signaling pathway is consistent with previous reports that constitutively active Raf-1 can, in some cell types, result in transformation or differentiation without activation of ERKs.
  • Our data indicate the presence of multiple Raf-1 activated pathways that lead to modification of transcription factors.
  • [MeSH-major] Calcium-Calmodulin-Dependent Protein Kinases / metabolism. Mitogen-Activated Protein Kinases. Protein-Serine-Threonine Kinases / physiology. Proto-Oncogene Proteins / physiology. Proto-Oncogene Proteins c-fos / metabolism. Proto-Oncogene Proteins c-jun / metabolism
  • [MeSH-minor] 3T3 Cells. Animals. Cell Membrane / metabolism. Cell Nucleus / metabolism. Electrophoresis, Gel, Two-Dimensional. Mice. Mitogen-Activated Protein Kinase 3. Nucleopolyhedrovirus / genetics. Peptide Mapping. Phosphorylation. Platelet-Derived Growth Factor / pharmacology. Proto-Oncogene Proteins c-raf. Proto-Oncogene Proteins p21(ras) / metabolism. Proto-Oncogene Proteins pp60(c-src) / metabolism. Recombinant Proteins. Signal Transduction. Spodoptera

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  • (PMID = 7543194.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA43803; United States / NICHD NIH HHS / HD / HD24926
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-fos; 0 / Proto-Oncogene Proteins c-jun; 0 / Recombinant Proteins; EC 2.7.10.2 / Proto-Oncogene Proteins pp60(c-src); EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
  • [Gene-symbol] ERK1; c-fos; c-jun; c-raf
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6. Agarwal K, Agarwal S: Helicobacter pylori vaccine: from past to future. Mayo Clin Proc; 2008 Feb;83(2):169-75
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  • [Title] Helicobacter pylori vaccine: from past to future.
  • Helicobacter pylori infection is highly prevalent worldwide and is an important cause of gastritis, peptic ulcer disease, gastric mucosa-associated lymphoid tissue lymphoma (MALToma), and gastric adenocarcinoma.
  • Infection is usually acquired during childhood and tends to persist unless treated.
  • Because eradication requires treatment with multidrug regimens, prevention of initial infection by a suitable vaccine is attractive.
  • Although immunization with H pylori protein subunits has been encouraging in animals, similar vaccine trials in humans have shown adjuvant-related adverse effects and only moderate effectiveness.
  • Newer immunization approaches (use of DNA, live vectors, bacterial ghosts, and microspheres) are being developed.
  • Several questions about when and whom to vaccinate will need to be appropriately answered, and a cost-effective vaccine production and delivery strategy will have to be useful for developing countries.
  • For this review, we searched MEDLINE using the Medical Subject Heading (MeSH) terms Helicobacter pylori and vaccines for articles in English from 1990 to 2007.
  • [MeSH-major] Bacterial Vaccines. Helicobacter Infections / prevention & control. Helicobacter pylori / immunology
  • [MeSH-minor] Humans

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  • (PMID = 18241627.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Vaccines
  • [Number-of-references] 90
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7. Darbari BS, Tiwari HL, Agarwal S: Pattern of cholera in Raipur: a twelve year appraisal. J Indian Assoc Commun Dis; 1982 Sep-Dec;5(3-4):83-7
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  • [Title] Pattern of cholera in Raipur: a twelve year appraisal.
  • Outbreaks of cholera were recorded in Raipur in the years 1970, 1975, 1977 and 1979-1981.
  • Change from V. cholerae classical inaba in 1970 to V. el tor ogawa in 1974 was also observed.
  • The el tor strain is persisting in this area since then.
  • In 1977, antigenic shift to V. el tor inaba was recorded but it again reverted to el tor ogawa which was responsible for outbreaks in 1979-1981.
  • V. cholerae was isolated in most of the months in the years 1975, 1977 and 1980.
  • Almost equal prevalence rates were seen in both sexes as well as in paediatric and adult groups.
  • NAG vibrio were also inoculated.
  • These data suggest endemicity of choloera in Raipur.
  • [MeSH-major] Disease
  • [MeSH-minor] Age Factors. India. Sex Factors

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  • (PMID = 12264640.001).
  • [ISSN] 0254-3575
  • [Journal-full-title] Journal of Indian Association for Communicable Diseases
  • [ISO-abbreviation] J Indian Assoc Commun Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] CPFH/ 12862cr982; POP/ 00116102
  • [Keywords] PIP ; Diseases (major topic) / Research Report (major topic) / Age Factors / India / Sex Factors
  • [General-notes] PIP/ TJ: JOURNAL OF INDIAN ASSOCIATION FOR COMMUNICABLE DISEASES
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8. Agarwal S, Fleisher JE: Reaching Those Most in Need - A Call to Action for Advanced Parkinson's Disease. Eur Neurol Rev; 2016;11(1):20-21
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  • [Title] Reaching Those Most in Need - A Call to Action for Advanced Parkinson's Disease.
  • Much of the clinical and research attention for Parkinson's Disease (PD) has focused on mild to moderate stages.
  • As the disease advances, it can become difficult for patients to attend clinical visits.
  • These patients are often lost to follow-up, and consequently, vanish from the pool of potential research subjects who could inform our management of this understudied population.
  • We aim to increase awareness about this population and potential interventions to improve continuity of care and foster research in advanced PD.

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  • (PMID = 27708720.001).
  • [ISSN] 1758-3837
  • [Journal-full-title] European neurological review
  • [ISO-abbreviation] Eur Neurol Rev
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / L30 NS084235; United States / United States NINDS / /
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Parkinson's Disease / health services research / models of care / unmet needs
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9. Rokadia HK, Agarwal S: Serum heavy metals and obstructive lung disease: results from the National Health and Nutrition Examination Survey. Chest; 2013 Feb 01;143(2):388-397
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  • [Title] Serum heavy metals and obstructive lung disease: results from the National Health and Nutrition Examination Survey.
  • BACKGROUND: Exposure to hazardous heavy metals such as cadmium and lead has been associated with several chronic diseases.
  • Heavy metal exposure may contribute to increased oxidative stress and inflammation in the lungs, resulting in tissue destruction manifesting clinically as obstructive lung disease (OLD).
  • We aimed to evaluate the association between serum cadmium and lead concentration and OLD.
  • METHODS: Pooled cross-sectional data from the National Health and Nutrition Examination Survey 2007-2010 were used.
  • OLD was defined as an FEV 1 /FVC ratio , 0.7 by spirometry.
  • Active smokers were defined as self-reported current smokers or those with measured serum cotinine 10 ng/mL.
  • Serum cadmium and lead levels were measured using mass spectrometry.
  • RESULTS: The prevalence of OLD was 12.4% (95% CI, 10.2%-13.6%).
  • The mean (SE) cadmium levels in the OLD group were significantly higher in comparison with normal control subjects (0.51 [1.04] vs 0.33 [1.02], P , .001).
  • Similarly, mean (SE) serum lead concentration was significantly higher in the OLD group compared with the control population (1.73 [1.02] vs 1.18 [1.0], P , .001).
  • The association between OLD and smoking was significantly attenuated after adjusting for serum cadmium concentration.
  • In addition, we demonstrated a progressive increase in serum cadmium concentrations with worsening FEV 1 % predicted values among smokers in our study population.
  • CONCLUSION: In a large representative sample of the US population, we demonstrated a significant association between OLD and serum cadmium and lead concentrations.
  • Cadmium appeared to partially mediate the association between smoking and OLD.
  • A dose-response effect between increasing cadmium concentration and progressively worsening lung function was observed in smokers.
  • [MeSH-major] Cadmium / blood. Lead / blood. Lung Diseases, Obstructive / physiopathology. Nutrition Surveys. Smoking / adverse effects
  • [MeSH-minor] Adult. Biomarkers / blood. Case-Control Studies. Cross-Sectional Studies. Female. Forced Expiratory Volume / physiology. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Severity of Illness Index. United States. Vital Capacity / physiology

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  • (PMID = 22911427.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 00BH33GNGH / Cadmium; 2P299V784P / Lead
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10. Agarwal S, Swami BL: Road traffic noise, annoyance and community health survey - a case study for an Indian city. Noise Health; 2011 Jul-Aug;13(53):272-6
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  • [Title] Road traffic noise, annoyance and community health survey - a case study for an Indian city.
  • The present study is aimed to investigate the impact of noise pollution on residents/community residing near roadside.
  • The degree of annoyance was assessed by means of a questionnaire.
  • It was found that among all noise-generating sources, road traffic was the major source of noise followed by factory/machines.
  • A health survey reported about 52% of population was suffering by frequent irritation.
  • 46% respondent felt hypertension, and 48.6% observed loss of sleep due to noise pollution.
  • Common noise descriptors were also recorded at all the selected sites.
  • It was found that the Leq values were higher (range 73-86) compared to the permissible values (65 dBA) prescribed by the Central Pollution Control Board, New Delhi.
  • Further, regression equations were developed between various noise indices and percentage of population highly annoyed, and a strong correlation was also observed.
  • [MeSH-major] Environmental Exposure / adverse effects. Health Status. Noise, Transportation / adverse effects
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Health Status Indicators. Health Surveys. Humans. Hypertension / epidemiology. Hypertension / etiology. India / epidemiology. Male. Middle Aged. Regression Analysis. Sleep Initiation and Maintenance Disorders / epidemiology. Sleep Initiation and Maintenance Disorders / etiology. Surveys and Questionnaires. Young Adult

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  • (PMID = 21768730.001).
  • [ISSN] 1463-1741
  • [Journal-full-title] Noise & health
  • [ISO-abbreviation] Noise Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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