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1. Goldberg RJ, Gore JM, Alpert JS, Dalen JE: Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study. Clin Cardiol; 1987 Jan;10(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study.
  • As part of an ongoing community-wide study of time trends in the incidence and case-fatality rates of patients hospitalized with acute myocardial infarction (MI) in all 16 Worcester, Massachusetts, metropolitan hospitals during the years 1975, 1978, 1981, and 1984, changes over time in the therapeutic management of 3263 patients with validated acute myocardial infarction were examined.
  • Lidocaine use increased between 1975 (31%) and 1978 (52%) and then leveled off to being used in approximately 45% of hospitalized patients with acute MI in 1981 and 1984.
  • A variety of demographic (e.g., age, sex, teaching hospital) and clinical characteristics (e.g., MI order, MI type, MI location, peak CPK findings, occurrence of acute clinical complications) were also associated with the use of these therapies for the combined study periods.
  • The results of this population-based study suggest considerable changes over time in the therapeutic management of patients hospitalized with acute myocardial infarction and of numerous patient demographic and clinical factors associated with their use.
  • [MeSH-major] Myocardial Infarction / drug therapy

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  • (PMID = 2880685.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Arrhythmia Agents; 0 / Nitrates; 73K4184T59 / Digoxin; 98PI200987 / Lidocaine
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2. Quah JL, Yap S, Cheah SO, Ng YY, Goh ES, Doctor N, Leong BS, Tiah L, Chia MY, Ong ME: Knowledge of signs and symptoms of heart attack and stroke among Singapore residents. Biomed Res Int; 2014;2014:572425
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Knowledge of signs and symptoms of heart attack and stroke among Singapore residents.
  • AIM: To determine the level of knowledge of signs and symptoms of heart attack and stroke in Singapore resident population, in comparison to the global community.
  • METHODS: A population based, random sample of 7,840 household addresses was selected from a validated national sampling frame.
  • Each participant was asked eight questions on signs and symptoms of heart attack and 10 questions on stroke.
  • The level of knowledge for preselected, common signs and symptoms of heart attack and stroke was 57.8% and 57.1%, respectively.
  • The respondents scored a mean of 5.0 (SD 2.4) out of 8 for heart attack, while they scored a mean of 6.8 (SD 2.9) out of 10 for stroke.
  • The level of knowledge of signs and symptoms of heart attack and stroke in Singapore is comparable to USA and Canada.
  • CONCLUSION: We found a comparable knowledge of stroke and heart attack signs and symptoms in the community to countries within the same economic, educational, and healthcare strata.
  • [MeSH-major] Health Knowledge, Attitudes, Practice. Heart Failure / epidemiology. Stroke / epidemiology
  • [MeSH-minor] Adult. Data Collection. Demography. Female. Humans. Logistic Models. Middle Aged. Risk Factors. Singapore / epidemiology

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  • [Cites] N Engl J Med. 1995 Dec 14;333(24):1581-7 [7477192.001]
  • [Cites] Ann Emerg Med. 1994 Feb;23(2):311-29 [8304613.001]
  • [Cites] Intern Med J. 2005 May;35(5):279-82 [15845109.001]
  • [Cites] Am Heart J. 2005 Sep;150(3):392-400 [16169313.001]
  • [Cites] Stroke. 2006 May;37(5):1248-53 [16556885.001]
  • [Cites] PLoS Med. 2006 Nov;3(11):e442 [17132052.001]
  • [Cites] JAMA. 2010 Apr 14;303(14):1392-400 [20388895.001]
  • [Cites] Eur J Emerg Med. 2011 Oct;18(5):268-71 [21317785.001]
  • [Cites] BMC Public Health. 2012;12:283 [22490185.001]
  • [Cites] Heart. 2000 Apr;83(4):388-93 [10722534.001]
  • [Cites] JAMA. 2000 Jun 28;283(24):3223-9 [10866870.001]
  • [Cites] BMC Public Health. 2001;1:14 [11734071.001]
  • [Cites] Neurology. 2002 Nov 26;59(10):1547-52 [12451195.001]
  • [Cites] Emerg Med (Fremantle). 2002 Sep;14(3):255-60 [12487042.001]
  • [Cites] JAMA. 2003 Jan 15;289(3):343-6 [12525235.001]
  • [Cites] MMWR Morb Mortal Wkly Rep. 2004 May 7;53(17):359-62 [15129192.001]
  • [Cites] Circulation. 1990 Aug;82(2):664-707 [2197021.001]
  • [Cites] Arch Intern Med. 1993 Nov 22;153(22):2558-61 [7598755.001]
  • [Cites] Med J Aust. 1997 Mar 3;166(5):233-6 [9076265.001]
  • (PMID = 24812623.001).
  • [ISSN] 2314-6141
  • [Journal-full-title] BioMed research international
  • [ISO-abbreviation] Biomed Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4000924
  •  go-up   go-down


3. Esmaeili R, Sadeghpour A, Darbandi-Azar A, Majidzadeh-A K, Vajhi A, Sadeghizadeh M: Echocardiographic assessment of myocardial infarction: comparison of a rat model in two strains. Iran J Vet Res; 2017;18(1):30-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Echocardiographic assessment of myocardial infarction: comparison of a rat model in two strains.
  • The purpose of this study was to induce myocardial infarction (MI) and compare the echocardiographic parameters and mortality ratio of Lewis inbred and Wistar outbred strain before and after the procedure to help choose the best one for MI studies.
  • In this study MI was induced in 46 Lewis and 34 Wistar by occlusion of left anterior descending artery (LAD).
  • Interventricular septum diastolic and systolic dimension (IVSd, s), diastolic and systolic left ventricular internal diameter (LVIDd, s), diastolic and systolic left ventricular posterior wall dimension (LVPWd, s), ejection fraction (EF), and fractional shortening (FS).
  • The significant changes were observed in systolic IVS, LVID and EF and FS before and after MI and no significant difference was detected between Lewis and Wistar.
  • As a conclusion the echocardiographic parameters of these two strains were similar, but according to mortality rate and more cardiac anatomic variation in Lewis rats, Wistar is better for MI studies.

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  • [Cites] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3324-9 [10716731.001]
  • [Cites] J Am Soc Echocardiogr. 2004 Feb;17(2):161-7 [14752491.001]
  • [Cites] Eur J Heart Fail. 2009 Feb;11(2):147-53 [19168512.001]
  • [Cites] PLoS One. 2012;7(6):e40061 [22768220.001]
  • [Cites] Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1168-73 [15831811.001]
  • [Cites] J Heart Lung Transplant. 2010 Sep;29(9):1039-46 [20488730.001]
  • [Cites] J Am Coll Cardiol. 1997 Dec;30(7):1765-72 [9385905.001]
  • [Cites] Cardiovasc Ultrasound. 2011 May 26;9:15 [21615917.001]
  • [Cites] Anticancer Res. 2015 Feb;35(2):989-95 [25667486.001]
  • [Cites] Hypertension. 2001 Feb;37(2):209-15 [11230273.001]
  • [Cites] Cardiovasc Ultrasound. 2012 Apr 03;10 :17 [22471966.001]
  • [Cites] Am J Physiol. 1997 Feb;272(2 Pt 2):H722-7 [9124430.001]
  • [Cites] Cardiovasc Res. 2007 Apr 1;74(1):29-38 [17188668.001]
  • [Cites] Eur J Pharmacol. 2013 Aug 15;714(1-3):456-63 [23850947.001]
  • [Cites] Lab Anim Sci. 1987 Dec;37(6):743-9 [3437750.001]
  • [Cites] Circulation. 1994 Nov;90(5):2457-67 [7955203.001]
  • [Cites] Lab Anim. 2008 Apr;42(2):171-84 [18435875.001]
  • [Cites] Arq Bras Cardiol. 2009 Oct;93(4):434-40, 426-32 [19936465.001]
  • [Cites] Biochem Biophys Res Commun. 2007 Jun 8;357(3):779-84 [17445769.001]
  • [Cites] Cardiovasc Res. 2009 Nov 1;84(2):273-82 [19542177.001]
  • [Cites] J Appl Physiol (1985). 1993 May;74(5):2598-605 [8335596.001]
  • [Cites] Lancet. 2008 Aug 16;372(9638):570-84 [18707987.001]
  • [Cites] Circulation. 1996 Feb 15;93(4):800-9 [8641010.001]
  • [Cites] Vet Anaesth Analg. 2005 Sep;32(5):261-70 [16135207.001]
  • [Cites] Biomaterials. 2012 Mar;33(7):2127-36 [22169824.001]
  • [Cites] Lab Anim. 2007 Jul;41(3):337-44 [17640461.001]
  • [Cites] Res Cardiovasc Med. 2014 Nov 01;3(4):e22941 [25785251.001]
  • [Cites] Sci Transl Med. 2014 Dec 10;6(266):266ra170 [25504881.001]
  • [Cites] J Chemother. 2017 Feb;29(1):49-53 [25579322.001]
  • (PMID = 28588630.001).
  • [ISSN] 1728-1997
  • [Journal-full-title] Iranian journal of veterinary research
  • [ISO-abbreviation] Iran J Vet Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Keywords] NOTNLM ; Echocardiography / Lewis / Mortality ratio / Myocardial infarction / Rat model
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4. Bastakoty D, Saraswati S, Joshi P, Atkinson J, Feoktistov I, Liu J, Harris JL, Young PP: Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct. Cell Stem Cells Regen Med; 2016 Nov;2(2)

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temporary, Systemic Inhibition of the WNT/β-Catenin Pathway promotes Regenerative Cardiac Repair following Myocardial Infarct.
  • AIMS: The WNT/β-catenin pathway is temporarily activated in the heart following myocardial infarction (MI).
  • Despite data from genetic models indicating both positive and negative roles for the WNT pathway depending on the model used, the effect of therapeutic inhibition of WNT pathway on post-injury outcome and the cellular mediators involved are not completely understood.
  • Using a newly available, small molecule, GNF-6231, which averts WNT pathway activation by blocking secretion of all WNT ligands, we sought to investigate whether therapeutic inhibition of the WNT pathway temporarily after infarct can mitigate post injury cardiac dysfunction and fibrosis and the cellular mechanisms responsible for the effects.
  • METHODS AND RESULTS: Pharmacologic inhibition of the WNT pathway by post-MI intravenous injection of GNF-6231 in C57Bl/6 mice significantly reduced the decline in cardiac function (Fractional Shortening at day 30: 38.71 ± 4.13% in GNF-6231 treated vs. 34.89 ± 4.86% in vehicle-treated), prevented adverse cardiac remodeling, and reduced infarct size (9.07 ± 3.98% vs. 17.18 ± 4.97%).
  • WNT inhibition augmented proliferation of interstitial cells, particularly in the distal myocardium, inhibited apoptosis of cardiomyocytes, and reduced myofibroblast proliferation in the peri-infarct region.
  • <i>In vitro</i> studies showed that WNT inhibition increased proliferation of Sca1<sup>+</sup> cardiac progenitors, improved survival of cardiomyocytes, and inhibited collagen I synthesis by cardiac myofibroblasts.
  • CONCLUSION: Systemic, temporary pharmacologic inhibition of the WNT pathway using an orally bioavailable drug immediately following MI resulted in improved function, reduced adverse remodeling and reduced infarct size in mice.
  • Therapeutic WNT inhibition affected multiple aspects of infarct repair: it promoted proliferation of cardiac progenitors and other interstitial cells, inhibited myofibroblast proliferation, improved cardiomyocyte survival, and reduced collagen I gene expression by myofibroblasts.
  • Our data point to a promising role for WNT inhibitory therapeutics as a new class of drugs to drive post-MI repair and prevent heart failure.

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  • [Cites] Circ Res. 2010 Nov 26;107(11):1304-12 [21106947.001]
  • [Cites] Circ Res. 2011 Dec 9;109(12):1363-74 [22034491.001]
  • [Cites] J Biol Chem. 1998 Mar 6;273(10 ):5423-6 [9488659.001]
  • [Cites] FASEB J. 2015 Dec;29(12 ):4881-92 [26268926.001]
  • [Cites] Cell Stem Cell. 2008 Jan 10;2(1):50-9 [18371421.001]
  • [Cites] Nat Chem Biol. 2010 Nov;6(11):829-36 [20890287.001]
  • [Cites] J Biol Chem. 2006 Oct 13;281(41):30979-89 [16920707.001]
  • [Cites] Cardiovasc Diagn Ther. 2012 Dec;2(4):278-89 [24282728.001]
  • [Cites] J Mol Cell Cardiol. 2015 Aug;85:215-25 [26071893.001]
  • [Cites] Cancer Res. 2014 Sep 1;74(17 ):4811-21 [24994715.001]
  • [Cites] PLoS One. 2013 Nov 04;8(11):e79374 [24223934.001]
  • [Cites] Nat Med. 1997 May;3(5):541-4 [9142123.001]
  • [Cites] Circ Res. 2010 Nov 12;107(10 ):1198-208 [21071717.001]
  • [Cites] Nature. 2003 Oct 9;425(6958):633-7 [14534590.001]
  • [Cites] PLoS One. 2010 Nov 29;5(11):e15521 [21170416.001]
  • [Cites] Mol Cell Biol. 2007 Nov;27(21):7551-9 [17785439.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18366-71 [19017790.001]
  • [Cites] Development. 2003 Nov;130(22):5297-305 [14530294.001]
  • [Cites] Rev Esp Cardiol. 2009 Feb;62(2):199-209 [19232193.001]
  • [Cites] Basic Res Cardiol. 2010 Sep;105(5):631-41 [20373104.001]
  • [Cites] Cell Rep. 2013 Jan 31;3(1):70-8 [23352663.001]
  • [Cites] J Mol Cell Cardiol. 2009 Mar;46(3):370-7 [19109969.001]
  • [Cites] Nat Rev Drug Discov. 2014 Jul;13(7):513-32 [24981364.001]
  • [Cites] Cell Stem Cell. 2011 Feb 4;8(2):214-27 [21295277.001]
  • [Cites] Dis Model Mech. 2011 Jul;4(4):469-83 [21324930.001]
  • [Cites] Dev Biol. 2011 Aug 15;356(2):421-31 [21663736.001]
  • [Cites] Nat Rev Cancer. 2013 Jan;13(1):11-26 [23258168.001]
  • [Cites] ACS Med Chem Lett. 2016 May 10;7(7):676-80 [27437076.001]
  • [Cites] Circulation. 2011 Oct 11;124(15):1626-35 [21931076.001]
  • [Cites] Circ Res. 2015 Oct 9;117(9):804-16 [26338900.001]
  • [Cites] J Am Soc Nephrol. 2009 Apr;20(4):765-76 [19297557.001]
  • [Cites] J Pharmacol Exp Ther. 2012 Jun;341(3):764-74 [22431204.001]
  • [Cites] Circ Res. 2009 Feb 27;104(4):e30-41 [19213953.001]
  • [Cites] Circ Res. 2007 May 11;100(9):1353-62 [17413044.001]
  • [Cites] Cell. 2001 May 18;105(4):533-45 [11371349.001]
  • [Cites] Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57 [22645348.001]
  • [Cites] Cancer Res. 2007 Jan 1;67(1):75-84 [17210685.001]
  • [Cites] Development. 2005 Jan;132(1):215-25 [15576399.001]
  • [Cites] Braz J Med Biol Res. 2011 Sep;44(9):890-8 [21829898.001]
  • [Cites] Circulation. 2015 Jan 27;131(4):e29-322 [25520374.001]
  • [Cites] Cold Spring Harb Perspect Biol. 2012 Sep 01;4(9):a007971 [22952393.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19762-7 [19073933.001]
  • [Cites] Am J Physiol Heart Circ Physiol. 2013 Nov 1;305(9):H1363-72 [23997102.001]
  • [Cites] Nat Commun. 2012 Mar 13;3:735 [22415826.001]
  • [Cites] EMBO J. 2012 Jan 18;31(2):429-42 [22085926.001]
  • [Cites] Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21110-5 [21078975.001]
  • [Cites] Circulation. 2003 Nov 4;108(18):2282-9 [14581414.001]
  • [Cites] Circ Res. 2010 May 28;106(10):1635-45 [20360256.001]
  • [Cites] Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1643-8 [17251350.001]
  • [Cites] Trends Mol Med. 2012 Aug;18(8):483-93 [22796206.001]
  • [Cites] Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9 [24277854.001]
  • [Cites] Circulation. 2000 Jun 27;101(25):2981-8 [10869273.001]
  • [Cites] Science. 2007 Aug 10;317(5839):807-10 [17690295.001]
  • (PMID = 28042617.001).
  • [Journal-full-title] Cell, stem cells and regenerative medicine
  • [ISO-abbreviation] Cell Stem Cells Regen Med
  • [Language] eng
  • [Grant] United States / BLRD VA / BX / I01 BX002337; United States / NIGMS NIH HHS / GM / R01 GM118300; United States / NIBIB NIH HHS / EB / R21 EB019509; United States / NCRR NIH HHS / RR / UL1 RR024975
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Myocardial infarct / Regenerative cardiac repair / WNT/β-Catenin Pathway
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5. Oser CS, Gohdes D, Fogle CC, Tadios F, Doore V, Bell DS, Harwell TS, Helgerson SD: Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010. Prev Chronic Dis; 2013 May 16;10:E80
MedlinePlus Health Information. consumer health - Stroke.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010.
  • INTRODUCTION: National initiatives to improve the recognition of heart attack and stroke warning signs have encouraged symptomatic people to seek early treatment, but few have shown significant effects in rural American Indian (AI) communities.
  • METHODS: During 2009 and 2010, the Montana Cardiovascular Health Program, in collaboration with 2 tribal health departments, developed and conducted culturally specific public awareness campaigns for signs and symptoms of heart attack and stroke via local media.
  • RESULTS: Knowledge of 3 or more heart attack warning signs and symptoms increased significantly on 1 reservation from 35% at baseline to 47% postcampaign.
  • On the second reservation, recognition of 2 or more stroke signs and symptoms increased from 62% at baseline to 75% postcampaign, and the level of awareness remained at 73% approximately 4 months after the high-intensity campaign advertisements ended.
  • Intent to call 9-1-1 did not increase in the heart attack campaign but did improve in the stroke campaign for specific symptoms.
  • Recall of media campaigns on both reservations increased significantly from baseline to postcampaign for both media outlets (ie, radio and newspaper).
  • CONCLUSION: Carefully designed, culturally specific campaigns may help eliminate disparities in the recognition of heart attack and stroke warning signs in AI communities.

  • MedlinePlus Health Information. consumer health - Native American Health.
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  • [Cites] Am J Epidemiol. 1998 Jun 1;147(11):995-1008 [9620042.001]
  • [Cites] Circulation. 1999 May 11;99(18):2389-95 [10318659.001]
  • [Cites] Prev Chronic Dis. 2004 Jul;1(3):A07 [15670428.001]
  • [Cites] Am J Prev Med. 2005 Apr;28(3):295-7 [15766619.001]
  • [Cites] Circulation. 2005 Oct 11;112(15):2263-7 [16203905.001]
  • [Cites] Circulation. 2006 Jul 11;114(2):168-82 [16801458.001]
  • [Cites] Ethn Dis. 2006 Summer;16(3):647-52 [16937600.001]
  • [Cites] Ethn Dis. 2006 Spring;16(2):345-50 [17682234.001]
  • [Cites] MMWR Morb Mortal Wkly Rep. 2008 Feb 22;57(7):175-9 [18288076.001]
  • [Cites] J Public Health Manag Pract. 2008 May-Jun;14(3):e17-22 [18408540.001]
  • [Cites] Ethn Dis. 2008 Spring;18(2):192-7 [18507273.001]
  • [Cites] Circulation. 2008 Oct 7;118(15):1577-84 [18809797.001]
  • [Cites] Prog Community Health Partnersh. 2011 Fall;5(3):273-9 [22080775.001]
  • [Cites] Stroke. 2001 Jan;32(1):280-99 [11136952.001]
  • [Cites] JAMA. 1998 Apr 22-29;279(16):1288-92 [9565010.001]
  • (PMID = 23680509.001).
  • [ISSN] 1545-1151
  • [Journal-full-title] Preventing chronic disease
  • [ISO-abbreviation] Prev Chronic Dis
  • [Language] ENG
  • [Grant] United States / NCCDPHP CDC HHS / DP / U50 DP000736; United States / NCCDPHP CDC HHS / DP / 5U50DP000736-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3666974
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6. Bahr RD: The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000. J Cardiovasc Manag; 1995 May-Jun;6(3):19-23
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000.
  • Within the last four years, more than 500 chest pain centers have developed in response to new paradigms for early heart attack care.
  • These shifting paradigms now focus on acute prevention, in terms of both early thrombolytic therapy and cardioprotection of patients with prodromal symptoms of a heart attack.
  • [MeSH-major] Cardiology Service, Hospital. Health Promotion / trends. Myocardial Infarction / therapy
  • [MeSH-minor] Cardiopulmonary Resuscitation. Chest Pain / diagnosis. Health Education. Humans. Pain Clinics. Thrombolytic Therapy / trends. United States

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  • (PMID = 10143350.001).
  • [ISSN] 1053-5330
  • [Journal-full-title] The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators
  • [ISO-abbreviation] J Cardiovasc Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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7. Dodsworth S: Patient's wishes are paramount in resuscitation. Nurs Stand; 2000 Apr 26;14(32):28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : My partner had a heart attack 18 months ago and he found it really distressing to be observed by his loved ones at his most vulnerable - you cannot get more vulnerable than lying bare chested and intubated on a resuscitation trolley.

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  • (PMID = 27959210.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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8. Valgimigli M, Costa F, Lokhnygina Y, Clare RM, Wallentin L, Moliterno DJ, Armstrong PW, White HD, Held C, Aylward PE, Van de Werf F, Harrington RA, Mahaffey KW, Tricoci P: Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial. Eur Heart J; 2017 Mar 14;38(11):804-810

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial.
  • Aims: Dual antiplatelet therapy reduces non-fatal ischaemic events after acute coronary syndrome (ACS) but increases bleeding to a similar extent.
  • We sought to determine the prognostic impact of myocardial infarction (MI) vs. bleeding during an extended follow-up period to gain insight into the trade-off between efficacy and safety among patients after ACS.
  • Methods and results: In 12 944 patients with non-ST-segment elevation ACS from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial, we investigated the relative impact of MI and bleeding occurring >30 days post-ACS and subsequent all-cause mortality.
  • MI was associated with a five-fold increase in mortality.
  • MI was associated with a greater risk of mortality compared with BARC 2 [relative risk (RR) 3.5; 95% confidence interval (CI) 2.08-4.77; P < 0.001] and BARC 3a bleeding (RR 2.23; 95% CI 1.36-3.64; P = 0.001), and a risk similar to BARC 3b bleeding (RR 1.37; 95% CI 0.81-2.30; P = 0.242).
  • Risk of death after MI was significantly lower than after BARC 3c bleeding (RR 0.22; 95% CI 0.13-0.36; P < 0.001).
  • MI and bleeding had similar time-associations with mortality, which remained significant for several months, still being higher early after the event.
  • Conclusion: In patients treated with antiplatelet therapy after ACS, both MI and bleeding significantly impacted mortality with similar time-dependency.
  • Although BARC 2 and 3a bleeding were less prognostic for death than MI, the risk of mortality was equivalent between BARC 3b bleeding and MI, and was higher following BARC 3c bleeding.

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  • (PMID = 28363222.001).
  • [ISSN] 1522-9645
  • [Journal-full-title] European heart journal
  • [ISO-abbreviation] Eur. Heart J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Acute coronary syndrome / Bleeding / DAPT / Myocardial infarction
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9. Silvet H, Spencer F, Yarzebski J, Lessard D, Gore JM, Goldberg RJ: Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med; 2003 Oct 13;163(18):2175-83
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study.
  • BACKGROUND: Despite the benefits associated with beta-blocker therapy in patients with acute myocardial infarction (AMI), limited recent data are available describing the extent of use of this therapy and the associated hospital and long-term outcomes, particularly from the perspective of a population-based study.
  • Data are also limited about the characteristics of patients with AMI who do not receive beta-blockers.
  • This study examines more than 2 decades of trends in the use of beta-blockers in hospitalized patients with AMI.
  • METHODS: Communitywide study of 10,374 patients hospitalized with confirmed AMI in all metropolitan Worcester hospitals during 12 annual periods between 1975 and 1999.
  • After controlling for other prognostic factors, patients treated with beta-blockers were less likely to develop heart failure (adjusted odds ratio [OR], 0.58; 95% confidence interval [CI], 0.53-0.63), cardiogenic shock (OR, 0.46; 95% CI, 0.39-0.54), and primary ventricular fibrillation (OR, 0.84; 95% CI, 0.65-1.08) and were less likely to die (OR, 0.26; 95% CI, 0.22-0.29) during hospitalization than were patients who did not receive this therapy.
  • CONCLUSIONS: The results of this observational study demonstrate encouraging trends in the use of beta-blockers in hospitalized patients with AMI and document the benefits to be gained from this treatment.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Myocardial Infarction / drug therapy. Practice Patterns, Physicians' / trends

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  • (PMID = 14557215.001).
  • [ISSN] 0003-9926
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL35434
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists
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10. Early warning signs of fatal heart attacks 'being missed' in hospitals. Nurs Stand; 2017 Mar 22;31(30):17

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early warning signs of fatal heart attacks 'being missed' in hospitals.
  • Symptoms may have been missed in up to one in six patients who died of a heart attack in hospital in England, new study results suggest.

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  • (PMID = 28327044.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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