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2. Rorabaugh BR, Seeley SL, Stoops TS, D'Souza MS: Repeated exposure to methamphetamine induces sex-dependent hypersensitivity to ischemic injury in the adult rat heart. PLoS One; 2017;12(6):e0179129
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  • [Title] Repeated exposure to methamphetamine induces sex-dependent hypersensitivity to ischemic injury in the adult rat heart.
  • BACKGROUND: We previously reported that adult female, but not male rats that were prenatally exposed to methamphetamine exhibit myocardial hypersensitivity to ischemic injury.
  • The goal of this study was to determine whether methamphetamine exposure during adulthood sensitizes the heart to ischemic injury.
  • METHODS: Adult male and female rats received daily injections of methamphetamine (5 mg/kg) or saline for 10 days.
  • Their hearts were isolated on day 11 and subjected to a 20 min ischemic insult on a Langendorff isolated heart apparatus.
  • Cardiac contractile function was measured by an intraventricular balloon, and infarct size was measured by triphenyltetrazolium chloride staining.
  • RESULTS: Hearts from methamphetamine-treated females exhibited significantly larger infarcts and suppressed postischemic recovery of contractile function compared to hearts from saline-treated females.
  • In contrast, methamphetamine had no effect on infarct size or contractile recovery in male hearts.
  • Subsequent experiments demonstrated that hypersensitivity to ischemic injury persisted in female hearts following a 1 month period of abstinence from methamphetamine.
  • Myocardial protein kinase C-ε expression, Akt phosphorylation, and ERK phosphorylation were unaffected by adult exposure to methamphetamine.
  • CONCLUSIONS: Exposure of adult rats to methamphetamine sex-dependently increases the extent of myocardial injury following an ischemic insult.
  • These data suggest that women who have a heart attack might be at risk of more extensive myocardial injury if they have a recent history of methamphetamine abuse.
  • [MeSH-major] Central Nervous System Stimulants / adverse effects. Heart / drug effects. Heart / physiopathology. Methamphetamine / adverse effects. Myocardial Infarction / etiology. Myocardial Ischemia / complications
  • [MeSH-minor] Animals. Female. Male. Myocardial Contraction / drug effects. Myocardium / pathology. Rats. Rats, Sprague-Dawley. Sex Factors

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  • (PMID = 28575091.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Central Nervous System Stimulants; 44RAL3456C / Methamphetamine
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3. Goldberg RJ, Gore JM, Alpert JS, Dalen JE: Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study. Clin Cardiol; 1987 Jan;10(1):3-8
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  • [Title] Therapeutic trends in the management of patients with acute myocardial infarction (1975-1984): the Worcester Heart Attack Study.
  • As part of an ongoing community-wide study of time trends in the incidence and case-fatality rates of patients hospitalized with acute myocardial infarction (MI) in all 16 Worcester, Massachusetts, metropolitan hospitals during the years 1975, 1978, 1981, and 1984, changes over time in the therapeutic management of 3263 patients with validated acute myocardial infarction were examined.
  • Lidocaine use increased between 1975 (31%) and 1978 (52%) and then leveled off to being used in approximately 45% of hospitalized patients with acute MI in 1981 and 1984.
  • A variety of demographic (e.g., age, sex, teaching hospital) and clinical characteristics (e.g., MI order, MI type, MI location, peak CPK findings, occurrence of acute clinical complications) were also associated with the use of these therapies for the combined study periods.
  • The results of this population-based study suggest considerable changes over time in the therapeutic management of patients hospitalized with acute myocardial infarction and of numerous patient demographic and clinical factors associated with their use.
  • [MeSH-major] Myocardial Infarction / drug therapy

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  • (PMID = 2880685.001).
  • [ISSN] 0160-9289
  • [Journal-full-title] Clinical cardiology
  • [ISO-abbreviation] Clin Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists; 0 / Anti-Arrhythmia Agents; 0 / Nitrates; 73K4184T59 / Digoxin; 98PI200987 / Lidocaine
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4. Patel MD, Wu D, Chase MR, Mavros P, Heithoff K, Hanson ME, Simpson RJ Jr: Antiplatelet Therapy and Clinical Outcomes Following Myocardial Infarction Among Patients in a U.S. Employer-Based Insurance Database. J Manag Care Spec Pharm; 2017 Jun;23(6):684-690

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antiplatelet Therapy and Clinical Outcomes Following Myocardial Infarction Among Patients in a U.S. Employer-Based Insurance Database.
  • BACKGROUND: Estimates of residual cardiovascular risks among patients who have experienced a recent acute myocardial infarction (MI) are predominantly derived from secondary prevention trial populations, patient registries, and population-based cohorts.
  • OBJECTIVE: To generate real-world evidence of antiplatelet treatment and recurrent events following MI in patients on antiplatelet treatment among commercial, employer-based insured patients in a large administrative database.
  • METHODS: This was a retrospective cohort claims database study using the Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental databases between 2007-2011.
  • Patients with an acute MI hospitalization with a discharge date between 2008 and 2010 were included.
  • Excluded were those patients with documentation of stroke, transient ischemic attack (TIA), or severe bleeding at or before index hospitalization and with concomitant use of anticoagulant therapy following index hospitalization.
  • Patients treated with clopidogrel following the index MI hospitalization were followed up to 1 year for repeat MI, stroke, and coronary revascularization.
  • RESULTS: Among 33,943 post-MI continuous clopidogrel users without history of stroke, TIA, or bleeding, 22% had diabetes, whereas angina and renal impairment were less prevalent (5% and 7%, respectively).
  • Over the 1-year follow-up, 2.4% experienced a repeat MI or stroke, and 8.2% underwent coronary revascularization.
  • Angina, diabetes, and renal impairment were associated with elevated 1-year risk of repeat MI or stroke.
  • CONCLUSIONS: This study suggests that there is residual cardiovascular risk, although relatively low, in an insured, secondary prevention population on antiplatelet treatment following an MI.
  • In patients with MI, identifying angina, diabetes, and renal impairment may aid risk stratification and guide the effective management of these higher-risk patients.

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  • (PMID = 28530518.001).
  • [ISSN] 2376-1032
  • [Journal-full-title] Journal of managed care & specialty pharmacy
  • [ISO-abbreviation] J Manag Care Spec Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Oser CS, Gohdes D, Fogle CC, Tadios F, Doore V, Bell DS, Harwell TS, Helgerson SD: Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010. Prev Chronic Dis; 2013 May 16;10:E80
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  • [Title] Cooperative strategies to develop effective stroke and heart attack awareness messages in rural american Indian communities, 2009-2010.
  • INTRODUCTION: National initiatives to improve the recognition of heart attack and stroke warning signs have encouraged symptomatic people to seek early treatment, but few have shown significant effects in rural American Indian (AI) communities.
  • METHODS: During 2009 and 2010, the Montana Cardiovascular Health Program, in collaboration with 2 tribal health departments, developed and conducted culturally specific public awareness campaigns for signs and symptoms of heart attack and stroke via local media.
  • RESULTS: Knowledge of 3 or more heart attack warning signs and symptoms increased significantly on 1 reservation from 35% at baseline to 47% postcampaign.
  • On the second reservation, recognition of 2 or more stroke signs and symptoms increased from 62% at baseline to 75% postcampaign, and the level of awareness remained at 73% approximately 4 months after the high-intensity campaign advertisements ended.
  • Intent to call 9-1-1 did not increase in the heart attack campaign but did improve in the stroke campaign for specific symptoms.
  • Recall of media campaigns on both reservations increased significantly from baseline to postcampaign for both media outlets (ie, radio and newspaper).
  • CONCLUSION: Carefully designed, culturally specific campaigns may help eliminate disparities in the recognition of heart attack and stroke warning signs in AI communities.

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  • (PMID = 23680509.001).
  • [ISSN] 1545-1151
  • [Journal-full-title] Preventing chronic disease
  • [ISO-abbreviation] Prev Chronic Dis
  • [Language] ENG
  • [Grant] United States / NCCDPHP CDC HHS / DP / U50 DP000736; United States / NCCDPHP CDC HHS / DP / 5U50DP000736-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3666974
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7. Ratkov I, Sipetić S, Vlajinac H, Sekeres B: [Mortality from heart attack in Belgrade population during the period 1990-2004]. Srp Arh Celok Lek; 2008 Nov-Dec;136(11-12):598-602
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  • [Title] [Mortality from heart attack in Belgrade population during the period 1990-2004].
  • INTRODUCTION: In most countries, cardiovascular diseases are the leading disorders, with ischemic heart diseases being the leading cause of death.
  • According to WHO data, every year about 17 million people die of cardiovascular diseases, which is 30% of all deaths.
  • Ischemic heart diseases contribute from one-third to one-half of all deaths due to cardiovascular diseases.
  • Three point eight million men and 3.4 million women in the world die every year from ischemic heart diseases, and in Europe about 2 million.
  • The highest mortality rate from ischemic heart diseases occurs in India, China and Russia.
  • OBJECTIVE: The aim of this descriptive epidemiological study was to determine heart attack mortality in Belgrade population during the period 1990-2004.
  • METHOD: In the study, we conducted investigation of Belgrade population during the period 1990-2004.
  • The mortality rates were standardized using the direct method of standardization according to the world (Segi) standard population.
  • RESULTS: In the Belgrade population during the period 1990-2004, the participation of mortality rate due to heart attack among deaths from cardiovascular diseases was 17% in males and 10% in females.
  • In Belgrade male population, mean standardized mortality rates (per 100,000 habitants) were 50.5 for heart attack, 8.3 for chronic ischemic heart diseases and 4.6 for angina pectoris, while in females the rates were 30.8, 6.7 and 4.2, respectively.
  • Mortality from ischemic heart diseases and from heart attack was higher in males than in females.
  • During the studied 15-year period, on average 755 males and 483 females died due to heart attack every year.
  • Males died 1.6 times more frequently from heart attack than females.
  • During the studied period, mean standardized mortality rates from heart attack, in the population aged over 30 increased with age both in male and female population.
  • However, males tended to die from heart attack at an earlier age than females, with death rates for males approximately the same as those for women who were 10 years older.
  • CONCLUSION: In Belgrade during the period from 1990-2004, we found that there was an increasing trend in mortality rate due to cardiovascular diseases, while the trend of mortality rate from heart attack was constant with insignificant oscillations.
  • [MeSH-major] Myocardial Infarction / mortality

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  • (PMID = 19177820.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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8. Bahr RD: The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000. J Cardiovasc Manag; 1995 May-Jun;6(3):19-23
MedlinePlus Health Information. consumer health - Heart Attack.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The EHAC (early heart attack care) strategy: Citizens Chart the Course for Healthy People in the Year 2000.
  • Within the last four years, more than 500 chest pain centers have developed in response to new paradigms for early heart attack care.
  • These shifting paradigms now focus on acute prevention, in terms of both early thrombolytic therapy and cardioprotection of patients with prodromal symptoms of a heart attack.
  • [MeSH-major] Cardiology Service, Hospital. Health Promotion / trends. Myocardial Infarction / therapy
  • [MeSH-minor] Cardiopulmonary Resuscitation. Chest Pain / diagnosis. Health Education. Humans. Pain Clinics. Thrombolytic Therapy / trends. United States

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  • (PMID = 10143350.001).
  • [ISSN] 1053-5330
  • [Journal-full-title] The Journal of cardiovascular management : the official journal of the American College of Cardiovascular Administrators
  • [ISO-abbreviation] J Cardiovasc Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] UNITED STATES
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9. Traffic noise increases the risk of heart attack in men. Nurs Stand; 2005 Mar 02;19(25):10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Traffic noise increases the risk of heart attack in men.
  • : Chronic exposure to high levels of traffic noise increases the risk for cardiovascular diseases in men but not in women.

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  • (PMID = 28055466.001).
  • [ISSN] 2047-9018
  • [Journal-full-title] Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • [ISO-abbreviation] Nurs Stand
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Silvet H, Spencer F, Yarzebski J, Lessard D, Gore JM, Goldberg RJ: Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study. Arch Intern Med; 2003 Oct 13;163(18):2175-83
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  • [Title] Communitywide trends in the use and outcomes associated with beta-blockers in patients with acute myocardial infarction: the Worcester Heart Attack Study.
  • BACKGROUND: Despite the benefits associated with beta-blocker therapy in patients with acute myocardial infarction (AMI), limited recent data are available describing the extent of use of this therapy and the associated hospital and long-term outcomes, particularly from the perspective of a population-based study.
  • Data are also limited about the characteristics of patients with AMI who do not receive beta-blockers.
  • This study examines more than 2 decades of trends in the use of beta-blockers in hospitalized patients with AMI.
  • METHODS: Communitywide study of 10,374 patients hospitalized with confirmed AMI in all metropolitan Worcester hospitals during 12 annual periods between 1975 and 1999.
  • After controlling for other prognostic factors, patients treated with beta-blockers were less likely to develop heart failure (adjusted odds ratio [OR], 0.58; 95% confidence interval [CI], 0.53-0.63), cardiogenic shock (OR, 0.46; 95% CI, 0.39-0.54), and primary ventricular fibrillation (OR, 0.84; 95% CI, 0.65-1.08) and were less likely to die (OR, 0.26; 95% CI, 0.22-0.29) during hospitalization than were patients who did not receive this therapy.
  • CONCLUSIONS: The results of this observational study demonstrate encouraging trends in the use of beta-blockers in hospitalized patients with AMI and document the benefits to be gained from this treatment.
  • [MeSH-major] Adrenergic beta-Antagonists / therapeutic use. Myocardial Infarction / drug therapy. Practice Patterns, Physicians' / trends

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  • (PMID = 14557215.001).
  • [ISSN] 0003-9926
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL35434
  • [Publication-type] Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic beta-Antagonists
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