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1. Schweitzer JB, Holcomb HH: Drugs under investigation for attention-deficit hyperactivity disorder. Curr Opin Investig Drugs; 2002 Aug;3(8):1207-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Animals. Antidepressive Agents / therapeutic use. Atomoxetine Hydrochloride. Benzhydryl Compounds / therapeutic use. Central Nervous System Stimulants / therapeutic use. Clinical Trials as Topic. Cyclobutanes / therapeutic use. Histamine Agonists / therapeutic use. Humans. Indans / therapeutic use. Nootropic Agents / therapeutic use. Piperidines / therapeutic use. Propylamines / therapeutic use

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  • (PMID = 12211416.001).
  • [ISSN] 1472-4472
  • [Journal-full-title] Current opinion in investigational drugs (London, England : 2000)
  • [ISO-abbreviation] Curr Opin Investig Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antidepressive Agents; 0 / Benzhydryl Compounds; 0 / Central Nervous System Stimulants; 0 / Cyclobutanes; 0 / Histamine Agonists; 0 / Indans; 0 / Nootropic Agents; 0 / Piperidines; 0 / Propylamines; 57WVB6I2W0 / Atomoxetine Hydrochloride; 8SSC91326P / donepezil; R3UK8X3U3D / modafinil; WV5EC51866 / sibutramine
  • [Number-of-references] 51
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2. STRUB IH, TALSO PJ, VALDEZ FC: Gastric response to frozen orange juice and betazole hydrochloride (histalog). J Am Med Assoc; 1957 Apr 27;163(17):1602-3
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  • [Title] Gastric response to frozen orange juice and betazole hydrochloride (histalog).
  • [MeSH-minor] Histamine / analogs & derivatives. Humans

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  • (PMID = 13415928.001).
  • [ISSN] 0002-9955
  • [Journal-full-title] Journal of the American Medical Association
  • [ISO-abbreviation] J Am Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 1C065P542O / Betazole; 820484N8I3 / Histamine
  • [Other-IDs] CLML/ 5732:13847
  • [Keywords] NLM ; CITRUS FRUITS (major topic) / GASTRIC JUICE (major topic) / HISTAMINE/related compounds (major topic) / PEPTIC ULCER/physiology (major topic)
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3. Enea NA, Hollis TM, Kern JA, Gardner TW: Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes. Arch Ophthalmol; 1989 Feb;107(2):270-4
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  • [Title] Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes.
  • To test the hypothesis that histamine receptors mediate increased blood-retinal barrier permeability in experimental diabetes, 51 rats were made diabetic by streptozocin injection (65 mg/kg; jugular vein) and were held for four weeks.
  • The seven animal groups were as follows: untreated controls; untreated diabetic rats; diabetic rats receiving diphenhydramine hydrochloride (Benadryl); diabetic rats receiving cimetidine hydrochloride (Tagamet); diabetic rats receiving diphenhydramine and cimetidine; diabetic rats receiving purified pork insulin (Iletin II); and diabetic rats receiving insulin and diphenhydramine.
  • These data indicate that retinal histamine H1-receptor activation may be partially responsible for initial blood-retinal barrier leakage of macromolecules into the vitreous and that this abnormal leakage can be prevented both by diphenhydramine and by insulin.
  • Histamine H1 receptors may play an important role in mediating increased blood-retinal barrier permeability in experimental diabetes.
  • [MeSH-major] Blood-Retinal Barrier. Diabetes Mellitus, Experimental / physiopathology. Receptors, Histamine H1 / physiology

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  • (PMID = 2521787.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Fluoresceins; 0 / Receptors, Histamine H1; 0 / Serum Albumin, Bovine; 0 / Thiocyanates; 5W494URQ81 / Streptozocin; I223NX31W9 / Fluorescein-5-isothiocyanate
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4. NEW and nonofficial remedies: methaphenilene hydrochloride. J Am Med Assoc; 1951 Oct 27;147(9):862
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  • [Title] NEW and nonofficial remedies: methaphenilene hydrochloride.
  • [MeSH-major] Anti-Allergic Agents. Histamine H1 Antagonists. Methapyrilene

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  • (PMID = 14873577.001).
  • [ISSN] 0002-9955
  • [Journal-full-title] Journal of the American Medical Association
  • [ISO-abbreviation] J Am Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; A01LX40298 / Methapyrilene; Q1MP2MRW1E / methaphenilene
  • [Other-IDs] CLML/ 5221:3689:29
  • [Keywords] NLM ; ANTIHISTAMINICS (major topic)
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5. Tsunemi Y, Saeki H, Tamaki K, Sato S, Nakamura K: Cetirizine hydrochloride suppresses the CCL17 production of epidermal keratinocytes and dermal fibroblasts. Int J Dermatol; 2012 Aug;51(8):1003-5
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  • [Title] Cetirizine hydrochloride suppresses the CCL17 production of epidermal keratinocytes and dermal fibroblasts.
  • [MeSH-major] Cetirizine / pharmacology. Chemokine CCL17 / antagonists & inhibitors. Epidermis / drug effects. Fibroblasts / drug effects. Histamine H1 Antagonists, Non-Sedating / pharmacology. Keratinocytes / drug effects

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  • (PMID = 22788822.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCL17 protein, human; 0 / Chemokine CCL17; 0 / Histamine H1 Antagonists, Non-Sedating; YO7261ME24 / Cetirizine
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6. Hatakeyama A, Fujii M, Hatakeyama R, Fukuoka Y, Satoh-Nakagawa T, Sasaki H: Azelastine hydrochloride on behavioral and psychological symptoms and activities of daily living in dementia patients. Geriatr Gerontol Int; 2008 Mar;8(1):59-61
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  • [Title] Azelastine hydrochloride on behavioral and psychological symptoms and activities of daily living in dementia patients.
  • [MeSH-major] Dementia / drug therapy. Histamine H1 Antagonists, Non-Sedating / therapeutic use. Phthalazines / therapeutic use

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  • (PMID = 18713191.001).
  • [ISSN] 1447-0594
  • [Journal-full-title] Geriatrics & gerontology international
  • [ISO-abbreviation] Geriatr Gerontol Int
  • [Language] eng
  • [Publication-type] Letter; Randomized Controlled Trial
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists, Non-Sedating; 0 / Phthalazines; ZQI909440X / azelastine
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7. Han D, Chen L, Cheng L, Liu S, Fu Z, Zhang W, Wang C, Xi L, Zhang L, Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G): A multicenter randomized double-blind 2-week comparison study of azelastine nasal spray 0.1% versus levocabastine nasal spray 0.05% in patients with moderate-to-severe allergic rhinitis. ORL J Otorhinolaryngol Relat Spec; 2011;73(5):260-5
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  • SUBJECTS AND METHODS: In a multicenter, randomized, double-blind, parallel-group trial, 244 patients with moderate-to-severe allergic rhinitis were randomized to receive either azelastine hydrochloride nasal spray (ANS) 0.1% or levocabastine hydrochloride nasal spray (LNS) 0.05% for 14 consecutive days.
  • [MeSH-major] Histamine H1 Antagonists, Non-Sedating / administration & dosage. Phthalazines / administration & dosage. Piperidines / administration & dosage. Rhinitis, Allergic, Seasonal / drug therapy

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21832863.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Histamine H1 Antagonists, Non-Sedating; 0 / Nasal Sprays; 0 / Phthalazines; 0 / Piperidines; H68BP06S81 / levocabastine; ZQI909440X / azelastine
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8. Hasegawa J, Tomono Y, Tanaka M, Fujita T, Sugiyama K, Hirose N: Pharmacokinetic and biopharmaceutical studies on azelastine hydrochloride in beagle dogs by quantitative selected-ion monitoring. Arzneimittelforschung; 1981;31(8):1215-20
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  • [Title] Pharmacokinetic and biopharmaceutical studies on azelastine hydrochloride in beagle dogs by quantitative selected-ion monitoring.
  • A quantitative selected-ion monitoring method for the determination of plasma concentrations of the new potent antiallergic agent, 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone hydrochloride (azelastine hydrochloride, A 5610), using N-methyl deuterium labelled azelastine as the internal standard, has been developed.
  • [MeSH-major] Histamine H1 Antagonists / metabolism. Phthalazines / metabolism. Pyridazines / metabolism

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  • (PMID = 6117292.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Phthalazines; 0 / Pyridazines; ZQI909440X / azelastine
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9. MACLAREN WR, BRUFF WC, EISENBERG BC, WEINER H, MARTIN WH: A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms. Ann Allergy; 1955 May-Jun;13(3):307-12
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  • [Title] A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms.
  • [MeSH-major] Anti-Allergic Agents. Diphenhydramine. Histamine H1 Antagonists / therapeutic use. Hypersensitivity / therapy. Pyridines. Tripelennamine / therapeutic use

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  • (PMID = 14377226.001).
  • [ISSN] 0003-4738
  • [Journal-full-title] Annals of allergy
  • [ISO-abbreviation] Ann Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Pyridines; 3C5ORO99TY / Tripelennamine; 8GTS82S83M / Diphenhydramine; 982A7M02H5 / carbinoxamine; T032BI7727 / bromodiphenhydramine
  • [Other-IDs] CLML/ 5528:28255:26:48:572
  • [Keywords] NLM ; ALLERGY/therapy (major topic) / ANTIHISTAMINICS/therapeutic use (major topic) / TRIPELENNAMINE/therapeutic use (major topic)
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10. Inoue Y: [Experimental study on an antihypersensitivity agent, 4-(p-chlorobenzyl)-2-[N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine)]. Nihon Ika Daigaku Zasshi; 1983 Jun;50(3):371-8
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  • [Title] [Experimental study on an antihypersensitivity agent, 4-(p-chlorobenzyl)-2-[N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine)].
  • [MeSH-major] Histamine H1 Antagonists / therapeutic use. Phthalazines / therapeutic use. Pyridazines / therapeutic use

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  • (PMID = 6136525.001).
  • [ISSN] 0048-0444
  • [Journal-full-title] Nihon Ika Daigaku zasshi
  • [ISO-abbreviation] Nippon Ika Daigaku Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Phthalazines; 0 / Pyridazines; ZQI909440X / azelastine
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11. Gielsdorf W, Hausleiter HJ, Arnemann W, Lichtenberger A, Achtert G: Determination of revenast hydrochloride in human plasma by gas chromatography with nitrogen-selective detection. J Chromatogr; 1987 Aug 7;419:351-6
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  • [Title] Determination of revenast hydrochloride in human plasma by gas chromatography with nitrogen-selective detection.
  • [MeSH-major] Histamine Antagonists / blood. Pyrazoles / blood. Pyrazolones. Pyridines / blood

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  • (PMID = 3667791.001).
  • [Journal-full-title] Journal of chromatography
  • [ISO-abbreviation] J. Chromatogr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Histamine Antagonists; 0 / Pyrazoles; 0 / Pyrazolones; 0 / Pyridines; 24G45TQO8A / revenast
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12. Hey JA, del Prado M, Sherwood J, Kreutner W, Egan RW: Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects. Arzneimittelforschung; 1996 Feb;46(2):153-8
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  • Terfenadine and astemizole belong to the second generation histamine H1 antagonists and are widely prescribed for allergic and upper respiratory diseases.
  • Recent clinical evidence that the second generation histamine H1 antagonists terfenadine and astemizole have the potential for inducing life threatening ventricular arrhythmias has raised questions as to whether other drugs in this class have similar cardiotoxic potential.
  • To determine the relative cardiotoxic potential of the antihistamines, the lowest dose producing significant prolongation of the QTc interval was compared with the dose required to inhibit by 50% the peripheral bronchospasm elicited by histamine at 10 micrograms/kg i.v. (antihistamine ED50).
  • The second generation antihistamines studied were astemizole (CAS 68844-77-9), carebastine (CAS 90729-42-3), cetirizine hydrochloride (CAS 83881-52-1), ebastine (CAS 90729-43-4), norastemizole (CAS 75970-99-9), terfenadine (CAS 50679-08-8) and terfenadine carboxylate (CAS 83799-24-0).
  • [MeSH-major] Benzimidazoles / adverse effects. Electrocardiography / drug effects. Heart Diseases / chemically induced. Histamine H1 Antagonists / adverse effects. Piperidines / adverse effects

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  • [CommentIn] Arzneimittelforschung. 1996 Aug;46(8):832-3 [9125289.001]
  • (PMID = 8720304.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Benzimidazoles; 0 / Histamine H1 Antagonists; 0 / Piperidines; W5DCO14M05 / tecastemizole
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13. Kudrin AN, Chernysheva LF, Gal'bershtam MA, Yur'ev YK: Antihistamine activity of N,N-dimethyl-N'-phenyl-N'-(selenyl-2)-ethylenediamine hydrochloride. Fed Proc Transl Suppl; 1965 Nov-Dec;24(6):1119-20
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  • [Title] Antihistamine activity of N,N-dimethyl-N'-phenyl-N'-(selenyl-2)-ethylenediamine hydrochloride.
  • [MeSH-major] Histamine H1 Antagonists / pharmacology
  • [MeSH-minor] Acetylcholine / pharmacology. Animals. Capillary Permeability / drug effects. Epinephrine / pharmacology. Guinea Pigs. Histamine / pharmacology. Intestine, Small / drug effects. Pilocarpine / pharmacology. Pituitary Hormones, Posterior / pharmacology. Selenium

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  • (PMID = 4378955.001).
  • [ISSN] 0430-2494
  • [Journal-full-title] Federation proceedings. Translation supplement; selected translations from medical-related science
  • [ISO-abbreviation] Fed Proc Transl Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Pituitary Hormones, Posterior; 01MI4Q9DI3 / Pilocarpine; 820484N8I3 / Histamine; H6241UJ22B / Selenium; N9YNS0M02X / Acetylcholine; YKH834O4BH / Epinephrine
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14. GAIDAMAK D, KAMINSKY A: [Diphenylpyraline hydrochloride. Therapeutic trial in cutaneous medicine]. Dia Med; 1961 Mar 16;33:276
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  • [Title] [Diphenylpyraline hydrochloride. Therapeutic trial in cutaneous medicine].
  • [MeSH-major] Anti-Allergic Agents. Dermatology / therapy. Histamine H1 Antagonists / therapy. Medicine. Piperidines

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  • (PMID = 13702932.001).
  • [ISSN] 0012-1762
  • [Journal-full-title] El Día médico
  • [ISO-abbreviation] Dia Med
  • [Language] spa
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Piperidines; 33361OE3AV / diphenylpyraline
  • [Keywords] NLM ; ANTIHISTAMINICS/therapy (major topic) / DERMATOLOGY/therapy (major topic)
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15. Nielsen HJ, Nielsen H, Jensen S, Moesgaard F: Ranitidine improves postoperative monocyte and neutrophil function. Arch Surg; 1994 Mar;129(3):309-15
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  • BACKGROUND: The histamine H2-receptor antagonist ranitidine hydrochloride has been shown to improve trauma-, blood transfusion-, and sepsis-induced immunosuppression.
  • METHODS: Twenty-four patients undergoing major elective abdominal surgery were randomized to receive adjuvant treatment with ranitidine hydrochloride (100 mg) administered twice a day intravenously from skin incision for 4 days, followed by oral ranitidine hydrochloride (150 mg) administered twice a day for 5 days (n = 11), or no adjuvant treatment (n = 13).

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  • (PMID = 8129609.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 884KT10YB7 / Ranitidine
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16. FRIEDLAENDER AS, FRIEDLAENDER S: Antihistaminic, antianaphylactic and antiallergic activity of N-(a-pyridyl)-N-(a-thenyl)-N, N -dimethylethylenediamine hydrochloride. Am J Med Sci; 1948 May;215(5):530-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antihistaminic, antianaphylactic and antiallergic activity of N-(a-pyridyl)-N-(a-thenyl)-N, N -dimethylethylenediamine hydrochloride.
  • [MeSH-major] Anti-Allergic Agents. Ethylenediamines. Histamine. Histamine Antagonists

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  • (PMID = 18101772.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Ethylenediamines; 0 / Histamine Antagonists; 110-70-3 / dimethylethylenediamine; 820484N8I3 / Histamine
  • [Other-IDs] CLML/ 4916:183l
  • [Keywords] NLM ; HISTAMINE/antagonists (major topic)
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17. Brabant C, Charlier Y, Tirelli E: The histamine H₃-receptor inverse agonist pitolisant improves fear memory in mice. Behav Brain Res; 2013 Apr 15;243:199-204
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  • [Title] The histamine H₃-receptor inverse agonist pitolisant improves fear memory in mice.
  • Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive disorders.
  • Pitolisant (BF2.649, 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride) was the first H3R inverse agonist that has been tested in human trials and is well tolerated.
  • [MeSH-major] Behavior, Animal / drug effects. Dizocilpine Maleate / pharmacology. Excitatory Amino Acid Antagonists / pharmacology. Histamine Agonists / pharmacology. Memory / drug effects. Piperidines / pharmacology

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23327739.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Antagonists; 0 / Histamine Agonists; 0 / Piperidines; 4BC83L4PIY / 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine; 6384-92-5 / N-Methylaspartate; 6LR8C1B66Q / Dizocilpine Maleate
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18. Leynadier F, Murrieta M, Dry J, Colin JN, Gillotin C, Steru D: Effects of acrivastine and terfenadine on skin reactivity to histamine. Ann Allergy; 1994 Jun;72(6):520-4
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  • [Title] Effects of acrivastine and terfenadine on skin reactivity to histamine.
  • The response to the histamine hydrochloride prick skin test was studied in 24 healthy volunteers who received, in random order and at least four days apart, acrivastine (8 mg), terfenadine (120 mg), and placebo.
  • The response to histamine was decreased markedly in the two active treatment groups.
  • [MeSH-major] Histamine / pharmacology. Histamine H1 Antagonists / pharmacology. Skin / drug effects. Terfenadine / pharmacology. Triprolidine / analogs & derivatives

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  • (PMID = 7911286.001).
  • [ISSN] 0003-4738
  • [Journal-full-title] Annals of allergy
  • [ISO-abbreviation] Ann Allergy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 2L8T9S52QM / Triprolidine; 7BA5G9Y06Q / Terfenadine; 820484N8I3 / Histamine; A20F9XAI7W / acrivastine
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19. Hashimoto T, Ishii N, Hamada T, Dainichi T, Karashima T, Nakama T, Yasumoto S: Effects of olopatadine hydrochloride, a histamine h(1) receptor antagonist, on histamine-induced skin responses. Dermatol Res Pract; 2010;2010
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  • [Title] Effects of olopatadine hydrochloride, a histamine h(1) receptor antagonist, on histamine-induced skin responses.
  • Effects of olopatadine hydrochloride, a histamine H(1) receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate.
  • Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration.
  • These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.

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  • (PMID = 20886023.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2945667
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20. Jamrógiewicz M, Wielgomas B: Detection of some volatile degradation products released during photoexposition of ranitidine in a solid state. J Pharm Biomed Anal; 2013 Mar 25;76:177-82
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  • The aim of this work was to study the emission of volatile degradation products generated during photoexposition of ranitidine hydrochloride in a solid state.
  • [MeSH-major] Gas Chromatography-Mass Spectrometry / methods. Histamine H2 Antagonists / chemistry. Photolysis. Ranitidine / chemistry

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
  • (PMID = 23333686.001).
  • [ISSN] 1873-264X
  • [Journal-full-title] Journal of pharmaceutical and biomedical analysis
  • [ISO-abbreviation] J Pharm Biomed Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Histamine H2 Antagonists; 884KT10YB7 / Ranitidine
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21. Pounder RE: New developments in Helicobacter pylori eradication therapy. Scand J Gastroenterol Suppl; 1997;223:43-5
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  • Ranitidine bismuth citrate is a co-precipitate of ranitidine hydrochloride and bismuth citrate, producing a high rate of H. pylori eradication when combined with clarithromycin.
  • [MeSH-minor] Anti-Bacterial Agents / administration & dosage. Bismuth / therapeutic use. Drug Therapy, Combination. Duodenal Ulcer / drug therapy. Duodenal Ulcer / microbiology. Histamine H2 Antagonists / administration & dosage. Humans. Ranitidine / analogs & derivatives

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  • (PMID = 9200305.001).
  • [ISSN] 0085-5928
  • [Journal-full-title] Scandinavian journal of gastroenterology. Supplement
  • [ISO-abbreviation] Scand. J. Gastroenterol. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] NORWAY
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Histamine H2 Antagonists; 7AJ51I17KG / ranitidine bismuth citrate; 884KT10YB7 / Ranitidine; U015TT5I8H / Bismuth
  • [Number-of-references] 27
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22. Ghebaur A, Garea SA, Iovu H: New polymer-halloysite hybrid materials--potential controlled drug release system. Int J Pharm; 2012 Oct 15;436(1-2):568-73
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  • New hybrid materials based on a natural host (halloysite), biodegradable polymer (poly(vinyl alcohol)) and diphenhydramine hydrochloride as drug were synthesized and tested as a potential controlled drug delivery system.
  • [MeSH-minor] Histamine H1 Antagonists / chemistry. Hydrogen-Ion Concentration. Microscopy, Electron, Scanning. Photoelectron Spectroscopy. Spectroscopy, Fourier Transform Infrared. Thermogravimetry

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  • [Copyright] Copyright © 2012. Published by Elsevier B.V.
  • (PMID = 22820481.001).
  • [ISSN] 1873-3476
  • [Journal-full-title] International journal of pharmaceutics
  • [ISO-abbreviation] Int J Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Aluminum Silicates; 0 / Delayed-Action Preparations; 0 / Histamine H1 Antagonists; 1302-87-0 / clay; 8GTS82S83M / Diphenhydramine; 9002-89-5 / Polyvinyl Alcohol
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23. FRIEDLAENDER S, FEINBERG SM: Histamine antagonists; the effect of oral and local use of beta-dimethylamincethyl benzhydryl ether hydrochloride on the whealing due to histamine, antigen-antibody reactions, and other whealing mechanisms; therapeutic results in allergic manifestations. J Allergy; 1946 May;17:129-41
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  • [Title] Histamine antagonists; the effect of oral and local use of beta-dimethylamincethyl benzhydryl ether hydrochloride on the whealing due to histamine, antigen-antibody reactions, and other whealing mechanisms; therapeutic results in allergic manifestations.
  • [MeSH-major] Anaphylaxis / therapy. Antigen-Antibody Reactions. Diphenhydramine / therapy. Ether. Histamine. Histamine Antagonists. Hypersensitivity / therapy. Immune System Diseases. Urticaria / therapy

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  • (PMID = 21027120.001).
  • [ISSN] 0021-8707
  • [Journal-full-title] The Journal of allergy
  • [ISO-abbreviation] J Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Histamine Antagonists; 0F5N573A2Y / Ether; 820484N8I3 / Histamine; 8GTS82S83M / Diphenhydramine
  • [Other-IDs] CLML/ 4610:1185k
  • [Keywords] NLM ; ANAPHYLAXIS AND ALLERGY/therapy (major topic) / BENADRYL/therapy (major topic) / HISTAMINE/antagonists (major topic) / URTICARIA/therapy (major topic)
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24. Guo Y, Han S, Cao J, Zhang T, He L: Histamine H1 receptor cell membrane chromatography online high-performance liquid chromatography with mass spectrometry method reveals houttuyfonate as an activator of the histamine H1 receptor. J Sep Sci; 2014 Nov;37(21):3188-94
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  • [Title] Histamine H1 receptor cell membrane chromatography online high-performance liquid chromatography with mass spectrometry method reveals houttuyfonate as an activator of the histamine H1 receptor.
  • Histamine is responsible for many of the acute symptoms of allergic diseases.
  • Many of the allergic and inflammatory actions of histamine are mediated by the histamine H1 receptor.
  • In the present study, we established a two-dimensional histamine H1 receptor/cell membrane chromatography with online high-performance liquid chromatography and mass spectrometry method for screening potential histamine-activating components in a traditional Chinese medicine injection.
  • The specification of the method was validated by screening, separating, and identifying a mixed standard solution of diphenhydramine hydrochloride, gefitinib, tamsulosin, and nitrendipine.
  • The Yujin injection, an example of traditional Chinese medicine injection, was screened and potential allergic components acting on the histamine H1 receptor were identified.
  • This suggests that houttuyfonate is an activator of the histamine H1 receptor.
  • This indicates that individuals with an overexpression of the histamine H1 receptor should be aware of possible allergic reactions when receiving the Yujin injection.
  • [MeSH-major] Alkanes / analysis. Chromatography, High Pressure Liquid / methods. Drugs, Chinese Herbal / analysis. Histamine Agonists / analysis. Mass Spectrometry / methods. Sulfites / analysis
  • [MeSH-minor] Automation. Cell Line. Humans. Receptors, Histamine H1 / analysis. Receptors, Histamine H1 / metabolism

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  • [Copyright] © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 25137637.001).
  • [ISSN] 1615-9314
  • [Journal-full-title] Journal of separation science
  • [ISO-abbreviation] J Sep Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Alkanes; 0 / Drugs, Chinese Herbal; 0 / Histamine Agonists; 0 / Receptors, Histamine H1; 0 / Sulfites; 0 / sodium houttuyfonate
  • [Keywords] NOTNLM ; Adverse drug reactions / Cell membrane chromatography / Cytosolic free Ca2+ / Histamine H1 receptor / Houttuyfonate
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25. Zakirov UB, Aliev KhU, Kamilov IK: [The pharmacologic properties of methylapogalanthamine hydrochloride]. Farmakol Toksikol; 1972 Nov-Dec;35(6):708-11
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  • [Title] [The pharmacologic properties of methylapogalanthamine hydrochloride].
  • [MeSH-minor] Animals. Blood Coagulation / drug effects. Brain / drug effects. Conditioning (Psychology) / drug effects. Dogs. Epinephrine / antagonists & inhibitors. Ganglia, Autonomic / drug effects. Gastrointestinal Motility / drug effects. Heart / drug effects. Histamine H1 Antagonists / pharmacology. Rabbits. Rats. Respiration / drug effects

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  • (PMID = 4405618.001).
  • [ISSN] 0014-8318
  • [Journal-full-title] Farmakologiia i toksikologiia
  • [ISO-abbreviation] Farmakol Toksikol
  • [Language] rus
  • [Publication-type] Journal Article
  • [Publication-country] USSR
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Histamine H1 Antagonists; 0D3Q044KCA / Galantamine; YKH834O4BH / Epinephrine
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26. McGill JI: A review of the use of olopatadine in allergic conjunctivitis. Int Ophthalmol; 2004 May;25(3):171-9
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  • Mast cell degranulation is central to all forms of ocular allergic disease and so treatment has concentrated on preventing this process or antagonizing the effects of the primary mediator, histamine.
  • [MeSH-major] Conjunctivitis, Allergic / drug therapy. Dibenzoxepins / therapeutic use. Histamine H1 Antagonists / therapeutic use
  • [MeSH-minor] Humans. Mast Cells / drug effects. Olopatadine Hydrochloride

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  • (PMID = 15847317.001).
  • [ISSN] 0165-5701
  • [Journal-full-title] International ophthalmology
  • [ISO-abbreviation] Int Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 2XG66W44KF / Olopatadine Hydrochloride
  • [Number-of-references] 53
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27. Sugiura K, Hirai S, Suzuki T, Usuda T, Kondo T, Azumi T, Masaki S, Yokoi T, Nitta Y, Kamiya S, Ando K, Mori T, Tomita Y: Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. Nagoya J Med Sci; 2008 Aug;70(3-4):97-106
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  • [Title] Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria.
  • [MeSH-major] Cetirizine / therapeutic use. Histamine H1 Antagonists, Non-Sedating / therapeutic use. Urticaria / drug therapy

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  • (PMID = 18954028.001).
  • [ISSN] 0027-7622
  • [Journal-full-title] Nagoya journal of medical science
  • [ISO-abbreviation] Nagoya J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists, Non-Sedating; YO7261ME24 / Cetirizine
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28. Bedi P, Devi PK, Chaudhury RR: Preliminary report of a trial of a long acting antihistaminic, buclizine hydrochloride in patients with bleeding after insertion of an intrauterine device. Indian J Med Res; 1968 Jun;56(6):884
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preliminary report of a trial of a long acting antihistaminic, buclizine hydrochloride in patients with bleeding after insertion of an intrauterine device.
  • [MeSH-major] Histamine H1 Antagonists / administration & dosage. Intrauterine Devices / adverse effects. Uterine Hemorrhage / drug therapy

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  • (PMID = 4386522.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] INDIA
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 0 / Histamine H1 Antagonists; 0 / Piperazines
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29. Velasco A, Arruza A, Maroto M, Carvajal A, Fernández del Busto E, García del Pozo J: Effect of venlafaxine hydrochloride in different preparations of isolated guinea-pig and rat organ tissues. J Auton Pharmacol; 1999 Apr;19(2):109-13
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  • [Title] Effect of venlafaxine hydrochloride in different preparations of isolated guinea-pig and rat organ tissues.
  • A study was undertaken to know better the effects of venlafaxine hydrochloride on the responses of isolated rat vas deferens to noradrenaline and dopamine, those of isolated rat uterus to serotonin and histamine, and those of isolated guinea-pig ileum to acetylcholine and histamine.
  • Venlafaxine hydrochloride increased the response of rat vas deferens to noradrenaline but not to dopamine.
  • In rat uterus, venlafaxine did not modify the response to histamine but was able to increase it in guinea-pig ileum.
  • [MeSH-minor] Acetylcholine / pharmacology. Adrenergic alpha-Agonists / pharmacology. Animals. Cardiotonic Agents / pharmacology. Dose-Response Relationship, Drug. Drug Interactions. Female. Guinea Pigs. Histamine / pharmacology. Ileum / drug effects. In Vitro Techniques. Male. Rats. Uterus / drug effects. Vas Deferens / drug effects. Venlafaxine Hydrochloride

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  • (PMID = 10466944.001).
  • [ISSN] 0144-1795
  • [Journal-full-title] Journal of autonomic pharmacology
  • [ISO-abbreviation] J Auton Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Adrenergic alpha-Agonists; 0 / Cardiotonic Agents; 0 / Cyclohexanols; 0 / Serotonin Uptake Inhibitors; 7D7RX5A8MO / Venlafaxine Hydrochloride; 820484N8I3 / Histamine; N9YNS0M02X / Acetylcholine; VTD58H1Z2X / Dopamine; X4W3ENH1CV / Norepinephrine
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30. McCaffrey TV, Kern EB: Laryngeal regulation of airway resistance. II. Pulmonary receptor reflexes. Ann Otol Rhinol Laryngol; 1980 Sep-Oct;89(5 Pt 1):462-6
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  • Irritant receptor stimulation with histamine hydrochloride produced tachypnea and a reduction in inspiratory laryngeal resistance.
  • [MeSH-minor] Animals. Capsaicin / pharmacology. Dogs. Histamine / pharmacology. Laryngeal Nerves. Reflex. Respiration

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  • (PMID = 7436254.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 820484N8I3 / Histamine; S07O44R1ZM / Capsaicin
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31. Lee JS, Lee JE, Kim N, Oum BS: Comparison of the conjunctival toxicity of topical ocular antiallergic agents. J Ocul Pharmacol Ther; 2008 Dec;24(6):557-62
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  • PURPOSE: The aim of this study was to investigate the cytotoxic effect of topical ocular allergic agents with H1-receptor antagonism and inhibition of histamine release from mast cells on the cultured conjunctival cells of rabbit in vitro.
  • METHODS: Cell damage by the topical ocular antiallergic agents (azelastine hydrochloride, ketotifen fumarate, and olopatadine hydrochloride) was determined by using the lactate dehydrogenase (LDH) leakage assay with the rate of dilution of 10, 20, and 30%, respectively, for a period of 0 and 30 min and 4, 12, and 24 h, and compared with the balanced salt solution-treated group.
  • [MeSH-minor] Animals. Cells, Cultured. Dibenzoxepins / toxicity. Hydrogen-Ion Concentration. Ketotifen / toxicity. L-Lactate Dehydrogenase / analysis. Microscopy, Electron. Microscopy, Phase-Contrast. Olopatadine Hydrochloride. Phthalazines / toxicity. Rabbits

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  • (PMID = 19049267.001).
  • [ISSN] 1557-7732
  • [Journal-full-title] Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • [ISO-abbreviation] J Ocul Pharmacol Ther
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Dibenzoxepins; 0 / Phthalazines; 2XG66W44KF / Olopatadine Hydrochloride; EC 1.1.1.27 / L-Lactate Dehydrogenase; X49220T18G / Ketotifen; ZQI909440X / azelastine
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32. Watthey JW, Gavin T, Desai M, Finn BM, Rodebaugh RK, Patt SL: Synthesis and biological properties of thiophene ring analogues of mianserin. J Med Chem; 1983 Aug;26(8):1116-22
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  • The antidepressant potential of 2 maleate (CGS 11049A) and 12 fumarate (CGS 15413A) were compared with that of mianserin hydrochloride in a variety of biochemical and pharmacological test systems.
  • [MeSH-minor] Animals. Brain / metabolism. Histamine Release / drug effects. Mice. Prazosin / metabolism

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  • (PMID = 6192241.001).
  • [ISSN] 0022-2623
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Dibenzazepines; 250PJI13LM / Mianserin; XM03YJ541D / Prazosin
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33. Mir GN, Sperow JW, Krebs JB, Eash JR, Rowles GS, Yelnosky J: Mechanism of action studies of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Arzneimittelforschung; 1978;28(8a):1454-61
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  • [Title] Mechanism of action studies of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent.
  • 1-(2,6-Dimethylphenyl)-3-methylamidinourea hydrochloride (WHR-1142A), lidamidine hydrochloride), a novel antidiarrheal agent, inhibited contractile activity in isolated guinea pig ileum stimulated by acetylcholine, histamine, serotonin, dimethylphenylpiperazinium, prostaglandin E2, BaCl2 and KCl.
  • [MeSH-minor] Analgesics. Animals. Autonomic Agents. Diphenoxylate / pharmacology. Dogs. Duodenum / drug effects. Female. Gastrointestinal Motility / drug effects. Guinea Pigs. Histamine H1 Antagonists. Histamine Release / drug effects. Ileum / drug effects. In Vitro Techniques. Male. Muscle Contraction / drug effects. Muscle, Smooth / drug effects. Naloxone / pharmacology. Rabbits

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  • (PMID = 89850.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Amidines; 0 / Analgesics; 0 / Antidiarrheals; 0 / Autonomic Agents; 0 / Histamine H1 Antagonists; 36B82AMQ7N / Naloxone; 73312P173G / Diphenoxylate
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34. Villalón CM, López-Muñoz FJ, Perusquía M, Terrón JA: External carotid effects of 2-(2-aminoethyl)-quinoline (D-1997) in vagosympathectomized dogs. Eur J Pharmacol; 1998 Aug 28;356(1):15-23
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  • However, the effects of D-1997 remained unaltered after blockade of alpha- and beta-adrenoceptors, muscarinic, nicotinic, histamine and dopamine receptors, or inhibition of 5-HT-uptake or cyclo-oxygenase, depletion of biogenic amines or blockade of Ca2+ channels.

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  • (PMID = 9761419.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / 2-(2-aminoethyl)quinoline hydrochloride; 0 / Quinolines; 0 / Serotonin Antagonists; 0 / Serotonin Receptor Agonists; 333DO1RDJY / Serotonin; 451W47IQ8X / Sodium Chloride; 55D94103HL / Methiothepin; 8R78F6L9VO / Sumatriptan
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35. Hamilton SA, Duddle J, Herdman MJ, Trigg CJ, Davies RJ: Comparison of a new antihistaminic and antiallergic compound KW 4679 with terfenadine and placebo on skin and nasal provocation in atopic individuals. Clin Exp Allergy; 1994 Oct;24(10):955-9
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  • Comparison of the effect of the treatments with either 2.5, 5 or 10 mg b.i.d. of KW 4679, 60 mg b.i.d. of terfenadine or placebo was made on the response to histamine and grass pollen skin-prick testing.
  • Compared with placebo all doses of KW 4679 and terfenadine significantly inhibited the skin weal response to histamine and grass pollen (P < 0.001).
  • The inhibitory effect of KW 4679 on both histamine and allergen induced skin weals was significantly greater than that of terfenadine (P = 0.001 and P = 0.049 respectively).
  • [MeSH-minor] Adult. Airway Resistance. Cross-Over Studies. Double-Blind Method. Female. Humans. Male. Nasal Provocation Tests. Olopatadine Hydrochloride. Placebos. Skin Tests. Sleep Stages / drug effects. Sneezing / drug effects. Sneezing / physiology

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  • (PMID = 7842365.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Dibenzoxepins; 0 / Placebos; 2XG66W44KF / Olopatadine Hydrochloride; 7BA5G9Y06Q / Terfenadine
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36. Kletzl H, Giraudon M, Ducray PS, Abt M, Hamilton M, Lum BL: Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: omeprazole and ranitidine. Anticancer Drugs; 2015 Jun;26(5):565-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Antineoplastic Agents / pharmacokinetics. Gastric Acid / chemistry. Histamine H2 Antagonists / pharmacokinetics. Omeprazole / pharmacokinetics. Proton Pump Inhibitors / pharmacokinetics. Quinazolines / pharmacokinetics. Ranitidine / pharmacokinetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cross-Over Studies. Drug Administration Schedule. Drug Interactions. Erlotinib Hydrochloride. Female. Humans. Hydrogen-Ion Concentration. Male. Middle Aged. Young Adult

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  • (PMID = 25643050.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Histamine H2 Antagonists; 0 / Proton Pump Inhibitors; 0 / Quinazolines; 884KT10YB7 / Ranitidine; DA87705X9K / Erlotinib Hydrochloride; KG60484QX9 / Omeprazole
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37. de Fabrizio F: GLC analysis of theophylline, hydroxyethyltheophylline, and diphenylpyraline hydrochloride syrup. J Pharm Sci; 1979 Apr;68(4):521-2
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  • [Title] GLC analysis of theophylline, hydroxyethyltheophylline, and diphenylpyraline hydrochloride syrup.
  • A GLC method for determining theophylline, hydroxyethyltheophylline, and diphenylpyraline hydrochloride is presented.
  • [MeSH-major] Histamine H1 Antagonists / analysis. Piperidines / analysis. Theophylline / analogs & derivatives. Theophylline / analysis

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  • (PMID = 35600.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Drug Combinations; 0 / Histamine H1 Antagonists; 0 / Piperidines; 0 / Solutions; C137DTR5RG / Theophylline
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38. Owen RT: Lurasidone: a new treatment option for schizophrenia. Drugs Today (Barc); 2011 Nov;47(11):807-16
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  • It has negligible affinity for α(1)-adrenoceptors, histamine H(1) receptors or muscarinic acetylcholine M(1) receptors.
  • [MeSH-minor] Clinical Trials as Topic. Drug Interactions. Humans. Lurasidone Hydrochloride

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  • [Copyright] Copyright 2011 Prous Science, S.A.U. or its licensors. All rights reserved.
  • (PMID = 22146224.001).
  • [ISSN] 1699-3993
  • [Journal-full-title] Drugs of today (Barcelona, Spain : 1998)
  • [ISO-abbreviation] Drugs Today
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Isoindoles; 0 / Thiazoles; O0P4I5851I / Lurasidone Hydrochloride
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39. Ohtani H, Kotaki H, Sawada Y, Iga T: Quantitative determination of epinastine in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl; 1996 Aug 30;683(2):281-4
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  • A high-performance liquid chromatographic (HPLC) method for the quantitative determination of epinastine, a non-sedating histamine H1 receptor antagonist, in rat plasma, was developed.
  • Both intra-assay variation and relative error were less than 5% for the plasma containing 50 ng/ml or 1000 ng/ml of epinastine hydrochloride.
  • [MeSH-major] Chromatography, High Pressure Liquid / methods. Dibenzazepines / blood. Histamine H1 Antagonists / blood. Imidazoles / blood

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  • (PMID = 8891928.001).
  • [ISSN] 1572-6495
  • [Journal-full-title] Journal of chromatography. B, Biomedical applications
  • [ISO-abbreviation] J. Chromatogr. B, Biomed. Appl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Dibenzazepines; 0 / Histamine H1 Antagonists; 0 / Imidazoles; Q13WX941EF / epinastine
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40. STRAUS B, EISENBERG J, GENNIS J: Hypnotic effects of an antihistamine; methapyrilene hydrochloride. Ann Intern Med; 1955 Mar;42(3):574-82
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  • [Title] Hypnotic effects of an antihistamine; methapyrilene hydrochloride.
  • [MeSH-major] Anti-Allergic Agents. Barbiturates / pharmacology. Histamine H1 Antagonists / pharmacology. Hypnotics and Sedatives. Methapyrilene. Placebos

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  • (PMID = 14350477.001).
  • [ISSN] 0003-4819
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Barbiturates; 0 / Histamine H1 Antagonists; 0 / Hypnotics and Sedatives; 0 / Placebos; A01LX40298 / Methapyrilene
  • [Other-IDs] CLML/ 5528:1122:48:70:287:443
  • [Keywords] NLM ; ANTIHISTAMINICS/effects (major topic) / BARBITURATES/effects (major topic) / HYPNOTICS AND SEDATIVES (major topic) / PLACEBOS (major topic)
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41. Mizuguchi H, Hatano M, Matsushita C, Umehara H, Kuroda W, Kitamura Y, Takeda N, Fukui H: Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats. J Pharmacol Sci; 2008 Dec;108(4):480-6
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  • [Title] Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats.
  • To determine the reason for the effectiveness of prophylactic treatment with antihistamines, the effects of repeated pre-treatment with antihistamines before provocation with toluene 2,4-diisocyanate (TDI) on their nasal allergy-like behavior and up-regulations of histamine H(1) receptors (H1R) and interleukin (IL)-4 mRNAs in their nasal mucosa were examined.
  • [MeSH-major] Histamine H1 Antagonists / pharmacology. Interleukin-4 / metabolism. Receptors, Histamine H1 / drug effects. Up-Regulation / drug effects
  • [MeSH-minor] Animals. Chlorpheniramine / administration & dosage. Chlorpheniramine / pharmacology. Dibenzazepines / administration & dosage. Dibenzazepines / pharmacology. Dibenzoxepins / administration & dosage. Dibenzoxepins / pharmacology. Drug Administration Schedule. Imidazoles / administration & dosage. Imidazoles / pharmacology. Male. Nasal Mucosa / drug effects. Nasal Mucosa / metabolism. Olopatadine Hydrochloride. RNA, Messenger / drug effects. RNA, Messenger / metabolism. Rats. Rats, Inbred BN. Sneezing / drug effects. Time Factors. Toluene 2,4-Diisocyanate. Transcription, Genetic

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  • [ErratumIn] J Pharmacol Sci.2009 Feb;109(2):324
  • (PMID = 19075512.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Dibenzazepines; 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 0 / Imidazoles; 0 / RNA, Messenger; 0 / Receptors, Histamine H1; 17X7AFZ1GH / Toluene 2,4-Diisocyanate; 207137-56-2 / Interleukin-4; 2XG66W44KF / Olopatadine Hydrochloride; 3U6IO1965U / Chlorpheniramine; Q13WX941EF / epinastine
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42. RAWITZ WE, MRRKSAMER D: Evaluation of methdilazine hydrochloride in therapy of alergic rhinitis. Curr Ther Res Clin Exp; 1962 Nov;4:564-7
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  • [Title] Evaluation of methdilazine hydrochloride in therapy of alergic rhinitis.
  • [MeSH-major] Anti-Allergic Agents. Histamine H1 Antagonists. Phenothiazines. Rhinitis. Rhinitis, Allergic, Seasonal

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  • (PMID = 13990850.001).
  • [ISSN] 0011-393X
  • [Journal-full-title] Current therapeutic research, clinical and experimental
  • [ISO-abbreviation] Curr Ther Res Clin Exp
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Phenothiazines; 4Q13LY9Z8X / methdilazine
  • [Keywords] NLM ; ANTIHISTAMINICS (major topic) / HAY FEVER (major topic)
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43. Callaway JK, King RG, Boura AL: Methoxyphenamine inhibits histamine-induced bronchoconstriction in anaesthetized guinea-pigs and histamine-induced contractions of guinea-pig ileum in vitro. Arch Int Pharmacodyn Ther; 1990 Nov-Dec;308:86-94
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  • [Title] Methoxyphenamine inhibits histamine-induced bronchoconstriction in anaesthetized guinea-pigs and histamine-induced contractions of guinea-pig ileum in vitro.
  • Measurements were made of the effects of methoxyphenamine hydrochloride on histamine-, acetylcholine- and U46619-induced bronchoconstriction in pentobarbitone-anaesthetized guinea-pigs, and on histamine- and acetylcholine-induced contractions of guinea-pig ileum in vitro.
  • However, it produced a parallel rightward shift [2.94-(1.79, 4.41) fold, 95% confidence limits in parentheses] of the curve relating bronchoconstrictor responses to log-dose of histamine at a total dose of 13 mg/kg, i.v., which was not significantly different from the shift [3.30-(1.93, 5.56) fold] produced by 3 micrograms/kg, i.v., of the histamine antagonist mepyramine maleate.
  • Histamine-induced contractions of the isolated guinea-pig ileum were antagonized by methoxyphenamine (10(-5) to 10(-3) M).
  • The histamine log-concentration-response curve was shifted to the right in a parallel manner by methoxyphenamine (10(-5) to 10(-4) M), without depression of maximum responses.
  • The degree of the rightward shift of the concentration-response curves to histamine, produced by 10(-5) M of methoxyphenamine [3.90-(2.83, 4.97) fold], was not significantly different from that produced by 3 x 10(-9) M of mepyramine [4.60-(2.86, 6.52) fold].
  • These results indicate that methoxyphenamine antagonizes the effects of histamine both in vivo and in vitro.
  • [MeSH-major] Adrenergic beta-Agonists / pharmacology. Bronchi / drug effects. Histamine Antagonists. Methamphetamine / analogs & derivatives. Muscle, Smooth / drug effects
  • [MeSH-minor] 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid. Acetylcholine / pharmacology. Anesthesia. Animals. Guinea Pigs. Histamine / pharmacology. Ileum / drug effects. In Vitro Techniques. Male. Prostaglandin Endoperoxides, Synthetic / pharmacology. Pyrilamine / pharmacology

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  • (PMID = 1983067.001).
  • [ISSN] 0003-9780
  • [Journal-full-title] Archives internationales de pharmacodynamie et de thérapie
  • [ISO-abbreviation] Arch Int Pharmacodyn Ther
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] BELGIUM
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Histamine Antagonists; 0 / Prostaglandin Endoperoxides, Synthetic; 44RAL3456C / Methamphetamine; 76898-47-0 / 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 820484N8I3 / Histamine; HPE317O9TL / Pyrilamine; J3Z5SRI26Z / methoxyphenamine; N9YNS0M02X / Acetylcholine
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44. Boyer HC, Downs DH, Goding GS Jr, Pernell KJ: Effect of topical diphenhydramine on the laryngeal chemoreflex. Arch Otolaryngol Head Neck Surg; 1996 Oct;122(10):1112-6
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  • In 7 piglets, diphenhydramine hydrochloride (5.0 mg/kg) was nebulized onto the laryngeal mucosa after a baseline response was obtained.
  • [MeSH-major] Diphenhydramine / administration & dosage. Histamine H1 Antagonists / administration & dosage. Larynx / physiology. Reflex / drug effects

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  • (PMID = 8859125.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Aerosols; 0 / Histamine H1 Antagonists; 451W47IQ8X / Sodium Chloride; 8GTS82S83M / Diphenhydramine
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45. Schwartz JC: The histamine H3 receptor: from discovery to clinical trials with pitolisant. Br J Pharmacol; 2011 Jun;163(4):713-21
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  • [Title] The histamine H3 receptor: from discovery to clinical trials with pitolisant.
  • The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat brain slices.
  • In 1990, the cloning of the gene of the H3-receptor, a member of the superfamily of heptahelical receptors coupled to G proteins, paved the way to the demonstration of the high constitutive activity of the receptor, including its native form, and its participation in the tonic control of histamine release; it also facilitated the development of H3-receptor inverse agonist programs in many drug companies.
  • Pitolisant (BF2.649, 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride) is the first inverse agonist to be introduced in the clinics.
  • [MeSH-major] Piperidines / pharmacology. Piperidines / therapeutic use. Receptors, Histamine H3 / metabolism
  • [MeSH-minor] Animals. Clinical Trials as Topic. Drug Discovery / methods. Histamine Agonists / pharmacology. Histamine Agonists / therapeutic use. Histamine Antagonists / pharmacology. Histamine Antagonists / therapeutic use. Humans. Ligands

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  • [Copyright] © 2011 The Author. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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  • (PMID = 21615387.001).
  • [ISSN] 1476-5381
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Histamine Agonists; 0 / Histamine Antagonists; 0 / Ligands; 0 / Piperidines; 0 / Receptors, Histamine H3; 4BC83L4PIY / 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine
  • [Other-IDs] NLM/ PMC3111674
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46. Takahashi H, Ishida-Yamamoto A, Iizuka H: Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance. Clin Exp Dermatol; 2004 Sep;29(5):526-32
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  • [Title] Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance.
  • We designed a double-blind, placebo-controlled, crossover study to compare the inhibitory effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced flare-and-wheal response.
  • Bepotastine (10 mg twice a day), cetirizine (10 mg once a day), fexofenadine (60 mg twice a day), and olopatadine (5 mg twice a day) or placebo was given in a double-blind manner to seven healthy volunteers before histamine challenge by iontophoresis.
  • At 0, 1, 2, 4, 8, 12, and 24 h following the oral administration of these drugs, histamine iontophoresis-induced wheal-and-flare response was measured.
  • Histamine iontophoresis induced marked wheal-and-flare response in all participants.
  • Bepotastine, cetirizine, fexofenadine, and olopatadine yielded significant reduction of histamine-induced wheal-and-flare response compared to placebo (P < 0.01).
  • Among the drugs, olopatadine and cetirizine suppressed most markedly and persistently histamine-induced wheal-and-flare response, while bepotastine and fexofenadine produced a significant, but less persistent suppression.
  • These results indicate that bepotastine, cetirizine, fexofenadine, and olopatadine inhibit histamine-induced wheal-and-flare response of humans in vivo and induce a variable systemic sedative effect and impaired psychomotor activity.
  • Although olopatadine and cetirizine showed the strongest and most persistent suppression of histamine-induced wheal-and-flare response, olopatadine showed a considerable sedative effect with impaired psychomotor performance.
  • [MeSH-major] Dermatitis, Atopic / drug therapy. Histamine H1 Antagonists / therapeutic use. Psychomotor Performance / drug effects. Terfenadine / analogs & derivatives
  • [MeSH-minor] Adult. Cetirizine / adverse effects. Cetirizine / therapeutic use. Cross-Over Studies. Dibenzoxepins / adverse effects. Dibenzoxepins / therapeutic use. Double-Blind Method. Female. Histamine. Humans. Iontophoresis. Male. Olopatadine Hydrochloride. Piperidines / adverse effects. Piperidines / therapeutic use. Pyridines / adverse effects. Pyridines / therapeutic use. Sleep Stages / drug effects

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  • (PMID = 15347340.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 0 / Piperidines; 0 / Pyridines; 2XG66W44KF / Olopatadine Hydrochloride; 7BA5G9Y06Q / Terfenadine; 820484N8I3 / Histamine; E6582LOH6V / fexofenadine; HYD2U48IAS / bepotastine; YO7261ME24 / Cetirizine
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47. Ali AH, Yanoff LB, Stern EA, Akomeah A, Courville A, Kozlosky M, Brady SM, Calis KA, Reynolds JC, Crocker MK, Barak N, Yanovski JA: Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial. Am J Clin Nutr; 2010 Dec;92(6):1290-7
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  • [Title] Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial.
  • In animal models, histamine receptor 1 (HRH1) agonists and histamine receptor 3 (HRH3) antagonists decrease food intake.
  • OBJECTIVE: The objective of this study was to examine the acute effects of betahistine hydrochloride (an HRH1 agonist and HRH3 antagonist) on food intakes and appetites.

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  • (PMID = 20881066.001).
  • [ISSN] 1938-3207
  • [Journal-full-title] The American journal of clinical nutrition
  • [ISO-abbreviation] Am. J. Clin. Nutr.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00459992
  • [Grant] United States / NICHD NIH HHS / HD / Z01-HD-00641
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] X32KK4201D / Betahistine
  • [Other-IDs] NLM/ PMC2980955
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48. Haavik S, Bryhni Frostad A, Smestad Paulsen B, Wold JK: Glycoprotein allergens in pollen of timothy. III. Immunochemical and biological properties of a basic glycoprotein. Int Arch Allergy Appl Immunol; 1987;83(2):182-9
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  • In quantitative skin prick tests, the mean activity of 2 micrograms/ml purified allergen in 7 patients was equivalent to that of a timothy pollen extract containing 10,000 BU/ml (assayed relatively to histamine in skin prick test).
  • The ability of the allergen to form a precipitate in rocket immunoelectrophoresis was lost when it was heated to 80 degrees C or incubated with 4 M guanidine hydrochloride.

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  • (PMID = 3294602.001).
  • [ISSN] 0020-5915
  • [Journal-full-title] International archives of allergy and applied immunology
  • [ISO-abbreviation] Int. Arch. Allergy Appl. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Allergens; 0 / Glycoproteins; 0 / Plant Proteins; 37341-29-0 / Immunoglobulin E
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49. McBAVACK TH, SCHULMAN PM, BOYD LJ: A clinical investigation of beta-morpholinoethyl benzhydryl ether hydrochloride (linadryl) as an antihistamine agent. J Allergy; 1948 Mar;19(2):141-5
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  • [Title] A clinical investigation of beta-morpholinoethyl benzhydryl ether hydrochloride (linadryl) as an antihistamine agent.
  • [MeSH-major] Anti-Allergic Agents. Ether. Histamine. Histamine Antagonists. Histamine H1 Antagonists

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  • (PMID = 18911789.001).
  • [ISSN] 0021-8707
  • [Journal-full-title] The Journal of allergy
  • [ISO-abbreviation] J Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine Antagonists; 0 / Histamine H1 Antagonists; 0F5N573A2Y / Ether; 820484N8I3 / Histamine
  • [Other-IDs] CLML/ 4814:910r
  • [Keywords] NLM ; HISTAMINE AND ANTIHISTAMINES (major topic) / LINADRYL (major topic)
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50. Haruno A: Inhibitory effects of propiverine hydrochloride on the agonist-induced or spontaneous contractions of various isolated muscle preparations. Arzneimittelforschung; 1992 Jun;42(6):815-7
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  • [Title] Inhibitory effects of propiverine hydrochloride on the agonist-induced or spontaneous contractions of various isolated muscle preparations.
  • Inhibitory effects of propiverine hydrochloride (P-4, CAS 60569-19-9), a new drug which reduces the frequency of micturition, were studied on the agonist-induced or spontaneous contractions of various isolated muscle preparations.
  • P-4 (10(-5)-10(-4) mol/l) inhibited the KCl-induced contraction of isolated rabbit aorta and the histamine-induced contraction of isolated guinea-pig tracheal chain.

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  • (PMID = 1418036.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY
  • [Chemical-registry-number] 0 / Benzilates; 0 / Parasympatholytics; 468GE2241L / propiverine; 660YQ98I10 / Potassium Chloride
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51. Coutts SM, Khandwala A, Weinryb I: Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). II. A lack of correlation between inhibition of mediator release and levels of cyclic AMP. Int Arch Allergy Appl Immunol; 1983;70(4):303-10
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  • [Title] Antiallergic activity of nylidrin hydrochloride (RHC 3432-A). II. A lack of correlation between inhibition of mediator release and levels of cyclic AMP.
  • Nylidrin hydrochloride has weak beta-adrenergic agonist properties with rat mast cells, and shows synergy with 3-isobutyl-1-methylxanthine (IBMX) in raising intracellular cAMP in purified mast cells; both of these properties can be blocked by dl-propranolol.
  • However, the action of nylidrin hydrochloride as an inhibitor of histamine secretion from purified rat mast cells is not antagonized by dl-propranolol, nor is it potentiated by IBMX.
  • Nylidrin-induced elevation of cellular cAMP in purified rat mast cells shows no correlation with nylidrin-induced inhibition of histamine release.
  • Thus, nylidrin hydrochloride inhibits release of histamine from mast cells by a novel, non-adrenergic mechanism, which is not dependent on increased levels of cAMP.
  • [MeSH-major] Cyclic AMP / analysis. Histamine H1 Antagonists. Histamine Release. Mast Cells / analysis. Nylidrin / pharmacology

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  • Hazardous Substances Data Bank. NYLIDRIN .
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  • (PMID = 6186609.001).
  • [ISSN] 0020-5915
  • [Journal-full-title] International archives of allergy and applied immunology
  • [ISO-abbreviation] Int. Arch. Allergy Appl. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SWITZERLAND
  • [Chemical-registry-number] 0 / Antibodies, Anti-Idiotypic; 0 / Histamine H1 Antagonists; 0 / Phosphodiesterase Inhibitors; 37341-29-0 / Immunoglobulin E; 695DKH33EI / Nylidrin; 9Y8NXQ24VQ / Propranolol; E0399OZS9N / Cyclic AMP
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52. Hioki Y, Takada J, Hidaka Y, Takeshita H, Hosoi M, Yano M: A newly synthesized pyridine derivative, (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine hydrochloride (AU-1421), as a reversible gastric proton pump inhibitor. Arch Int Pharmacodyn Ther; 1990 May-Jun;305:32-44
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  • [Title] A newly synthesized pyridine derivative, (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine hydrochloride (AU-1421), as a reversible gastric proton pump inhibitor.
  • A newly synthesized pyridine derivative, (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4-piperidinopyridine hydrochloride (AU-1421), was found to inhibit the gastric proton pump in vitro and in vivo.
  • In the isolated rabbit gastric glands, AU-1421 inhibited the histamine-, dibutyryl cAMP- and K(+)-stimulated uptake of [14C]aminopyrine into gastric glands with similar IC50 values of about 1 microM.

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  • (PMID = 2173509.001).
  • [ISSN] 0003-9780
  • [Journal-full-title] Archives internationales de pharmacodynamie et de thérapie
  • [ISO-abbreviation] Arch Int Pharmacodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] BELGIUM
  • [Chemical-registry-number] 0 / Gastrins; 0 / Gastrointestinal Hormones; 0 / Naphthalenes; 0 / Proteins; 0 / Pyridines; 0 / hydrogen potassium ATPase, gastric endogenous activator protein, mammal; 01704YP3MO / Aminopyrine; 115717-83-4 / AU 1421; 80061L1WGD / Cimetidine; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.3.10 / H(+)-K(+)-Exchanging ATPase
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53. Dong Y, Ishikawa H, Wu Y, Yoshitomi T: Vasodilatory mechanism of levobunolol on vascular smooth muscle cells. Exp Eye Res; 2007 Jun;84(6):1039-46
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  • Topical application of levobunolol hydrochloride, a beta-adrenergic antagonist used for treatment of glaucoma, is reported to increase ocular blood flow.
  • Levobunolol relaxed ciliary artery rings that were pre-contracted with either high-K solution, 1microM histamine, 10microM phenylephrine, or 100nM endothelin-1.
  • Histamine-induced contractions were inhibited by the histamine H(1) antagonist pyrilamine.
  • Further, histamine induced transient contraction in Ca(2+)-free solution, and levobunolol inhibited this contraction by 74.6+/-11.0%.
  • In cultured smooth muscle cells in the presence of extracellular Ca(2+), levobunolol significantly inhibited the histamine-induced elevation of [Ca(2+)](i).
  • However, it did not inhibit the increase of [Ca(2+)](i) in histamine-stimulated cells incubated in Ca(2+)-free solution.

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  • (PMID = 17459374.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Vasoconstrictor Agents; 0 / Vasodilator Agents; 1WS297W6MV / Phenylephrine; EE92BBP03H / Diltiazem; G6317AOI7K / Levobunolol; SY7Q814VUP / Calcium
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54. Onodera K, Yamatodani A, Watanabe T: Effect of alpha-fluoromethylhistidine on brain histamine and noradrenaline in muricidal rats. Methods Find Exp Clin Pharmacol; 1993 Sep;15(7):423-7
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  • [Title] Effect of alpha-fluoromethylhistidine on brain histamine and noradrenaline in muricidal rats.
  • Once the muricide tendency appeared, it remained during the entire experimental period, even after subsequent administration of thiamine hydrochloride for 30 days.
  • The effect of alpha-fluoromethylhistidine (FMH) on muricide in this animal model was examined, and histamine and noradrenaline levels in several brain regions were measured.
  • Significant decrease in histamine levels was found in the hypothalamus, thalamus, amygdala, striatum and pituitary of muricidal rats.
  • [MeSH-major] Aggression / physiology. Brain / metabolism. Histamine / metabolism. Histidine Decarboxylase / antagonists & inhibitors. Methylhistidines / pharmacology. Norepinephrine / metabolism

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  • (PMID = 8255120.001).
  • [ISSN] 0379-0355
  • [Journal-full-title] Methods and findings in experimental and clinical pharmacology
  • [ISO-abbreviation] Methods Find Exp Clin Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] SPAIN
  • [Chemical-registry-number] 0 / Methylhistidines; 70050-43-0 / alpha-fluoromethylhistidine; 820484N8I3 / Histamine; EC 4.1.1.22 / Histidine Decarboxylase; X4W3ENH1CV / Norepinephrine
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55. Howarth PH, Stern MA, Roi L, Reynolds R, Bousquet J: Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. J Allergy Clin Immunol; 1999 Nov;104(5):927-33
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  • [Title] Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis.
  • BACKGROUND: Fexofenadine hydrochloride (HCl) is a new H(1) antihistamine used twice daily in some countries.
  • [MeSH-major] Anti-Allergic Agents / therapeutic use. Cetirizine / therapeutic use. Histamine H1 Antagonists / therapeutic use. Rhinitis, Allergic, Seasonal / drug therapy. Terfenadine / analogs & derivatives

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  • (PMID = 10550734.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 7BA5G9Y06Q / Terfenadine; E6582LOH6V / fexofenadine; YO7261ME24 / Cetirizine
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56. Ozadali K, Ozkannli F, Erol D, Doğan AE, Erol K: Synthesis and biological activities of some thiazolidin-4-ones. Arzneimittelforschung; 2006;56(10):678-81
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  • Compound 15 (3-[3-(2-methyl-piperidine-1-yl)propyl]-2-(4-methyl-phenyl)thiazolidin-4-one hydrochloride) showed the highest inhibition (53 %).
  • [MeSH-major] Cholinergic Antagonists / chemical synthesis. Cholinergic Antagonists / pharmacology. Histamine Antagonists / chemical synthesis. Histamine Antagonists / pharmacology. Thiazolidines / chemical synthesis. Thiazolidines / pharmacology

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  • (PMID = 17225562.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cholinergic Antagonists; 0 / Histamine Antagonists; 0 / Indicators and Reagents; 0 / Schiff Bases; 0 / Thiazolidines; 0 / Vasodilator Agents; N9YNS0M02X / Acetylcholine
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57. Hazama H, Nakajima T, Hisada T, Hamada E, Omata M, Kurachi Y: Effects of azelastine on membrane currents in tracheal smooth muscle cells isolated from the guinea-pig. Eur J Pharmacol; 1994 Jul 1;259(2):143-50
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  • Azelastine [4-(p-chlorobenzyl)-2-(hexahydro-1-methyl -1H-azepin-4-yl)-1-(2H)-phthalazinone hydrochloride], an anti-allergic agent, inhibited the high K(+)-induced contraction in tracheal smooth muscle cells isolated from the guinea-pig.
  • [MeSH-minor] Animals. Calcium / antagonists & inhibitors. Cell Membrane / drug effects. Cell Membrane / physiology. Electrophysiology. Guinea Pigs. Histamine H1 Antagonists. In Vitro Techniques. Muscle Contraction / drug effects. Muscle Contraction / physiology. Patch-Clamp Techniques. Potassium / antagonists & inhibitors

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  • (PMID = 7957608.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] NETHERLANDS
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Phthalazines; RWP5GA015D / Potassium; SY7Q814VUP / Calcium; ZQI909440X / azelastine
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58. Watanabe M, Osada H, Shimizu S, Goto S, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Ohmori K: Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. Am J Vet Res; 2016 Sep;77(9):969-75
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  • OBJECTIVE To characterize platelet-activating factor (PAF)-induced edema and erythema in the skin of dogs and compare those reactions with histamine-induced cutaneous reactions.
  • Each dog received ID injections (5 μg/site) of PAF C16, PAF C18, lyso-PAF, and histamine.
  • Dogs received ID injections of PAF and histamine each with various concentrations of WEB 2086 (PAF receptor antagonist) or underwent ID testing with PAF and histamine before and 3 hours after oral administration of cetirizine hydrochloride or prednisolone (at 2 doses each).
  • The PAF-induced edema and erythema peaked at 30 minutes and lasted for 6 hours after the injection; histamine-induced edema and erythema peaked at 30 minutes and lasted for 3 hours after the injection.
  • Edema sizes and erythema scores were significantly smaller and lower, respectively, for PAF than for histamine.
  • The WEB 2086 inhibited PAF-induced but not histamine-induced edema and erythema.
  • Cetirizine slightly, but significantly, repressed PAF-induced edema and erythema as well as histamine-induced cutaneous reactions.
  • Prednisolone suppressed both PAF-induced and histamine-induced edema and erythema.
  • CONCLUSIONS AND CLINICAL RELEVANCE In canine skin, the duration of PAF-induced inflammation was longer than that of histamine-induced inflammation.
  • The PAF- and histamine-induced cutaneous reactions were effectively suppressed by oral administration of prednisolone.
  • [MeSH-minor] Animals. Azepines / pharmacology. Dogs. Histamine / pharmacology. Male. Platelet Membrane Glycoproteins / antagonists & inhibitors. Prednisolone / pharmacology. Receptors, G-Protein-Coupled / antagonists & inhibitors. Skin / drug effects. Triazoles / pharmacology

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  • (PMID = 27580108.001).
  • [ISSN] 1943-5681
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Azepines; 0 / Platelet Activating Factor; 0 / Platelet Membrane Glycoproteins; 0 / Receptors, G-Protein-Coupled; 0 / Triazoles; 0 / platelet activating factor receptor; 105219-56-5 / WEB 2086; 820484N8I3 / Histamine; 9PHQ9Y1OLM / Prednisolone
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59. Huq A, Stephens PW: Subtleties in crystal structure solution from powder diffraction data using simulated annealing: ranitidine hydrochloride. J Pharm Sci; 2003 Feb;92(2):244-9
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  • [Title] Subtleties in crystal structure solution from powder diffraction data using simulated annealing: ranitidine hydrochloride.
  • [MeSH-major] Histamine H2 Antagonists / chemistry. Ranitidine / chemistry

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  • [Copyright] Copyright 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 92:244-249, 2003
  • (PMID = 12532373.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histamine H2 Antagonists; 884KT10YB7 / Ranitidine
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60. Chand N, Diamantis W, Pillar J, Sofia RD: Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists. Br J Pharmacol; 1984 Dec;83(4):899-902
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  • [Title] Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists.
  • Bepridil, TMB-8 (8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride), diltiazem, verapamil and nifedipine exerted concentration-dependent inhibition of antigen and calcium ionophore A23187-induced histamine release from rat peritoneal mast cells.
  • The inhibitory effects of verapamil and bepridil against calcium ionophore A23187-induced histamine secretion were antagonized by increased Ca2+ concentrations in the extracellular medium.
  • The inhibitory activities of five different Ca2+ channel blockers on allergic and non-allergic histamine secretion from rat peritoneal mast cells varied considerably depending upon the nature of the secretagogue as well as concentration and type of Ca2+-antagonist examined.
  • [MeSH-major] Calcium Channel Blockers / pharmacology. Histamine Release / drug effects. Hypersensitivity / metabolism. Mast Cells / secretion

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  • [Cites] Int Arch Allergy Appl Immunol. 1975;49(1-2):183-207 [49313.001]
  • [Cites] Annu Rev Pharmacol Toxicol. 1981;21:63-81 [6263175.001]
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  • [Cites] Biochem Pharmacol. 1984 Mar 1;33(5):821-6 [6608945.001]
  • [Cites] Eur J Pharmacol. 1984 Feb 10;98(1):157-8 [6325208.001]
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  • (PMID = 6083814.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Calcium Channel Blockers; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC1986983
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61. Richter G, Kühn E: [Talastine (Ahanon) as a cause of allergic drug exanthema]. Dermatol Monatsschr; 1990;176(2-3):111-3
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  • Described are two drug eruptions from talastine hydrochloride (Ahanon).
  • [MeSH-major] Drug Eruptions / etiology. Histamine H1 Antagonists / adverse effects. Phthalazines / adverse effects. Pyridazines / adverse effects

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  • (PMID = 1973126.001).
  • [ISSN] 0011-9083
  • [Journal-full-title] Dermatologische Monatschrift
  • [ISO-abbreviation] Dermatol Monatsschr
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] GERMANY, EAST
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Phthalazines; 0 / Pyridazines; 49AB2PA48B / talastine
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62. Mochizuki Y, Furuta A, Furuya A, Kanai K, Asano K, Suzaki H: Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. In Vivo; 2008 Jan-Feb;22(1):13-20
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  • [Title] Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro.
  • The influence of a histamine H1 receptor antagonist, epinastine hydrochloride (EP), on eosinophil functions was examined in vitro and in vivo.
  • [MeSH-major] Dibenzazepines / pharmacology. Eosinophils / drug effects. Histamine H1 Antagonists / pharmacology. Imidazoles / pharmacology. Platelet Aggregation Inhibitors / pharmacology

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  • (PMID = 18396776.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ccl5 protein, mouse; 0 / Chemokine CCL4; 0 / Chemokine CCL5; 0 / Dibenzazepines; 0 / Drug Combinations; 0 / Histamine H1 Antagonists; 0 / Imidazoles; 0 / Platelet Aggregation Inhibitors; 0 / Stem Cell Factor; 2CU6TT9V48 / Leukotriene C4; 37341-29-0 / Immunoglobulin E; Q13WX941EF / epinastine
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63. Ohmura T, Kawasaki T: [Pharmacological and clinical profile of epinastine hydrochloride (Alesion Dry Syrup 1%)]. Nihon Yakurigaku Zasshi; 2006 Jan;127(1):37-46
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  • [Title] [Pharmacological and clinical profile of epinastine hydrochloride (Alesion Dry Syrup 1%)].
  • [MeSH-major] Dibenzazepines / pharmacology. Dibenzazepines / therapeutic use. Histamine H1 Antagonists / pharmacology. Histamine H1 Antagonists / therapeutic use. Imidazoles / pharmacology. Imidazoles / therapeutic use

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  • (PMID = 16508222.001).
  • [ISSN] 0015-5691
  • [Journal-full-title] Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • [ISO-abbreviation] Nippon Yakurigaku Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Dibenzazepines; 0 / Histamine H1 Antagonists; 0 / Imidazoles; Q13WX941EF / epinastine
  • [Number-of-references] 43
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64. MACLAREN WR: Parabromdylamine maleate, chlorprophenpyridamine maleate, and tripelennamine hydrochloride in chronic allergic rhinitis. J Allergy; 1959 May-Jun;30(3):235-40
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  • [Title] Parabromdylamine maleate, chlorprophenpyridamine maleate, and tripelennamine hydrochloride in chronic allergic rhinitis.
  • [MeSH-major] Anti-Allergic Agents. Brompheniramine. Chlorpheniramine. Histamine H1 Antagonists / therapeutic use. Hyperthermia, Induced. Maleates. Rhinitis, Allergic. Rhinitis, Allergic, Seasonal / therapy. Tripelennamine / therapeutic use

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  • (PMID = 13640851.001).
  • [ISSN] 0021-8707
  • [Journal-full-title] The Journal of allergy
  • [ISO-abbreviation] J Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Maleates; 3C5ORO99TY / Tripelennamine; 3U6IO1965U / Chlorpheniramine; H57G17P2FN / Brompheniramine
  • [Other-IDs] CLML/ 5936:14743:48:235:543
  • [Keywords] NLM ; ANTIHISTAMINICS/therapeutic use (major topic) / HAY FEVER/therapy (major topic) / TRIPELENNAMINE/therapeutic use (major topic)
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65. Kajiwara D, Aoyagi H, Shigeno K, Togawa M, Tanaka K, Inagaki N, Miyoshi K: Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis. Eur J Pharmacol; 2011 Sep 30;667(1-3):389-95
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  • We investigated the role of hematopoietic prostaglandin D synthase (H-PGDS) in biphasic nasal obstruction in allergic rhinitis using a new specific inhibitor, (N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride (TAS-204).
  • Eosinophil infiltration in nasal lavage fluid and nasal hyperresponsiveness to histamine was also reduced by TAS-204 administration.
  • [MeSH-minor] Animals. Dinoprostone / metabolism. Disease Models, Animal. Eosinophils / immunology. Guinea Pigs. Histamine / immunology. Histamine / metabolism. Humans. Leukotrienes / metabolism. Male. Nasal Lavage Fluid / immunology. Nasal Mucosa / drug effects. Nasal Mucosa / immunology. Ovalbumin / immunology. Prostaglandin D2 / biosynthesis. Prostaglandin D2 / metabolism. Time Factors

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  • [Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.
  • (PMID = 21645503.001).
  • [ISSN] 1879-0712
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / (N-methoxy-N-methyl)-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide hydrochloride; 0 / Benzimidazoles; 0 / Leukotrienes; 0 / Lipocalins; 0 / Pyrroles; 820484N8I3 / Histamine; 9006-59-1 / Ovalbumin; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.2 / prostaglandin R2 D-isomerase; K7Q1JQR04M / Dinoprostone; RXY07S6CZ2 / Prostaglandin D2
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66. Roland PS, Marple BF, Wall GM: Olopatadine nasal spray for the treatment of allergic rhinitis. Expert Rev Clin Immunol; 2010 Mar;6(2):197-204
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  • Olopatadine hydrochloride nasal spray (Patanase Nasal Spray, Alcon Laboratories, TX, USA) was approved by the US FDA in 2008, and is indicated for the relief of symptoms of seasonal allergic rhinitis (SAR), also referred to as allergic rhinosinusitis.
  • [MeSH-major] Dibenzoxepins / therapeutic use. Histamine H1 Antagonists, Non-Sedating / therapeutic use. Rhinitis, Allergic, Seasonal / drug therapy
  • [MeSH-minor] Activities of Daily Living. Administration, Intranasal. Clinical Trials as Topic. Drug Approval. Epistaxis / etiology. Nasal Obstruction. Olopatadine Hydrochloride. Quality of Life

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  • (PMID = 20402382.001).
  • [ISSN] 1744-666X
  • [Journal-full-title] Expert review of clinical immunology
  • [ISO-abbreviation] Expert Rev Clin Immunol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists, Non-Sedating; 2XG66W44KF / Olopatadine Hydrochloride
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67. Fischer D, Breyer-Pfaff U: Variability of diphenhydramine N-glucuronidation in healthy subjects. Eur J Drug Metab Pharmacokinet; 1997 Apr-Jun;22(2):151-4
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  • The intraindividual variability in the amount of N-glucuronide excretion in urine was investigated in two female volunteers who repeatedly took single doses of 25 mg diphenhydramine hydrochloride without and with concomitant administration of ascorbic acid or ammonium chloride for urine acidification.
  • [MeSH-major] Diphenhydramine / metabolism. Histamine H1 Antagonists / metabolism

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  • [Cites] Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):391-404 [4445562.001]
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  • (PMID = 9248784.001).
  • [ISSN] 0378-7966
  • [Journal-full-title] European journal of drug metabolism and pharmacokinetics
  • [ISO-abbreviation] Eur J Drug Metab Pharmacokinet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Glucuronates; 0 / Histamine H1 Antagonists; 8GTS82S83M / Diphenhydramine; PQ6CK8PD0R / Ascorbic Acid
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68. Zhou HY, Chen XG, Liu CS, Meng XH, Yu LJ, Liu XY, Liu N: Chitosan/cellulose acetate microspheres preparation and ranitidine release in vitro. Pharm Dev Technol; 2005;10(2):219-25
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  • Ranitidine hydrochloride, as a model drug, was investigated for its release properties in vitro.
  • [MeSH-major] Cellulose / analogs & derivatives. Cellulose / chemistry. Chitosan / chemistry. Excipients / chemistry. Histamine H2 Antagonists / administration & dosage. Ranitidine / administration & dosage

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  • (PMID = 15926670.001).
  • [ISSN] 1083-7450
  • [Journal-full-title] Pharmaceutical development and technology
  • [ISO-abbreviation] Pharm Dev Technol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Delayed-Action Preparations; 0 / Excipients; 0 / Histamine H2 Antagonists; 3J2P07GVB6 / acetylcellulose; 884KT10YB7 / Ranitidine; 9004-34-6 / Cellulose; 9012-76-4 / Chitosan
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69. Kamada S, Sakanoue M, Iwata M, Takeuchi M, Shinpo K, Tanabe T: [Effects of intravenous administration of ranitidine hydrochloride on the fertility of the male and female rats]. J Toxicol Sci; 1984 Jun;9 Suppl 1:13-28
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  • [Title] [Effects of intravenous administration of ranitidine hydrochloride on the fertility of the male and female rats].
  • The effects of ranitidine hydrochloride, a histamine H2-receptor antagonist, on the reproductivity of male and female rats of Crj:CD (SD) strain and the development of their fetuses were examined.
  • Ranitidine hydrochloride was intravenously administered once daily at dose levels of 5, 15 and 40 mg/kg in base weight respectively, to males from 60 days before mating until the completion of mating, and to females from 14 days before mating up to day 7 of gestation.
  • Treatment with ranitidine hydrochloride did not have any influence on mating performances and pregnancy at all dose levels.
  • In observation of the fetuses, there was no influence of ranitidine hydrochloride administration on fetal growth and development.
  • These results indicated that ranitidine hydrochloride intravenously administered to males and females before mating and to pregnant females in early stages of gestation had no toxic effects on reproductivity in either sex at the dose of 40 mg/kg/day or less.

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  • (PMID = 6092656.001).
  • [ISSN] 0388-1350
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 884KT10YB7 / Ranitidine
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70. Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K: Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin. Hum Psychopharmacol; 2009 Oct;24(7):540-8
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  • [Title] Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin.
  • The purpose of the present study is to measure histamine H(1) receptor (H(1)R) occupancy following oral administration of cetirizine (10 and 20 mg) in order to examine dose dependency.
  • [MeSH-major] Brain. Cetirizine / administration & dosage. Cetirizine / pharmacology. Doxepin. Histamine Antagonists. Histamine H1 Antagonists, Non-Sedating / pharmacology. Receptors, Histamine H1 / metabolism

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  • (PMID = 19697300.001).
  • [ISSN] 1099-1077
  • [Journal-full-title] Human psychopharmacology
  • [ISO-abbreviation] Hum Psychopharmacol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carbon Isotopes; 0 / Histamine Antagonists; 0 / Histamine H1 Antagonists, Non-Sedating; 0 / Receptors, Histamine H1; 1668-19-5 / Doxepin; 30S50YM8OG / Hydroxyzine; YO7261ME24 / Cetirizine
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71. GILL-CAREY MC: Chlorcyclizine hydrochloride poisoning in an infant. Br Med J; 1954 Mar 20;1(4863):687-8
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  • [Title] Chlorcyclizine hydrochloride poisoning in an infant.
  • [MeSH-major] Anti-Allergic Agents. Histamine H1 Antagonists / poisoning. Piperazines. Poisoning

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  • [Cites] Br Med J. 1950 May 13;1(4662):1115-6 [15420411.001]
  • (PMID = 13126592.001).
  • [ISSN] 0007-1447
  • [Journal-full-title] British medical journal
  • [ISO-abbreviation] Br Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Piperazines; M26C4IP44P / chlorcyclizine
  • [Other-IDs] CLML/ 5425:48035:37:369; NLM/ PMC2084756
  • [Keywords] NLM ; ANTIHISTAMINICS/poisoning (major topic) / POISONING (major topic)
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72. Okabe S, Nishida T, Igata H, Takagi K: [Effects of IT-066, a new histamine H2-receptor antagonist, on gastric acid secretion and experimental gastric ulcers in rats and dogs]. Nihon Yakurigaku Zasshi; 1990 May;95(5):247-56
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  • [Title] [Effects of IT-066, a new histamine H2-receptor antagonist, on gastric acid secretion and experimental gastric ulcers in rats and dogs].
  • We examined the effects of a new histamine H2-receptor antagonist, 3-amino-4-(4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2- butenylamino)-3- cyclobutene-1,2-dione hydrochloride (IT-066), on gastric acid secretion and the healing process of experimental ulcers in rats and dogs.
  • In addition, the agent significantly inhibited histamine-stimulated acid secretion in both normal rats and rats with acetic acid ulcers.
  • IT-066, when given i.v. or p.o., dose-dependently inhibited the gastric acid secretion stimulated by histamine, pentagastrin, or carbachol in dogs.
  • The antisecretory effects of the agent on histamine-stimulated acid secretion significantly persisted for more than 6 hr.
  • [MeSH-major] Anti-Ulcer Agents / pharmacology. Gastric Acid / secretion. Histamine H2 Antagonists / pharmacology. Piperidines / pharmacology. Pyridines / pharmacology. Stomach Ulcer / drug therapy
  • [MeSH-minor] Acetates. Animals. Carbachol / antagonists & inhibitors. Depression, Chemical. Dogs. Famotidine / pharmacology. Famotidine / therapeutic use. Female. Histamine Antagonists. Male. Pentagastrin / antagonists & inhibitors. Rats. Rats, Inbred Strains

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  • (PMID = 1972370.001).
  • [ISSN] 0015-5691
  • [Journal-full-title] Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • [ISO-abbreviation] Nippon Yakurigaku Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] JAPAN
  • [Chemical-registry-number] 0 / Acetates; 0 / Anti-Ulcer Agents; 0 / Histamine Antagonists; 0 / Histamine H2 Antagonists; 0 / Piperidines; 0 / Pyridines; 126463-66-9 / IT 066; 5QZO15J2Z8 / Famotidine; 8Y164V895Y / Carbachol; EF0NX91490 / Pentagastrin
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73. Tamura T, Amano T, Ohmori K, Manabe H: The effects of olopatadine hydrochloride on the number of scratching induced by repeated application of oxazolone in mice. Eur J Pharmacol; 2005 Nov 7;524(1-3):149-54
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  • [Title] The effects of olopatadine hydrochloride on the number of scratching induced by repeated application of oxazolone in mice.
  • It is suggested that atopic dermatitis is a skin disease associated with itching as subjective symptoms, and histamine H(1) receptor antagonists are used in order to prevent the itching, and the deterioration for scratch by itching.
  • Histamine H(1) receptor selective anti-histamine olopatadine hydrochloride (olopatadine; Allelock shows consistent efficacy and safety in the treatment of allergic disorders.
  • These results indicate that olopatadine inhibited not only the increased production of cytokines but also NGF and substance P unlike other histamine H(1) receptor antagonists.
  • Therefore, olopatadine appears to exert additional biological effects besides its blockade of a histamine H(1) receptor.
  • [MeSH-major] Dibenzoxepins / therapeutic use. Histamine H1 Antagonists / therapeutic use. Pruritus / prevention & control
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / therapeutic use. Antipruritics / therapeutic use. Chlorpheniramine / therapeutic use. Cytokines / metabolism. Dermatitis, Contact / etiology. Dermatitis, Contact / metabolism. Dermatitis, Contact / prevention & control. Dose-Response Relationship, Drug. Ear / pathology. Immunoglobulin E / blood. Male. Mice. Mice, Inbred BALB C. Nerve Growth Factor / metabolism. Olopatadine Hydrochloride. Oxazolone / administration & dosage. Oxazolone / toxicity. Prednisolone / therapeutic use. Severity of Illness Index

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  • (PMID = 16259975.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antipruritics; 0 / Cytokines; 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 15646-46-5 / Oxazolone; 2XG66W44KF / Olopatadine Hydrochloride; 37341-29-0 / Immunoglobulin E; 3U6IO1965U / Chlorpheniramine; 9061-61-4 / Nerve Growth Factor; 9PHQ9Y1OLM / Prednisolone
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74. COMBES FC, ZUCKERMAN R, CANIZARES O: Diatrin hydrochloride; a new antibistaminic agent for the treatment of pruritus and allergic dermatoses. Ann Allergy; 1949 Sep-Oct;7(5):676-8
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  • [Title] Diatrin hydrochloride; a new antibistaminic agent for the treatment of pruritus and allergic dermatoses.
  • [MeSH-major] Dermatitis, Atopic. Histamine. Histamine Antagonists. Pruritus

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  • (PMID = 18141474.001).
  • [ISSN] 0003-4738
  • [Journal-full-title] Annals of allergy
  • [ISO-abbreviation] Ann Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Histamine Antagonists; 820484N8I3 / Histamine
  • [Other-IDs] CLML/ 4917:1049o
  • [Keywords] NLM ; HISTAMINE/antagonists (major topic)
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75. Karsten W, Müller A: Radical formation in single crystals of aromatic amines and radical transformation by light. Int J Radiat Biol Relat Stud Phys Chem Med; 1981 Mar;39(3):235-52
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  • Single crystals of the four aromatic bioamine salts phenylethylamine hydrochloride, tyramine hydrochloride, tryptamine hydrochloride, and histamine dihydrochloride were grown in various states of deuteration.
  • Among the seven different aromatic radicals found only one is identified in histamine but two in each of the three other bioamines.
  • One hydrogen addition radical is found in each of the three compounds phenylethylamine, tyramine and histamine.
  • [MeSH-major] Histamine / radiation effects. Phenethylamines / radiation effects. Tryptamines / radiation effects. Tyramine / radiation effects

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  • (PMID = 6262261.001).
  • [ISSN] 0020-7616
  • [Journal-full-title] International journal of radiation biology and related studies in physics, chemistry, and medicine
  • [ISO-abbreviation] Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Free Radicals; 0 / Phenethylamines; 0 / Tryptamines; 820484N8I3 / Histamine; X8ZC7V0OX3 / Tyramine
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76. Zarrindast MR, Taheri S, Rezayof A: The effects of histaminergic agents in the nucleus accumbens of rats in the elevated plus-maze test of anxiety. Iran J Psychiatry; 2010;5(1):11-7
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  • There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
  • METHODS: Rats were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then were placed in a stereotaxic apparatus.
  • RESULTS: Intra-NAc administration of histamine (0.01, 0.1 and 1 µg/rat) increased the percentage of open arm time (%OAT) and open arm entries (%OAE), but not locomotor activity, indicating an anxiolytic response.
  • However, both histamine and histamine receptor antagonists showed an anxiolytic-like effect; the antagonists (1 µg/rat) also decreased the histamine response.
  • CONCLUSION: The results may indicate a modulatory effect for the H(1) and H(2) histamine receptors of nucleus accumbens in the anxiety behavior of rats.

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  • (PMID = 22952484.001).
  • [ISSN] 1735-4587
  • [Journal-full-title] Iranian journal of psychiatry
  • [ISO-abbreviation] Iran J Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3430404
  • [Keywords] NOTNLM ; Anxiety / Histamine / Maze learning / Pyrilamine / Ranitidine / Rats
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77. Yamada H, Tajima S: Inhibition of collagen expression by azelastine hydrochloride in cultured skin fibroblasts from normal individuals and scleroderma patients. Arch Dermatol Res; 1996 Sep;288(10):575-8
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  • [Title] Inhibition of collagen expression by azelastine hydrochloride in cultured skin fibroblasts from normal individuals and scleroderma patients.
  • The effects of azelastine hydrochloride on cell proliferation and collagen synthesis in cultured human skin fibroblasts were studied.
  • [MeSH-major] Collagen / biosynthesis. Histamine H1 Antagonists / pharmacology. Phthalazines / pharmacology. Skin / drug effects. Skin Diseases / drug therapy

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  • (PMID = 8919039.001).
  • [ISSN] 0340-3696
  • [Journal-full-title] Archives of dermatological research
  • [ISO-abbreviation] Arch. Dermatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists; 0 / Phthalazines; 0 / RNA, Messenger; 9007-34-5 / Collagen; ZQI909440X / azelastine
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78. CRAVER BN, BARRETT W, CAMERON A, HERROLD E, YONKMAN FF: Some pharmacological properties of 2(phenylbenzylaminomethyl)-imidazoline hydrochloride (antistine), an antihistamine. Ann Allergy; 1951 Jan-Feb;9(1):34-44
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  • [Title] Some pharmacological properties of 2(phenylbenzylaminomethyl)-imidazoline hydrochloride (antistine), an antihistamine.
  • [MeSH-major] Antazoline. Anti-Allergic Agents. Histamine Antagonists. Histamine H1 Antagonists. Imidazolines

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  • (PMID = 14800189.001).
  • [ISSN] 0003-4738
  • [Journal-full-title] Annals of allergy
  • [ISO-abbreviation] Ann Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine Antagonists; 0 / Histamine H1 Antagonists; 0 / Imidazolines; DHA8014SS1 / Antazoline
  • [Other-IDs] CLML/ 5120:31225:442
  • [Keywords] NLM ; HISTAMINE ANTAGONISTS (major topic)
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79. Food and Drug Administration, HHS: Labeling of diphenhydramine-containing drug products for over-the-counter human use. Final rule. Fed Regist; 2002 Dec 2;67(235):72555-9
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  • The Food and Drug Administration (FDA) is issuing a final rule amending the final monographs for over-the-counter (OTC) antiemetic, antihistamine, antitussive, and nighttime sleep-aid drug products to add a warning statement for oral products containing diphenhydramine citrate or diphenhydramine hydrochloride.
  • This final rule also includes the agency's conclusions on additional warning statements and a direction statement for OTC external analgesic drug products containing diphenhydramine hydrochloride.
  • [MeSH-minor] Administration, Topical. Analgesics / administration & dosage. Analgesics / adverse effects. Analgesics / therapeutic use. Analgesics / toxicity. Antiemetics / administration & dosage. Antiemetics / adverse effects. Antiemetics / therapeutic use. Antiemetics / toxicity. Antitussive Agents / administration & dosage. Antitussive Agents / adverse effects. Antitussive Agents / therapeutic use. Antitussive Agents / toxicity. Chickenpox / drug therapy. Consumer Product Safety / legislation & jurisprudence. Dermatitis, Toxicodendron / drug therapy. Histamine H1 Antagonists / administration & dosage. Histamine H1 Antagonists / adverse effects. Histamine H1 Antagonists / therapeutic use. Histamine H1 Antagonists / toxicity. Humans. Hypnotics and Sedatives / administration & dosage. Hypnotics and Sedatives / adverse effects. Hypnotics and Sedatives / therapeutic use. Hypnotics and Sedatives / toxicity. Measles / drug therapy. Nonprescription Drugs / adverse effects. Nonprescription Drugs / therapeutic use. Nonprescription Drugs / toxicity. Sunburn / drug therapy. United States. United States Food and Drug Administration

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  • (PMID = 12474879.001).
  • [ISSN] 0097-6326
  • [Journal-full-title] Federal register
  • [ISO-abbreviation] Fed Regist
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics; 0 / Antiemetics; 0 / Antitussive Agents; 0 / Histamine H1 Antagonists; 0 / Hypnotics and Sedatives; 0 / Nonprescription Drugs; 8GTS82S83M / Diphenhydramine
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80. Lekhanont K, Park CY, Combs JC, Suwan-Apichon O, Rangsin R, Chuck RS: Effect of topical olopatadine and epinastine in the botulinum toxin B-induced mouse model of dry eye. J Ocul Pharmacol Ther; 2007 Feb;23(1):83-8
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  • [MeSH-major] Dibenzazepines / therapeutic use. Dibenzoxepins / therapeutic use. Disease Models, Animal. Histamine H1 Antagonists / therapeutic use. Imidazoles / therapeutic use. Keratoconjunctivitis Sicca / drug therapy
  • [MeSH-minor] Administration, Topical. Animals. Botulinum Toxins / toxicity. Botulinum Toxins, Type A. Female. Mice. Mice, Inbred CBA. Olopatadine Hydrochloride. Tears / secretion

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  • (PMID = 17341156.001).
  • [ISSN] 1080-7683
  • [Journal-full-title] Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • [ISO-abbreviation] J Ocul Pharmacol Ther
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dibenzazepines; 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 0 / Imidazoles; 0Y70779M1F / rimabotulinumtoxinB; 2XG66W44KF / Olopatadine Hydrochloride; EC 3.4.24.69 / Botulinum Toxins; EC 3.4.24.69 / Botulinum Toxins, Type A; Q13WX941EF / epinastine
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81. Folco GC, Omini C, Viganò T, Nicosia S, Lombroso M, Brunelli G, Rossoni G, Niada R, Berti F: New pharmacological aspects on the antiasthmatic activity of tiaramide-HCl. Arzneimittelforschung; 1982;32(9):1092-5
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  • Tiaramide hydrochloride (THC) is a benzothiazoline derivative with a remarkable antianaphylactic activity: in anaesthetized guinea-pig it shows protecting effects against histamine (H)- and bradykinin (Bk)-induced bronchoconstriction, preventing increase of lung resistance and decrease of dynamic compliance.

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  • (PMID = 6890832.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Benzothiazoles; 0 / Calcium Channel Blockers; 0 / Piperazines; BB17WGM686 / tiaramide; RWP5GA015D / Potassium; SY7Q814VUP / Calcium
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82. Sakurai H, Takeshima S: Acid dissociation of 2-mercaptohistamine and its related compounds. Talanta; 1977 Aug;24(8):531-2
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  • The acid dissociation constants of 2-mercaptohistamine hydrochloride (2-MH) and its related compounds ergothioneine (Erg), 2-mercaptoimidazole (MI), N-methyl-2-mercaptoimidazole (MMI) and histamine dihydrochloride were determined by potentiometry at 15 degrees , 25 degrees and 35 degrees and mu = 0.1 (NaClO(4)).

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  • (PMID = 18962138.001).
  • [ISSN] 0039-9140
  • [Journal-full-title] Talanta
  • [ISO-abbreviation] Talanta
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Gupta A, Khosla R, Gupta S, Tiwary AK: Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+. Indian J Exp Biol; 2004 May;42(5):481-5
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  • [Title] Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: role of intrasperm Ca2+.
  • Histamine reduced sperm viability in a dose- and time-dependent manner, accompanied by rise in intrasperm Ca2+.
  • Further, 2',4'-dichlorobenzamil hydrochloride (DBZ), a Na+-Ca2+ exchange inhibitor, known to elevate intrasperm Ca2+, potentiated both, elevation of intrasperm Ca2+ and spermicidal action of histamine.
  • Pretreatment of sperm with very low doses of H1-receptor antagonists (chlorpheniramine, promethazine or diphenhydramine) prevented the histamine-induced elevation of intrasperm Ca2+ as well as its spermicidal action.
  • The results strongly suggest that histamine elicits its spermicidal action via H1-receptors present on sperm cells.
  • [MeSH-major] Calcium / metabolism. Histamine / metabolism. Histamine Antagonists / pharmacology. Histamine H1 Antagonists / pharmacology. Sperm Motility / drug effects. Spermatozoa / drug effects

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  • (PMID = 15233472.001).
  • [ISSN] 0019-5189
  • [Journal-full-title] Indian journal of experimental biology
  • [ISO-abbreviation] Indian J. Exp. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Histamine Antagonists; 0 / Histamine H1 Antagonists; 3U6IO1965U / Chlorpheniramine; 820484N8I3 / Histamine; 8GTS82S83M / Diphenhydramine; FF28EJQ494 / Promethazine; SY7Q814VUP / Calcium
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84. Breier AR, Paim CS, Menegola J, Steppe M, Schapoval EE: Development and validation of a liquid chromatographic method for fexofenadine hydrochloride in capsules. J AOAC Int; 2004 Sep-Oct;87(5):1093-7
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  • [Title] Development and validation of a liquid chromatographic method for fexofenadine hydrochloride in capsules.
  • [MeSH-major] Histamine H1 Antagonists / analysis. Terfenadine / analogs & derivatives. Terfenadine / analysis

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  • (PMID = 15493665.001).
  • [ISSN] 1060-3271
  • [Journal-full-title] Journal of AOAC International
  • [ISO-abbreviation] J AOAC Int
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsules; 0 / Histamine H1 Antagonists; 7BA5G9Y06Q / Terfenadine; E6582LOH6V / fexofenadine
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85. Altınbaş K, Guloksuz S, Oral ET: Clinical potential of cariprazine in the treatment of acute mania. Psychiatr Danub; 2013 Sep;25(3):207-13
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  • Cariprazine (RGH-188, trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl}-N,N-dimethylcarbamoyl-cyclohexyl-amine hydrochloride), is a novel antipsychotic with dopamine D2 and D3 receptors antagonist-partial agonist properties.
  • Although cariprazine treatment was associated with a higher incidence of treatment-emergent adverse events, particularly akathisia and tremor, common side effects of marketed second generation antipsychotics such as weight gain, metabolic disturbances, prolactin increase or QTc prolongation were not associated with cariprazine, probably due to its moderate to low binding affinity for histamine H1 and 5-HT2C receptors.

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  • (PMID = 24048386.001).
  • [ISSN] 0353-5053
  • [Journal-full-title] Psychiatria Danubina
  • [ISO-abbreviation] Psychiatr Danub
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antipsychotic Agents; 0 / Piperazines; F6RJL8B278 / cariprazine
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86. Brodsky M, Berger WE, Butrus S, Epstein AB, Irkec M: Evaluation of comfort using olopatadine hydrochloride 0.1% ophthalmic solution in the treatment of allergic conjunctivitis in contact lens wearers compared to placebo using the conjunctival allergen-challenge model. Eye Contact Lens; 2003 Apr;29(2):113-6
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  • [Title] Evaluation of comfort using olopatadine hydrochloride 0.1% ophthalmic solution in the treatment of allergic conjunctivitis in contact lens wearers compared to placebo using the conjunctival allergen-challenge model.
  • PURPOSE: Olopatadine hydrochloride 0.1% ophthalmic solution is a topical antiallergy agent indicated for treatment of the signs and symptoms of allergic conjunctivitis.
  • [MeSH-major] Allergens / adverse effects. Anti-Allergic Agents / therapeutic use. Conjunctiva / drug effects. Conjunctivitis, Allergic / drug therapy. Contact Lenses / utilization. Dibenzoxepins / therapeutic use. Histamine H1 Antagonists / therapeutic use
  • [MeSH-minor] Adult. Double-Blind Method. Drug Evaluation. Female. Humans. Male. Models, Biological. Olopatadine Hydrochloride. Ophthalmic Solutions. Patient Satisfaction

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  • (PMID = 12695716.001).
  • [ISSN] 1542-2321
  • [Journal-full-title] Eye & contact lens
  • [ISO-abbreviation] Eye Contact Lens
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Anti-Allergic Agents; 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 0 / Ophthalmic Solutions; 2XG66W44KF / Olopatadine Hydrochloride
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87. Bouhlal H, Blondin C, Haeffner-Cavaillon N, Goldschmidt P: [N acetyl-aspartyl glutamic acid (NAAGA) inhibits the adhesion of leukocytes to activated endothelial cells and down-modulates the cytokine-induced expression of adhesion molecules]. J Fr Ophtalmol; 2002 Dec;25(10):993-1000
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  • Their expression is up-regulated by pro-inflammatory stimuli such as cytokines, histamine or complement-derived anaphylatoxins.
  • NAAGA is known to inhibit leukotriene synthesis, histamine release by mast cells, and complement-derived anaphylatoxin production.
  • METHODS: Human blood-derived leukocytes were co-cultured with human umbilical vein endothelial cells (HUVECs) in the absence or the presence of 1000 UI/mL human recombinant TNFalpha, 10(-4) M histamine di-hydrochloride or 5x10(-6) M human recombinant C5a, and in the absence or presence of NAAGA (final concentration 2.45%).
  • RESULTS: NAAGA was found to totally inhibit adhesion of unstimulated leukocytes, or leukocytes activated with C5a, TNFalpha, or histamine, to TNFalpha-stimulated HUVECs (P=0.0001).
  • Similar results were obtained with endothelial cells stimulated by histamine or C5a.
  • At the molecular level, NAAGA inhibited histamine-induced expression of CD11b (P=0.0004) and CD49d (P=0.0045) on granulocytes.

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  • (PMID = 12527821.001).
  • [ISSN] 0181-5512
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD11b; 0 / Cell Adhesion Molecules; 0 / Dipeptides; 0 / E-Selectin; 0 / ICAM2 protein, human; 0 / Vascular Cell Adhesion Molecule-1; 126547-89-5 / Intercellular Adhesion Molecule-1; 143198-26-9 / Integrin alpha4; 3106-85-2 / N-acetyl-1-aspartylglutamic acid
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88. Dal Monte PR, Fiore E, Lodi L, Cremonini R: [Comparative study of gastric secretion after administration of histamine, betazole hydrochloride and mixed amino acids]. Boll Soc Ital Biol Sper; 1967 Feb 15;43(3):154-7
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  • [Title] [Comparative study of gastric secretion after administration of histamine, betazole hydrochloride and mixed amino acids].
  • [MeSH-major] Amino Acids / pharmacology. Gastric Juice / drug effects. Histamine / pharmacology. Pyrazoles / pharmacology

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  • (PMID = 6057664.001).
  • [ISSN] 0037-8771
  • [Journal-full-title] Bollettino della Società italiana di biologia sperimentale
  • [ISO-abbreviation] Boll. Soc. Ital. Biol. Sper.
  • [Language] ita
  • [Publication-type] Journal Article
  • [Publication-country] ITALY
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Pyrazoles; 820484N8I3 / Histamine
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89. Hindmarch I, Parrott AC: A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour. Arzneimittelforschung; 1978;28(3):483-6
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  • The side effects of five antihistamines (chlorpheniramine maleate, mebhydrolin, clemastine hydrogen fumarate, Tavegil; ketotifen, and promethazine hydrochloride) were measured on subjective assessments of sleep and the integrity of early morning behaviour and objective assessments of complex psychomotor behaviour and central nervous system arousal.
  • [MeSH-major] Arousal / drug effects. Histamine H1 Antagonists / adverse effects. Motor Skills / drug effects. Sleep / drug effects

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  • (PMID = 26361.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Histamine H1 Antagonists
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90. Maples MD, Lea JW 4th, O'Leary JP: Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg; 1981 Dec;47(12):519-21
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  • [Title] Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog.
  • Betazole hydrochloride, a histamine analogue that stimulates the H2 receptor, causes an immediate and significant increase in common bile duct pressure.

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  • (PMID = 7316286.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Guanidines; 0 / Pyrazoles; 1C065P542O / Betazole; 80061L1WGD / Cimetidine
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91. Simons KJ, Singh M, Gillespie CA, Simons FE: An investigation of the H1-receptor antagonist triprolidine: pharmacokinetics and antihistaminic effects. J Allergy Clin Immunol; 1986 Feb;77(2):326-30
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  • A single oral dose of triprolidine hydrochloride, 0.04 mg/kg (mean dose 2.7 +/- SD 0.4 mg) was administered to seven healthy, fasting adult volunteers who had never been treated previously with H1-receptor antagonists.
  • Blood sampling and intradermal tests with 0.01 ml of histamine phosphate (0.1 mg/ml) were performed at -0.25, 1, 2, 3, 4, 5, 6, 7, 8, and 12 hours after the dose.
  • [MeSH-minor] Adult. Chromatography, High Pressure Liquid. Half-Life. Histamine / pharmacology. Humans. Hypersensitivity, Immediate / etiology. Kinetics. Skin Tests

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  • (PMID = 3944383.001).
  • [ISSN] 0091-6749
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Pyridines; 2L8T9S52QM / Triprolidine; 820484N8I3 / Histamine
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92. Latch DE, Stender BL, Packer JL, Arnold WA, McNeill K: Photochemical fate of pharmaceuticals in the environment: cimetidine and ranitidine. Environ Sci Technol; 2003 Aug 1;37(15):3342-50
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  • The photochemical fates of the histamine H2-receptor antagonists cimetidine and ranitidine were studied.
  • Reaction of ranitidine hydrochloride with *OH proceeds with a rate constant of 1.5 +/- 0.2 x 10(10) M(-1) s(-1).
  • [MeSH-major] Cimetidine / chemistry. Histamine H2 Antagonists / chemistry. Ranitidine / chemistry

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  • (PMID = 12966980.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Environmental Pollutants; 0 / Histamine H2 Antagonists; 0 / Oxidants; 3352-57-6 / Hydroxyl Radical; 80061L1WGD / Cimetidine; 884KT10YB7 / Ranitidine
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93. Chow WH, Finkle WD, McLaughlin JK, Frankl H, Ziel HK, Fraumeni JF Jr: The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the esophagus and gastric cardia. JAMA; 1995 Aug 9;274(6):474-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Medications were grouped into H2 antagonists (cimetidine, ranitidine, famotidine, and nizatidine) and anticholinergics (propantheline bromide, dicyclomine hydrochloride, Donnatal [combination of atropine sulfate, hyoscyamine sulfate, phenobarbital, and scopolamine hydrobromide], and Librax [combination of chlordiazepoxide hydrochloride and clidinium bromide]).

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  • Hazardous Substances Data Bank. CHLORDIAZEPOXIDE .
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  • (PMID = 7629956.001).
  • [ISSN] 0098-7484
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CP / N01 CP 95680
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholinergic Antagonists; 0 / Drug Combinations; 0 / Histamine H2 Antagonists; 0 / Quinuclidines; 6RZ6XEZ3CR / Chlordiazepoxide; 8015-20-1 / chlordiazepoxide, clidinium drug combination
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94. Laitinen LA, Elkin RB, Empey DW, Jacobs L, Mills J, Nadel JA: Bronchial hyperresponsiveness in normal subjects during attenuated influenza virus infection. Am Rev Respir Dis; 1991 Feb;143(2):358-61
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  • Prior to administration of virus or placebo, histamine diphosphate aerosol increased airway resistance only slightly, and there was no difference between the virus and placebo groups.
  • Isoproterenol hydrochloride reversed and prevented the increase in airway resistance after histamine, suggesting that the bronchoconstriction was caused by smooth muscle contraction.
  • [MeSH-minor] Adult. Aerosols. Airway Resistance / drug effects. Bronchoconstriction / drug effects. Hemagglutination Inhibition Tests. Histamine / pharmacology. Humans. Isoproterenol / pharmacology. Male

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  • [CommentIn] Am Rev Respir Dis. 1991 Dec;144(6):1422-3 [1660232.001]
  • (PMID = 1990953.001).
  • [ISSN] 0003-0805
  • [Journal-full-title] The American review of respiratory disease
  • [ISO-abbreviation] Am. Rev. Respir. Dis.
  • [Language] eng
  • [Grant] United States / FIC NIH HHS / TW / F05TW2129; United States / NHLBI NIH HHS / HL / HL-14201
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Aerosols; 820484N8I3 / Histamine; L628TT009W / Isoproterenol
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95. Ogawa T, Ohhara H, Tsunoda H, Kuroki J, Shoji T: Cardiovascular effects of the new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate. 1st communication: studies on isolated guinea pig cardiac muscles. Arzneimittelforschung; 1989 Jan;39(1):33-7
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  • [Title] Cardiovascular effects of the new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate. 1st communication: studies on isolated guinea pig cardiac muscles.
  • Cardiotonic effects and the mechanism of action of 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride monohydrate (E-1020), a new cardiotonic agent, were investigated in vitro.
  • The inotropic effect of E-1020 on papillary muscles was not altered by treatment with beta-adrenoceptor or histamine H2-receptor blockade, but was attenuated by the muscarinic agonist, carbachol.
  • [MeSH-minor] Adrenergic beta-Antagonists / pharmacology. Animals. Carbachol / pharmacology. Cyclic AMP / metabolism. Guinea Pigs. Heart Rate / drug effects. Histamine H2 Antagonists / pharmacology. In Vitro Techniques. Isoproterenol / pharmacology. Male. Myocardial Contraction / drug effects. Myocardium / enzymology. Ouabain / pharmacology. Papillary Muscles / drug effects. Phosphoric Diester Hydrolases / metabolism. Sodium-Potassium-Exchanging ATPase / metabolism

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  • (PMID = 2566308.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] GERMANY, WEST
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Cardiotonic Agents; 0 / Histamine H2 Antagonists; 0 / Imidazoles; 0 / Pyridones; 4Y8BMI9YGC / olprinone; 5ACL011P69 / Ouabain; 8Y164V895Y / Carbachol; E0399OZS9N / Cyclic AMP; EC 3.1.4.- / Phosphoric Diester Hydrolases; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase; L628TT009W / Isoproterenol
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96. Watase F, Watanabe S, Kanai K, Yamada N, Sakaue S, Asano K, Hisamitsu T, Suzaki H: Modulation of eosinophil survival by epinastine hydrochloride, an H1 receptor antagonist, in vitro. In Vivo; 2008 Nov-Dec;22(6):687-91
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  • [Title] Modulation of eosinophil survival by epinastine hydrochloride, an H1 receptor antagonist, in vitro.
  • The influence of epinastine hydrochloride (EP) on eosinophil survival was examined by an in vitro cell culture technique.
  • [MeSH-major] Cell Survival / drug effects. Dibenzazepines / pharmacology. Eosinophils / cytology. Histamine H1 Antagonists / pharmacology. Imidazoles / pharmacology

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  • (PMID = 19180992.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Dibenzazepines; 0 / Histamine H1 Antagonists; 0 / Imidazoles; 0 / Tumor Necrosis Factor-alpha; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor; Q13WX941EF / epinastine
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97. Ichikawa T, Ishihara K, Kusakabe T, Kawakami T, Hotta K: Stimulant effect of nitric oxide generator and roxatidine on mucin biosynthesis of rat gastric oxyntic mucosa. Life Sci; 1999;65(4):PL41-6
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  • In this paper, we report the effect of the exogenous NO-donor, isosorbide dinitrate (ISDN), and second-generation histamine H2 receptor antagonist roxatidine (2-acetoxy-N-(3-[m-(1-piperidinylmethyl)phenoxy]propyl)acetamide hydrochloride) which is demonstrated to accelerate the mucin metabolism mediated by endogenous NO, on the mucin biosynthesis in distinct sites and layers of the rat gastric mucosa using an organ culture technique.
  • [MeSH-major] Gastric Mucosa / drug effects. Histamine H2 Antagonists / pharmacology. Isosorbide Dinitrate / pharmacology. Mucins / biosynthesis. Nitric Oxide / metabolism. Piperidines / pharmacology

  • Hazardous Substances Data Bank. NITRIC OXIDE .
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  • (PMID = 10421431.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] ENGLAND
  • [Chemical-registry-number] 0 / Histamine H2 Antagonists; 0 / Mucins; 0 / Piperidines; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type I; EC 1.14.13.39 / Nos1 protein, rat; IA7306519N / Isosorbide Dinitrate; N08U5BOQ1K / Glucosamine; ZUP3LSD0DO / roxatidine acetate
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98. NEW and nonofficial remedies: chlorcyclizine hydrochloride. J Am Med Assoc; 1952 Jan 26;148(4):286-7
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  • [Title] NEW and nonofficial remedies: chlorcyclizine hydrochloride.
  • [MeSH-major] Anti-Allergic Agents. Histamine H1 Antagonists. Piperazines

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  • (PMID = 14888466.001).
  • [ISSN] 0002-9955
  • [Journal-full-title] Journal of the American Medical Association
  • [ISO-abbreviation] J Am Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Not Available
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Histamine H1 Antagonists; 0 / Piperazines; M26C4IP44P / chlorcyclizine
  • [Other-IDs] CLML/ 5221:18835:29
  • [Keywords] NLM ; ANTIHISTAMINICS (major topic)
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99. Tanioka H, Terahara A, Sasaki Y: Radiographic assessment of nocturnal gastric juice secretion after administration of roxatidine acetate hydrochloride. Clin Ther; 1991 Jan-Feb;13(1):22-4
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  • [Title] Radiographic assessment of nocturnal gastric juice secretion after administration of roxatidine acetate hydrochloride.
  • The treatment group received 75 mg of roxatidine acetate hydrochloride at 9 PM and 12 to 13 hours later gastric juice secretion was measured with gastric x-ray films in both groups.
  • [MeSH-major] Gastric Juice / secretion. Histamine H2 Antagonists / pharmacology. Piperidines / pharmacology

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  • (PMID = 1674230.001).
  • [ISSN] 0149-2918
  • [Journal-full-title] Clinical therapeutics
  • [ISO-abbreviation] Clin Ther
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Histamine H2 Antagonists; 0 / Piperidines; ZUP3LSD0DO / roxatidine acetate
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100. Johansen S: [Opatanol]. Ugeskr Laeger; 2003 Jul 21;165(30):2957
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anti-Allergic Agents / administration & dosage. Anti-Inflammatory Agents, Non-Steroidal / administration & dosage. Conjunctivitis, Allergic / drug therapy. Dibenzoxepins / administration & dosage. Histamine H1 Antagonists / administration & dosage
  • [MeSH-minor] Humans. Olopatadine Hydrochloride. Ophthalmic Solutions. Tablets

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  • (PMID = 12926197.001).
  • [ISSN] 0041-5782
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Dibenzoxepins; 0 / Histamine H1 Antagonists; 0 / Ophthalmic Solutions; 0 / Tablets; 2XG66W44KF / Olopatadine Hydrochloride
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